scholarly journals Solvo-thermal Assisted-Synthesis; Experimental and Theoretical Characterization; and Biological Evaluations of Azo-Chelator-Ligand Chelates of Fe(II) and Zn(II) ions

2021 ◽  
pp. 40-56
Author(s):  
Festus Chioma
Keyword(s):  
Condensation Reaction ◽  
Test Methods ◽  
Molar Conductance ◽  
Ionization Mass ◽  
Metallic Ions ◽  
Bivalent Ions ◽  
Iron Sulphate ◽  
Methods Analytical ◽  
Micro Analysis

Background and Objectives: The resistance of microbes against anti-bacteriological drugs leading to countless deaths and terminal ailments remains a basis for concern. Hence, the main interest of this study was to design, synthesize and report unusual compounds with basic hydrophilic moieties plus hydrophobic functions for anti-bacteriological studies. Materials and Methods: Analytical (melting points, micro-analysis (C. H.N.S) magnetic susceptibility (µeff), molar conductance plus solubility test) methods; spectral (Fourier Transform Infrared(FTIR)), electrospray ionization mass spectrometry (ESI-MS), nuclear magnetic resonance (1H- plus 13C-NMR), electronic(UV-Vis)) measurements; theoretical (DFT) evaluations were utilized for the characterization of the chelator and its chelates. All synthesized compounds were examined for antimicrobial and antioxidant potentials while the chelator was singly evaluated for solvent extractive capacity. Results: A nitrogenous based chelator-ligand, (E)-1-(((4,6-dimethylpyrimidin-2-yl)imino)methyl) naphthalen-2-ol(LH) synthesized through reflux-condensation reaction of 2-amino-4,6-dimethylpyrimidine with 2-hydroxy-1-napthaldehyde was acquired. Further reflux of the chelator-ligand with bivalent ions of iron-sulphate and zinc-acetate salts plus 2,2’-bipyridine resulted into separate bivalent-heteroleptic metallic chelates. The deprotonated nitrogen of the amine moiety and carbon of the carbonyl gave rise to the chelator-ligand with N2O2 chromophore detected around the metallic atom in the chelates. The µeff data plus UV-Vis spectral values of the chelates conformed to 6-coordinate octahedral geometry. All the chelates were high spin and non-ionic in dimethylsulfoxide (DMSO). The antimicrobial and antioxidant screening of the compounds presented moderate to fantastic results, while the metallic extractive proficiency of the chelator showed outstanding extractability for Fe2+ and Zn2+ions with an efficiency of 79.34% and 51.92% correspondingly. Conclusion: All the synthesized compounds are novel and demonstrated prospective biological, plus metallic ions’ extractive potentials required for designs plus isolation of products also for such actions.

scholarly journals SYNTHESIS AND CHARACTERIZATION OF BENZOHYDROXAMIC ACID METAL COMPLEXES AND THEIR CYTOTOXICITY STUDY

2018 ◽  
Vol 80 (6) ◽  
Author(s):  
Latifah Robbaniyyah Hassan ◽  
Kalavathy Ramasamy ◽  
Siong Meng Lim ◽  
Hadariah Bahron ◽  
Amalina Mohd Tajuddin
Keyword(s):  
Metal Complexes ◽  
Anticancer Agents ◽  
Condensation Reaction ◽  
Reaction Medium ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Benzohydroxamic Acid ◽  
Pyramidal Geometry ◽  
Ic50 Values

Hydroxamic acids (RCONHOH) are versatile compounds that constitute a significant biological importance. The syntheses, physico-chemical and characterization of benzohydroxamic acid (BHA) and its metal complexes (VO(IV), Cr(III) and Ni(II)) are reported herein. The metal complexes were synthesized via condensation reaction of BHA and metal salts in 2:1 molar ratio using ethanol as reaction medium. The compounds were characterized by elemental analysis, spectral (infrared, UV-Vis, 1H and 13C NMR,), TGA, magnetic susceptibility as well as molar conductance. The spectral study analysis reveals that all complexes coordinated to the metal via oxygen atoms (O,O) in bidentate manner to form octahedral for [Cr(BHA2).2H2O]H2O, tetrahedral for [Ni(BHA)2] and square pyramidal geometry for [VO(BHA)2]. The molar conductance values suggested that all complexes were non-electrolytes. A cytotoxicity study against HCT116 displayed that VO(IV) has better IC50 values than the parent ligand, BHA but not considered as potent anticancer agents.

scholarly journals Synthesis and characterization of N, N′-bis (isatin) diamino zirconium (IV) complexes

2019 ◽  
Vol 54 (4) ◽  
pp. 297-306
Author(s):  
A Sarker ◽  
T Hossain ◽  
MN Bashir ◽  
KJ Fatema ◽  
AKML Rahman
Keyword(s):  
Condensation Reaction ◽  
Analytical Data ◽  
Carbonyl Oxygen ◽  
Molar Conductance ◽  
Azomethine Group ◽  
Molar Ratios ◽  
Vibrational Bands ◽  
Ft Ir ◽  
1Hnmr Spectroscopy

N, N′-bis (isatin) diamine schiff base ligands were synthesized by the condensation reaction of Isatin with various diamine (ethane-1,2-diamine, propane-1,3-diamine and hexane-1,6-diamine) in 2:1 molar ratios. These ligands were used to prepare Zr (IV) complexes. Prepared ligands and complexes were characterized by using conductance measurement, FT-IR, UV-Visible and 1HNMR spectroscopy. The presence of FT-IR band for azomethine group supports the formation of ligand. Vibrational bands for Zr←N and Zr←O in complexes signify the coordination through O and N sites of ligands. 1HNMR peak for NH moiety in ligand gets almost disappeared in complex reveals tautomerism of NH with nearby carbonyl oxygen due to the effect of complexation. The absence of peak above 500 nm in the electronic spectra indicates d0 system of zirconium in complexes. The elemental analytical data was analogous to theoretical composition of ligands and complexes. The molar conductance values obtained for the complexes represent their non-electrolytic character. Bangladesh J. Sci. Ind. Res.54(4), 297-306, 2019

scholarly journals Evidence for Phytoremediation and Phytoexcretion of NTO from Industrial Wastewater by Vetiver Grass

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 74
Author(s):  
Abhishek RoyChowdhury ◽  
Pallabi Mukherjee ◽  
Saumik Panja ◽  
Rupali Datta ◽  
Christos Christodoulatos ◽  
...  
Keyword(s):  
Stress Reduction ◽  
Industrial Wastewater ◽  
Plant Biomass ◽  
Ionization Mass ◽  
Vetiver Grass ◽  
Insensitive Munitions ◽  
Treatment Technologies ◽  
And Control ◽  
Near Future

The use of insensitive munitions such as 3-nitro-1,2,4-triazol-5-one (NTO) is rapidly increasing and is expected to replace conventional munitions in the near future. Various NTO treatment technologies are being developed for the treatment of wastewater from industrial munition facilities. This is the first study to explore the potential phytoremediation of industrial NTO-wastewater using vetiver grass (Chrysopogon zizanioides L.). Here, we present evidence that vetiver can effectively remove NTO from wastewater, and also translocated NTO from root to shoot. NTO was phytotoxic and resulted in a loss of plant biomass and chlorophyll. The metabolomic analysis showed significant differences between treated and control samples, with the upregulation of specific pathways such as glycerophosphate metabolism and amino acid metabolism, providing a glimpse into the stress alleviation strategy of vetiver. One of the mechanisms of NTO stress reduction was the excretion of solid crystals. Scanning electron microscopy (SEM), electrospray ionization mass spectrometry (ESI-MS), and Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of NTO crystals in the plant exudates. Further characterization of the exudates is in progress to ascertain the purity of these crystals, and if vetiver could be used for phytomining NTO from industrial wastewater.

scholarly journals Statistical Approach for Risk Assessment of Aflatoxin Sampling Plan Used by Manufacturers for Raw Shelled Peanuts

2002 ◽  
Vol 85 (4) ◽  
pp. 925-932 ◽  
Author(s):  
Mark Vandeven ◽  
Thomas Whitaker ◽  
Andy Slate
Keyword(s):  
Test Methods ◽  
Sampling Plan ◽  
Raw Material ◽  
Contamination Level ◽  
Acceptance Probability ◽  
Preparation Methods ◽  
Crop Varieties ◽  
Analytical Test ◽  
Acceptance Sampling Plans ◽  
Methods Analytical

Abstract Processed food manufacturers often use acceptance sampling plans to screen out lots with unacceptable levels of contamination from incoming raw material streams. Sampling plan designs are determined by specifying sample sizes, sample preparation methods, analytical test methods, and accept/reject criteria. Sampling plan performance can be indicated by plotting acceptance probability versus contamination level as an operating characteristic (OC) curve. In practice, actual plan performance depends on the level of contamination in the incoming lot stream. This level can vary considerably over time, among different crop varieties, and among locales. To better gauge plan performance, a method of coupling an OC curve and crop distributions is proposed. The method provides a precise probabilistic statement about risk and can be easily performed with commercial spreadsheet software.

Synthesis and characterization of periphery-functionalized porphyrazines containing mixed pyrrolyl and pyridylmethylamino groups

2009 ◽  
Vol 13 (02) ◽  
pp. 223-234 ◽  
Author(s):  
Tomasz Goslinski ◽  
Ewa Tykarska ◽  
Wojciech Szczolko ◽  
Tomasz Osmalek ◽  
Aleksandra Smigielska ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Chemical Sensors ◽  
Electronic Materials ◽  
Condensation Reaction ◽  
Synthesis And Characterization ◽  
X Ray ◽  
Coordination Properties ◽  
Perpendicular Orientation ◽  
Selective Sensor

The condensation reaction of 2-amino-3-[(3-pyridylmethyl)amino]-2(Z)-butene-1,4-dinitrile with a series of diketones led to novel dinitriles, of which 2-(2,5-dimethyl-1H-pyrrol-1-yl)-3-[methyl(3-pyridylmethylene)amino]-2(Z)-butene-1,4-dinitrile, the product of the Paal-Knorr reaction, was successfully utilized in the Linstead macrocyclization towards symmetrical and unsymmetrical porphyrazines. NMR and X-ray study revealed an almost perpendicular orientation of the pyrrolyl groups in relation to the porphyrazine platform. The newly synthesized macrocycles with different peripheral groups show interesting spectroscopic and electrochemical properties. Due to selective sensor/coordination properties they are expected to find applications as chemical sensors and electronic materials.

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