scholarly journals Study on Knowledge and Practices of Ayurvedic Preventive Measures for Respiratory Tract Infections

2021 ◽  
pp. 29-37
Author(s):  
B. L. Edirisinghe ◽  
W. M. S. S. K. Kulathunga
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Preventive Measures ◽  
Good Practice ◽  
World Health ◽  
Survey Study ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
The Mean ◽  
Tract Infections

Respiratory diseases have become world health burden. It has been estimated that 65 million people have moderate severe chronic obstructive pulmonary diseases from which about 3 million die each year. Objective of this survey study was to assess knowledge and practice of Intern medical officers on Ayurvedic preventive measures for managing respiratory tract infectious diseases. A cross sectional descriptive study was carried out among the Intern Medical Officers during their training program. 85 respondents out of 150 were assessed for their knowledge and practices on Ayurvedic preventive measures for Respiratory tract infections by using pre-structured questionnaire. Among the sampled students, most of them were female 92.9% (79) and unmarried 51.8% (44). The mean age and the standard deviation of the respondents were 28.25 + 0.815 years. There were 41(48.2%) Intern medical students with good knowledge, 42(49.4%) were with satisfactory knowledge and 2.4% of the study group was having the little knowledge. Most of the respondents 56(65.9%) were doing good practice on preventing RTI and 29 (34.1%) respondents were doing bad practice. Overall the respondents have good practice on prevention of RTI with the mean score of 19.9 + 2.589.

scholarly journals Distribution of Respiratory Tracy Infectious Diseases in Relation to Particulate Matter (PM2.5) Concentration in Selected Urban Centres in Niger Delta Region of Nigeria

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Tamuno-owunari Perri ◽  
Vincent Ezikornwor Weli ◽  
Bright Poronakie ◽  
Tombari Bodo
Keyword(s):  
Particulate Matter ◽  
Respiratory Tract ◽  
Niger Delta ◽  
Respiratory Tract Infections ◽  
World Health ◽  
Chronic Obstructive ◽  
Delta Region ◽  
Niger Delta Region ◽  
Tract Infections ◽  
Pm2.5 Concentration

Due to the visibility of soot in the environment of the Niger Delta especially Rivers State that has led to the increase of  espiratory Tract Infections (RTIs) in the region, this study was undertaken to determine the relationship between Particulate Matter (PM2.5) concentration and the incident of Respiratory Tract Infections (RTIs) in selected urban centres of the Niger Delta. Data on RTIs were collected from the Hospital Management Boards of the Ministries of Health of Rivers, Bayelsa and Delta States and the data for PM2.5 were remotely sensed from 2016 to 2019, and subsequently analyzed with ANOVA and Spearman’s rank correlation statistics. The findings of this study revealed that there was significant variation in the occurrence of PM2.5 across the selected urban centres in the Niger Delta Region. The PM2.5 for the reviewed years was far above the World Health Organization (WHO) annual permissible limit of 10 µg/m3 thereby exacerbating Respiratory Tract Infections (RTIs).The epidemiology of the RTIs showed that there are basically four (4) prominent RTI diseases: Asthma, Tuberculosis, Pneumonia and Chronic Obstructive Pulmonary Disease (COPD). The result of this study showed that the concentration of PM2.5 varies in all the selected cities, and the mean monthly variation (2016-2019) showed that Port Harcourt had 47.27 µg/m3 for January while Yenagoa and Asaba had 46 µg/m3 and 47.51 µg/m3 respectively for January; while the lowest mean value in the cities were seen within the month of September and October, which also had a strong seasonal influence on the concentration of PM2.5. The concentration of PM2.5 and the numbers of RTIs also gradually increases in the study areas from 2016 to 2019. The study recommends that the necessary regulatory bodies should closely monitor the activities of the companies likely to cause such pollution; guild them through their operations and give prompt sanctions and heavy fines to defaulters of the accepted standards.

Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the treatment of respiratory tract infections

2021 ◽  
Vol 21 ◽  
Author(s):  
Shadma Wahab ◽  
Irfan Ahmad ◽  
Safia Irfan ◽  
Ayesha Siddiqua ◽  
Shazia Usmani ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Clinical Medicine ◽  
Respiratory Infections ◽  
Glycyrrhiza Glabra ◽  
World Health ◽  
Chronic Obstructive ◽  
Virus Growth ◽  
The World ◽  
Tract Infections

: Respiratory tract infections are underestimated because they are mild and disabling, but in clinical medicine, these are the most prevalent problems. According to the World Health Organization third-most comprehensive cause of death in the world till 2030 would be chronic obstructive pulmonary disease (COPD). Dominating viruses of respiratory infections are influenza, respiratory syncytial virus, rhinoviruses, and human coronaviruses. Antibiotics are mostly used to treat bacterial infections, and they do not effectively manage viral infections like sinusitis, sore throats, bronchitis, influenza, and common respiratory infections. Presently no medication is available only symptomatic interventions is an option in our hand. However, a lot of research is going on the vaccine and drugs-based approaches against respiratory viruses worldwide. Traditional medicines are getting the attraction to treat many diseases. It is vital to screen the medicinal plants to find the potential of new compounds for treatment against antiviral and antimicrobial activities. Glycyrrhiza glabra L. (Licorice) pharmacological actions modulate the immune system, inhibit virus growth, produce anti-inflammatory activity, and inactivate viruses. This comprehensive review mainly focuses on the role of licorice in managing respiratory infections caused by viruses and bacteria, including complications associated with its excess intake. There has been limited human research’s exhibited licorice effectiveness in respiratory infections; therefore, there is a need for uncompromising and long-term research. This paper will be a valuable reference for biologists and physicians looking for a medication for respiratory infections. Glycyrrhiza glabra could open the door to novel agents in drug discovery and development.

scholarly journals Respiratory-tract infections among geriatrics: prevalence and factors associated with the treatment outcomes

2021 ◽  
Vol 15 ◽  
pp. 175346662097114
Author(s):  
Ali Akhtar ◽  
Mohamed Azmi Ahmad Hassali ◽  
Hadzliana Zainal ◽  
Irfhan Ali ◽  
Muhammad Shahid Iqbal ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Treatment Outcomes ◽  
Respiratory Tract Infections ◽  
Community Acquired Pneumonia ◽  
Chronic Obstructive ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Tract Infections

Background: Geriatric individuals are more susceptible to different infections, especially respiratory-tract infections (RTIs) due to their compromised immune system. Hence, the objectives of the present study were to evaluate the prevalence, medication regimen complexity and factors associated with the treatment outcomes of different RTIs among geriatrics. Methods: A retrospective cross-sectional study (5 years) was conducted at the respiratory department, Hospital Pulau Pinang. Patients aged ⩾65 years with confirmed diagnosis of RTI were included in the study. Results: A total of 474 patients were included, and the most prevalent RTIs were community-acquired pneumonia (65.6%) followed by chronic obstructive pulmonary disease (20.7%), bronchitis (8.2%) and hospital-acquired pneumonia (5.5%). Amoxicillin/clavulanate (69.8%), ampicillin/sulbactam (9.1%) and cefuroxime (6.5%) are the most common antibiotics prescribed to treat RTIs among geriatrics. Smoking, alcohol consumption, polypharmacy and presence of other co-morbidities are statistically significant factors associated with treatment outcomes of RTIs among geriatrics. Conclusion: Prevalence of community-acquired pneumonia (65.6%) among older patients aged 65 years and older higher than other RTIs. Smoking, alcohol use, presence of polypharmacy and other co-morbidities are important factors associated with the treatment outcomes of RTIs. The reviews of this paper are available via the supplemental material section.

scholarly journals Pharmacological Efficacy of Ginseng against Respiratory Tract Infections

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4095
Author(s):  
Abdulrhman Alsayari ◽  
Abdullatif Bin Muhsinah ◽  
Dalia Almaghaslah ◽  
Sivakumar Annadurai ◽  
Shadma Wahab
Keyword(s):  
Clinical Trials ◽  
Respiratory Tract ◽  
Animal Studies ◽  
Respiratory Tract Infections ◽  
Clinical Medicine ◽  
Structural Features ◽  
World Health ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Tract Infections

Respiratory tract infections are underestimated, as they are mild and generally not incapacitating. In clinical medicine, however, these infections are considered a prevalent problem. By 2030, the third most comprehensive reason for death worldwide will be chronic obstructive pulmonary disease (COPD), according to the World Health Organization. The current arsenal of anti-inflammatory drugs shows little or no benefits against COPD. For thousands of years, herbal drugs have been used to cure numerous illnesses; they exhibit promising results and enhance physical performance. Ginseng is one such herbal medicine, known to alleviate pro-inflammatory chemokines and cytokines (IL-2, IL-4, IFN-γ, TNF-α, IL-5, IL-6, IL-8) formed by macrophages and epithelial cells. Furthermore, the mechanisms of action of ginsenoside are still not fully understood. Various clinical trials of ginseng have exhibited a reduction of repeated colds and the flu. In this review, ginseng’s structural features, the pathogenicity of microbial infections, and the immunomodulatory, antiviral, and anti-bacterial effects of ginseng were discussed. The focus was on the latest animal studies and human clinical trials that corroborate ginseng’s role as a therapy for treating respiratory tract infections. The article concluded with future directions and significant challenges. This review would be a valuable addition to the knowledge base for researchers in understanding the promising role of ginseng in treating respiratory tract infections. Further analysis needs to be re-focused on clinical trials to study ginseng’s efficacy and safety in treating pathogenic infections and in determining ginseng-drug interactions.

scholarly journals Risk Factors for Respiratory Syncytial Virus Lower Respiratory Tract Infections: Evidence from an Indonesian Cohort

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 331
Author(s):  
Rowena Crow ◽  
Kuswandewi Mutyara ◽  
Dwi Agustian ◽  
Cissy B. Kartasasmita ◽  
Eric A. F. Simões
Keyword(s):  
Risk Factors ◽  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
World Health ◽  
Lower Respiratory Tract Infections ◽  
Cross Sectional ◽  
Syncytial Virus ◽  
Tract Infections

Although risk factors for hospitalization from a respiratory syncytial virus (RSV) are well known, RSV lower respiratory tract infections (LRIs) in the community are much less studied or understood, especially in developing countries. In a prospective, cohort study we studied factors predisposing Indonesian infants and children under 5 years of age to developing RSV LRIs. Subjects were enrolled in two cohorts: a birth cohort and a cross-sectional cohort of children <48 months of age. Subjects were visited weekly at home to identify any LRI, using the World Health Organization’s criteria. RSV etiology was determined through analysis of nasal washings by enzyme immunoassay and polymerase chain reaction. Risk factors for the development of the first documented RSV LRI were identified by multivariate analysis using logistic regression and Cox proportional hazard modeling. Of the 2014 children studied, 999 were enrolled within 30 days of birth. There were 149 first episodes of an RSV. Risk factors for an RSV LRI were poverty (p < 0.01), use of kerosene as a cooking fuel (p < 0.05), and household ownership of rabbits and chickens (p < 0.01). Our findings suggested that in a middle-income country such as Indonesia, with a substantial burden of RSV morbidity and mortality, lower socioeconomic status, environmental air quality, and animal exposure are predisposing factors for developing an RSV LRI.

Reappraisal of respiratory syncytial virus as an aetiology of severe acute lower respiratory tract infections in children younger than 5 years in Nigeria

2019 ◽  
Vol 113 (8) ◽  
pp. 446-452
Author(s):  
Damilola M Oladele ◽  
Dimeji P Oladele ◽  
Rasheedat M Ibraheem ◽  
Mohammed B Abdulkadir ◽  
Rasaki Adewole Raheem ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Preventive Strategy ◽  
Lower Respiratory Tract Infections ◽  
Cross Sectional ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Tract Infections

Abstract Background Acute lower respiratory tract infections (ALRIs) especially severe ALRIs, constitute a global high burden of morbidity and mortality in children <5 y of age and respiratory syncytial virus (RSV) has been documented to a play a major aetiological role. However, Nigerian reports on severe childhood RSV ALRIs are rare and most reports are old. With recent advances in RSV preventive strategy, arises the need for a recent appraisal of RSV infection in children with severe ALRI. The current study thus set out to determine the prevalence of RSV infection among hospitalized children <5 y of age and describe the related social determinants. Methods We performed a descriptive cross-sectional study conducted over 1 y of 120 children, ages 2–59 months, diagnosed with ALRI. Relevant data were obtained and an antigen detection assay was used for viral studies. Results The prevalence of RSV infection was 34.2% and its peak was in the rainy months. The proportion of infants in the RSV-positive group was significantly higher than that in the RSV-negative group (82.9% vs 54.4%; p=0.002). These findings were largely consistent with those of earlier reports. Conclusions RSV has remained a common cause of severe ALRI in infants, especially during the rainy months in Nigeria. It is thus suggested that more effort be focused towards implementing the current global recommendations for the prevention of RSV-associated LRI, particularly in infants.

scholarly journals A cross sectional study on prescription pattern of drugs in upper respiratory tract infections in a tertiary care hospital

2020 ◽  
Vol 9 (2) ◽  
pp. 271
Author(s):  
Divya Bade ◽  
Shivashankaramurthy K. G. ◽  
Kiran L. J. ◽  
Raghuprasada M. S. ◽  
Harishkumar V. S. ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Cross Sectional Study ◽  
Prescribing Patterns ◽  
Essential Medicines ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Cross Sectional ◽  
Upper Respiratory ◽  
Tract Infections

Background: Upper respiratory tract infections are one of the leading causes of hospital visits worldwide. Judicious use of antibiotics is challenging for upper respiratory tract infections (URTIs) in developing countries like India. This leads to inappropriate use of antibiotics causing many dreaded conditions like antibacterial resistance among other things. Hence rational use of drugs, mainly antibacterial, is a priority to reduce the burden of treatment failure. The objective of this study is to study the prescribing patterns and rationality of drugs prescribed in the management of URTIs.Methods: This was a cross-sectional study. Data was collected from records of 300 outpatients clinically diagnosed as URTIs from SSIMS and RC Hospital, Davangere between January 2015 and June 2016. The prescribing patterns, approval status and listing of drugs in World Health Organization (WHO) essential medicines list/ National List of Essential Medicines (NLEM) were analysed. The data was presented as percentages, mean and standard deviations.Results: A total of 300 cases were studied. Among these, acute pharyngitis (29%) and acute sinusitis (26%) are the most common infections. Of the 300 cases studied, 283 (94.3%) were prescribed antimicrobials. Of the total 740 medications prescribed, 393 (53.1%) were fixed-dose combinations (FDCs). A total of 724 medications (97.8%) were approved by Drugs Controller General of India and 248 (33.5%) by Food and Drug Administration. Only 5.8% of the prescribed drugs have been listed in WHO’s and NLEM. The most common class of antibacterials prescribed was Beta-lactams.Conclusions: Oral formulations were preferred over parenteral formulations and FDCs were preferred over single drug formulations. Beta-lactams comprised the major class of antibacterial prescribed.

Prothrombotic Changes in Hemostatic Parameters and C-reactive Protein in the Elderly with Winter Acute Respiratory Tract Infections

2001 ◽  
Vol 85 (02) ◽  
pp. 245-249 ◽  
Author(s):  
John Horan ◽  
Charles Francis ◽  
Ann Falsey ◽  
John Kolassa ◽  
Brian Smith ◽  
...  
Keyword(s):  
Older Adults ◽  
Heart Disease ◽  
Respiratory Tract ◽  
Ischemic Heart Disease ◽  
Respiratory Tract Infections ◽  
C Reactive Protein ◽  
Acute Respiratory Tract Infections ◽  
Reactive Protein ◽  
The Mean ◽  
Tract Infections

SummaryMortality rates attributable to cerebrovascular and ischemic heart disease increase among older adults during the winter. Prothrombotic changes in the hemostatic system related to seasonal factors, such as ambient temperature changes, and winter acute respiratory tract infections, may contribute to this excess seasonal mortality. A prospective nested case-control study was conducted to assess the impact of winter acute respiratory tract infections on fibrinogen, factor VII, factor VIIa, D-dimer, prothrombin fragment 1.2, PAI-1, soluble P-selectin and C-reactive protein (CRP) in older adults. The change in laboratory parameters from baseline (fall) to the time of infection in both middle-aged and elderly individuals was compared with matched non-infected controls. In older adult participants with winter acute respiratory tract infections, significant increases occurred in fibrinogen and C-reactive protein, but not in any other markers. The mean fibrinogen increased 1.52 g/L (38%) and the mean CRP increased 37 mg/L (370%) over baseline (both p < 0.001). In a multivariate analysis, both infection and season were associated with the increase in fibrinogen, but only infection was associated with the CRP increase. Old age magnified the increase in CRP but not in fibrinogen. Winter acute respiratory tract infections induce an exaggerated inflammatory response in older adults. The associated increase in fibrinogen, an independent risk factor for ischemic heart disease, may be partly responsible for the excess winter vascular mortality.

scholarly journals Antibiotic Prescribing Practices and Errors among Hospitalized Pediatric Patients Suffering from Acute Respiratory Tract Infections: A Multicenter, Cross-Sectional Study in Pakistan

Medicina ◽  
2019 ◽  
Vol 55 (2) ◽  
pp. 44 ◽  
Author(s):  
Sadia Iftikhar ◽  
Muhammad Rehan Sarwar ◽  
Anum Saqib ◽  
Muhammad Sarfraz ◽  
Qurat-ul-ain Shoaib
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Public Hospitals ◽  
P Value ◽  
Antibiotic Prescribing ◽  
Prescribing Errors ◽  
Prescribing Practices ◽  
Cross Sectional ◽  
Acute Respiratory Tract Infections ◽  
Tract Infections

Background and objective: The noncompliance of treatment guidelines by healthcare professionals, along with physiological variations, makes the pediatric population more prone to antibiotic prescribing errors. The present study aims to evaluate the prescribing practices and errors of the most frequently prescribed antibiotics among pediatric patients suffering from acute respiratory tract infections who had different lengths of stay (LOS) in public hospitals. Methods: A retrospective, cross-sectional study was conducted in five tertiary-care public hospitals of Lahore, Pakistan, between 1 January 2017 and 30 June 2017. The study population consisted of pediatric inpatients aged 0 to 9 years. Results: Among the 11,892 pediatric inpatients, 82.8% were suffering from lower acute respiratory tract infections and had long LOS (53.1%) in hospital. Penicillins (52.4%), cephalosporins (16.8%), and macrolides (8.9%) were the most frequently prescribed antibiotics. Overall, 40.8% of the cases had antibiotic prescribing errors related to wrong dose (19.9%), wrong frequency (18.9%), and duplicate therapy (18.1%). Most of these errors were found in the records of patients who had long LOS in hospital (53.1%). Logistic regression analysis revealed that the odds of prescribing errors were lower in female patients (OR = 0.6, 95% CI = 0.1–0.9, p-value = 0.012). Patients who were prescribed with ≥3 antibiotics per prescription (OR = 1.724, 95% CI = 1.1–2.1, p-value = 0.020), had long LOS (OR = 12.5, 95% CI = 10.1–17.6, p-value < 0.001), and were suffering from upper respiratory tract infections (URTI) (OR = 2.8, 95% CI = 1.7–3.9, p-value < 0.001) were more likely to experience prescribing errors. Conclusion: Antibiotics were commonly prescribed to patients who had long LOS. Prescribing errors (wrong dose, wrong frequency, and duplicate therapy) were commonly found in cases of lower respiratory tract infections (LRTIs), especially among those who had prolonged stay in hospital.

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