Kinematic variables of gait and quality of life in Parkinsonians after different treadmill trainings: a randomized control trial

The aim of this study was to analyse and compare the effects of gait training on a treadmill associated with partial body weight support (PBWS) or auditory stimulus (AS) and the kinematic variables of gait and quality of life (QOL) in patients with Parkinson's disease (PD). Twenty-one volunteers with PD participated and were divided into: group with PBWS (GPBWS) with AS (GAS), and control group (CG). Soil step length (SL), SL variability (SLV), step width (SW), SW variability (SWV), gait speed (GS), and QOL were evaluated by the Parkinson’s Disease Questionnaire-39 (PDQ-39). The training was performed for six weeks, with three weekly sessions of 30 minutes. The results showed homogeneity of groups (p> 0.05). There was an increase of SW in the GPBWS (p= 0.006) and GS in the GAS (p= 0.048) and decreased PDQ-39 in the CG (p= 0.005) and GAS (p= 0.006). For groups, regardless of evaluation, there were differences in SWV between the GPBWS and GAS (p= 0.030); for evaluations, independently of groups, there were differences in GS (p= 0.048) and PDQ-39 (p= 0.002). It was concluded that, among the studied conditions, there was a significant improvement for the groups: AS in GS and QOL, CG in QOL and GPBWS did not improve. Thus, considering the clinical effect, treadmill training, independently of the stimuli, is clinically advantageous for gait improvements and QOL. The aim of this study was to analyse and compare the effects of gait training on a treadmill associated with partial body weight support (PBWS) or auditory stimulus (AS) and the kinematic variables of gait and quality of life (QOL) in patients with Parkinson's disease (PD). Twenty-one volunteers with PD participated and were divided into: group with PBWS (GPBWS) with AS (GAS), and control group (CG). Soil step length (SL), SL variability (SLV), step width (SW), SW variability (SWV), gait speed (GS), and QOL were evaluated by the Parkinson’s Disease Questionnaire-39 (PDQ-39). The training was performed for six weeks, with three weekly sessions of 30 minutes. The results showed homogeneity of groups (p> 0.05). There was an increase of SW in the GPBWS (p= 0.006) and GS in the GAS (p= 0.048) and decreased PDQ-39 in the CG (p= 0.005) and GAS (p= 0.006). For groups, regardless of evaluation, there were differences in SWV between the GPBWS and GAS (p= 0.030); for evaluations, independently of groups, there were differences in GS (p= 0.048) and PDQ-39 (p= 0.002). It was concluded that, among the studied conditions, there was a significant improvement for the groups: AS in GS and QOL, CG in QOL and GPBWS did not improve. Thus, considering the clinical effect, treadmill training, independently of the stimuli, is clinically advantageous for gait improvements and QOL.

Download Full-text

Feasibility of a Brazilian samba protocol for patients with Parkinson's disease: a clinical non-randomized study

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20190140 ◽

2020 ◽

Vol 78 (1) ◽

pp. 13-20 ◽

Cited By ~ 1

Author(s):

Ana Cristina TILLMANN ◽

Alessandra SWAROWSKY ◽

Clynton Lourenço CORRÊA ◽

Alexandro ANDRADE ◽

Jéssica MORATELLI ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Randomized Study ◽

General Information ◽

Control Group ◽

Action Strategies ◽

And Control ◽

Experimental Group

Abstract Background: New protocols applied in the rehabilitation of Parkinson's disease enable different action strategies for health professionals, as well as a new range of activities for these individuals. However, no valid samba protocol with activity prescription for this population was found in the literature. Objective: To investigate the feasibility of a Brazilian samba protocol in individuals with Parkinson's disease. Methods: Twenty participants, mean age of 66.4±10.7 years, diagnosed with idiopathic Parkinson 's disease, divided into: experimental group that received the intervention of Brazilian samba dance classes (10 individuals); and control group that maintained their routine activities (10 individuals). For data collection, a divided questionnaire was used: General Information; Disability stages scale; Balance and Quality of Life. Results: During class implementation, there were no falls, as all dance activities adhered to the details of the protocol steps without any changes. On average, patients completed 82.7% of activities. After 12 weeks, the experimental group had improvements in the UPDRS global score, in daily activities, and on motor examination. There was also improvement in balance scores and in the mobility domain of the quality of life in the experimental group. Conclusion: The samba protocol seems to be feasible and safe for patients with PD. Moreover, it has pleasant characteristics and offers sufficient physical benefits for combination with drug treatment. There were also benefits in social relationships and as a possible rehabilitation tool in individuals with Parkinson's disease.

Download Full-text

Motor Symptom Asymmetry Predicts Non-motor Outcome and Quality of Life Following STN DBS in Parkinson's Disease

10.21203/rs.3.rs-871480/v1 ◽

2021 ◽

Author(s):

Julie Péron ◽

Philippe Voruz ◽

Jordan Pierce ◽

Kévin Ahrweiller ◽

Claire Haegelen ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Symptom ◽

Control Group ◽

Motor Symptoms ◽

Healthy Control ◽

The Impact ◽

Stn Dbs

Abstract Risk factors for long-term non-motor disorders and quality of life following subthalamic nucleus deep-brain stimulation (STN DBS) have not yet been fully identified. In the present study, we investigated the impact of motor symptom asymmetry in Parkinson’s disease.Data were extracted for 52 patients with Parkinson’s disease (half with left-sided motor symptoms and half with right-sided ones) who underwent bilateral STN and a matched healthy control group. Performances for cognitive tests and neuropsychiatric and quality-of-life questionnaires at 12 months post-DBS were compared with a pre-DBS baseline. Results indicated a deterioration in cognitive performance post-DBS in patients with left-sided motor symptoms. Performances of patients with right-sided motor symptoms were maintained, except for a verbal executive task. These differential effects had an impact on patients’ quality of life. The results highlight the existence of two distinct cognitive profiles of Parkinson’s disease, depending on motor symptom asymmetry. This asymmetry is a potential risk factor for non-motor adverse effects following STN DBS.

Download Full-text

Group-based music intervention in Parkinson’s disease – findings from a mixed-methods study

Clinical Rehabilitation ◽

10.1177/0269215520907669 ◽

2020 ◽

Vol 34 (4) ◽

pp. 533-544

Author(s):

Petra Pohl ◽

Ewa Wressle ◽

Fredrik Lundin ◽

Paul Enthoven ◽

Nil Dizdar

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Freezing Of Gait ◽

Intervention Group ◽

Group Differences ◽

Control Group ◽

Music Intervention ◽

Post Intervention

Objective: To evaluate a group-based music intervention in patients with Parkinson’s disease. Design: Parallel group randomized controlled trial with qualitative triangulation. Setting: Neurorehabilitation in primary care. Subjects: Forty-six patients with Parkinson’s disease were randomized into intervention group ( n = 26), which received training with the music-based intervention, and control group ( n = 20) without training. Interventions: The intervention was delivered twice weekly for 12 weeks. Main measures: Primary outcome was Timed-Up-and-Go subtracting serial 7’s (dual-task ability). Secondary outcomes were cognition, balance, concerns about falling, freezing of gait, and quality of life. All outcomes were evaluated at baseline, post-intervention, and three months post-intervention. Focus groups and individual interviews were conducted with the intervention group and with the delivering physiotherapists. Results: No between-group differences were observed for dual-task ability. Between-group differences were observed for Falls Efficacy Scale (mean difference (MD) = 6.5 points; 95% confidence interval (CI) = 3.0 to 10.0, P = 0.001) and for Parkinson Disease Questionnaire-39 items (MD = 8.3; 95% CI = 2.7 to 13.8, P = 0.005) when compared to the control group post-intervention, but these were not maintained at three months post-intervention. Three themes were derived from the interviews: Expectations versus Results, Perspectives on Treatment Contents, and Key Factors for Success. Conclusion: Patient-reported outcomes and interviews suggest that the group-based music intervention adds value to mood, alertness, and quality of life in patients with Parkinson’s disease. The study does not support the efficacy in producing immediate or lasting gains in dual-tasking, cognition, balance, or freezing of gait.

Download Full-text

Influence of the COVID-19 Pandemic on Quality of Life of Patients with Parkinson’s Disease

Parkinson s Disease ◽

10.1155/2020/1216568 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Dengjun Guo ◽

Bing Han ◽

Yuqiang Lu ◽

Chenling Lv ◽

Xiaoling Fang ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Prevention And Control ◽

Control Period ◽

And Control ◽

Disease Questionnaire ◽

Gradual Release

Introduction. This study investigated the influence of lockdown during the 2019 coronavirus disease (COVID-19) pandemic on the quality of life of patients with Parkinson’s disease (PD). Methods. We conducted a questionnaire survey involving 113 patients with PD from Xihu District, Hangzhou, Zhejiang. During the epidemic prevention and control period (February 1 to March 31, 2020), patients enrolled were asked to fill out questionnaires, including the “COVID-19 Questionnaire for PD Patients during the Period of Epidemic Prevention and Control” and “39-item Parkinson’s Disease Questionnaire (PDQ-39).” During the phase of gradual release of epidemic prevention and control (April 1 to April 30, 2020), all patients were followed up again, and PDQ-39 questionnaires were completed. Results. The quality of life for patients during the period of epidemic prevention and control was worse than that after epidemic prevention and control (P < 0.001). The biggest problem that they faced was that they could not receive their doctor’s advice or guidance regularly. The quality of life of patients who had difficulty getting doctors’ guidance or those who changed their routine medication due to lockdown was even worse. Telemedicine was quite effective and efficient for patients to get doctors’ guidance during lockdown. Conclusions. The inconvenient treatment during the pandemic directly caused the aggravation of patients’ symptoms and the decline in their quality of life. It is suggested that social media (such as WeChat or Tencent QQ) are used for regular interactions and follow-up appointments for patients with inconvenient medical treatment.

Download Full-text

Evaluation of quality of life and psychological aspects of Parkinson's disease patients who participate in a support group

Dementia & Neuropsychologia ◽

10.1590/1980-57642015dn93000013 ◽

2015 ◽

Vol 9 (3) ◽

pp. 295-300 ◽

Cited By ~ 4

Author(s):

Nathalie Ribeiro Artigas ◽

Vera Lúcia Widniczck Striebel ◽

Arlete Hilbig ◽

Carlos Roberto de Mello Rieder

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Social Phobia ◽

Support Group ◽

Neurodegenerative Disorder ◽

Control Group ◽

Asymmetric Distribution ◽

Cross Sectional

Parkinson's disease (PD) is a neurodegenerative disorder that can dramatically impair patient quality of life (QoL). Objective: To analyze the QoL, motor capacity, depression, anxiety and social phobia of individuals who attended a patient support group (PSG) compared to non-participants. Methods: A cross-sectional study was performed. The sample consisted of 20 individuals with PD who attended a PSG and another 20 PD patients who did not attend a support group for PD patients, serving as the control group (nPSG). All patients answered questionnaires on motor capacity (UPDRS), QoL (Parkinson's Disease Questionnaire- PDQ-39), depression (Beck Depression Inventory), anxiety (Beck Anxiety Inventory) and social phobia (Liebowitz Social Anxiety Scale). To determine data distribution, the Shapiro-Wilk test was performed. For comparison of means, Student's t-test was applied. In cases of asymmetry, the Mann-Whitney test was employed. To assess the association between the scales, Pearson's correlation coefficient (symmetric distribution) and Spearman's coefficient (asymmetric distribution) were applied. For the association between qualitative variables, Pearson's Chi-squared test was performed. A significance level of 5% (p≤0.05) was adopted. Results: Individuals in the PSG had a significantly better QoL (p=0.002), and lower depression (p=0.026), anxiety (p<0.001) and social phobia (p=0.01) scores compared to the nPSG. Conclusion: The participation of PD patients in social activities such as support groups is associated with better QoL and fewer symptoms of depression, anxiety and social phobia.

Download Full-text

Effect of physical therapy on posture and quality of life in subject with parkinson\'s disease

IP Journal of Nutrition, Metabolism and Health Science ◽

10.18231/j.ijnmhs.2021.020 ◽

2021 ◽

Vol 4 (3) ◽

pp. 104-115

Author(s):

Nensi Vaibhav Gandhi ◽

Rachana Rabari ◽

Kinjal Rathve ◽

Shreya Patel

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Physical Therapy ◽

Mean Value ◽

Body Posture ◽

Control Group ◽

P Value ◽

Sf 36 ◽

And Control

It is a chronic progressive degenerative disorder of extra pyramidal system caused by loss of dopaminergic neurons in the substantia nigra and characterized by tremors, rigidity, bradykinesia, and disturbance of gait and posture.The neuropsychiatric symptoms of PD may include depression, psychosis, apathy, impulse control disorders that are linked with the poor quality of life due to the progression of disease. Despite, cognitive impairment in PD is of great significance in terms of therapeutic approaches in order to deal with motor deficits of disorder. Multiple studies have revealed that exercise has been proven to be effective for the maintenance of health and well-being in Parkinson’s. More importantly it is shown to play a significant role in addressing secondary prevention based on strength, flexibility, functional independence as well as gait and balance respectively.To evaluate the effect of physical therapy on posture and quality of life in subject with Parkinson’s diseaseSource of Data: Radha multispecielist Hospital, Shreeji Hospital, Parul Shevashram,Venus.Sampaling Method: Convenience,samplingSample Size: 30 subject were included (15 in) each groupsSelection f Sample: convenientStudy Design: experimentalStudy Duration: 30 min/day/7 week(1)Patient with 50 to 75 years of age (2)Participants patient diagnosed with Parkinson’s diseases (3) Both gender are included (4) The participants were at stage 3 of Parkinson’s disease, according the Hoehn and Yahr scale. (1) The examined patients did not have other coexisting neurodegenerative. (2)Mentally challenged (3) Orthopedic deformity. (1) Short form health survey. (20) Body posture questionnaire.This study included 30 patient 18 male and 12 female giving a sex ratio. Mean age of participant was 62 year. There were 15 patients in control group and 15 patients in experimental group. All patients completed treatment and evaluated at baseline and at the end of study. Mean value of sf-36 was 50.59 and 52.59 for experimental and control group respectively. These means later increase to 74.90 and 59.00 respectively with p value 0.001. Mean value of body posture questionnaire was 47.27 and50.07 for experimental and control group respectively. These mean later increase to72.47 and 59 respectively with p value 0.001 Statistically significant change was present for posture and quality of life with p<0.001 for both group.Post intervention assessment will be done by body posture questionnaire and SF-36, for posture and quality of life assessment in 30 subjects meeting inclusion and exclusion criteria dividing in to two group by convenience.Group AGroup BThe obtained results revealed that the influence of applied program had a positive influence on posture and quality of life in people with Parkinson’s disease.When functional movement is applied on a regular basis, improvement of quality of life and everyday life activities can be noticed.

Download Full-text

Drug utilization pattern and analysis of quality of life in Indian patients of Parkinson’s disease

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20194121 ◽

2019 ◽

Vol 8 (9) ◽

pp. 2092

Author(s):

Jugal Shah ◽

Pranav Joshi ◽

Shikha V. Sood ◽

Devang Rana ◽

Supriya D. Malhotra

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Drug Utilization ◽

Memory Loss ◽

Control Group ◽

Anticholinergic Drugs ◽

Psychological Consequences ◽

Utilization Pattern

Background: Parkinson's disease (PD) is a highly debilitating disease characterized by tremors, bradykinesia and rigidity. It leads to lowered self-esteem and psychological consequences which affect quality of life. The aim of this study is to study the drug utilization pattern and assess the quality of life in patients of Parkinson’s Disease.Methods: 40 patients of PD at least 1 month duration and 20 age-based controls were analyzed for quality of life using Parkinson’s Disease Questionnaire-39 (PDQ-39). Drug prescriptions were analyzed.Results: Mean number of anti-Parkinson drugs prescribed is 2.65±1.21. Of 106 anti-Parkinson drugs prescribed, 45% were levodopa and carbidopa combinations, followed by dopamine agonists (18%), anticholinergic drugs (15%), amantadine (12%), MAO inhibitors (5%) and COMT inhibitors (5%). There were significant problems in speech, performance of daily chores and daytime somnolence (p<0.0001). Depression, isolation, cognitive decline and memory loss were noteworthy in the patients as compared to controls (p<0.05). 25% patients felt embarrassed due to their disease; 59% felt affected by others’ opinion, 60% felt difficulty in communicating with others (p<0.05). Almost 2/3rd patients needed help in personal care as compared to the control group (p<0.0001).Conclusions: Quality of life of parkinsonian patients is severely affected in spite of them receiving a large number of drugs. This may be both due to disease progression as well as medication. Levodopa-carbidopa combination is the most prescribed medication. Use of levodopa and carbidopa combination must be evaluated properly. Newer guidelines and interventions are the need of the hour which may provide a better outcome on the quality of life of parkinsonian patients.

Download Full-text

Respiratory muscle strength and lung function in the stages of Parkinson’s disease

Jornal Brasileiro de Pneumologia ◽

10.1590/1806-3713/e20180148 ◽

2019 ◽

Vol 45 (6) ◽

Author(s):

Rejane Barreto dos Santos ◽

Anderson Santos Fraga ◽

Maria das Graças Wanderley de Sales Coriolano ◽

Bruna Ferreira Tiburtino ◽

Otávio Gomes Lins ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Muscle Strength ◽

Lung Function ◽

Motor Function ◽

Respiratory Muscle ◽

Respiratory Muscle Strength ◽

And Control

ABSTRACT Objective: To investigate parameters of lung function and respiratory muscle strength in different stages of Parkinson’s disease (PD), as well as to determine their correlation with motor function and quality of life. Methods: This was a cross-sectional study conducted at a referral center for PD in the city of Recife, Brazil. Respiratory muscle strength and lung function, as well as their relationship with motor function and quality of life, were evaluated in patients with PD, stratified by the level of severity, and were compared with the data obtained for a control group. After confirming the normality of data distribution, we performed one-way ANOVA with a post hoc t-test. Results: The sample comprised 66 individuals, in two groups: PD (n = 49) and control (n = 17). All of the parameters investigated showed inverse correlations with PD severity, and there were significant differences among the levels of severity, as well as between the PD and control groups, in terms of the MIP, MEP, FVC, FEV1, and FEF25-75%. The lung function parameters also showed moderate to weak inverse correlations with bradykinesia and rigidity. On a quality of life questionnaire, the total score and mobility domain score both presented a moderate inverse correlation with FVC, FEV1, PEF, and MEP. Conclusions: Respiratory muscle strength and some lung function parameters are impaired from the early stages of PD onward, bradykinesia and rigidity being the cardinal signs that correlate most strongly with impairment of those parameters. Such alterations negatively affect the quality of life of patients with PD.

Download Full-text

Efficacy of pramipexole combined with levodopa for Parkinson’s disease treatment and their effects on QOL and serum TNF-α levels

Journal of International Medical Research ◽

10.1177/0300060520922449 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052092244

Author(s):

Jinzhong Huang ◽

Wei Hong ◽

Zhilong Yang ◽

Jian Ding ◽

Yi Ren

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mental State ◽

Mini Mental State Examination ◽

Control Group ◽

Study Group ◽

Tnf Α ◽

State Examination

Purpose To investigate the efficacy of combining the dopamine receptor agonist pramipexole with levodopa for Parkinson’s disease (PD) treatment and to measure their effects on quality of life and tumor necrosis factor (TNF)-α levels in PD patients. Basic Procedure In total, 160 PD patients who were admitted to our hospital were equally randomized into a control treatment group (levodopa alone) and the study group (pramipexole combined with levodopa). Both groups were treated for 12 weeks. Findings After treatment, scores from the Unified Parkinson’s Disease Rating Scales (1–3), the Hamilton Depression Scale, and the Parkinson’s Disease Questionnaire (PDQ-39) were significantly decreased in both groups, whereas Mini-Mental State Examination scores were significantly increased. After treatment, the study group had significantly lower scores for all scales except the Mini-Mental State Examination, for which those who received combined treatment had significantly higher scores than the control group. The incidence of adverse reactions was significantly lower in the study group than in the control group. Furthermore, after treatment, serum TNF-α levels were significantly decreased in both groups compared with pre-treatment levels. Conclusion Pramipexole combined with levodopa relieved PD symptoms and improved the quality of life of PD patients, potentially by suppressing serum TNF-α levels.

Download Full-text

A Manipulation of Visual Feedback during Gait Training in Parkinson's Disease

Parkinson s Disease ◽

10.1155/2012/508720 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Quincy J. Almeida ◽

Haseel Bhatt

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Optic Flow ◽

Visual Cues ◽

Step Length ◽

Gait Training ◽

Control Group ◽

Training Interventions ◽

Visual Cueing ◽

Walking Velocity

Visual cues are known to improve gait in Parkinson's disease (PD); however, the contribution of optic flow continues to be disputed. This study manipulated transverse line cues during two gait training interventions (6 weeks). PD subjects (N=42) were assigned to one of three groups: treadmill (TG), overground (OG), or control group (CG). Participants walked across lines placed on either treadmills or 16-meter carpets, respectively. The treadmill (TG) offered a reduced dynamic flow from the environment, while lines presented on the ground (OG) emphasized optic flow related to the participant's own displacement. Both interventions significantly improved (and maintained through retention period) step length, thus improving walking velocity. Only the OG improved in the TUG test, while only the TG showed hints of improving (and maintaining) motor symptoms. Since gait improvements were found in both training groups, we conclude that by reducing optic flow, gait benefits associated with visual cueing training can still be achieved.

Download Full-text