scholarly journals The Effect of Ethanol Extract of Carica papaya Seed towards Lipid Profile on Rats Induced Rifampicin and Isoniazid

2021 ◽  
pp. 213-219
Author(s):  
. Liana ◽  
I. Nyoman Ehrich Lister ◽  
Edy Fachrial ◽  
. Adrian
Keyword(s):  
Lipid Metabolism ◽  
Treatment Group ◽  
Total Cholesterol ◽  
Carica Papaya ◽  
Ethanol Extract ◽  
Potential Effect ◽  
Normal Group ◽  
Group I ◽  
Carica Papaya Seed ◽  
Papaya Seed

Aims: Rifampicin one of the most commonly used front-line drugs in antituberculosis therapy, has been known to be hepatotoxic. The oxidative stress that is formed in the mitochondria due to rifampicin and isoniazid causes an imbalance in lipid metabolism. This study aims to determine the effect of lowering total cholesterol, triglyceride, and LDL levels and increasing HDL levels of papaya seed ethanol extract in rats induced by rifampin and isoniazid. Study design: This study is experimental study. Methodology: This study was divided into 9 groups including normal group, negative group 1, 2, 3, positive 1, 2, treatment group I (EECP 100 mg/kgbw), treatment group II (EECP 300 mg/kgbw), and treatment group III (EECP 500 mg/kgbw). Rifampicin (50 mg/kgbw), isoniazid (50 mg/kgbw), and EECP were given 28 days, on day 29 rats were dissected and blood was taken and the total cholesterol, triglyceride, LDL and HDL levels were measured. Results: The results showed that the ethanol extract of papaya seeds at a dose of 100 mg / kgbb, 300 mg / kgbb, and 500 mg / kgbw could reduce levels of total cholesterol, triglycerides, LDL and increase HDL levels. The dose of 500 mg / kgbw was not statistically significant (P> 0.05) with the normal group. Conclusion: Ethanol extract of Carica papaya has a potential effect of preventing the destruction of lipid metabolism effect by reducing the LDL, Trygliseride, Cholesterol Total, and increasing the level of HDL.

scholarly journals Hepatoprotective Effect of Papaya Seed Ethanol Extract on Rifampicin Isoniazid-induced Rats

2021 ◽  
pp. 78-83
Author(s):  
Yessi Sunari Wahfar ◽  
I. Nyoman Ehrich Lister ◽  
Edy Fachrial
Keyword(s):  
Treatment Group ◽  
Carica Papaya ◽  
Ethanol Extract ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Immunomodulatory Activity ◽  
Negative Group ◽  
Group I ◽  
Papaya Seeds ◽  
Papaya Seed

Aims: Hepatotoxicity induced by anti-tuberculosis drugs, including rifampicin and isoniazid (AT- DILI, Anti Tuberculosis-Drug Induced Liver Injury), is an adverse reaction followed by significant morbidity. Several in vivo and in vitro research has confirmed that papaya seeds contain various non-essentials, minerals, and fiber. Carica papaya role in disease prevention through modulation of various processes, such as anti-inflammatory, anti-diabetes, immunomodulatory activity, and antioxidant activity, suggests a role in neutralizing free radical generation and ultimately preventing pathogenesis. This study aimed to determine the hepatoprotective effect of ethanol extract of papaya seeds on rifampicin and isoniazid- induced rats. Study Design:  This study is experimental study. Methodology: The experimental animals in this study were divided into eight groups, including normal group, negative group 1, negative group 2, negative group 3, positive group, treatment group I (papaya seed ethanol extract dose of 100 mg/kgBW), treatment group II (papaya seed ethanol extract dose of 300 mg/kgBW), and treatment group III (papaya seed ethanol extract dose of 500 mg/kgBW), then the rats were dissected, and blood was taken for AST, ALT, ALP, GGT, and Bilirubin level measurements. Results: The results showed that papaya seed ethanol extract could reduce ALT, AST, ALP, GGT, and Bilirubin levels that were significantly different (P <0.05) than those in the negative control group. Conclusion: Flavonoid contains in the extract ethanol carica papaya has vita role to prevent the liver toxicity caused by isoniazid and rifampicin.

scholarly journals Gastroprotective effect of ethanol extract of carica papaya seed on rats induced rifampicin and isoniazid

2021 ◽  
Vol 12 (2) ◽  
pp. 1506-1512
Author(s):  
Elviyanti ◽  
Nyoman Ehrich Lister I ◽  
Edy Fachrial
Keyword(s):  
Carica Papaya ◽  
Ethanol Extract ◽  
Potential Effect ◽  
First Line Therapy ◽  
Gastroprotective Effect ◽  
Long Time ◽  
Papaya Seeds ◽  
Group 2 ◽  
Carica Papaya Seed ◽  
Ph Level

The first-line therapy for tuberculosis is Rifampicin, in combination with Isoniazid (INH), Ethambutol (ETB), and Pyrazinamide (PZA). The side effects of TB drugs that may arise if the drug use for a long time include hepatotoxicity and gastrointestinal disturbances. Carica papaya seeds has a potential effect to prevent the gastrointestinal distrubances caused by rifampicin and isoniazid. This study aimed to evaluate the gastroprotective effect of carica papaya seeds on rats induced rifampicin and isoniazid. Experimental design group was divided into 8 group, including normal, negative 1 (rif 50 mg/kgbb), negative 2 (IN 50 mg/kgbw), negative 3 (rif and inh 50 mg/kgbw), positive 1 (rif and inh 50 mg/kgbw + cimetidtine 18 mg/kgbw), group 1(rif and inh 50 mg/kgbw + EECP 100 mg/kgbb) +, group 2 (rif and inh 50 mg/kgbw + EECP 300 mg/kgbb), group 3 (rif and inh 50 mg/kgbw + EECP 500 mg/kgbb). Rifampicin, isoniazid, and EECP was given 20 days. The result showed that rifampicin and isoniazid induced alteration gastric organ, histopathology of the negative group also showed alteration and also decreased pH level.

scholarly journals HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT

2017 ◽  
Vol 9 (3) ◽  
pp. 170 ◽  
Author(s):  
E. Sovia ◽  
W. Ratwita ◽  
D. Wijayanti ◽  
D. R. Novianty
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ethanol Extract ◽  
Normal Group ◽  
Islet Of Langerhans ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Annona Muricata ◽  
Cholesterol Levels

Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups.Conclusion: In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.

scholarly journals Methanolysis of Carica papaya Seed Oil for Production of Biodiesel

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Foluso O. Agunbiade ◽  
Tolulope A. Adewole
Keyword(s):  
Specific Gravity ◽  
Carica Papaya ◽  
Seed Oil ◽  
Fossil Fuel ◽  
Biodiesel Production ◽  
Copper Strip ◽  
Saponification Value ◽  
Biodiesel Synthesis ◽  
Carica Papaya Seed ◽  
Papaya Seed

The future of fossil fuel sources of energy has necessitated the need to search for renewable alternatives. Thus, Carica papaya seed oil (CPSO) was employed as feedstock for the production of biodiesel by methanolysis. The seed was obtained locally, dried, and extracted with n-hexane. The CPSO was analyzed for specific gravity, viscosity, iodine value, and saponification value, among others using standard methods. The oil was transesterified by two-stage catalysis with oil to methanol mole ratio of 1 : 9. The biodiesel produced was subjected to standard fuel tests. The seed has an oil yield of 31.2% which is commercially viable. The kinematic viscosity of the oil at 313 K was 27.4 mm2s−1 while that of Carica papaya oil methylester (CPOME) was reduced to 3.57 mm2s−1 and the specific gravity was 0.84 comparable with other seed-oil biodiesels and number 2 diesel. Other oil properties were compared favourably with seed oils already documented for biodiesel synthesis. CPOME’s cloud and pour points were 275 K and 274 K, respectively, and relatively higher than other biodiesels and number 2 diesel. CPOME exhibits moderate corrosion of copper strip. The methanolysis improved the fuel properties of the CPOME similar to other biodiesels. CPSO therefore exhibits a potential for biodiesel production.

Nutritive Potentials of Pawpaw (Carica Papaya) Seed Meal as Additive on the Haematological Profile of Catfish Fingerlings

2018 ◽  
Vol 9 (11) ◽  
Author(s):  
Paterson Adogbeji Ekokotu ◽  
Arnold Ebuka Irabor ◽  
Oster Francis Nwachi ◽  
Aminu Abubakar Garuba
Keyword(s):  
Carica Papaya ◽  
Seed Meal ◽  
Haematological Profile ◽  
Carica Papaya Seed ◽  
Papaya Seed
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