scholarly journals EVALUATION OF ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACTS OF ROOT AND STEM OF GMELINA ARBORIA ROXB. IN STREPTOZOCIN INDUCED DIABETIC RATS

2015 ◽  
Vol 6 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Satish Chand Gupta ◽  
Subhash Chand Yadav ◽  
Trilok Chand
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Methanolic Extracts

Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats

2019 ◽  
Vol 5 (2) ◽  
pp. 126-131
Author(s):  
C.K. Tyagi ◽  
Pawan Porwal ◽  
Neeraj Mishra ◽  
Amit Sharma ◽  
A. Chandekar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Elevated Serum ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Thuja Occidentalis ◽  
Methanolic Extracts ◽  
Elevated Serum Cholesterol

Objective and Background: In hyperglycemic and alloxan-induced diabetic rats, the effect of Thuja occidentalis methanolic residue extract on blood glucose levels and some biochemical parameters were investigated. Methods: Significantly decreased blood glucose level by 22.85% and 27.66%, in hyperglycemic rats, respectively after 3 h, were seen in a single oral administration of the extract at a dose of 200 and 400 mg/kg. Blood glucose level was decreased by 50% in alloxan-induced diabetic rats within three weeks of daily treatment of Thuja occidentalis methanolic residue extract (200 and 400 mg/kg p.o). Alloxan-induced diabetic rats showed significant hypercholesterolemia in comparison with the control in alloxan induced rats. Results: In both normal and diabetic rats, there was also a significant decrease of elevated serum cholesterol and triglycerides. Hypertriglyceridemia was also shown to be prevented by treatment with plant extract (200 and 400mg/kg p.o) (p<0. 05). As compared with the control animals, diabetic control rats did not show any change in a level of creatinine and urea. Conclusion: Thuja occidentalis treatment may improve glucose homeostasis in alloxaninduced diabetes and alleviate kidney and liver function. Thuja occidentalis twigs could be a potential source of the new oral antidiabetic drug.

scholarly journals Antidiabetic Activity ofVinca roseaExtracts in Alloxan-Induced Diabetic Rats

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed Fazil Ahmed ◽  
Syed Mohammed Kazim ◽  
Syed Safiullah Ghori ◽  
Syeda Sughra Mehjabeen ◽  
Shaik Rasheed Ahmed ◽  
...  
Keyword(s):  
Body Weight ◽  
Plant Extract ◽  
Low Dose ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
High Dose ◽  
Vinca Rosea ◽  
Methanolic Extracts ◽  
Whole Plant ◽  
Histopathological Studies

The present study was carried out to evaluate the antidiabetic activity ofVinca roseamethanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration ofβ-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolicVinca roseaextracts, as a possible mechanism of their antidiabetic activity.

scholarly journals Antidiabetic Activity ofArtemisia amygdalinaDecne in Streptozotocin Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Khalid Ghazanfar ◽  
Bashir A. Ganai ◽  
Seema Akbar ◽  
Khan Mubashir ◽  
Showkat Ahmad Dar ◽  
...  
Keyword(s):  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Traditional Use ◽  
Glucose Levels ◽  
Methanolic Extracts ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Histopathological Results ◽  
Serum Glutamate

Artemisiaspecies have been extensively used for the management of diabetes in folklore medicine. The current study was designed to investigate the antidiabetic and antihyperlipidemic effects ofArtemisia amygdalina. Petroleum ether, ethyl acetate, methanol, and hydroethanolic extracts ofArtemisia amygdalinawere tested for their antidiabetic potentials in diabetic rats. The effect of extracts was observed by checking the biochemical, physiological, and histopathological parameters in diabetic rats. The hydroethanolic and methanolic extracts each at doses of 250 and 500 mg/kg b. w significantly reduced glucose levels in diabetic rats. The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), serum creatinine, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alkaline phosphatise (ALP), were found to be reduced by the hydroethanolic and methanolic extracts. The extracts also showed reduction in the feed and water consumption of diabetic rats when compared with the diabetic control. The histopathological results of treated groups showed the regenerative/protective effect onβ-cells of pancreas in diabetic rats. The current study revealed the antidiabetic potential ofArtemisia amygdalinabeing effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.

Antidiabetic Activity of Pistia strateotes L.Aqueous Extract in Alloxan-induced Diabetic Rats

2019 ◽  
Vol 3 (3) ◽  
pp. 91-94
Author(s):  
Mudassir Lawal ◽  
◽  
Abdulaziz Suleiman ◽  
Nasiruddin Matazu ◽  
Fatima Dawud ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Activity

Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots

2020 ◽  
Vol 16 (1) ◽  
pp. 33-41
Author(s):  
Mohini C. Upadhye ◽  
Uday Deokate ◽  
Rohini Pujari ◽  
Vishnu Thakare
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Oral Glucose ◽  
Ficus Glomerata

Background: Ficus glomerata (F. glomerata) Linn. Family Moraceace is a large tree found all over India including outer Himalayan ranges, Punjab, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and also as a common plant in South India. It is planted around the home and temples. It is cultivated throughout the year, distributed in evergreen forests and moist localities. Objective: The Ethanolic Extract of roots of F. Glomerata (EEFG) belonging to the family Moraceace, was investigated for its antidiabetic activity using alloxan induced diabetic rats. Methods: Thirty rats were divided into 5 groups having 6 rats in each group. The alloxan was administered to the rats of all groups except normal control group through intraperitoneal route at a concentration of 140mg/kg body weight. A dose of 100mg/kg and 200 mg/kg body weight of EEFG was administered to alloxan induced diabetic rats. The administration of the extract was lasted for 11 days. Effectiveness of the extract on glucose, cholesterol, triglycerides, and high density lipoprotein and protein concentrations was analyzed. Results: Significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride of the diabetic rats was observed after treatment with ethanolic extract. After subjecting to oral glucose tolerance test EEFG also showed significant improvement in glucose tolerance. Conclusion: F. glomerata root ethanolic extract showed that it possesses antidiabetic effect and can be found useful for the management of diabetes mellitus.

scholarly journals Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats

2011 ◽  
Vol 3 (2) ◽  
pp. 242 ◽  
Author(s):  
BK Mehta ◽  
DC Jain ◽  
Himanshu Misra ◽  
Manish Soni ◽  
Narendra Silawat ◽  
...  
Keyword(s):  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Antidiabetic Activity

scholarly journals Alcoholic Stem Extract ofCoscinium fenestratumRegulates Carbohydrate Metabolism and Improves Antioxidant Status in Streptozotocin–Nicotinamide Induced Diabetic Rats

2005 ◽  
Vol 2 (3) ◽  
pp. 375-381 ◽  
Author(s):  
I. R. Punitha ◽  
K. Rajendran ◽  
Arun Shirwaikar ◽  
Annie Shirwaikar
Keyword(s):  
Carbohydrate Metabolism ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Glutathione Synthetase ◽  
Alcoholic Extract ◽  
Enzymatic Antioxidants ◽  
Stem Extract ◽  
Gluconeogenic Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase

Alcoholic extract of the stems ofCoscinium fenestratum, a medicinal plant indigenous to India and Sri Lanka used in ayurveda and siddha medicine for treating diabetes, was studied for its carbohydrate metabolism effect and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetic rats. Oral administration ofC. fenestratumstem extract in graded doses caused a significant increase in enzymatic antioxidants such as catalase, superoxide dismutase, glutathione synthetase, peroxidase, and glutathione peroxidase and in the nonenzymatic antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of alcoholic extract on glycolytic enzymes such as glucose-6-phosphate dehydrogenase, lactate dehydrogenase and hexokinase showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme, glucose-6-phosphatase and alanine aminotransferase in treated diabetic rats. Serum creatinine and urea levels also declined significantly. This investigation demonstrates significant antidiabetic activity ofC. fenestratum.

Sign in / Sign up

Export Citation Format

Share Document