scholarly journals Root Bark of Cordia millenii Essential Oil: Anti-inflammatory and Anti-nociceptive Activities

2019 ◽  
pp. 1-7
Author(s):  
Opeyemi N. Avoseh ◽  
Isiaka A. Ogunwande ◽  
Yahaya Yakubu ◽  
Peter O. Afolabi
Keyword(s):  
Essential Oil ◽  
Inflammatory Activity ◽  
Root Bark ◽  
Significant Activity ◽  
Hot Plate ◽  
Traditional Use ◽  
Inflammatory Conditions ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Plate Analysis

Aims: Considering the lack of scientific studies focused on the pharmacological activity of Cordia millenii essential oil, this work was designed to evaluate the anti-inflammatory and anti-nociceptive activities of essential oil from the root bark. Study Design: The design of the study include collection of root bark of Cordia millenii, hydrodistillation of essential oil from the plant and evaluation of its anti-inflammatory and anti-nociceptive potentials. Place and Duration of Study: Department of Chemistry, Lagos State University, Nigeria between May 2017 and April 2018. Methodology: The root bark of C. millenii were collected from Ayetoro, Ilesha (7°37¢0N 4°43¢0E), Osun State, Nigeria in June 2017. Essential oils were obtained from the air-dry sample by hydrodistillation procedure in an all glass Clevenger-apparatus. The anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema. The anti-nociceptive action was established from the hot-plate analysis. Statistical analysis was performed using GraphPad Prism (version 7.02). Results: The anti-inflammatory activity of the essential oil was statistically significant (p < 0.001) at 1st and 3rd h for the 100 mg/kg p.o., at 1st-3rd h for the 200/kg mg p.o. and at 3rd and 4th h for the 400 mg/kg p.o. In addition, the 100 mg/kg p.o. showed significant activity (p < 0.01) at 2nd h. Also, the anti-inflammatory activity was significant (p < 0.05) for 100 mg/kg p.o. (4th h), 200 mg/kg p.o. (4th h) and 400 mg/kg p.o (1st h). The essential oil of C. millenii displayed high activity (p <0.001) for all doses in the hot plate anti-nociceptive assay which was time and dose independent. Conclusion: Results demonstrate that the essential oil of C. millenii was effective in the treatment of inflammatory conditions, thereby supporting the traditional use of this herb.

Analgesic and Anti-inflammatory Activity of Ficus glomerata in Experimental Animal Models

2011 ◽  
Vol 4 (3) ◽  
pp. 1501-1505
Author(s):  
Cylma Menezes ◽  
Kunal G ◽  
Reema N ◽  
Satyanarayana D ◽  
Jagadish K
Keyword(s):  
Analgesic Activity ◽  
Inflammatory Activity ◽  
Significant Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Anti Inflammatory ◽  
Ficus Glomerata

The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carageenan induced hind paw edema in rats and the paw volume was measured plethysmometrically after 3 hours of injection. The extracts were also evaluated for analgesic activity using Eddy’s hot plate method in Swiss albino mice. The extracts of Ficus glomerata significantly reduced carageenan induced hind paw edema in rats and analgesic activity evidenced by increase in the reaction time by Eddy’s hot plate method in Swiss albino mice. The extracts showed a similar anti-inflammatory and analgesic effect comparative to the standard drugs indomethacin and diclofenac sodium respectively. The present results indicated the ethanolic extract of Ficus glomerata exhibited more significant activity than other extracts in the treatment of pain and inflammation.

scholarly journals Analgesic and Antiinflammatory Activities of the Essential Oil of the Unique Plant Zhumeria majdae

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Seyyedeh Ghazal Miraghazadeh ◽  
Hamed Shafaroodi ◽  
Jinous Asgarpanah
Keyword(s):  
Acetic Acid ◽  
Essential Oil ◽  
Diclofenac Sodium ◽  
Biologically Active ◽  
Significant Activity ◽  
Paw Edema ◽  
Active Constituent ◽  
Hot Plate ◽  
Standard Drug ◽  
Anti Inflammatory

The analgesic and anti-inflammatory properties of Zhumeria majdae essential oil were investigated in mice and rats. The analgesic activity of the oil was assessed by acetic acid-induced writhing and Eddy's hot plate methods while the acute anti-inflammatory effect was investigated by inflammatory paw edema in rat. Z. majdae oil significantly decreased the number of acetic acid-induced writhes in mice compared with animals that received vehicle only. Also it exhibited a central analgesic effect as evidenced by a significant increase in reaction time in the hot plate method. The oil also significantly reduced carrageenan induced paw edema in rats. The inhibitory activity of Z. majdae essential oil was found to be very close to that of the standard drug, diclofenac sodium (50 mg/kg). The studied oil was analyzed by GC and GC–MS and seventeen constituents were identified, representing 99.2% of the oil. The major components of the oil were characterized as linalool (63.4%) and camphor (27.5%), which might be responsible for these observed activities. The results suggest that Z. majdae essential oil possesses biologically active constituent(s) that have significant activity against acute inflammation and have central and peripheral antinociceptive effects which support the ethnomedicinal claims of the plant application in the management of pain and inflammation.

scholarly journals Investigation of Active Anti-Inflammatory Constituents of Essential Oil from Pinus koraiensis (Sieb. et Zucc.) Wood in LPS-Stimulated RBL-2H3 Cells

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 817
Author(s):  
Ji-Yoon Yang ◽  
Won-Sil Choi ◽  
Ki-Joong Kim ◽  
Chang-Deuk Eom ◽  
Mi-Jin Park
Keyword(s):  
Essential Oil ◽  
Inflammatory Cytokines ◽  
Positive Control ◽  
Inflammatory Activity ◽  
Pinus Koraiensis ◽  
Korean Pine ◽  
Inflammatory Conditions ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

In a previous study, we demonstrated the anti-inflammatory activity of the essential oil extracted from Korean pine (Pinus koraiensis, Sieb. et Zucc.) wood. This study aims to investigate the active anti-inflammatory constituents of P. koraiensis oil. The essential oil was extracted from P. koraiensis wood by hydrodistillation and was divided into six fractions (A–F) through fractional distillation. Then, the anti-inflammatory activities of the fractions (A–F) were determined. Fractions A and F markedly downregulated the production of pro-inflammatory cytokines as well as the secretion of β-hexosaminidase in lipopolysaccharide (LPS)-stimulated RBL-2H3 cells. The main constituents of the active anti-inflammatory A and F fractions were (+)-α-pinene, (−)-β-pinene, (+)-α-terpineol, 3-carene, (+)-limonene, and longifolene. These six single compounds decreased the expression of inflammatory-related genes (i.e., IL-4 and IL-13) as well as the secretion of β-hexosaminidase in LPS-stimulated RBL-2H3 cells. (+)-α-Pinene, (−)-β-pinene, (+)-α-terpineol, and longifolene exhibited the strongest effects; these effects were comparable to those of the positive control (i.e., dexamethasone). The findings indicate that the interactions between these components exhibit potential for the management and/or treatment of inflammatory conditions as well as base structures for the development of novel anti-inflammatory drugs.

scholarly journals Preliminary screening of Waltheria indica (L.) plant for its anti-inflammatory activity

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Amol Chandekar ◽  
Amber Vyas ◽  
Neeraj Upamanyu ◽  
Atul Tripathi ◽  
Surendra Agrawal
Keyword(s):  
Inflammatory Activity ◽  
In Vivo Model ◽  
Significant Activity ◽  
Standard Drug ◽  
Rat Paw Edema ◽  
Test Models ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Acute And Chronic Inflammation

<p dir="ltr"><span>The investigation on anti-inflammatory activity of the various extract of </span><span>Waltheria indica </span><span>L. </span><span>was reported to find out the pharmacological basis for its ethnomedical use. </span><span>The anti-inflammatory activity of the pet ether (PEW) and methanol (MEW) extracts of the leaves of </span><span>Waltheria indica </span><span>L. (</span><span>Malvaceae</span><span>)</span><span>were evaluated by using in vivo (Carrageenan &amp; histamine induced rat paw edema, cotton pellet granuloma test) models. It was observed that, all the extracts showed significant activity in the in-vivo model at the dose of 500 mg/kg b.w. orally, when compared with control and standard drugs. Of the two extracts tested, methanol extract MEW showed most significant activity well in comparison to the standard drug.  Therefore, present study suggests, potential of leaves of </span><span>Waltheria indica </span><span>L. in both models of acute and chronic inflammation.</span></p><p dir="ltr"> </p>

scholarly journals Fractions of Selaginella convoluta (Arn.) Spring (Selaginellaceae) attenuate the nociceptive behavior events in mice

2020 ◽  
Vol 80 (1) ◽  
pp. 57-65 ◽  
Author(s):  
L. A. R. Oliveira-Macêdo ◽  
A. G. M. Pacheco ◽  
S. R. G. Lima-Saraiva ◽  
J. C. Silva ◽  
R. G. Oliveira-Júnior ◽  
...  
Keyword(s):  
Motor Coordination ◽  
Antinociceptive Effect ◽  
Phytochemical Analysis ◽  
Second Phase ◽  
Significant Activity ◽  
Nociceptive Behavior ◽  
Hot Plate ◽  
Traditional Use ◽  
Rota Rod Test ◽  
Anti Inflammatory

Abstract Selaginella convoluta (Arn.) Spring is a species popularly known as “jericó”, and used in folk medicine as analgesic and anti-inflammatory. This study aimed to investigate in mice the antinociceptive and anti-inflammatory activities of the hexane (Sc-Hex) and chloroform (Sc-CHCl3) fractions (100, 200 and 400 mg/kg) obtained by partition of crude ethanol extract from S. convoluta. The preliminary phytochemical analysis of the fractions was performed. Antinociceptive activity was evaluated by writhing, formalin and hot-plate tests. Anti-inflammatory activity was evaluated using carrageenan-induced pleurisy. The rota-rod test was used to evaluate motor coordination. Preliminary phytochemical screening showed that the Sc-Hex and the Sc-CHCl3 were positive for the presence of flavonoids, anthracene derivatives, quinones, triterpenes and steroids. Inhibition of writhing was observed for fractions tested. The Sc-Hex at all doses tested was effective in reducing the nociceptive behavior produced by formalin only in the second phase. However, the Sc-CHCl3 decreased the paw licking time in the first and second phases. In the hot plate no significant effect was observed for any fraction. In the rota-rod test, treated mice did not demonstrate any significant motor performance changes. In the carrageenan-induced pleurisy, Sc-CHCl3 (200 mg/kg) reduced cell migration to the pleural cavity. These results reveal the antinociceptive properties of S. convoluta , which support, in part, its traditional use, since the fractions did not presented significant activity in the inflammatory response profile. We further verify that this antinociceptive effect could be by activation of nociceptive peripheral pathway.

scholarly journals Anti-inflammatory Activity of Pistacia lentiscus Essential Oil: Involvement of IL-6 and TNF-α

2011 ◽  
Vol 6 (10) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Andrea Maxia ◽  
Cinzia Sanna ◽  
Maria Assunta Frau ◽  
Alessandra Piras ◽  
Manvendra Singh Karchuli ◽  
...  
Keyword(s):  
Essential Oil ◽  
Inflammatory Activity ◽  
Pistacia Lentiscus ◽  
Paw Edema ◽  
Rat Paw Edema ◽  
Tnf Α ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Rat Paw

The topical anti-inflammatory activity of essential oil of Pistacia lentiscus L. was studied using carrageenan induced rat paw edema and cotton pellet induced granuloma. The effect on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats inserted with cotton pellet was also investigated. On topical application, the oil exhibited a significant decrease in paw edema. The oil also inhibited cotton pellet-induced granuloma, and reduced serum TNF-α and IL-6. It can be concluded that the essential oil of Pistacia lentiscus reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.

scholarly journals Anti-Inflammatory Effect ofEmblica officinalisin Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mahaveer Golechha ◽  
Vikas Sarangal ◽  
Shreesh Ojha ◽  
Jagriti Bhatia ◽  
Dharmveer S. Arya
Keyword(s):  
Chronic Inflammation ◽  
Experimental Models ◽  
Inflammatory Activity ◽  
Prostaglandin E ◽  
Emblica Officinalis ◽  
Inflammatory Conditions ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Acute And Chronic Inflammation

Emblica officinalis, commonly known as amla in Ayurveda, is unarguably the most important medicinal plant for prevention and treatment of various ailments. The present study investigated the anti-inflammatory activity of hydroalcoholic extract ofEmblica officinalis(HAEEO). Acute inflammation in rats was induced by the subplantar injection of carrageenan, histamine, serotonin, and prostaglandin E2and chronic inflammation was induced by the cotton pellet granuloma. Intraperitoneal (i.p.) administration of HAEEO at all the tested doses (300, 500, and 700 mg/kg) significantly(P<0.001)inhibited rat paw edema against all phlogistic agents and also reduced granuloma formation. However, at the dose of 700 mg/kg, HAEEO exhibited maximum anti-inflammatory activity in all experimental models, and the effects were comparable to that of the standard anti-inflammatory drugs. Additionally, in paw tissue the antioxidant activity of HAEEO was also measured and it was found that HAEEO significantly(P<0.001)increased glutathione, superoxide dismutase, and catalase activity and subsequently reduced lipid peroxidation evidenced by reduced malondialdehyde. Taken all together, the results indicated that HAEEO possessed potent anti-inflammatory activity and it may hold therapeutic promise in the management of acute and chronic inflammatory conditions.

scholarly journals Chemical Constituents, Anti-nociceptive and Anti-inflammatory Activities of Essential Oil of Phyllanthus muellerianus

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984635 ◽  
Author(s):  
Isiaka A. Ogunwande ◽  
Opeyemi N. Avoseh ◽  
Daniel O. Igile ◽  
Oladipupo A. Lawal ◽  
Roberta Ascrizzi ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Chemical Constituents ◽  
Opioid Analgesics ◽  
Dry Weight ◽  
Standard Drug ◽  
Flame Ionization ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Plate Analysis

The aim of the present study was to characterize the chemical composition and to evaluate the anti-inflammatory and anti-nociceptive properties of the essential oil from the leaves of Phyllanthus muellerianus (Kuntze) Exell. The essential oil was hydrodistilled and characterized by gas chromatography-flame ionization detection and gas chromatography coupled with mass spectrometry analyses. The anti-inflammatory activity was evaluated on carrageenan-induced rat paw edema while the anti-nociceptive test was based on hot plate analysis. The hydrodistillation afforded 0.09% (dry weight basis) of pale yellow oil. Thirty-eight compounds representing 94.8% were identified in the oil. The major components of the oil were hexahydrofarnesyl acetone (11.6%), isocaryophyllene (9.8%), and limonene (9.4%). The oils of P. muellerianus displayed anti-nociceptive effect at a rate independent of reaction time and dose ( P < 0.001). The rate of inhibition increased exponentially as the dose increases with optimum activity at 400 mg/kg. The carrageenan-induced edema model revealed the suppression of inflammatory mediators at a very high significant value ( P < 0.001) for all doses, showing activity comparable to a standard drug at 4 hours after carrageenan injection. Collectively, the essential oils depressed the nociceptors and most likely acted as centrally mediated opioid analgesics while the anti-inflammatory mechanisms of the oil might be related to the decrease in the level of iNOS, and cyclo-oxygenase-2 in the edema paw via the suppression of pro-inflammatory cytokines (TNF-α, IL1-β), NO, and PGE2 production. This study confirms the analgesics and inflammatory activities of P. muellerianus.

scholarly journals Anti-Inflammatory Potential Evaluation (In-Vitro and In-Vivo) of Arthrophytum scoparium Aerial Part

2020 ◽  
Vol 10 (5) ◽  
pp. 213-218
Author(s):  
Sabrina Manel Kaddour ◽  
Lekhmici Arrar ◽  
Abderrahmane Baghiani
Keyword(s):  
Protein Denaturation ◽  
Radical Scavenging Activity ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
Inflammatory Activity ◽  
Traditional Use ◽  
Rat Paw Edema ◽  
Anti Inflammatory

Arthrophytum scoparium is plant commonly used in folk medicine in Algeria to treat numerous human diseases especially infectious, Rheumatism, diabetes and cancer. However, its anti-inflammatory activity and the underlying mechanisms have not been studied systematically. The present study aims to assess both the in vitro and in vivo anti-inflammatory potential and antioxidant activity of the plant. Results showed that A. scoparium chloroform extract (ChE) contains the largest amount of phenolic and flavonoid compounds. In-vitro bioassay consisted of investigating the effect of the plant extracts against protein denaturation (BSA and egg albumin). In-vivo anti-inflammatory activity was evaluated by measuring the percentage inhibition of carrageenan-induced rat paw edema after oral administration of the extracts. Results showed that inhibition of protein denaturation was maximum in case of A. scoparium crude extract (CrE) with dose dependant manner. Similarly in the in-vivo study, carrageenan induced inflammation was significantly antagonized by CrE with inhibition of 87.02% at 400 mg/kg. CrE extracts showed the highest scavenger effect against hydroxyl and hydrogen peroxide. The CrE showed potent anti-inflammatory activity in both the conditions in vivo and in vitro. In conclusion different A. scoparium extracts scavenged reactive oxygen species efficiently; it may be due to the presence of its flavonoids and polyphenols. These results support the traditional use of this plant. Keywords: Arthrophytum scoparium, polyphenols, anti-inflammatory activity, radical scavenging activity.

scholarly journals Anti-inflammatory, analgesic, and acute toxicity evaluation of Litchi chinensis seed extract in albino rat

2021 ◽  
Author(s):  
Sindhu KC ◽  
Bipindra Pandey ◽  
Sistu KC ◽  
Santosh Gurung ◽  
Ashish Gautam
Keyword(s):  
Acute Toxicity ◽  
Seed Extract ◽  
Albino Rats ◽  
Paw Edema ◽  
Hot Plate ◽  
Traditional Use ◽  
Albino Rat ◽  
Litchi Chinensis ◽  
Rat Paw Edema ◽  
Anti Inflammatory

Litchi chinensis is a edible fruits of soapberry family commonly known as lychee; is traditionally used for the treatment of inflammation, headache, and body pain. The present study investigated the toxicity, anti-inflammatory, and analgesic activity of the ethanolic crude extract of Litchi chinensis to support its traditional use in its folk medicine and to screen the phytochemical constituents. 70% ethanolic extract of seeds of Litchi chinensis (LCSE) was prepared and preliminary phytochemical screening was performed. Acute toxicity of LCSE was carried out based on OECD guidelines 423. In vivo anti-inflammatory and analgesic effect of the extract was evaluated using carrageenan-induced paw edema and hot plate methods in Wistar albino rat's model. Results revealed that LCSE contains phenols, tannins, flavonoids, saponins, steroids, and alkaloids. LD50 values were found to be higher than 5000 mg/kg body weight; no any sign of toxicity, behavior changes, moribund, and mortality were observed in LCSE treated animals. Oral administration of LCSE at the dose of 150, 300, and 600 mg/kg produced a significant (p<0.05) dose-dependent inhibition in carrageenan-induced rat paw edema and hot plate. These results suggest that LCSE is non-toxic, and shows potent anti-inflammatory and analgesic activities over Wistar albino rats. These finding demonstrate that lychee seed extract acts as a good therapeutic candidate for the safe anti-inflammatory agents.

Sign in / Sign up

Export Citation Format

Share Document