scholarly journals Urban Economy of Orlovskaya and Tambovskaya Guberniyas in the Late 18th-Early 19th Centuries (General Land Survey Data)

2020 ◽  
pp. 62-79
Author(s):  
Dmitrii Anatol'evich Chernenko
Keyword(s):  
Urban Economy ◽  
Early Stage ◽  
Gis Mapping ◽  
Small Enterprises ◽  
Total Size ◽  
Urban Network ◽  
Stage Of Development ◽  
Land Survey ◽  
To Come ◽  
General Land Survey

The article poses a problem of a multi-style character of the urban economy in Russia in the late 18th - early 19th centuries and its reflection in the General Land Survey taken in European Russia at that period. These are the Economic Comments to the General Land Survey which recorded the main parameters of the urban economy within the framework of the unified description program that provide for comparing its agrarian, commercial and industrial components. The study uses the materials of the Economic Comments on 26 cities of two Black Earth Region Guberniyas of Russia – Orlovskaya and Tambovskaya ones. The specificity of the region is determined by its relatively late development and the formation of the urban network within the framework of large defensive projects of the Moscow state. Statistical analysis and GIS-mapping of the Comments data allowed one to come to the following conclusions. This region is commonly characterized by the formation of large agricultural complexes with large (more than 5 thousand desyatins) areas of arable and hay fields surrounding the cities during the General Land Survey. This circumstance significantly increased the area of the city within the framework of the "general urban boundary", but to a much lesser extent influenced the total size of its population. The industry of the cities of the region consisted almost exclusively of small "plants" while big manufacturing production was at its early stage of development and was not dependent on the processes of concentration of small enterprises in individual cities. The function of the cities of the region as centers of trade was much more pronounced. Fairs and/ or weekly auctions were held in most of them. The results of the Economic Comments statistics correlation analysis allow one to assume that further development of the Black Earth Region cities was mainly related to commercial and industrial branches of their economy.

Inhibitors Influencing Plant Enzymes of the Polyamine Biosynthetic Pathway

1989 ◽  
Vol 44 (1-2) ◽  
pp. 49-54 ◽  
Author(s):  
Marbeth Christ ◽  
Hansruedi Felix ◽  
Jost Harr
Keyword(s):  
Biosynthetic Pathway ◽  
Early Stage ◽  
Arginine Decarboxylase ◽  
Polyamine Biosynthesis ◽  
Polyamine Synthesis ◽  
Adenosylmethionine Decarboxylase ◽  
Stage Of Development ◽  
Decarboxylase Inhibitors ◽  
Plant Enzymes ◽  
To Come

Absract Several enzymes involved in polyamine biosynthesis namely ornithine, arginine and S-adenosylmethionine decarboxylase as well as spermidine synthase, were analyzed in partially purified wheat extracts. For all enzymes effective inhibitors were found. Among them the most interesting was l-aminooxy-3-aminopropane, which inhibited all three decarboxylases. Classical polyamine biosynthesis inhibitors like difluoromethylornithine, difluoromethylarginine. methyl glyoxal bis- (guanylhydrazone) and cyclohexylamine were also inhibitory on plant enzymes. A remarkable difference in the amount of arginine and ornithine decarboxylase existed in wheat. Arginine decarboxylase seems to be more important at least during the early stage of development. Influence of polyamine synthesis inhibitors on polyamine levels is more likely to come from arginine decarboxylase inhibitors. As inhibitors of all essential enzymes involved in plant polyamine biosynthesis were found, the study of the importance of polyamines in plant physiology will be considerably facilitated.

The Application of UX Research in New Energy Vehicle Innovation

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Menghan TAO ◽  
Ning XIAO ◽  
Xingfu ZHAO ◽  
Wenbin LIU
Keyword(s):  
Early Stage ◽  
Rapid Expansion ◽  
The Other ◽  
Innovative Product ◽  
Stage Of Development ◽  
New Energy ◽  
New Energy Vehicle ◽  
The One ◽  
New Energy Vehicles ◽  
Degree Of Innovation

New energy vehicles(NEV) as a new thing for sustainable development, in China, on the one hand has faced the rapid expansion of the market; the other hand, for the new NEV users, the current NEVs cannot keep up with the degree of innovation. This paper demonstrates the reasons for the existence of this systematic challenge, and puts forward the method of UX research which is different from the traditional petrol vehicles research in the early stage of development, which studies from the user's essence level, to form the innovative product programs which meet the needs of users and being real attractive.

scholarly journals Learning health systems in primary care: a systematic scoping review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Danielle M. Nash ◽  
Zohra Bhimani ◽  
Jennifer Rayner ◽  
Merrick Zwarenstein
Keyword(s):  
Primary Care ◽  
Quality Improvement ◽  
Health Systems ◽  
Scoping Review ◽  
Early Stage ◽  
Point Of Care ◽  
The United States ◽  
Stage Of Development ◽  
Integrated Health ◽  
Google Search

Abstract Background Learning health systems have been gaining traction over the past decade. The purpose of this study was to understand the spread of learning health systems in primary care, including where they have been implemented, how they are operating, and potential challenges and solutions. Methods We completed a scoping review by systematically searching OVID Medline®, Embase®, IEEE Xplore®, and reviewing specific journals from 2007 to 2020. We also completed a Google search to identify gray literature. Results We reviewed 1924 articles through our database search and 51 articles from other sources, from which we identified 21 unique learning health systems based on 62 data sources. Only one of these learning health systems was implemented exclusively in a primary care setting, where all others were integrated health systems or networks that also included other care settings. Eighteen of the 21 were in the United States. Examples of how these learning health systems were being used included real-time clinical surveillance, quality improvement initiatives, pragmatic trials at the point of care, and decision support. Many challenges and potential solutions were identified regarding data, sustainability, promoting a learning culture, prioritization processes, involvement of community, and balancing quality improvement versus research. Conclusions We identified 21 learning health systems, which all appear at an early stage of development, and only one was primary care only. We summarized and provided examples of integrated health systems and data networks that can be considered early models in the growing global movement to advance learning health systems in primary care.

scholarly journals Experts’ opinion on the detection and management of prediabetes in Lebanon

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110294
Author(s):  
Emile Andari ◽  
Paola Atallah ◽  
Sami Azar ◽  
Akram Echtay ◽  
Selim Jambart ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preliminary Report ◽  
Early Stage ◽  
National Guidelines ◽  
Lifestyle Modifications ◽  
Multiple Tests ◽  
Lebanese Population ◽  
To Come ◽  
Near Future

Given that the complications of type 2 diabetes can start at an early stage, early detection and appropriate management of prediabetes are essential. We aimed to develop an expert opinion on prediabetes in Lebanon to pave the way for national guidelines tailored for the Lebanese population in the near future. A panel of seven diabetes experts conducted a thorough literature review and discussed their opinions and experiences before coming up with a set of preliminary recommendations for the detection and management of prediabetes in Lebanon. Lebanese physicians employ multiple tests for the diagnosis of prediabetes and no national cut-off values exist. The panel agreed that prediabetes screening should be focused on patients exceeding 45 years of age with otherwise no risk factors and on adults with risk factors. The panel reached that fasting plasma glucose (FPG) and HbA1c should be used for prediabetes diagnosis in Lebanon. FPG values of 100–125 mg/dL or HbA1c values of 5.7%–6.4% were agreed upon as indicative of prediabetes. For the management of prediabetes, a three-step approach constituting lifestyle modifications, pharmacological treatment and bariatric surgery is recommended. There should be more focus on research on prediabetes in Lebanon. This preliminary report will be further discussed with the Lebanese Society of Endocrinology, Diabetes and Lipids in 2021 in order to come up with the first Lebanese national guidelines for the detection and management of prediabetes in Lebanon.

scholarly journals Open Research Data and Open Peer Review: Perceptions of a Medical and Health Sciences Community in Greece

Publications ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 14
Author(s):  
Eirini Delikoura ◽  
Dimitrios Kouis
Keyword(s):  
Peer Review ◽  
Evaluation System ◽  
Early Stage ◽  
Open Science ◽  
Health Sciences ◽  
Research Data ◽  
Stage Of Development ◽  
Open Research ◽  
Proper Training ◽  
To Receive

Recently significant initiatives have been launched for the dissemination of Open Access as part of the Open Science movement. Nevertheless, two other major pillars of Open Science such as Open Research Data (ORD) and Open Peer Review (OPR) are still in an early stage of development among the communities of researchers and stakeholders. The present study sought to unveil the perceptions of a medical and health sciences community about these issues. Through the investigation of researchers` attitudes, valuable conclusions can be drawn, especially in the field of medicine and health sciences, where an explosive growth of scientific publishing exists. A quantitative survey was conducted based on a structured questionnaire, with 179 valid responses. The participants in the survey agreed with the Open Peer Review principles. However, they ignored basic terms like FAIR (Findable, Accessible, Interoperable, and Reusable) and appeared incentivized to permit the exploitation of their data. Regarding Open Peer Review (OPR), participants expressed their agreement, implying their support for a trustworthy evaluation system. Conclusively, researchers need to receive proper training for both Open Research Data principles and Open Peer Review processes which combined with a reformed evaluation system will enable them to take full advantage of the opportunities that arise from the new scholarly publishing and communication landscape.

scholarly journals Primary Care Networks and Starfield’s 4Cs: A Case for Enhanced Chronic Disease Management

2021 ◽  
Vol 18 (6) ◽  
pp. 2926
Author(s):  
Chuan De Foo ◽  
Shilpa Surendran ◽  
Geronimo Jimenez ◽  
John Pastor Ansah ◽  
David Bruce Matchar ◽  
...  
Keyword(s):  
Primary Care ◽  
Chronic Disease ◽  
Disease Management ◽  
Chronic Disease Management ◽  
Early Stage ◽  
Healthcare Delivery ◽  
Stage Of Development ◽  
Facilitators And Barriers ◽  
Design Options ◽  
First Contact

The primary care network (PCN) was implemented as a healthcare delivery model which organises private general practitioners (GPs) into groups and furnished with a certain level of resources for chronic disease management. A secondary qualitative analysis was conducted with data from an earlier study exploring facilitators and barriers GPs enrolled in PCN’s face in chronic disease management. The objective of this study is to map features of PCN to Starfield’s “4Cs” framework. The “4Cs” of primary care—comprehensiveness, first contact access, coordination and continuity—offer high-quality design options for chronic disease management. Interview transcripts of GPs (n = 30) from the original study were purposefully selected. Provision of ancillary services, manpower, a chronic disease registry and extended operating hours of GP practices demonstrated PCN’s empowering features that fulfil the “4Cs”. On the contrary, operational challenges such as the lack of an integrated electronic medical record and disproportionate GP payment structures limit PCNs from maximising the “4Cs”. However, the enabling features mentioned above outweighs the shortfalls in all important aspects of delivering optimal chronic disease care. Therefore, even though PCN is in its early stage of development, it has shown to be well poised to steer GPs towards enhanced chronic disease management.

The magic bullet for rural development? Exploring the impacts of community telecenters in Bangladesh

2021 ◽  
pp. 026666692199750
Author(s):  
Noore Alam Siddiquee ◽  
Md Gofran Faroqi
Keyword(s):  
Service Delivery ◽  
Rural Areas ◽  
Early Stage ◽  
Rural Livelihoods ◽  
Value Added ◽  
Magic Bullet ◽  
Government Information ◽  
Individual Interviews ◽  
Stage Of Development ◽  
Marginalized Groups

This paper explores the impacts of Bangladesh’s Union Digital Centers (UDCs) as government information and service delivery hubs in rural areas. Drawing on user-surveys and semi-structured individual interviews it demonstrates that the UDCs have produced generally positive yet modest impacts on governance of service delivery. It shows that the UDCs are at an early stage of development, and that they offer only a limited set of services. While they helped extend ICT-enabled services to sections of population that would otherwise have missed them, the UDCs do not have much to do with rural livelihoods and empowerment of the poor and marginalized groups. These findings point to current inadequacies and pitfalls of the UDC approach to development. We argue that enhanced viability and effectiveness of the UDC experiment would warrant embedding more value-added governmental services and further strengthening of their capacity, mandate, and connectivity with government agencies at various levels, among others.

Targets, triggers, and directionality in non-local and local place assimilation in child and adult language

2014 ◽  
Vol 50 (3) ◽  
pp. 273-307
Author(s):  
Mi-Hui Cho ◽  
Shinsook Lee
Keyword(s):  
Longitudinal Study ◽  
Early Development ◽  
Early Stage ◽  
Decisive Role ◽  
Diary Study ◽  
Consonant Harmony ◽  
Stage Of Development ◽  
Place Assimilation ◽  
Korean Child ◽  
Non Local

Abstract Data collected from one Korean child in a longitudinal diary study present novel patterns of consonant harmony in that labials, coronals, and velars can be triggers and targets of both progressive and regressive non-local place assimilation in an early stage of development. The same child also shows some cases of local regressive place assimilation. In another study where 4 children's data were gathered from a naturalistic longitudinal study, local regressive place assimilation as well as conso-nant harmony is witnessed regardless of place features. In adult Korean, however, only coronal to labial/velar and labial to velar local regressive assimilation occurs. This paper argues that the non-local and local place assimilation is connected and shows that the connection can be accounted for in terms of different constraint rankings within the Optimality-theoretic framework. More specifically, it is shown that the Ident-Onset(place) constraint plays a decisive role even in the early stage of acquisition, unlike child English, accounting for the predominant regressive assimilation. Also, the Agree-Place constraint is exploded into two sub-constraints in Stage 3, capturing the asymmetrical behavior of assimilation. Further, the unranking of place features in early development gradually evolves to the fixed ranking which reflects the universal markedness hierarchy in adult Korean.

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