scholarly journals Ameliorative Effects of the Methanolic Extract of the Rind of Citrullus lanatus on Lead Acetate Induced Toxicity on Semen Parameters and Reproductive Hormones of Male Albino Wistar Rats

2014 ◽  
Vol 4 (9) ◽  
pp. 1125-1137 ◽  
Author(s):  
T. Kolawole
Keyword(s):  
Lead Acetate ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Reproductive Hormones ◽  
Semen Parameters

scholarly journals Hepatotherapeutic Tendency of Citrullus lanatus Rind Methanolic Extract on Liver Markers in Male Wistar Rats

2019 ◽  
pp. 1-10
Author(s):  
Ilochi Ogadinma ◽  
Chuemere Arthur Nwafor ◽  
Bassy Samuel
Keyword(s):  
Liver Function ◽  
Wistar Rats ◽  
Liver Enzymes ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Left Ventricular ◽  
Normal Male ◽  
High Dose ◽  
Serum Total Bilirubin ◽  
Male Wistar Rats

It is a common practice to dispose the peel or rind of fruits. Interestingly, some parts of fruits humans find unacceptable to eat actually possess bioactive nutrients that can be used for medicinal purposes.  The effect of methanolic extract of Citrullus lanatus rind on liver function in normal male wistar rats was studied. 24 wistar rats with body weight between 150-250 g were used for this study. The animals were randomly divided into four groups, with 6 rats in each. Group 1 contained the control given normal saline and feed; group 2, low dose, 50mg/kg of methanolic extract of  Citrullus lanatus rind was administered, group 3 and 4 were administered medium and high dose of Citrullus lanatus rind extract 100 mg/kg and 200 mg/kg respectively. The Citrullus lanatus rind extract was administered via orogastric route and the experiment lasted for a period of 56 days. Blood samples were collected by left ventricular cardiac puncture for liver function test at the last day of the experiment.  The outcome of this research revealed that medium and high dose administration of citrullus lanatus rind significantly (p≤0.05) reduced the serum level of liver enzymes alanine transaminase, aspartate transaminase and alkaline phosphatase and also total protein.There was a non-significant (P≤0.05) change in serum total bilirubin and albumin when all doses were compared to the control. Prolonged and moderate ingestion of Citrullus lanatus rind may be of benefit in regulating blood level of liver enzymes; hence, this part of the fruit has therapeutic value.

scholarly journals Preliminary Study on the Effect of Methanolic Extract of Watermelon (Citrullus lanatus) Rind on Prednisolone Suppressed Immunity in Male Wistar Rats

2021 ◽  
pp. 1-6
Author(s):  
Nyejirime Young Wike ◽  
Mobisson Samuel Kelechi ◽  
Godspower Onyeso ◽  
Okekem Amadi ◽  
Elizabeth Eepho Krukru
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Control Group ◽  
Group 4 ◽  
Watermelon Rind ◽  
Male Wistar Rats ◽  
Group 3 ◽  
Group 2

Citrullus lanatus thumb (Cucurbitaceae) commonly called watermelon is widely consumed in this part of the world as food and medicine. This study was carried out to examine the effect of methanolic extract of watermelon (Citrullus lanatus) rind on prednisolone suppressed immunity in male wistar rats. A total of 20 male wistar rats weighing 150-294g were used in 4 groups with five rats each. Group 1, the control group was given distilled water and feed, Group 2 was given 200 mg/kg body weight of methanolic extract of watermelon rind, Group 3 rats were given 2.5 mg/kg body weight of prednisolone and Group 4 rats were given 2.5 mg/kg body weight of prednisolone and 200 mg/kg body weight of methanolic extract of watermelon rind. Prednisolone and the methanolic extract of watermelon rind were administered orally for a period of 30 days. Blood samples were collected by cardio puncture from the rats for white blood cell (WBC), lymphocyte, and granulocyte and monocyte counts at the end of the experiment.  The data were statistically analysed using one-way ANOVA (Analysis of variance). Data were considered significant at p<0.05. The results obtained showed that methanolic extract of watermelon rind caused a significant increasen in immune function of rats when compared with the control and immune suppressed rats.

scholarly journals EVALUATION OF THE CHELATING EFFECT OF METHANOLIC EXTRACT OF CORIANDRUM SATIVUM AND ITS FRACTIONS ON WISTAR RATS POISONED WITH LEAD ACETATE

2017 ◽  
Vol 14 (2) ◽  
pp. 92-102 ◽  
Author(s):  
Miguel Angel Tellez-lopez ◽  
Gabriela Mora-Tovar ◽  
Iromi Marlen Ceniceros-Mendez ◽  
Concepcion Garcia-Lujan ◽  
Cristo Omar Puente-Valenzuela ◽  
...  
Keyword(s):  
Lead Acetate ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Coriandrum Sativum ◽  
Chelating Effect

scholarly journals Assessment of histo-reparative effect of methanolic extract of Camellia sinensis in rat model of Lead-induced testicular damage

2020 ◽  
Vol 10 (4-s) ◽  
pp. 46-52
Author(s):  
Dayo Rotimi Omotoso ◽  
Adeniran Oluwadamilare Akinola ◽  
Winners Prince Ehiemere
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Camellia Sinensis ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Control Group ◽  
Testicular Damage ◽  
Male Wistar Rats ◽  
Reparative Effect

Objective: To assess reparative effect of methanolic extract of Camellia sinensis on testicular histomorphology of male Wistar rats exposed to lead-induced testicular damage.  Methods: Twenty four male Wistar rats were grouped into four A–D (n = 6). These include normal control group A (distilled water 5 ml/kg), test control group B (lead acetate 30 mg/kg), treatment group C (lead acetate 30 mg/kg + MECS 5 mg/kg) and treatment group D (lead acetate 30 mg/kg + MECS 10 mg/kg). Administrations were through oral route for a period of 60 days and body weight of study animals was recorded during days 0, 20, 40 and 60 of study. Phytochemical analysis of extract was done using GCMS. At the end of sudy, testicular tissue weight of study animals was measured followed by histopathological study. Results: The extract significantly ameliorated body weight loss and exhibited histo-reparative effect on testicular histomorphology of study animals following lead exposure. Conclusion: Methanolic extract of Camellia sinensis exhibits reparative effect against toxic effect of tissue toxicant due to its antioxidant activity. Keywords: Camellia sinensis, Lead toxicity, Testis histomorphology, Wistar rats

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

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