Effect of Diabetic Medication on Cardiovascular Risk and Microvascular Complication in Diabetic Patients: Retrospective Cohort Study

Background: New integrative hidradenitis suppurativa (HS) lesion pattern phenotypes have been proposed, an inflammatory phenotype (IP) and a follicular phenotype (FP). They are characterized by different lesion patterns, symptoms, and risks of disease progression. Objectives: To evaluate whether lesion pattern phenotypes (1) have a different cardiovascular risk factor profile, and (2) are associated with a different therapeutic approach in the setting of an HS clinic. Methods: A retrospective cohort study was conducted on 233 patients with HS. They were classified according to lesion pattern phenotype criteria. Data regarding cardiovascular risk factors and treatment decisions were gathered. Results: One hundred and seventeen HS patients (50.21%) were classified as FP and 112 (48.07%) as IP. IP was associated with more severe disease and greater impairment of quality of life. Regardless of disease severity, patients with IP may have a higher cardiovascular risk, assessed according to higher C-reactive protein (CRP) levels (12.75 vs. 5.89, p = 0.059). The lesion pattern phenotype also influenced treatment decisions regardless of disease severity. Patients with IP were more likely to be treated with systemic corticosteroids and adalimumab, showing that lesion pattern phenotypes are associated with different therapeutic approaches. Conclusions: IP is associated with higher CRP values, suggesting a greater cardiovascular risk in these patients and also a different therapeutic approach. This information could help guide dermatologists in the management of HS patients and help to determine future treatment recommendations.

Download Full-text

Role of nurse practitioners in reducing cardiovascular risk factors: a retrospective cohort study

Journal of Clinical Nursing ◽

10.1111/jocn.12889 ◽

2015 ◽

Vol 24 (21-22) ◽

pp. 3077-3083 ◽

Cited By ~ 6

Author(s):

Zalika Klemenc-Ketis ◽

Alenka Terbovc ◽

Bostjan Gomiscek ◽

Janko Kersnik

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Nurse Practitioners ◽

Retrospective Cohort Study ◽

Retrospective Cohort

Download Full-text

Dental implants in diabetic patients: retrospective cohort study reporting on implant survival and risk indicators for excessive marginal bone loss at 5 years

Journal of Oral Rehabilitation ◽

10.1111/joor.12435 ◽

2016 ◽

Vol 43 (11) ◽

pp. 863-870 ◽

Cited By ~ 12

Author(s):

M. de Araújo Nobre ◽

P. Maló ◽

Y. Gonçalves ◽

A. Sabas ◽

F. Salvado

Keyword(s):

Cohort Study ◽

Bone Loss ◽

Dental Implants ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Risk Indicators ◽

Diabetic Patients ◽

Implant Survival ◽

Marginal Bone Loss

Download Full-text

Guideline Concordance of Statin Treatment Decisions: A Retrospective Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm9113719 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3719

Author(s):

Yael Rachamin ◽

Stefan Markun ◽

Thomas Grischott ◽

Thomas Rosemann ◽

Rahel Meier

Keyword(s):

Cohort Study ◽

Cardiovascular Risk ◽

General Practitioners ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Small Deviation ◽

Statin Treatment ◽

Treatment Decisions ◽

High Cardiovascular Risk ◽

Very High

Guidelines recommend initiation of statins depending on cardiovascular risk and low-density lipoprotein cholesterol (LDL-C) levels. In this retrospective cohort study, we aimed to assess guideline concordance of statin treatment decisions and to find determinants of undertreatment in Swiss primary care in the period 2016–2019. We drew on electronic medical records of 8060 statin-naive patients (50.0% female, median age 59 years) with available LDL-C levels and cardiovascular risk. Guideline concordance was assessed based on the recommendations of the European Society of Cardiology, and multilevel logistic regression was performed to find determinants of undertreatment. We found that statin treatment was initiated in 10.2% of patients during one year of follow up. Treatment decisions were classified as guideline-concordant in 63.0%, as undertreatment in 35.8% and as overtreatment in 1.2%. Among determinants of undertreatment were small deviation from LDL-C treatment thresholds (odds ratio per decrease by 1 mmol/L: 2.09 [95% confidence interval 1.87–2.35]), high compared with very high cardiovascular risk (1.64 [1.30–2.05]), female sex (1.31 [1.05–1.64]), and being treated by older general practitioners (per 10 year decrease: 0.74 [0.61–0.90]). In conclusion, undertreatment of patients at high or very high cardiovascular risk was common, but general practitioners considered cardiovascular risk and LDL-C in their treatment decisions.

Download Full-text

Early life factors in relation to cardiovascular risk and cardiovascular disease in old age in Bergen: a Norwegian retrospective cohort study based on the Hordaland Health Study (HUSK)

JRSM Open ◽

10.1177/2054270414527935 ◽

2014 ◽

Vol 5 (7) ◽

pp. 205427041452793

Author(s):

Jens Christoffer Skogen ◽

Robert Stewart ◽

Marit Knapstad ◽

Simon Øverland ◽

Arnstein Mykletun

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Cardiovascular Risk ◽

Old Age ◽

Retrospective Cohort Study ◽

Early Life ◽

Retrospective Cohort ◽

Health Study ◽

Early Life Factors

Download Full-text

Factor Associated with Abnormal Ankle-Brachial Index Among Diabetic Patients in Songklanagarind Hospital: A Retrospective Cohort Study

Journal of Health Science and Medical Research ◽

10.31584/jhsmr.201828 ◽

2018 ◽

Vol 36 (4) ◽

pp. 299 ◽

Cited By ~ 1

Author(s):

Supakorn Sripaew ◽

Thanittha Sirirak

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Coronary Revascularization ◽

Ankle Brachial Index ◽

Smoking History ◽

Diabetic Patients ◽

Coronary Syndrome ◽

Previous Stroke ◽

History Of

Objective: To find the correlation between type 2 diabetic patients who had abnormal ankle-brachial index (ABI) among factors affected diabetes and cardiovascular outcomes including acute coronary syndrome (ACS), myocardial infarction (MI), coronary revascularization stroke, renal replacement therapy, leg revascularization and limb amputation Material and Methods: Retrospective cohort study collecting the data of 548 diabetic patients examined ABI at Outpatient Departments from 1st January 2009 to 31st December 2015. Results: From 548 medical records including only normal-ABI group and low-ABI group, we found that hypertension, chronic kidney disease (CKD), smoking, history of previous MI, history of previous stroke and age were the significant associated factor of low-ABI. The survival analyses revealed the significantly higher rate of ACS, MI, and coronary revascularization in low-ABI group (p-value=0.04, <0.01, <0.01 respectively) after exposed to low-ABI around 4 years. However, the study found no significant difference of other outcomes between the 2 groups. Conclusion: Songklanagarind’s diabetic patients with low-ABI were associated with the significantly higher rate of multiple cardiovascular risk factors including hypertension, CKD, smoking, history of previous MI, history of previous stroke and age and they tend to significantly experience more ACS, MI and coronary revascularization after 4 years exposed to low-ABI.

Download Full-text

Survival Analysis on Time-To-Recovery of Diabetic Patients at Minlik Referral Hospital, Ethiopia: Retrospective Cohort Study

10.21203/rs.3.rs-1015864/v1 ◽

2021 ◽

Author(s):

Assaye Belay ◽

Bizuwork Derebew ◽

Solomon Abebaw

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Intensive Therapy ◽

Rank Test ◽

Diabetic Patients ◽

Fast Blood Glucose Level ◽

Global Test ◽

Oral Agents

Abstract AimThe study aimed to determine the time to recovery of diabetic patients who have been treated in the hospital under follow-up. Subject and MethodsA retrospective cohort study design was carried out. The fast blood glucose level of diabetic patients who are under follow-up in the hospital was measured from 2016 to 2020. One thousand seven hundred diabetic patients were included in the study. Kaplan-Meier, Log-rank test, global test, Schoenfeld residuals, and Cox-PH model were used for statistical analysis.ResultsOut of the total of 1278 patients, 27.4% were censored (withdrawal from follow-up) and 72.6% recovered from the diabetic disease. For sex, the expected hazard is 1.322 times higher in males than female diabetic patients or there is a 32.2% increase in the expected hazard in males relative to female diabetic patients. For Spdrt, The expected hazard is 1.164 times higher in the patients who had taken leute than diabetic patients who took doanied. For regimen, the expected hazard is 1.495 times higher in the patients who had been treated by insulin agent only than diabetic patients who were treated by oral agents only ConclusionThe intensive-therapy regimen, Spdrt, and gender differences were statistically significant and critically contribute to the survival time to recovery of diabetic patients.

Download Full-text

Anemia in Diabetic Patients without Underlying Nephropathy. a Retrospective Cohort Study

Blood ◽

10.1182/blood.v128.22.4809.4809 ◽

2016 ◽

Vol 128 (22) ◽

pp. 4809-4809

Author(s):

Ali R. Mahjoub ◽

Eshan Patel ◽

Sami Ali ◽

Kendal Webb ◽

Alan Astrow ◽

...

Keyword(s):

Cohort Study ◽

Kidney Function ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Deficiency Anemia ◽

Diabetic Patients ◽

Normal Kidney ◽

Normal Kidney Function ◽

Patients With Diabetes ◽

Prevalence Of Anemia

Background: Anemia (defined by the World Health Organization as a hemoglobin level of less than 13 mg/dl in men and less than 12 mg/dl in women) is common in diabetic patients, particularly in those with reduced renal function. Most studies attribute anemia in diabetic patients to kidney function impairment. There are no controlled systematic studies of the prevalence and predictors of anemia in patients with diabetes in the absence of overt nephropathy. Objective: This retrospective cohort study was designed to measure the prevalence of anemia in diabetic patients with normal kidney function (estimated glomerular filtration rate (EGFR) greater than 90 ml/min/1.73 m2 and negative micro albuminuria) and compare it to a control group of non-diabetic patients. The study was designed to investigate diabetes as an independent risk for causing anemia. Methods: We undertook a retrospective review of medical records of 400 patients (older than 18 years old) visiting the outpatient clinic in our institution between January and June 2015. 200 patients with diabetes (glycosylated hemoglobin (HgA1C) greater than 7) were compared to 200 non-diabetic patients (HgA1C level below 5.6), to identify the prevalence of anemia, with and without kidney disease and any other associated factors. Results:The prevalence of anemia in all diabetic patients was 22% vs. 9% in non-diabetic group (OR: 2.69, 95% CI; 1.49 to 4.86, P = 0.001). Out of the 22% (n = 44) anemic patients, 18 patients had anemia with normal kidney function, out of those; 5 had iron deficiency anemia and one had autoimmune disease, while the remaining 12 patients (6%) did not have any obvious cause of anemia other than diabetes vs. 2 patients (1%) in non-diabetic patients who we did not find any explanation for the their anemia (OR: 6.6, 95% CI; 1.45 to 30, P < 0.015). Conclusion: Most studies have highlighted an association between anemia and nephropathy in diabetic patients. This retrospective cohort study suggests a high incidence of anemia with unidentified pathology in the diabetic population. The mechanism of this anemia is not well understood, although direct glucose toxicity to erythrocyte precursors in the bone marrow or oxidative stress to mature erythrocytes are both possibilities. Prospective study of hemoglobin levels in patients with diabetes may help elucidate the precise mechanism of anemia in this group. Disclosures No relevant conflicts of interest to declare.

Download Full-text