scholarly journals Chronic Osteomyelitis of Skull due to Pseudomonas aeruginosa : A Delayed Uncommon Complication Following Craniotomy

2016 ◽  
Author(s):  
Swati Khullar
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Chronic Osteomyelitis ◽  
Uncommon Complication

scholarly journals Bacterial resistance trends among intraoperative bone culture of chronic osteomyelitis in an affiliated hospital of South China for twelve years

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xianghong Zhang ◽  
Qiong Lu ◽  
Tang Liu ◽  
Zhihong Li ◽  
Weiliang Cai
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
South China ◽  
Chronic Osteomyelitis ◽  
Enterobacter Cloacae ◽  
Bone Culture ◽  
Acinetobacter Baumanii ◽  
Unified Protocol ◽  
Positive Rate

Abstract Background The purpose of this study was to gather temporal trends on bacteria epidemiology and resistance of intraoperative bone culture from chronic ostemyelitis at an affiliated hospital in South China. Method Records of patients with chronic osteomyelitis from 2003 to 2014 were retrospectively reviewed. The medical data were extracted using a unified protocol. Antimicrobial susceptibility testing was carried out by means of a unified protocol using the Kirby-Bauer method, results were analyzed according to Clinical and Laboratory Standards Institute definitions. Result Four hundred eighteen cases met our inclusion criteria. For pathogen distribution, the top five strains were Staphylococcus aureus (27.9%); Pseudomonas aeruginosa (12.1%); Enterobacter cloacae (9.5%); Acinetobacter baumanii (9.0%) and Escherichia coli (7.8%). Bacterial culture positive rate was decreased significantly among different year-groups. Mutiple bacterial infection rate was 28.1%. One strain of Staphylococcus aureus was resistant to linezolid and vancomycin. Resistance of Pseudomonas aeruginosa stains to Cefazolin, Cefuroxime, Cefotaxime, and Cefoxitin were 100% nearly. Resistance of Acinetobacter baumanii stains against Cefazolin, Cefuroxime were 100%. Ciprofloxacin resistance among Escherichia coli isolates increased from 25 to 44.4%. On the contrary, resistance of Enterobacter cloacae stains to Cefotaxime and Ceftazidime were decreased from 83.3 to 36.4%. Conclusions From 2003 to 2014, positive rate of intraoperative bone culture of chronic osteomyelitis was decreased; the proportion of Staphylococcus aureus was decreased gradually, and our results indicate the importance of bacterial surveilance studies about chronic osteomyelitis.

scholarly journals SalmonellaTyphi Vertebral Osteomyelitis and Epidural Abscess

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Hau Wei Khoo ◽  
Ying Ying Chua ◽  
John L. T. Chen
Keyword(s):  
Epidural Abscess ◽  
Chronic Osteomyelitis ◽  
Vertebral Osteomyelitis ◽  
Neurological Deficits ◽  
Lower Back ◽  
Wound Culture ◽  
Segmental Instrumentation ◽  
Thoracic And Lumbar Spine ◽  
Antibiotics Susceptibility ◽  
Uncommon Complication

Salmonellavertebral osteomyelitis is an uncommon complication ofSalmonellainfection. We report a case of a 57-year-old transgender male who presented with lower back pain for a period of one month following a fall. Physical examination only revealed tenderness over the lower back with no neurological deficits. MRI of the thoracic and lumbar spine revealed a spondylodiscitis at T10-T11 and T12-L1 and right posterior epidural collection at the T9-T10 level. He underwent decompression laminectomy with segmental instrumentation and fusion of T8 to L3 vertebrae. Intraoperatively, he was found to have acute-on-chronic osteomyelitis in T10 and T11, epidural abscess, and discitis in T12-L1. Tissue and wound culture grewSalmonellaTyphi and with antibiotics susceptibility guidance he was treated with intravenous ceftriaxone for a period of six weeks. He recovered well with no neurological deficits.

scholarly journals Activity of isolated specific bacteriophage in treatment of chronic osteomyelitis induced by multiple drug resistance Pseudomonas aeruginosa in Rabbits

2018 ◽  
Vol 41 (2) ◽  
pp. 146-156
Author(s):  
Sarhan Rashid Sarhan
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Chronic Osteomyelitis ◽  
Multiple Drug Resistance ◽  
Inflammatory Cells ◽  
Treated Group ◽  
Sewage Water ◽  
Multiple Drug ◽  
In Vivo Evaluation ◽  
Specific Bacteriophage

     This study was conducted to find out the possibility of using the Pseudomonas aeruginosa specific-bacteriophage as an alternative to antibiotics in treatment of chronic osteomyelitis in rabbits by injection of Pseudomonas aeruginosa suspension in tibia. The current study included an isolation of bacteriophage from sewage water by using agar overlay method and also an isolation of the bacteria from patients suffering from post-traumatic bone infection. The second experiment was in-vivo evaluation of phage activity in treatment of chronic osteomyelitis in rabbits. All animals of infected groups with Pseudomonas aeruginosa before treatment exhibited histopathological changes after 35 days of infection, the infected groups showed chronic osteomyelitis represented by sever chronic inflammatory cells infiltrates mainly lymphocytes, and macrophages and hemorrhage between bone trabeculae, also some sections showed extensive fibrosis in the marrow spaces. The treated group with P. aeruginosa specific – bacteriophage (1.5 ×107) PFU/ml for 10 days showed early repair elucidated by presence whorls of chondrocytes, and also the presence of multiple osteoblasts indicated bone formations. Also the presence of extensive fibrosis in the marrow space with present of osteoblasts indicated bone formations and repair.

CHARACTERISTICS OF ORGANIC ORGANISMS ABLE TO CAUSE ACUTE AND CHRONIC EXPERIMENTAL OSTEOMYELITIS

2021 ◽  
Vol 2 (1) ◽  
pp. 14-19
Author(s):  
Vali Ergashev ◽  
◽  
Nekkadam Nuraliev
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Laboratory Animal ◽  
Chronic Osteomyelitis ◽  
Laboratory Animals ◽  
Experimental Osteomyelitis

The goal was to selectinfectious strains of microorganisms for the formation of experimental acute and chronic osteomyelitis. For this purpose,Staphylococcus aureus and Pseudomonas aeruginosa were selected. They were introduced 2 times in the amount of 6x109 mt / ml in each laboratory animal. Microbiological, clinical, and morphological signs of experimental acute and chronic osteomyelitis were observed in the pathological focus.Keywords: acute and chronic experimental osteomyelitis, laboratory animals, strains of microorganisms

scholarly journals Bacteriophages as Adjuvant to Antibiotics for the Treatment of Periprosthetic Joint Infection Caused by Multidrug-Resistant Pseudomonas aeruginosa

2019 ◽  
Vol 64 (1) ◽  
Author(s):  
Tamta Tkhilaishvili ◽  
Tobias Winkler ◽  
Michael Müller ◽  
Carsten Perka ◽  
Andrej Trampuz
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Side Effects ◽  
Periprosthetic Joint Infection ◽  
Chronic Osteomyelitis ◽  
Joint Infection ◽  
Multidrug Resistant ◽  
Bacteriophage Therapy ◽  
Content Type ◽  
Phage Treatment

ABSTRACT We documented the adjunctive bacteriophage therapy to treat a chronic relapsing periprosthetic joint infection of the knee and chronic osteomyelitis of the femur caused by multidrug-resistant Pseudomonas aeruginosa. The combined antibiotic-phage treatment eradicated the infection, and no side effects to phages were observed.

scholarly journals Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient

2019 ◽  
Vol 64 (4) ◽  
Author(s):  
Zain I. Alamarat ◽  
Jessica Babic ◽  
Truc T. Tran ◽  
Susan H. Wootton ◽  
An Q. Dinh ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Chronic Osteomyelitis ◽  
Polymyxin B ◽  
Adolescent Male ◽  
Drug Resistant ◽  
Content Type ◽  
Extensively Drug Resistant ◽  
Extended Spectrum

ABSTRACT We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying blaNDM-1 and an extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.

scholarly journals An uncommon organism causing necrotizing pneumonia in a toddler

2021 ◽  
Vol 8 (12) ◽  
pp. 1990
Author(s):  
Manju Reka S. B. ◽  
Arulkumaran Arunagirinathan ◽  
Anupriya Chandrasekaran ◽  
Yuvarajan S.
Keyword(s):  
Computed Tomography ◽  
Pseudomonas Aeruginosa ◽  
Bronchoalveolar Lavage ◽  
Bacterial Pneumonia ◽  
Severe Pneumonia ◽  
Poor Response ◽  
Paediatric Population ◽  
Necrotizing Pneumonia ◽  
First Line ◽  
Uncommon Complication

Necrotizing pneumonia (NP) is an uncommon complication of bacterial pneumonia in children, which must be looked into if a severe pneumonia has poor response to recommended antibiotics. The present case is a toddler with NP in whom fever and cough persisted despite treatment with first-line antimicrobial therapy, computed tomography (CT) scan revealed consolidation with multiple cavities, pseudomonas aeruginosa was the pathogen isolated from bronchoalveolar lavage, which a very uncommon organism is causing NP. Community acquired necrotizing pneumonia caused by pseudomonas is not reported in paediatric population. Hence, we report this case.

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