scholarly journals Does Parathyroidectomy Affect the Neutrophil/Lymphocyte Ratio, a Systemic Inflammatory Marker?

Cureus ◽  
2021 ◽  
Author(s):  
Hüseyin Alakuş ◽  
Mustafa Göksu
Keyword(s):  
Inflammatory Marker ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Systemic Inflammatory Marker

Blood Cell Parameters and Predicting Coronary In-Stent Restenosis

Angiology ◽  
2019 ◽  
Vol 70 (8) ◽  
pp. 711-718 ◽  
Author(s):  
Zhichao Wang ◽  
Chi Liu ◽  
Hong Fang
Keyword(s):  
Blood Cell ◽  
Platelet Activation ◽  
Blood Cells ◽  
Inflammatory Marker ◽  
Distribution Width ◽  
Cell Parameters ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Stent Restenosis ◽  
In Stent Restenosis

Major advances in coronary interventional techniques and pharmacotherapy as well as the use of drug-eluting stents (DESs) have considerably reduced the risk of in-stent restenosis (ISR). However, ISR remains a major clinical challenge. Inflammation and platelet activation are important processes that underlie the pathophysiology of ISR. Parameters related to blood cells, entailing both cell count and morphology, are useful markers of the inflammatory response and platelet activation in clinical practice. Recent studies have highlighted several new combined or derived parameters related to blood cells that independently predict ISR after DES implantation. The neutrophil/lymphocyte ratio, an inflammatory marker, is regarded as a predictor of the risk of ISR and the stability of atherosclerotic plaques. The mean platelet volume, a widely used platelet activation parameter, has been shown to be a predictor of the risk of ISR and the efficacy of antiplatelet therapy. Other markers considered include the platelet/lymphocyte ratio, red blood cell distribution width, and platelet distribution width. This review provides an overview of these parameters that may help stratify the risk of coronary angiographic and clinical outcomes related to ISR.

Comparison of the Neutrophil/Lymphocyte Ratio and C-Reactive Protein Levels in Patients With Amputation for Diabetic Foot Ulcers

2017 ◽  
Vol 16 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Hasan Metineren ◽  
Turan Cihan Dülgeroğlu
Keyword(s):  
Diabetic Foot ◽  
Inflammatory Marker ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
C Reactive Protein ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Protein Levels ◽  
Reactive Protein ◽  
Before And After

This study compared the effectiveness of the neutrophil/lymphocyte ratio (NLR) versus C-reactive protein (CRP) for evaluating the prognosis and degree of inflammation in patients with amputation for a diabetic foot ulcer (DFU). This study enrolled 56 patients with amputations for DFU with gangrene and compared the CRP levels and NLR measured before and after surgery. Overall, 24 patients (42%) died within 2 weeks postoperatively. Mortality increased with a preoperative/postoperative CRP difference ≤1.5 ( P < .001) and age 73 years or older ( P < .001). The postoperative NLR was lower than the preoperative value but was not significant as a prognostic or inflammatory marker ( P = .945). An increasing serum CRP level is a significant predictor of mortality. CRP and old age are reliable prognostic factors in patients with DFU.

Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Oktay Bulur ◽  
Doğan Öztürk ◽  
Derun Taner Ertuğrul ◽  
Selim Sayın ◽  
Zeliha Asiltürk ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Sleeve Gastrectomy ◽  
Inflammatory Marker ◽  
Sleep Apnea Syndrome ◽  
Low Grade ◽  
Protective Effects ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Obstructive Sleep ◽  
Important Health

Abstract Objectives Obesity and related diseases have become one of the most important health problems in the modern age. In addition to its clinical use in the treatment of obesity, bariatric surgery reduces obesity-induced inflammation. Neutrophil–lymphocyte ratio (NLR) is a cheap and easily attainable inflammatory marker. The purpose of this study is to show the effect of bariatric surgery on NLR at preoperative and postoperative 3rd, 6th, and 12th months after SG. Methods 298 patients, who underwent sleeve gastrectomy (SG) in general surgery clinic between 2015 and 2017, were included in the study. We excluded the patients younger than 18 years old, and did not have any inflammatory, infectious, hematological, and comorbide diseases such as diabetes mellitus, cardiovascular diseases, ischemic heart disease, hypertension, renal insufficiency, cancer, and respiratory problems like asthma, obstructive sleep apnea syndrome. We evaluated the levels of NLR at preoperative and postoperative 3rd, 6th, and 12th months visits. Results There were a total of 298 adult patients (age: mean 38.6, minimum 18, maximum 69 years old). Of whom 247 were female (82.9%) and 51 were male (17.1%). We found that NLR levels decreased significantly at 3rd, 6th, and 12th month visits after SG (p<0.001). Conclusions We concluded that NLR levels decrease after surgery in a proportional reduction in adipose tissue. The decrease in NLR levels may also be associated with the protective effects of sleeve gastrectomy against low-grade inflammation-related diseases.

scholarly journals Postoperative Inflammatory Marker Surveillance in Colorectal Peritoneal Carcinomatosis

2021 ◽  
Author(s):  
Sasinthiran Thiagarajan ◽  
Joey Wee-Shan Tan ◽  
Siqin Zhou ◽  
Qiu Xuan Tan ◽  
Josephine Hendrikson ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Prognostic Significance ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Cox Proportional Hazard ◽  
Kaplan Meier ◽  
Clinicopathologic Parameters ◽  
Cox Proportional Hazard Regression

Abstract Background The prognostic significance of inflammatory markers in solid cancers is well-established, albeit with considerable heterogeneity. This study sought to investigate the postoperative inflammatory marker trend in peritoneal carcinomatosis (PC), with a focus on colorectal PC (CPC), and to propose optimal surveillance periods and cutoffs. Methods Data were collected from a prospectively maintained database of PC patients treated at the authors’ institution from April 2001 to March 2019. The platelet–lymphocyte ratio (PLR), the neutrophil–lymphocyte ratio (NLR), and the lymphocyte–monocyte ratio (LMR) were collected preoperatively and on postoperative days 0, 1 to 3, 4 to 7, 8 to 21, 22 to 56, and 57 to 90 as averages. Optimal surveillance periods and cutoffs for each marker were determined by maximally selected rank statistics. The Kaplan–Meier method and Cox proportional hazard regression models were used to investigate the association of inflammatory markers with 1-year overall survival (OS) and recurrence-free survival (RFS) using clinicopathologic parameters. Results The postoperative inflammatory marker trend and levels did not differ between the patients with and those without hyperthermic intraperitoneal chemotherapy (HIPEC). Low postoperative LMR (days 4–7), high postoperative NLR (days 8–21), and high postoperative PLR (days 22–56) were optimal for prognosticating poor 1-year OS, whereas high postoperative PLR and NLR (days 57–90) and low postoperative LMR (days 8–21) were associated with poor 1-year RFS. A composite score of these three markers was prognostic for OS in CPC. Conclusions The reported cutoffs should be validated in a larger population of CPC patients. Future studies should account for the inflammatory response profile when selecting appropriate surveillance periods.

scholarly journals Atherosclerosis Is Associated with Neutrophil Lymphocyte Ratio As An Inflammatory Marker in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

2016 ◽  
Vol 24 (1) ◽  
pp. 24-29
Author(s):  
Mohammad Monzurul Alam Bhuiyan ◽  
Tuhin Sultana ◽  
Md Saiful Islam ◽  
Dhiman Borua ◽  
Mostaque Ahmed ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Inflammatory Marker ◽  
Clinical Pathology ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Type 2 Dm ◽  
Artery Disease

Background: Increased neutrophil lymphocyte ratio is associated with major adverse outcomes of cardiac events in type 2 diabetes mellitus (DM) patients.Objective: To assess the NLR as an inflammatory marker in atherosclerosis in type 2 DM patients with coronary artery disease (CAD).Methods: This case control study was conducted in the Department of Clinical Pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for coronary angiography in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (DM with CAD) and 50 controls were Group II (DM without CAD). A 2 ml of blood was collected in EDTA tube from the patients prior to coronary angiogram for complete blood count (CBC) were measured by haematology autoanalyzer, rechecked manually and NLR was calculated in the Department of Clinical Pathology, BSMMU. Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by coronary angiography were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis that was diagnosed by coronary angiography was included in this study as control.Results: NLR was higher in CAD positive group compared to group without CAD negative in type 2 DM patients (2.76 (±0.74) vs. 1.56 (±0.15), p<0.001).Conclusion: With the help of neutrophil lymphocyte ratio we can take preventive measure and precaution to reduce the progression of atherosclerosis in type 2 diabetic patients with coronary artery disease.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 24-29

scholarly journals Neutrophil-Lymphocyte Ratio as a Potential Biomarker for Delirium in the Intensive Care Unit

2021 ◽  
Vol 12 ◽  
Author(s):  
Chai Lee Seo ◽  
Jin Young Park ◽  
Jaesub Park ◽  
Hesun Erin Kim ◽  
Jaehwa Cho ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Early Detection ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Icu Admission ◽  
Potential Biomarker ◽  
Significant Difference

Background: Recognition and early detection of delirium in the intensive care unit (ICU) is essential to improve ICU outcomes. To date, neutrophil-lymphocyte ratio (NLR), one of inflammatory markers, has been proposed as a potential biomarker for brain disorders related to neuroinflammation. This study aimed to investigate whether NLR could be utilized in early detection of delirium in the ICU.Methods: Of 10,144 patients who admitted to the ICU, 1,112 delirium patients (DE) were included in the current study. To compare among inflammatory markers, NLR, C-reactive protein (CRP), and white blood cell (WBC) counts were obtained: the mean NLR, CRP levels, and WBC counts between the initial day of ICU admission and the day of initial delirium onset within DE were examined. The inflammatory marker of 1,272 non-delirium patients (ND) were also comparatively measured as a supplement. Further comparisons included a subgroup analysis based on delirium subtypes (non-hypoactive vs. hypoactive) or admission types (elective vs. emergent).Results: The NLR and CRP levels in DE increased on the day of delirium onset compared to the initial admission day. ND also showed increased CRP levels on the sixth day (the closest day to average delirium onset day among DE) of ICU admission compared to baseline, while NLR in ND did not show significant difference over time. In further analyses, the CRP level of the non-hypoactive group was more increased than that of the hypoactive group during the delirium onset. NLR, however, was more significantly increased in patients with elective admission than in those with emergent admission.Conclusion: Elevation of NLR was more closely linked to the onset of delirium compared to other inflammatory markers, indicating that NLR may play a role in early detection of delirium.

Influence of blood neutrophil to lymphocyte ratio on oncologic outcomes in peritoneal carcinomatosis of appendiceal origin.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14184-e14184
Author(s):  
Kamran Idrees ◽  
Jason Luciano ◽  
Frances Austin ◽  
Magesh Sathaiah ◽  
Lekshmi Ramalingam ◽  
...  
Keyword(s):  
Overall Survival ◽  
Peritoneal Cancer Index ◽  
Inflammatory Marker ◽  
Multivariable Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Oncologic Outcomes ◽  
Peritoneal Cancer ◽  
Lymphocyte Ratio ◽  
The Impact ◽  
Systemic Inflammatory Marker

e14184 Background: The Neutrophil to lymphocyte ratio (NLR), a marker of systemic inflammatory response, is associated with prognosis in various cancers. The aim of this study is to evaluate the association of pre-operative NLR with oncologic outcomes in patients with appendiceal carcinomatosis. Methods: Clinico-pathological data were obtained from a prospectively maintained database of patients with appendiceal carcinomatosis who underwent cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemoperfusion (HIPEC) between 2001 and 2010. Pre-operative absolute neutrophil and lymphocyte counts were used to compute NLR, with elevated NLR defined a priori as >5. Logistic regression modeling and Kaplan-Meier analyses were performed on the available data. Results: 195 patients, with a median age of 54.5 years, underwent CRS and HIPEC. The median follow up time was 1.96 years. There were 41 patients (21%) who had elevated NLR preoperatively. Factors associated with overall survival (OS) were grade (p=0.01), simplified peritoneal cancer index (SPCI) (p=0.013), and age (p=0.02). In patients who did not undergo splenectomy at the time of CRS, elevated NLR, lymph node involvement, SPCI, age and pre-operative albumin were statistically significant predictors of OS on multivariable analysis. None of these factors were significant in patients who underwent splenectomy at the time of CRS. The 5-year overall survival was 57% vs. 31% in patients with NLR<5 compared to NLR>5 respectively (p<0.0001). Time to progression was 30 months compared to 14 months in patients with NLR<5 vs. >5 (p=0.001). Strikingly, the 5-year OS in patients with NLR<5 with or without splenectomy was 63% and 50% compared to patients with NLR>5 with or without splenectomy 37.5% vs. 23%, respectively (p=0.0001). Conclusions: In patients with appendiceal carcinomatosis, pre-operative NLR is a potential systemic inflammatory marker that independently predicts oncologic outcomes. The impact of NLR appears to be influenced by the performance of splenectomy at the time of CRS. Further studies will be required to prospectively validate this systemic inflammatory marker and its interaction with splenectomy.

Neutrophil–lymphocyte ratio – a simple, accessible measure of inflammation, morbidity and prognosis in psychiatric disorders?

2020 ◽  
Vol 28 (4) ◽  
pp. 454-458 ◽  
Author(s):  
Zlatan Zulfic ◽  
Cynthia Shannon Weickert ◽  
Thomas W Weickert ◽  
Dennis Liu ◽  
Nicholas Myles ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Inflammatory Marker ◽  
Psychiatric Research ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Wide Range ◽  
Inflammatory Phenotype ◽  
Inflammatory Processes ◽  
Two Measures ◽  
Psychiatric Conditions

Objective: A narrative review to describe the utility of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker in psychiatric and non-psychiatric disorders and to discuss the potential role of NLR in psychiatric research. Conclusions: NLR is inexpensive and readily available using division of two measures obtained on routine blood testing. NLR is elevated in a number of psychiatric disorders. It can predict morbidity and mortality in a wide range of non-psychiatric conditions, but this has not been confirmed in psychiatric conditions. It can be calculated in large, pre-existing datasets to investigate clinical correlates of inflammatory processes. NLR may have a future role in identifying patients with an inflammatory phenotype who could benefit from adjunctive anti-inflammatory medications.

scholarly journals AB0845 THE COMBINATION OF PLASMA FIBRINOGEN CONCENTRATION AND NEUTROPHIL-LYMPHOCYTE RATIO (F-NLR) AS A NOVEL INFLAMMATORY MARKER OF RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1446.2-1446
Author(s):  
M. Liu ◽  
Z. Huang ◽  
Y. Huang ◽  
Z. Huang ◽  
Q. Huang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Predictive Factor ◽  
Inflammatory Marker ◽  
Plasma Fibrinogen ◽  
Fibrinogen Concentration ◽  
Clinical Value ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Potential Marker

Background:The combined index of fibrinogen and neutrophil-lymphocyte ratio (F-NLR) has recently been reported as a new predictive factor in patients with cancer. However, the fibrinogen and NLR have not been simultaneously evaluated in rheumatoid arthritis (RA).Objectives:This study aimed to explore the clinical value of F-NLR in RA and its relationship with disease activity.Methods:This retrospective study collected 143 RA patients and 82 age- and gender-matched healthy controls. Neutrophil, lymphocyte, monocyte, platelet, fibrinogen, NLR, monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Disease Activity Score of 28 joints-ESR (DAS28-ESR) and other laboratory parameters were recorded. Receiver operating characteristic (ROC) curves were used to defined the optimization cut-off values of fibrinogen and NLR, which were 3.9g/L and 2.42. The F-NLR score was 2 for patients with high fibrinogen (> 3.9g/L) and elevated NLR (> 2.42), while those with one or neither were indexed as 1 or 0. The correlations between F-NLR as well as other inflammatory indexes and DAS28-ESR were measured.Results:The F-NLR score was higher in RA patients than that in healthy individuals (P < 0.05). The proportion of higher F-NLR score increased significantly along with the disease activity (P < 0.05). According to the ROC curve which was conducted to discriminate RA patients from healthy subjects, the area under curve (AUC) of F-NLR (0.803, 95% CI: 0.744 - 0.861) was higher than that of fibrinogen (0.735, 95% CI: 0.670 - 0.801), NLR (0.724, 95% CI: 0.655 - 0.794), MLR (0.687, 95% CI: 0.615 - 0.759) and PLR (0.732, 95% CI: 0.664 - 0.800). Furthermore, F-NLR was more strongly associated with DAS28-ESR (r = 0.572, P < 0.001) when compared with fibrinogen (r = 0.518, P < 0.001), NLR (r = 0.365, P < 0.001), MLR (r = 0.140, P = 0.096), PLR (r = 0.239, P = 0.004), CRP (r = 0.539, P < 0.001) and ESR (r = 0.487, P < 0.001).Conclusion:The results demonstrated that the F-NLR score was elevated in RA patients. The F-NLR score may be a potential marker to monitor the disease activity of RA patients.References:[1]Wang H, Zhao J, Zhang M, Han L, Wang M, Xingde L. The combination of plasma fibrinogen and neutrophil lymphocyte ratio (F-NLR) is a predictive factor in patients with resectable non small cell lung cancer. J Cell Physiol. 2018 May; 233(5):4216-4224.Disclosure of Interests:None declared

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