Case Study of Polycystic Ovary Syndrome -An Overview

2021 ◽  
pp. 56-60
Author(s):  
Pratiksha Chitalkar ◽  
Rakesh Kumar Jha ◽  
Dhruba Hari Chandi
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Daily Basis ◽  
The Body ◽  
Ovary Syndrome ◽  
Indian Women ◽  
High Insulin ◽  
Ovarian Syndrome ◽  
Improve Health

Introduction: Polycystic ovarian syndrome (PCOS) is also known as polycystic ovarian disorder (POD). The disease is mainly metabolic (hyper androgenic) one. It usually affects women between the ages of 18 and 44. PCOS has no clear origin, although it seems to work at home. It is related to the effects of high levels of hormones in the body, such as high insulin levels. PCOS affects more than a million people in India each year. PCOS affects one in five Indian women (20%). Left untreated, the disease can lead to serious health problems. Conclusion: There is no permanent treatment for it since it is an irreversible syndrome/disease. The best way to improve health conditions is to change one's lifestyle and take drugs. One of the most effective methods is to make a healthy food/bad food chart and stick to it with exercise and medicine on a daily basis.

scholarly journals Article Review: Coloration Biochemistry and Molecular Biology Between Polycystic Ovary Syndrome and Diabetes Mellitus Type 2

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Noora Wael Rasheed ◽  
Abeer Ali Marhoon
Keyword(s):  
Diabetes Mellitus ◽  
Multiple Testing ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Premenopausal Women ◽  
Ovary Syndrome ◽  
Indian Women ◽  
Reproductive Endocrine ◽  
Ovarian Syndrome

Polycystic ovarian syndrome is the most common reproductive endocrine disorder in premenopausal women Given the clinical overlap between PCOS and type 2 diabetes mellitus (T2DM), this research sought to investigate if genes associated with T2DM were similarly connected to PCOS vulnerability. In either the univariate or multivariate scenario, none of the 16 SNPs was significantly associated with Polycystic Ovarian Syndrome after Bonferroni correction for multiple testing. The nine T2DM genes investigated in this preliminary research may not be the main PCOS risk factors in Indian women. Our findings add to the absence of evidence of a link between T2DM genes and PCOS in Chinese and Caucasians, suggesting that this trend may be universal. To determine the exact significance of the diabetes genes, researchers will need to conduct extensive studies that involve women with T2DM and PCOS.

scholarly journals Adnexal Torsion during Pregnancy after Oocyte In Vitro Maturation and Intracytoplasmic Sperm Injection Cycle

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Simone Giulini ◽  
Giulia Dante ◽  
Susanna Xella ◽  
Antonio La Marca ◽  
Tiziana Marsella ◽  
...  
Keyword(s):  
In Vitro Maturation ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Adnexal Torsion ◽  
Term Pregnancy ◽  
Ovary Syndrome ◽  
Clinical Disorder ◽  
Injection Cycle ◽  
Ovarian Syndrome

We report a case of right adnexal torsion during pregnancy after an oocyte in vitro maturation and intracitoplasmic sperm injection cycle in patient with polycystic ovary syndrome. A 31-year-old woman with a typical clinical disorder of polycystic ovarian syndrome was included in an oocyte in vitro maturation program. Right adnexal torsion occurred two days after embryo transfer, and laparoscopy detorsion was successfully performed with preservation of adnexa. The patient had a full-term pregnancy and delivered a healthy infant at 40 weeks of gestation. To our knowledge this is the first report of adnexal torsion after an oocyte in vitro maturation and intracitoplasmic sperm injection program.

scholarly journals Correlation of serum androgen and gonadotropin with anti-mullerian hormone in polycystic ovarian syndrome in Eastern Indian population

2019 ◽  
Vol 8 (1) ◽  
pp. 256
Author(s):  
Somnath Singh Raghuvanshi ◽  
Anirban Sinha ◽  
Animesh Maiti ◽  
Partha Pratim Chakraborty ◽  
Asish Kumar Basu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Pulse Generator ◽  
Polycystic Ovary ◽  
Serum Testosterone ◽  
Pulse Frequency ◽  
Strong Positive Correlation ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Ovarian Syndrome

Background: Ovarian steroidogenesis requires gonadotropin stimulation, Luteinizing Hormone (LH) is a key factor in the hyperandrogenaemia of the polycystic ovary syndrome. Progesterone is the primary regulator of Gonadotropin-Releasing Hormone (GnRH) pulse frequency; however, in the polycystic ovary syndrome, the GnRH pulse generator is relatively resistant to the negative feedback effects of progesterone.  Study aims to evaluate the association of Anti-mullerian hormone with serum androgen and gonadotropin level in adolescents and young women of Polycystic Ovary Syndrome (PCOS).Methods: This was a single centre observational Cross-sectional study carried out in the department of Endocrinology and metabolism, Medical College, Kolkata from March 2017 to January 2019. Total number of study subjects were 207 out of which 138 were cases.Results: The AMH had strong positive correlation with serum testosterone in both case and control groups (r 0.542, p<0.001 and r 0.57, p<0.001) respectively .After the adjustment of age and BMI , the AMH moderately positive  but extremely significant correlation with serum testosterone as compare to control.Conclusions: Hyperandrogenaemia and higher ratio of LH and FSH associated with higher serum AMH level is associated with the higher serum AMH in polycystic ovarian syndrome.

scholarly journals The Early Coasting Method during Ovarian Stimulation in Antagonist Protocols with Combined Use of Cabergoline is Useful in Patients with Polycystic Ovary Syndrome

2021 ◽  
Vol 6 (3) ◽  
pp. 1-6
Author(s):  
Akira Nakashima ◽  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Gnrh Antagonist ◽  
Polycystic Ovary ◽  
Gonadotropin Releasing Hormone ◽  
Ovary Syndrome ◽  
Early Administration ◽  
Combined Use ◽  
Gnrh Antagonist Protocol ◽  
Ovarian Syndrome ◽  
Antagonist Protocol

Purpose: This study aimed to investigate the efficacy of withholding gonadotropins (coasting) and early administration of cabergoline in a flexible Gonadotropin-Releasing Hormone (GnRH) antagonist protocol for patients with Polycystic Ovarian Syndrome (PCOS).

scholarly journals Role of Anti-mullerian Hormone (AMH), As A Prediction of Clinical Pregnancy Outcome in Women with Polycystic Ovarian Syndrome with Sub Fertility

2018 ◽  
Vol 9 (1) ◽  
pp. 3-5
Author(s):  
Ashia Khatun ◽  
Afroza Kutubi ◽  
Khairun Nahar ◽  
Israt Jahan ◽  
Hasina Begum ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Clinical Pregnancy ◽  
Age Group ◽  
Serum Samples ◽  
Ovary Syndrome ◽  
Randomized Sampling ◽  
Ovarian Syndrome ◽  
Good Linear Correlation

Background: Anti-mullerian hormone (AMH) in largely expressed throughout folliculogenisis (by granulosa cells in ovarian follicles) but highest in pre-antral and small antral steges (<4mm) drameter of development.Objective: To analyse the usefulness of plasma anti-mullerian hormone (AMH) measurement as a test for assessing ovarian reserve in Polycystic ovary syndrome with sub fertility,Methodology: Women with PCOS and sub fertility, were included in this study with age group 18-35yrs. This Prospetive cohort study done in 30 cases in ShSMC with purposive randomized sampling, from January 2015 to December 2015. Serum, plasma & for evaluation of PCOS, preferably TV-USG was done.Result: In this study we analyze 30 serum samples from patient aged between 18-35 years and transvaginal ultrasonography was done simultaneously. Mean age group of my patient was 25.2±4.7 years which correlates with AMH level in PCOS which is statistically significant (p<0.001). Mean level of AMH is 5.7±4.9 mg/ml which is also correlate with transvaginal USG scan with the feature of PCOS (p<.0.001). More than 50% woman presents with features of subfertility with PCOS and 46.7% are normal ovaries. Mean menstrual day 7.6 (4-12 days) which have a good linear correlation with irregularities of menstrual cycle and PCOS (p<0.05).Conclusion: To conclude AMH appears to have a major inhibiting role during folliculogenesis, which may contribute to anovulation in PCOS. The reason for the raised AMH in PCOS may give clues as to the mechanism os anovulation.J Shaheed Suhrawardy Med Coll, June 2017, Vol.9(1); 3-5

scholarly journals The effect of progressive muscle relaxation on depression in polycystic ovarian syndrome

2018 ◽  
Vol 7 (8) ◽  
pp. 3029
Author(s):  
Jyoti Parle ◽  
Aishwarya D. Savant
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Muscle Relaxation ◽  
Progressive Muscle Relaxation ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Exclusion Criteria ◽  
Before And After ◽  
Muscle Groups ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Authors explored the effects of progressive muscle relaxation (PMR) on depression in females with polycystic ovarian syndrome (PCOS).Methods: In a 4-week study duration in which the intervention was for three times a week, 30 females which were selected according to the inclusion and exclusion criteria received a PMR protocol in which subjects were taught to contract and relax 16 muscle groups. The Becks Depression Inventory (BDI) was taken before and after the intervention as a depression analysis tool.Results: After 4 weeks of intervention, the patients showed significant improvement in depression (P < 0.05).Conclusions: In conclusion, this study suggests that PMR practice is effective in improving depression, in patients with PCOS.

scholarly journals MULTIPLE APPROACHES IN AYURVEDA FOR PATHO-PHYSIOLOGY IN POLYCYSTIC OVARIAN SYNDROME

2021 ◽  
Vol 10 (3) ◽  
pp. 3055-3058
Author(s):  
R Andhare
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Clinical Presentation ◽  
Polycystic Ovary ◽  
Modern Science ◽  
Metabolic Function ◽  
Complete Understanding ◽  
Ovary Syndrome ◽  
Menstrual Dysfunction ◽  
Ovarian Syndrome

The most prevalent endocrine condition in women is polycystic ovary syndrome (pcos).the clinical presentation of pcos ranges between mild menstrual dysfunction and extreme reproductive and metabolic function disruption. According to modern science, the physiology related to ovulation is controlled by hormones of hypothalamo – pituitary – ovarian axis. This axis is disturbed in pcos. According to ayurveda, patho-physiology involves vitiated doshas i.e. Vata, pitta, kapha and agni – especially dhatwagni. The pathophysiology of pcos is analysed to clarify the precise cause of the disorder in order to prepare therapy for a full cure. Multiple approaches in ayurveda for patho-physiology in polycystic ovarian syndrome. It is evident in conclusion that pcos is an enigma. There is no complete understanding of its fundamental pathophysiology as per modern science. No therapy is a panacea, as therapies have so far been targeted at the symptoms but not at the syndrome itself.

scholarly journals Metformin throughout Pregnancy in Women with Polycystic Ovary Syndrome: Safety and Advantages

2011 ◽  
Vol 2 (2) ◽  
pp. 61-64 ◽  
Author(s):  
Bharti Bansal ◽  
Rutvij Jay Dalal ◽  
P Palshetkar Nandita ◽  
D Pai Hrishikesh ◽  
Takhtani Manisha ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Maternal Complications ◽  
Ovary Syndrome ◽  
Trimester Abortion ◽  
Metformin Therapy ◽  
High Incidence ◽  
Ovarian Syndrome ◽  
In Pregnancy

ABSTRACT Objective To study the incidence of spontaneous abortions, congenital malformations, neonatal and maternal hypoglycemia after metformin therapy in pregnancy. Design Prospective study. Setting Outpatient. Patient(s) 56 women previously oligomenorrheic, nondiabetic women with polycystic ovarian syndrome, who conceived while on metformin. Intervention(s) Metformin 1 to 1.5 gm/day throughout pregnancy. Main outcome Incidence of 1st trimester abortions, gestational diabetes, teratogenicity and maternal complications, like gastritis and hypoglycemia. Results On metformin, the incidence of 1st trimester abortion was 11% and the incidence of gestational diabetes was 7%, which is much lower than the incidence otherwise cited for PCOS women. No major congenital abnormalities were observed. Conclusion Metformin therapy in pregnancy reduces the otherwise high incidence of 1st trimester abortions, and gestational diabetes in PCOS women is tolerated well and is not found to be teratogenic.

scholarly journals Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Sairish Ashraf ◽  
Mudasar Nabi ◽  
Shayaq ul Abeer Rasool ◽  
Fouzia Rashid ◽  
Shajrul Amin
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Follicular Development ◽  
Pulse Frequency ◽  
Ovary Syndrome ◽  
Ovarian Morphology ◽  
Genetic And Environmental Factors ◽  
Hallmark Feature ◽  
Ovarian Syndrome

Abstract Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by anovulation, hyperandrogenism, and polycystic ovarian morphology. The pathophysiology of PCOS is not clear; however, disturbance in hypothalamic-pituitary-ovarian axis and abnormal steroidogenesis along with genetic and environmental factors act as main contributors to this disorder. Main text Hyperandrogenism, the hallmark feature of PCOS, is clinically manifested as hirsutism, acne, and alopecia. Excessive androgen production by ovaries as well as from adrenals contributes to hyperandrogenism. Abnormalities in the neuroendocrine system like increased pulse frequency of gonadotropin-releasing hormone, stimulating the pituitary for excessive production of luteinizing hormone than that of follicle-stimulating hormone is seen in PCOS women. Excess LH stimulates ovarian androgen production, whereas a relative deficit in FSH impairs follicular development. The imbalance in LH: FSH causes proliferation of ovarian theca cells leading to increased steroidogenesis, and ultimately leading to hyperandrogenism in PCOS women. Various genetic factors have been shown to be associated with abnormal steroidogenesis. CYP genes involved in steroidogenesis play an important role in androgen production and are considered as key players in hyperandrogenism in PCOS. Conclusion Polymorphisms in CYP genes can aggravate the hyperandrogenic phenotype in women with PCOS by either upregulating or downregulating their expression, thus increasing androgens further. However, this hypothesis needs to be validated by further studies.

scholarly journals Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Manal Madany Abdalqader ◽  
Shatha Sami Hussein
Keyword(s):  
Roc Analysis ◽  
Polycystic Ovarian Syndrome ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
Iraqi Women ◽  
Ovarian Syndrome ◽  
Control Study

Objective. Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers. Study Design. A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women diagnosed as PCOS, 22 women with BMI ≥ 25 kg/m2 and 22 women with BMI < 25 kg/m2, and another 43 women without PCOS, 22 women with BMI ≥ 25 kg/m2 and 21 women with BMI < 25 kg/m2. Hormonal, metabolic profiles, and hirsutism scores, as well as serum kisspeptin level, were assessed by using Human Kisspeptin 1(KISS-1) ELISA Kit. The blood samples between days 2 and 5 of menstrual cycle were drawn by an disposable sterile syringe and collected in EDTA containing tubes (as anticoagulant), and the hormonal profile was measured using a biotech ELISA reader. Result. Serum level of kisspeptin was significantly higher in PCOS compared to control (322.4 vs. 235.3 ng/L, respectively). There was no significant difference in age, BMI, and parity between control and PCOS; the frequency of hirsutism, acne, elevated LH, and increased free testosterone (fTT) were significantly higher in PCOS compared to control. Kisspeptin shows a direct significant correlation with hirsutism and fTT (r = 0.648, 0.238, respectively). In ROC analysis, kisspeptin had AUC (95% CI) = 0.874 (0.785–0.935) for predicting PCOS. Conclusion. Kisspeptin levels might be used as a marker for hyperandrogenemia in polycystic ovarian syndrome.

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