scholarly journals Current Progress in the Treatment of Metaplastic Breast Carcinoma

2013 ◽  
Vol 14 (11) ◽  
pp. 6221-6225 ◽  
Author(s):  
Qing Hu ◽  
Wei-Xian Chen ◽  
Shan-Liang Zhong ◽  
Jian Li ◽  
Zhou Luo ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Metaplastic Breast Carcinoma

Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast

2019 ◽  
Vol 15 (3) ◽  
pp. 338-348
Author(s):  
Hale Aydin ◽  
Bahar Guner ◽  
Isil Esen Bostanci ◽  
Nazan Ciledag ◽  
Melda Boyacioglu Bulut ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Multimodality Imaging ◽  
Metaplastic Carcinoma ◽  
Imaging Features ◽  
Mri Findings ◽  
Radiologic Findings ◽  
Round Shape ◽  
Malignant Feature ◽  
Imaging Results ◽  
Metaplastic Breast Carcinoma

Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma. Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results. Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients. Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.

scholarly journals Diagnostic utility of snail in metaplastic breast carcinoma

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Aziza Nassar ◽  
Nicole Sookhan ◽  
Marta Santisteban ◽  
Sandra C Bryant ◽  
Judy C Boughey ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Diagnostic Utility ◽  
Metaplastic Breast Carcinoma

Spindle Cell Metaplastic Breast Carcinoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Vithya Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Nazimah Ab Mumin ◽  
Kartini Rahmat
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Final Diagnosis ◽  
Spindle Cell Carcinoma ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Breast Lump ◽  
Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

scholarly journals Metaplastic Carcinoma of the Breast with Neuroectodermal Stromal Component

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tibor Tot ◽  
Juan José Badani De La Parra ◽  
Leif Bergkvist
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Brain Metastases ◽  
Lymph Node Metastases ◽  
Metaplastic Carcinoma ◽  
Unique Case ◽  
Carcinoma Of The Breast ◽  
Stromal Component ◽  
Node Metastases ◽  
Metaplastic Breast Carcinoma

A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

Metaplastic breast carcinoma: tumour histogenesis or dedifferentiation?

2011 ◽  
Vol 224 (4) ◽  
pp. 434-437 ◽  
Author(s):  
Carolien HM van Deurzen ◽  
Andrew HS Lee ◽  
Muhammad S Gill ◽  
Marian BE Menke-Pluijmers ◽  
Agnes Jager ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Metaplastic Breast Carcinoma

scholarly journals Triple negative mixed metaplastic breast carcinoma with squamous and spindle cells in an 84-year-old woman: a rare entity with unclear management strategy and poor prognosis

2012 ◽  
Vol 2012 (feb25 1) ◽  
pp. bcr1020115044-bcr1020115044 ◽  
Author(s):  
S. Murukutla ◽  
V. R. Bhatt ◽  
A. Vivekanandarajah ◽  
C. Coomer ◽  
S. Gupta
Keyword(s):  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Management Strategy ◽  
Triple Negative ◽  
Rare Entity ◽  
Spindle Cells ◽  
Metaplastic Breast Carcinoma

scholarly journals Oral Metastasis of Metaplastic Breast Carcinoma in a Patient with Neurofibromatosis 1

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Paula Molina Vivas ◽  
Luana Eschholz Bomfin ◽  
Clovis Antonio Lopes Pinto ◽  
Ulisses Ribaldo Nicolau ◽  
Fabio Abreu Alves
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
English Literature ◽  
Neurofibromatosis Type ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Increased Risk ◽  
Multiple Metastases ◽  
Metaplastic Breast Carcinoma ◽  
Oral Metastasis

Neurofibromatosis type 1 (NF1) has been associated with an increased risk for development of malignancy, especially malignant peripheral nerve sheath tumors. In addition, recently, literature has demonstrated an increased risk of breast cancer in women with NF1. The present paper shows a 53-year-old woman with NF1 who presented with metaplastic breast carcinoma and developed multiple metastases, including mandible. Furthermore, we reviewed the English literature, found 63 cases showing the association between NF1 and breast cancer, and added one more case. The present study demonstrated an important association between NF1 and breast cancer. Until the present time, there has been only one case of metaplastic breast carcinoma associated with NF1. Curiously, in our case the oral metastasis corresponded to sarcomatous component of metaplastic breast carcinoma.

An unusual case of metaplastic breast carcinoma following neoadjuvant chemotherapy

2011 ◽  
Vol 62 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Giulio Bigotti ◽  
Simona Di Filippo ◽  
Franco Di Filippo ◽  
Pasquale Perri ◽  
Antonella Coli
Keyword(s):  
Breast Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Unusual Case ◽  
Metaplastic Breast Carcinoma
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