scholarly journals Effects of Highly Active Antiretroviral Treatment on Complete Blood Count Parameters

2019 ◽  
pp. 1-12
Author(s):  
Simon Bannison Bani ◽  
William K. B. A. Owiredu ◽  
Christian Obirikorang ◽  
Samuel A. Sakyi ◽  
Kwabena O. Danquah ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Clinical Information ◽  
Well Being ◽  
Erythroid Cell ◽  
Full Blood Count ◽  
Highly Active ◽  
The Individual ◽  
Control Study ◽  
Baseline Demographic

Aim: This study assesses the effects of HAART on complete blood count parameters among HIV infected participants. Study Design: Case control study. Place and Methods: This study was conducted in Tamale, Ghana from August, 2016 to December, 2017. Methodology: A total of 300 HIV infected participants with ages ranging from 19–79 years, administered with HAART for at least 6 months were recruited. Pre-HAART administration (baseline) demographic and clinical information, with initial full blood count results were retrieved from the medical records of the participants. Post HAART administration blood sample (5mLs) was taken from each participant into an EDTA vacutainer tube and complete blood count (CBC) performed using URIT 5250 haematology analyser. Participants transfused with blood over the last 4 months were excluded from the study. Results: The study recorded significant decreases in WBC and Neutrophil (%) post HAART administration. Lymphocyte (%), Haemoglobin, Haematocrit, MCV, MCHC, RDW-SD were all significantly higher post HAART administration. Total Platelets count, MPV, PDW-SD, PCT and P-LCR were significantly lower post-HAART administration. A comparison of the effects of EFV and NVP administered with AZT/3TC backbone yielded the following results. The NVP group recorded a significantly higher HCT compared with the EFV group (p-0.0073). A significantly higher mean PCT, MPV, P-LCR, PLCC, PDW-SD were recorded in the EFV group compared to the NVP group respectively. Conclusion: The administration of HAART is associated with significant improvements in erythroid and lymphoid lineages, reduce anaemia, improves immunity and general patient well-being. NVP improve erythroid cell indices while EFV ameliorate platelet indices. HAART regimen should be chosen based on the pre-HAART laboratory tests conducted on the individual.

scholarly journals A follow-up audit of the completion of bone marrow specimen request forms at an academic laboratory

2020 ◽  
pp. 96-99
Author(s):  
L Budding ◽  
M Coetzee ◽  
G Joubert
Keyword(s):  
Bone Marrow ◽  
Clinical Examination ◽  
Blood Count ◽  
Clinical Information ◽  
Full Blood Count ◽  
Hiv Status ◽  
Medication History ◽  
Bone Marrow Specimen ◽  
Transfusion History

Background: In order to ensure that patients receive individualised treatment following bone marrow biopsy, it is necessary for clinicians to provide complete clinical information on bone marrow request forms (BMRFs). An audit of BMRFs six years previously showed poor completion, especially with regard to filling in full blood count results, transfusion history, medication history, information about the clinical examination and HIV status. This lead the laboratory to design a new bone marrow specimen request form. We did a follow-up audit to see if the new form had helped to improve the completion rates. Methods: We compared 400 forms to the 357 that were audited in 2013. The following details were recorded: date and time of collection, patient demographics, requesting doctor’s details, clinical information, current medication, transfusion history and HIV status, and details of the procedure completed by technologists, registrars and pathologists. Results: The 2019 follow-up audit showed significant improvements in the completion of the transfusion history, as well as the clinical examination and HIV status. Registrars and pathologists signed off forms regularly. The completion of patient demographic details, and requesting doctors’ names and telephone numbers worsened. Discussion and conclusion: We recommend that the form be simplified so the requesting doctors only need to tick yes or no, in a tick-box format, if a full blood count has been done in the preceding 24 hours. There needs to be a dedicated space for the hospital and laboratory stickers. Only the name and telephone number of one doctor should be requested. This doctor should preferably be the most senior doctor involved with patient care. All referring laboratories and hospitals will be consulted before updating the form. Unfortunately, it seems that the only way to force the completion of request forms is to introduce an electronic order entry system that does not accept incomplete forms.

COVID-19 Detection from CBC using Machine Learning Techniques

2021 ◽  
Vol 1 (2) ◽  
pp. 65-78
Author(s):  
Asma Akhtar ◽  
Samia Akhtar ◽  
Birra Bakhtawar ◽  
Ashfaq Ali Kashif ◽  
Nauman Aziz ◽  
...  
Keyword(s):  
Machine Learning ◽  
Blood Count ◽  
Nearest Neighbor ◽  
Complete Blood Count ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Full Blood Count ◽  
Support Vector ◽  
K Nearest Neighbor ◽  
Critical Requirement

Covid-19 pandemic has seriously affected the mankind with colossal loss of life around the world. There is a critical requirement for timely and reliable detection of Corona virus patients to give better and early treatment to prevent the spread of the infection. With that being said, current researches have revealed some critical benefits of utilizing complete blood count tests for early detection of COVID-19 positive individuals. In this research we employed different machine learning algorithms using full blood count for the prediction of COVID-19. These algorithms include: “K Nearest Neighbor, Radial Basis Function, Naive Bayes, kStar, PART, Random Forest, Decision Tree, OneR, Support Vector Machine and Multi-Layer Perceptron”. Further, “Accuracy, Recall, Precision, and F-Measure” are the performance evaluation measures that are utilized in this study.

The Complete Blood Count

2010 ◽  
Vol 29 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Terri Lynne Milcic
Keyword(s):  
Gestational Age ◽  
Laboratory Tests ◽  
Blood Count ◽  
Neonatal Period ◽  
Complete Blood Count ◽  
Clinical Information ◽  
Diagnostic Assessment ◽  
Reference Ranges ◽  
Hematopoietic System ◽  
Common Laboratory

THE COMPLETE BLOOD COUNT (CBC) is one of the more common laboratory tests ordered during the neonatal period. The CBC may be obtained to evaluate for anemia, infection, and thrombocytopenia.1 The test offers a wealth of clinical information about the hematopoietic system, including erythrocyte, leukocyte, and thrombocyte values. Establishing normal neonatal ranges has been difficult because blood has not been drawn on healthy neonates of similar ages.2 Reference ranges that consist of the 5th to 95th percentile compiled from various studies have been used to approximate normal neonatal values.3 A variety of factors such as sample site, timing of the sample, gestational age, and the neonate’s degree of health can affect the CBC.1 Therefore, the astute practitioner must be able to recognize the clues and nuances of the CBC to guide the diagnostic assessment.4

scholarly journals Evaluation of Beta Globin Gene Mutations in Beta Thalassemia Carrier Children in Aydın Province and its Environment

2021 ◽  
Author(s):  
Deniz İlgün ◽  
Yusuf Ziya Aral ◽  
Mediha Akcan ◽  
Özgür Cartı ◽  
Gökay Bozkurt
Keyword(s):  
Mutation Analysis ◽  
Blood Count ◽  
Complete Blood Count ◽  
Gene Region ◽  
Full Blood Count ◽  
Beta Thalassemia ◽  
Distribution Width ◽  
Intron 1 ◽  
Hbf Level ◽  
Mutation Type

INTRODUCTION: Beta thalassemia carriers (BTC) in Turkey is observed with a frequency of 2.1%, and it is the most common cause of anemia after iron deficiency. There are few studies showing the effect of genotype on phenotype in beta thalassemia carrying children. The aim of this study is to determine the mutation diversity of these children in and around Aydın and evaluate the effects of these mutations on complete blood count parameters and hemoglobin electrophoresis. METHODS: This study included mutation analysis of 65 patients who were diagnosed as BTC in Adnan Menderes University, Faculty of Medicine, Department of Child Health and Diseases, Pediatric Hematology Outpatient Clinic between 01.01.2014 and 01.08.2019. Complete blood count, hemoglobin electrophoresis and mutation analysis results were obtained from the computer data system and patient files. Research data were evaluated by using SPSS 21.0 statistics program. RESULTS: 39 (60.0%) of the sixty-five patients were male, 26 (40.0%) were female, and the mean age was 8.34±4.94 years. When full blood count parameters were analyzed, 87.7% had anemia, 100% microcytosis and high red cell distribution width (RDW) level, 49.2% hypochromia and 87.7% high red blood cell (RBC) count. RDW level was ≥16 in 66.2% of the cases. Seventeen different mutations were detected. The mutations most frequently occurred in “intron 1” gene region (66.1%). The most common ones were IVS I-110 (44.11%), IVS I-1 G>A Heterozygotes (8.8%,) IVS I-6 T>C Heterozygotes (7.5%) and IVS II-745 (7.5%). RDW level was ≥16 in 66.2% of the cases. Seventeen different mutations were detected. The mutations most frequently occurred in “intron 1” (66.1%) gene region. IVS I-110 (44.11%), IVS I-1 G>A Heterozygotes (8.8%,) IVS I-6 T>C Heterozygotes (7.5%) and IVS II-745 (7.5%) were observed most commonly. In patients with IVS I-110 mutation, mean Hb level was 10.55 gr/dL, MCV level was 58.44 fL, RDW level was 16.51, RBC level was 5680x10⁹/L, HbA2 level was 4.77%, HbF level was 2.34%. Mutations detected in 12 patients with HbF level above 5% were as IVS I-110 (5 people), IVS I-6 T>C Heterozygotes, Codon 39 C>T Heterozygotes, IVS I-116, c.25-26 del AA (plys9Valfs) Heterozygotes, c.27dupG (pSer10valfs*14), c316-373 (IVSII-478 C>A Heterozygotes), -87 C>T Heterozygotes. Mentzer index was calculated as >13 in six patients (9.2%). The mutations seen in these patients were IVS-I 110, c.27dupG (p.Ser10valfs*14), c316-373 (IVS II-478 C>A Heterozygotes), -87 C>T Heterozygotes. There were four patients (6.1%) with a RDW index >220. Two of these patients had c.27dupG (p.Ser10valfs*14) and others had c316-373 (IVS II-478 C>A Heterozygotes) and -87 C>T Heterozygotes mutations. Mutations detected in four patients with HbF levels in the range of 9.48-15.67 were IVS I-116 T>G Heterozygotes, IVS I-110 G>A Heterozygotes, c.25-26 del AA (p.lys59valfs) Heterozygotes, c27 dupG (pSer10 valfs*14) and three of these mutations carrying β° mutation type were located in exon 1 and one of them carrying β⁺ mutation type (IVS I-110) was in intron 1. DISCUSSION AND CONCLUSION: The same mutations detected in patients with beta thalassemia carriers have different effects on complete blood count parameters. HbA2 and HbF levels suggest that these mutations are not effective on the phenotype alone and there may be additional factors which should be clarified. We think that there may be BTC in cases with low RBC, Mentzer index ≥13 and RDW index ≥220, HbA2 <3.5 and studying the mutation analysis of these patients will contribute significantly to the literature.

Drug-Induced Agranulocytosis: A Mini Review

2016 ◽  
Vol 2 (1) ◽  
pp. 57-59
Author(s):  
Pavithra D ◽  
Praveen D ◽  
Vijey Aanandhi M
Keyword(s):  
Bone Marrow ◽  
Complete Blood Count ◽  
Genetic Manipulation ◽  
White Blood Cells ◽  
Deep Infection ◽  
Morbidity Rate ◽  
Drug Induced ◽  
Serious Adverse Event ◽  
Mortality And Morbidity ◽  
The Individual

Agranulocytosis is also known to be granulopenia, causing neutropenia in circulating blood streams .The destruction of white blood cells takes place which leads to increase in the infection rate in an individual where immune system of the individual is suppressed. The symptoms includes fever, sore throat, mouth ulcers. These are commonly seen as adverse effects of a particular drug and are prescribed for the common diagnostic test for regular monitoring of complete blood count in an admitted patient. Drug-induced agranulocytosis remains a serious adverse event due to occurrence of severe sepsis with deep infection leading to pneumonia, septicaemia, and septic shock in two/third of the patient. Antibiotics seem to be the major causative weapon for this disorder. Certain drugs mainly anti-thyroid drugs, ticlopidine hydrochloride, spironolactone, clozapine, antileptic drugs (clozapine), non-steroidal anti-inflammatory agents, dipyrone are the potential causes. Bone marrow insufficiency followed by destruction or limited proliferative bone marrow destruction takes place. Chemotherapy is rarely seen as a causative agent for this disorder. Genetic manipulation may also include as one of the reason. Agranulocytosis can be recovered within two weeks but the mortality and morbidity rate during the acute phase seems to be high, appropriate adjuvant treatment with broad-spectrum antibiotics are prerequisites for the management of complicated neutropenia. Drugs that are treated for this are expected to change as a resistant drug to the patient. The pathogenesis of agranulocytosis is not yet known. A comprehensive literature search has been carried out in PubMed, Google Scholar and articles pertaining to drug-induced agranulocytosis were selected for review.

Engaged Study of the Qur'an: Gauging its Effect on the Life of the Individual and of Society

2003 ◽  
Vol 5 (2) ◽  
pp. 202-207
Author(s):  
Ruqayya Ṭā Hā Jābir al-cUlwānī
Keyword(s):  
Social Conflict ◽  
Well Being ◽  
Arabic Language ◽  
Modern World ◽  
Educational Systems ◽  
Functional Perspective ◽  
Number Of Factors ◽  
Social Advancement ◽  
Freedom Of Thought ◽  
The Individual

An engaged and perceptive contemplation of the Qur'an forms one of the most important bases for the cultural and social advancement of Muslims in all walks of life, and the absence of such study is one of the reasons behind the general cultural attenuation in the modern world. Reflection is one of the means of the construction and formation of a civilised society. The applied faculty of intellect creates an environment which allows reflective and considered thought to be developed from a functional perspective for the general well-being of society. Meanwhile the effective neglect of such study leads to the proliferation of superstition, dissent and social conflict. Indeed it can even be argued that it diminishes the significance of the laws and conventions which serve as the backbone of society. This paper reveals a number of factors which can impede the achievement of such an engaged study of the text: thus, for instance, thoughtless obedience to societal conventions; shortcomings in educational systems and syllabi; and a failure to encompass the significance of the Arabic language. Furthermore this paper presents several effective suggestions for nurturing students' potential, encouraging an environment which allows freedom of thought, and its refinement.

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