Association between dry eye disease and asthma: a nationwide population-based study

Background Dry eye disease (DED), a chronic ocular disease, is associated with numerous medical issues, including asthma. However, studies on these associations are limited. In this study, we investigated the incidence of DED among patients with asthma and its correlation with other allergic comorbidities. Methods We retrospectively analyzed data from the National Health Insurance Research Database of Taiwan. We compared the data of 41,229 patients with asthma with those of 164,916 sex- and age-matched non-asthma controls. We followed up the patient and control groups from 1998 to 2010, and compared the rate of DED in these two groups. We further analyzed the allergic comorbidities and asthma-related medication use among the patients with asthma to verify whether these factors were associated with DED. Results The patients in the asthma group were more likely to have DED than were the controls (6.35% vs. 4.92%, p < 0.0001). In the asthma group, female had a higher risk of DED (odds ratio (OR) = 1.70, 95% confidence interval (CI) [1.57–1.85]) than males did. After adjustment for sex, age, income, urbanization, and the other two allergic comorbidities, patients with allergic rhinitis (adjusted OR = 1.58, 95% CI [1.46–1.72]) and urticaria (adjusted OR = 1.25, 95% CI [1.12–1.38]) were more likely to have DED, but not patients with atopic dermatitis (adjusted OR = 1.17, 95% CI [0.98–1.40]). Patients with asthma who had prescriptions of leukotriene receptor antagonists (LTRAs) (adjusted OR = 1.29, 95% CI [1.01–1.64]), oral antihistamines (adjusted OR = 2.02, 95% CI [1.84–2.21]), and inhaled corticosteroids (adjusted OR = 1.19, 95% CI [1.04–1.36]) exhibited association with DED. Discussion Our findings reveal that patients with asthma—particularly females—were more likely to have DED, with comorbidities such as allergic rhinitis and urticaria, and prescriptions including LTRAs, antihistamines, and inhaled corticosteroids. The results suggest that in clinical practice, physicians should pay attention to DED, particularly in patients with a high risk of DED.

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Shift Work and Dry Eye Disease in the Korean Working Population: A Population-Based Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105492 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5492

Author(s):

Joonho Ahn ◽

So-Jung Ryu ◽

Jihun Song ◽

Hyoung-Ryoul Kim

Keyword(s):

Shift Work ◽

Dry Eye ◽

Population Based ◽

Cross Sectional Study ◽

Dry Eye Disease ◽

Eye Disease ◽

Chi Square ◽

Cross Sectional ◽

Shift Workers ◽

Chi Square Test

This study aimed to evaluate the association between shift work and dry eye disease (DED) in the general population. The 2011 Korea Health Panel (KHP) was used. Chi-square test and multivariate logistic regression were used to assess the relationship between shift work and DED. Stratification analysis was conducted by sex and age. Overall, the odds ratio (OR) of DED according to shift work did not showed significant results (adjusted OR = 1.230, 95% CI 0.758–1.901). When findings were stratified based on age older or younger than 40 years, the OR of DED increased to 2.85 (95% CI: 1.25–5.90) in shift workers under 40 years of age. Our results show an association between shift work and DED in a group of younger subjects.

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The Development of Dry Eye Disease after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17113829 ◽

2020 ◽

Vol 17 (11) ◽

pp. 3829

Author(s):

Chia-Yi Lee ◽

Kun-Lin Yang ◽

Chi-Chin Sun ◽

Jing-Yang Huang ◽

Hung-Chih Chen ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Dry Eye ◽

Dry Eye Disease ◽

Sinus Surgery ◽

Eye Disease ◽

Cumulative Probability ◽

Control Group ◽

Study Group ◽

Diagnostic Code ◽

Research Database

We aim to evaluate the risk of dry eye disease (DED) occurrence in patients with surgery-indicated chronic rhinosinusitis (CRS) via the national health insurance research database in Taiwan. After exclusion, patients with a diagnostic code of CRS and had received functional endoscopic sinus surgery (FESS) were regarded as having surgery-indicated CRS and enrolled in the study group, then each patient in the study group was age- and gender-matched to four non-CRS patients that served as the control group. The outcome was considered as the development of DED and Cox proportional hazard regression was used for the statistical analysis, which involved multiple potential risk factors of DED. A total of 6076 patients with surgery-indicated CRS that received FESS and another 24,304 non-CRS individuals were enrolled after exclusion. There were 317 and 770 DED events in the study group and the control group during the 16-year follow-up interval, and the study group demonstrated a significantly higher adjusted hazard ratio (1490, 95% confidence intervals (CI): 1.303-1.702) of DED development compared to the control group in the multivariable analysis. In addition, the cumulative probability analysis illustrated a positive correlation of DED occurrence and the disease period of surgery-indicated CRS (p < 0.0001). In the subgroup analysis, both genders revealed a higher but not significant incidence of developing DED in the study group. In conclusion, the existence of surgery-indicated CRS will increase the risk of developing DED, which correlated to the disease interval.

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Association Between Dry Eye Disease and Migraine Headaches in a Large Population-Based Study

JAMA Ophthalmology ◽

10.1001/jamaophthalmol.2019.0170 ◽

2019 ◽

Vol 137 (5) ◽

pp. 532 ◽

Cited By ~ 5

Author(s):

Omar M. Ismail ◽

Zachary B. Poole ◽

Shane L. Bierly ◽

Eric D. Van Buren ◽

Feng-Chang Lin ◽

...

Keyword(s):

Dry Eye ◽

Large Population ◽

Population Based ◽

Dry Eye Disease ◽

Eye Disease ◽

Population Based Study ◽

Migraine Headaches

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Dry Eye Disease and Allergic Conditions: A Korean Nationwide Population-Based Study

American Journal of Rhinology and Allergy ◽

10.2500/ajra.2016.30.4361 ◽

2016 ◽

Vol 30 (6) ◽

pp. 397-401 ◽

Cited By ~ 7

Author(s):

Minkyeong Kim ◽

Jong-Hyun Oh ◽

Choul Yong Park ◽

Sang Wha Lee

Keyword(s):

Dry Eye ◽

Population Based ◽

Dry Eye Disease ◽

Eye Disease ◽

Population Based Study

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Association Between Migraine and Dry Eye Disease: A Nationwide Population-Based Study

Current Eye Research ◽

10.1080/02713683.2016.1262876 ◽

2017 ◽

Vol 42 (6) ◽

pp. 837-841 ◽

Cited By ~ 4

Author(s):

Soonwon Yang ◽

Woojun Kim ◽

Hyun Seung Kim ◽

Kyung-Sun Na ◽

Keyword(s):

Dry Eye ◽

Population Based ◽

Dry Eye Disease ◽

Eye Disease ◽

Population Based Study

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A Brief Overview Presented at Dry Eye University of Inflammation in Chronic Dry Eye Disease

Journal of Dry Eye Disease ◽

10.22374/jded.v3i(sp1).23 ◽

2020 ◽

Vol 3 ((SP1)) ◽

pp. e17-e18

Author(s):

Jerry Robben

Keyword(s):

Chronic Inflammation ◽

Dry Eye ◽

Inflammatory Disease ◽

Chronic Inflammatory Disease ◽

Dry Eye Disease ◽

Eye Disease ◽

Common Enemy ◽

And Control

Inflammation is a common enemy of any chronic inflammatory disease. Dry eye is no different. Once this diagnosis is made, then one of the first objectives is to address and control the chronic inflammation appropriately.

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Gout as a Risk Factor for Dry Eye Disease: A Population-Based Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm8010062 ◽

2019 ◽

Vol 8 (1) ◽

pp. 62 ◽

Cited By ~ 2

Author(s):

Chia-Yi Lee ◽

Hung-Chi Chen ◽

Chi-Chin Sun ◽

Hung-Yu Lin ◽

Ko-Hsiu Lu ◽

...

Keyword(s):

Risk Factors ◽

Dry Eye ◽

Dry Eye Disease ◽

Age Related Macular Degeneration ◽

Eye Disease ◽

Cumulative Probability ◽

Control Group ◽

Study Group ◽

Research Database ◽

Increased Risk

This study evaluated the effect of gout on the risk of dry eye disease (DED) by using the National Health Insurance Research Database (NHIRD). Data for 30,192 gout patients (21,081 men and 9111 women) and 30,192 non-gout patients (21,005 men and 9187 women) were analyzed. Approximately 1 million patients were randomly sampled from the NHIRD registry. After applying exclusion criteria, patients diagnosed with gout were enrolled in the study group. Thereafter, each individual in the study group underwent the matching process via the propensity score with another non-gout individual, which constituted the control group. The main outcome was defined as the development of DED in accordance with the corresponding International Classification of Diseases, Ninth Revision. In addition to DED, other risk factors including age, sex, and urbanization, and several co-morbidities were included in the multivariate model. The incidence of DED with the adjusted hazard ratio (aHR) and cumulative probability were evaluated in the gout and non-gout patients. A total of 2913 DED events were observed in the study group, whereas 2631 DED events were observed in the control group. A higher incidence rate ratio was found in the study group after adjustment (aHR: 1.065). Moreover, the cumulative probability indicated a significantly increased risk of DED in the study group (p = 0.001). The other potential risk factors of DED according to the multivariate analysis include older age, female gender, higher degree of urbanization, keratopathy, age-related macular degeneration, glaucoma, cataract, ischemic heart disease, hyperlipidemia, peripheral vascular disease, chronic pulmonary disease, rheumatic disease, peptic ulcer disease, liver disease, and malignancy. In conclusion, gout increased the risk of DED after adjustment, and the risk is positively correlated to a longer disease period.

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Comorbidities of dry eye disease: a nationwide population-based study

Acta Ophthalmologica ◽

10.1111/j.1755-3768.2010.01993.x ◽

2010 ◽

Vol 90 (7) ◽

pp. 663-668 ◽

Cited By ~ 52

Author(s):

Tsung-Jen Wang ◽

I-Jong Wang ◽

Chao-Chien Hu ◽

Herng-Ching Lin

Keyword(s):

Dry Eye ◽

Population Based ◽

Dry Eye Disease ◽

Eye Disease ◽

Population Based Study

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The global prevalence of dry eye disease and its association with economy: a systematic review

10.21203/rs.2.10986/v1 ◽

2019 ◽

Author(s):

Yu Wan ◽

Mingzhou Zhang ◽

Xuemin Li

Keyword(s):

Dry Eye ◽

Economic Status ◽

National Income ◽

Population Based ◽

Dry Eye Disease ◽

Gdp Per Capita ◽

Eye Disease ◽

Middle Income ◽

Global Prevalence ◽

Per Capita

Abstract Objective To investigate the relationship between the economy and the prevalence of dry eye disease (DED) worldwide. Methods Literature search on PubMed, Cochrane and Embase database was conducted to identify eligible records published from January 2008 to December 2018. Gross domestic product (GDP) per capita and gross national income (GNI) per capita was chosen to evaluate national economic status. Pearson coefficient, linear regression, and t test were performed in the statistical analyses. Results 32 population-based surveys conducted in 17 countries were included, with a total of 184255 subjects. The pooled mean prevalence of DED was 14.6%, and female individuals presented a higher prevalence than males (16.8% versus 11.5%, 𝑃 < 0.001). The prevalence of DED was negatively correlated with GNI per capita (𝑃 < 0.001, r = 0.603) and GDP per capita (𝑃 < 0.001, r = 0.600). Grouped by World Bank Income classifications, the prevalence of DED progressively declined with an increase in economic level from lower-middle-income countries (LMICs) to high-income countries (HICs). Remarkable difference was found between the prevalence of DED in LMICs and that in HICs (𝑃 < 0.001). Conclusions This study suggested a correlation between the economy and the prevalence of DED worldwide. These findings may provide valuable information on the global prevalence of DED from a distinctive epidemiologic perspective.

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