scholarly journals Neurophysiological Study of Alzheimer’s Disease and Diabetes Mellitus Type 2 Patients. Is there a Common Link?

2021 ◽  
pp. 10-15
Author(s):  
Vasileios Papaliagkas ◽  
Mara Gkioka ◽  
Athanasios Mousiolis ◽  
Maria Chatzidimitriou ◽  
Petros Skepastianos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuropsychological Tests ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Group 2 ◽  
Age Range ◽  
Group 1

Introduction:  Recent studies have shown that insulin resistance and deficiency, a marker of Diabetes mellitus type 2 (DM), interact with beta amyloid and tau protein phosphorylation, which are the basic neuropathological hallmarks of Alzheimer’s Disease (AD). Based on these results, it was recently proposed that AD might be considered as ‘Diabetes type 3’. Aim of the current study is to assess the cognitive function of DM patients and Mild cognitive impairment (MCI) patients with neurophysiological and neuropsychological measures and seek possible correlations. Methods: The study participants were divided into two groups: group 1 and group 2. Group 1 consisted of 24 DM patients (7 men, 17 women; age 70.6±6.5 (mean ± SD) years; age range 55-86 years. Group 2 consisted of 16 MCI patients  age 72.61±7.42 (mean ± SD)years; age range 58-89 years)   age-matched (t-value=1.06,  p=0.30) and gender matched (χ2=0.084,  p=0.772) with group 1 patients. All patients were assessed with auditory event-related potentials (AERPs) and neuropsychological tests, which include MMSE, MOCA, IADL, and HAMILTON depression scale. Latencies and amplitudes of the major AERP waves (N200, P300 and Slow Wave) were determined, Results: No statistically significant difference was observed in the AERP characteristics and the performance of the patients in the neuropsychological tests between the two groups (p>0.05). Conclusions: From the results of the current study, it appears that the higher cognitive functions of DM patients as assessed with ERPs and neuropsychological tests are affected in a similar way with that of MCI patients; a finding which supports the existence of common pathophysiological mechanisms between the two diseases.

scholarly journals Association of Diabetes Mellitus Type 2 and Alzheimer's Disease

2019 ◽  
Vol 4 (4) ◽  
pp. 86-89
Author(s):  
Sasan Andalib ◽  
◽  
Amirreza Ghayeghran ◽  
Yaser Moadabi ◽  
Kamran Asadi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type

scholarly journals Relação entre doença de alzheimer e diabetes mellitus tipo 2 / Relationship between alzheimer's disease and diabetes mellitus type 2

2020 ◽  
Vol 3 (6) ◽  
pp. 16326-16334
Author(s):  
Lis Mariana da Silva Menezes ◽  
Liliane Rodrigues Garcia ◽  
Antonio José Ferreira Maia Russo ◽  
Karen Larissa Dias Corrêa ◽  
Raíssa do Socorro Silva Jacob ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type

An Evaluation of Hemoglobin Concentration in Patients with Diabetes Mellitus Type 2

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Karem Kdaer Karem ◽  
Saba Ibrahim Salih ◽  
Wafaa Kadhim Jassim
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Hemoglobin Concentration ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Other Information ◽  
Patients With Diabetes ◽  
Age Range

The second type of diabetes Mellitus is the most common type of diabetes, its represent about 90-95% of diabetes cases. In this disease, the response of the body to insulin does not occur properly in a condition known as insulin resistance. The diabetes may accompany with anemia because the hormone erythropoietin (EPO) which is produced by the kidneys is regulates red blood cell production and the Kidney has been damaged at several levels as a complication of diabetes, the complication range from diabetic nephropathy to chronic kidney disease. This study was conducted at the AL-Kafeel Hospital, Kerbala from October 2016 to December2016. The study included 60 adult patients with age range from 43-67 years and having diabetes mellitus type 2. Fasting blood sugar and Hb tests were made and accompanied with other information like age and duration of diabetes mellitus. The results show that 43% of diabetic patients had anemia and there is a strong negative connection between Hb levels and the duration of getting diabetes (p0.01). We conclude from this study that anemia is may developed in Type 2DM patients and the diabetic patients should be taken care of toprevent the development of diseases and other complications.

scholarly journals High Prevalence of Hypoglycemia in People Above the Age of 75 without Diabetes Mellitus

2021 ◽  
Author(s):  
Jille Gelders ◽  
Siddhartha Lieten ◽  
Tony Mets ◽  
Ivan Bautmans ◽  
Sebastiaan Engelborghs ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cognitive Deficits ◽  
Diabetes Mellitus Type 2 ◽  
Older Persons ◽  
Glucose Monitoring ◽  
High Prevalence ◽  
Group 2 ◽  
Hba1c Levels ◽  
Group 1

Abstract Background: Hypoglycemia, especially at old age, can lead to several major problems, such as falls and cognitive deficits. The aim of our study was to detect hypoglycemia in older persons with and without diabetes mellitus type 2 (T2DM).Methods: The frequency and duration of hypoglycemia/hyperglycemia was studied in ambulatory geriatric (>75 years), non-diabetic persons (Group 1, n=10), using real time Continuous Glucose Monitoring (CGM, Dexcom G6), and in age- and sex-matched cognitively-healthy, T2DM patients having HbA1c levels < 9.0% (Group 2, n=10). The device was used during 20 days per person, who was blinded for the values on the receiver (except in case of severe hypo- or hyperglycemia). Data were stored for further analysis on the Dexcom Clarity Portal.Results: Hypoglycemia occurred frequently in older persons without T2DM, despite absence of hypoglycemia-inducing medication. In this group, people had 0.50% (median value) of the time glycemic values below 70 mg/dL, most of the episodes happened during nighttime. Conclusions: Our study demonstrates that hypoglycemia occurs frequently in non-diabetic older persons. Further studies are needed to determine whether this could be part of the normal aging process, and to determine if hypoglycemia might contribute to cognitive deterioration.

scholarly journals THE CONDITION OF BRAINSTEM PART OF THE AUDITORY ANALYZER IN DIABETES MELLITUS TYPE 2 PATIENTS WITH HEARING IMPAIRMENT

2021 ◽  
Vol 67 (6) ◽  
pp. 68-73
Author(s):  
T.A. Shydlovska ◽  
◽  
T.V. Shydlovska ◽  
N.Y. Navalkivska ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
The State ◽  
Sensorineural Hearing ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Auditory Analyzer ◽  
Group I ◽  
Group 2 ◽  
Group 1

The purpose of our study is to examine the condition of brainstem part of the auditory analyzer based on examination of the short-latent auditory evoked potentials (SLAEP) in 43 patients with diabetes mellitus (DM) type 2 with disorders of auditory function. We revealed sensorineural hearing loss (SNHL) of the I-II degree according to the internation- al classification. The registration of SLAEP was conducted by the system «Eclipse» «Interacoustics» (Denmark). We detected a lengthening of the latent periods of the peaks (LPP) of the II, III, IV and V waves of SLAEP, as well as the inter-peak intervals of I-III and I-V comparing to the control values. So, LPP of III wave SLAEP was 3.85 ± 0.04 ms, and of V wave was 5.83 ± 0.05 ms. According to the severity of DM type II, we divided the patients into two groups: without (group I) and with (group II) complica- tions. A comparative analysis revealed that the values of LPP III wave and also I-III in group 2 not only significantly exceeded the normal values, but also significantly differed from the same indicators in group 1. Thus, the LPP of the III wave of SLAEP was 3.81 ± 0.03 and 3.95 ± 0.05 ms, in group 1 and 2, respectively. In group 2 inter-peak interval I-III was 2.29 ± 0.03 ms, inter-peak interval I-V was 4.21 ± 0.04 ms. This indicates the possible influence of the complicated course of diabetes mellitus II on the development of disorders in the central departments of the auditory analyzer, particular in its brainstem structures. Therefore, among all studied groups of patients with SNHL on the background of DM type II there are a pronounced deviations from the norm in the state of the brainstem part of the auditory analyzer. The obtained data indicate an important role of the state of brainstem part of auditory analyzer in the development of sensorineural hearing disorders in diabetes mellitus type II.

scholarly journals Myogenic vasomotions in postmenopausal women with normoglycemia, prediabetes and diabetes mellitus type 2

2016 ◽  
Vol 15 (3) ◽  
pp. 36-43
Author(s):  
I. S. Iskhakova ◽  
L. A. Ruyatkina ◽  
K. Y. Nikolaev ◽  
D. S. Ruyatkin
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Carbohydrate Metabolism ◽  
Postmenopausal Women ◽  
Diabetes Mellitus Type 2 ◽  
Statistical Significance ◽  
Diabetes Mellitus Type ◽  
Doppler Flowmetry ◽  
Group 1

The aim of the study. Estimate microcirculatory parameters of myogenic range in postmenopausal women with normoglycemia, prediabetes and diabetes mellitus type 2. Material and methods. Among the surveyed 94 women (58.0 (53.0; 63.0) years old), in the natural menopause (duration 7.0 (2.0; 13.0) years), depending on the status of carbohydrate metabolism (WHO, 2011) by measuring the levels of glycated hemoglobin, we identified three groups: group 1 (n = 52) - with diabetes mellitus 2 type, 2 (n = 16) - with prediabetes, 3 (n = 26) - with normoglycaemia. We evaluated anthropometric and biochemical parameters; microcirculation was assessed by laser Doppler flowmetry. Statistical analysis was performed using the SPSS software (version 17.0). The level of statistical significance of differences was at p ≤ 0.05. Results. Women with impaired glucose metabolism (group 1 and 2) with increased abdominal fat deposition have the elevated basal vasospasm and impaired microvascular reactivity due to increased myogenic tone. We found that group 1 has negative association of LDF parameters of myogenic range with blood pressure and duration of hypertension. We identified that increasing concentrations of atherogenic lipids contribute to basal and postocclusive vasodilation independently of the state of glucose metabolism. Conclusion. Identified associations and differences in the LDF parameters of myogenic range at the basal and reperfusion microcirculation reflect the increase of vasospasm and microcirculatory disturbances during progression of carbohydrate metabolism disorders in postmenopausal women.

Bone quality in diabetes mellitus type 2

2014 ◽  
Author(s):  
Peter Jackuliak ◽  
Zdenko Killinger ◽  
Juraj Payer
Keyword(s):  
Diabetes Mellitus ◽  
Bone Quality ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type
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