scholarly journals Issues of Animal Welfare Regulations on Pharmacy Education and Research in India

2021 ◽  
pp. 185-194
Author(s):  
Anuradha Girme ◽  
Anil Pawar
Keyword(s):  
Biomedical Research ◽  
Animal Experiments ◽  
Well Being ◽  
Animal Experimentation ◽  
Pharmacy Education ◽  
Continuous Increase ◽  
Alternative Technologies ◽  
Research Activities ◽  
Animal Use ◽  
The Impact

Biomedical research is essential to the health and well-being of our society. Animal use for biomedical research has a long history and is routinely performed in new drug discovery and development processes. Animal experiments are an integral part of the curriculum for students in the life sciences, including pharmacy, to learn how to conduct animal experiments. These experiments may cause pain and distress to the animals. Laws and regulations have been enacted to make it illegal to cause undue pain or suffering to animals. These guidelines provide that due and full consideration should be given to alternative technologies not involving animal testing. Despite the movement to minimize animal use in research, pieces of evidence show that there has been a continuous increase in the worldwide use of laboratory animals over 10 years, from 115.2 animals to 192.1 million. The lack of suitable animal-alternative technologies and unavailability of required infrastructures are some of the reasons for animal use. As per directives of the University Grant Commission, the Pharmacy Council of India has decided to prohibit animal experimentation in pharmacy education. This adversely affected teaching and research activities in pharmacy institutions. As a result, the number of seats available for the postgraduate course (Master of Pharmacy) in Pharmacology is decreasing every year. In 2021, the highest number of seats are available for Pharmaceutics (9510, 35%) followed by that for the Pharmacology (4620, 17%). This article mainly focuses on the background of Indian legislation for animal experimentation and the impact of these regulations on animal experiments for pharmacy education and research in India.

scholarly journals Aspects of chemical training of the personnel for organic farming

2021 ◽  
Vol 11 (3) ◽  
pp. 154-165
Author(s):  
M. D. Grigorieva ◽  
S. L. Belopukhov
Keyword(s):  
Organic Farming ◽  
Raw Materials ◽  
Well Being ◽  
Safety Control ◽  
Research Activities ◽  
Russian State ◽  
Qualified Personnel ◽  
Products Analysis ◽  
Instrumental Methods ◽  
The Impact

Organic farming is aimed at providing the population with high-quality safe agricultural products and preserving the ecological well-being of agrocenoses and adjacent territories. The implementation of this project is currently associated with a number of problems, for the solution of which educational institutions must train qualified personnel. The authors investigated the aspects of chemical training of specialists necessary for the development of organic farming. The article considers three groups of specialties: 1) farm specialists working with soil and plants (agronomists, soil scientists, ecologists); 2) specialists engaged in product processing (food production technologists, medicinal and essential oil raw materials technologists, biotechnologists, etc.); 3) specialists of laboratories for quality control of raw materials and finished products. Analysis of the labor functions of specialists, the goals and objectives of organic farming, as well as the experience of cooperation of the Department of Chemistry of the Russian State Agricultural University-Moscow Agricultural Academy named after K. A. Timiryazev with agricultural farms for the implementation of organic technology, showed that the most important components of chemical education are as follows: 1) basic chemical training that allows to understand and manage the dynamic processes occurring in the agrosphere; 2) modern instrumental methods of analysis necessary for quality and safety control of raw materials and products, agrochemical diagnostics of soils and water sources; environmental monitoring to assess the impact of agriculture on soil fertility; research activities; evaluation of processing, storage, packaging methods. Laboratory specialists should have the competence to perform physico-chemical determinations of test samples. Other groups of specialists should know the purpose of the methods, be able to interpret the results of determinations. The article presents educational programs of different levels (bachelor’s, master’s, qualification enhancement), which allow to form the necessary chemical competencies.

Epistemology and the Ethics of Animal Experimentation

2021 ◽  
pp. 67-96
Author(s):  
Mylan Engel Jr.
Keyword(s):  
Animal Models ◽  
Biomedical Research ◽  
Human Disease ◽  
Animal Experiments ◽  
Animal Experimentation ◽  
Proper Treatment ◽  
Continued Use

In this chapter, Mylan Engel Jr. argues that animal experimentation is neither epistemically nor morally justified and should be abolished. Engel argues that the only serious attempt at justifying animal experimentation is the benefits argument, according to which animal experiments are justified because the benefits that humans receive from the experiments outweigh the costs imposed on the animal subjects. According to Engel, the benefits we allegedly receive from animal-based biomedical research are primarily epistemic, in that experimenting on animal models is supposed to provide us with knowledge of the origin and proper treatment of human disease. However, Engel argues that animal models are extremely unreliable at predicting how drugs will behave in humans, whether candidate drugs will be safe in humans, and whether candidate drugs will be effective in humans. Engel concludes that animal-based research fails to provide the epistemic, and thereby moral, benefits needed to justify its continued use.

Investigative approach to frog gastrocnemius laboratory: potential impact on animal use in teaching laboratories.

1995 ◽  
Vol 269 (6) ◽  
pp. S42
Author(s):  
I G Welsford ◽  
A E Flamm ◽  
J Barr ◽  
B Fenton ◽  
J R Wright ◽  
...  
Keyword(s):  
Student Attitudes ◽  
Animal Experiments ◽  
Animal Experimentation ◽  
Undergraduate Teaching ◽  
Teaching Laboratory ◽  
Laboratory Exercise ◽  
Physiological Processes ◽  
Negative Comments ◽  
Animal Use ◽  
Investigative Approach

With growing concern over the use of animal experimentation in the teaching of physiology, many biology departments are reassessing the use of animal experiments in the teaching lab. However, it may be just as important to assess how animal experimentation is used in the undergraduate teaching laboratory rather than simply assessing if animal experimentation should be used at all. In our study, sophomore-level life science students enrolled in a core organismal biology course undertook a laboratory exercise designed to elucidate properties of muscles and neuromuscular communication following two protocols: 1) a standard demonstrational model wherein students were told to undertake the exercise as a means to understand physiological processes that they had been exposed to previously in lecture or 2) an investigative model wherein the use of the gastrocnemius preparation was a logical next step in an ongoing investigation, the content of which was driven by student-generated hypotheses. We have observed a significant decrease in a number of the negative comments concerning the use of animals in experimentation (25.6 vs. 3.6%) since the implementation of the investigative approach to the laboratory, suggesting that curricular approaches to the use of animals in the teaching laboratory may have an impact on student attitudes concerning animal experimentation.

scholarly journals Do vody bez obav

2013 ◽  
Vol 7 (3) ◽  
pp. 211-221
Author(s):  
Viktor Pacholík
Keyword(s):  
Social Sciences ◽  
Subjective Experience ◽  
Positive Impact ◽  
Water Environment ◽  
Well Being ◽  
Point Of View ◽  
Research Activities ◽  
Power And Energy ◽  
The Impact

This list deals with the impact of the Halliwick Swimming Concept on subjective experience and psychical states of people with physical impairment. By means of the Halliwick Swimming Concept, that consisted of 10 swimming lessons, we observed the psychical response of the tested persons to individual lessons as well as to the whole programme within a frame of a case study. The acquired data indicate a positive impact of the swimming programme in the field of elimination of negative psychical state in water environment such as anxiety, discomfort and despondency and gradual increase of psychical well-being, activity and feelings of power and energy connected with positive expectations. Most of these changes proved not only in individual lessons, but also from the point of view of the whole programme evaluation. This paper has been written within a project OP VK CZ.1.07/2.4.00/17.0037 „Development of Pedagogical and Research Activities within the Department of Social Sciences in Sport at the FSpS MU“.

Continuing Entomological Research During the Covid-19 Pandemic

2021 ◽  
Vol 32 (3) ◽  
pp. 114-119
Author(s):  
Sotiria Boutsi ◽  
Heather Campbell ◽  
Eugenia Fezza ◽  
Ross George ◽  
Cindayniah Godfrey ◽  
...  
Keyword(s):  
Public Health ◽  
Research Group ◽  
Well Being ◽  
Early Career ◽  
Widening Participation ◽  
Public Health Campaign ◽  
Health Campaign ◽  
Health Measures ◽  
Research Activities ◽  
The Impact

In response to the global COVID-19 pandemic, the UK has experienced three national lockdowns and a public health campaign designed to stop the spread of the virus. The first national lockdown, starting in March 2020, led to the closure of university campuses, and laboratories having to pause practical research and move research student supervision online. During this time, laboratories had to develop way for research activities to resume whilst also complying with public health measures. The entomology group at Harper Adams University is in the Agriculture and Environment Department and forms part of the Centre for Integrated Pest Management. At present our group consists of seven staff members, ranging from early career researchers to those with over 20 years of experience in academia and industry, who collectively supervise 10 PhD students at varying stages of their research. Two of these students are completing their research at an external institute. The group carries out research across multiple sites, office buildings, research laboratories, including the Jean Jackson Entomology Laboratory (https://www.infraportal.org.uk/node/1880), as well as field and glasshouse facilities. Here we provide a narrative account of the challenges in maintaining an active research group during a year of highly restricted activities. We begin by outlining the impact that national lockdowns and public health measures had on researchers working on PhD projects through to larger UKRI and levy-funded multi-institute, multi-year projects. We address four key areas: i) maintaining productivity, ii) student-supervisor interactions, iii) accessibility and widening participation and iv) well-being and mental health. We then outline how lessons learnt from lockdown can inform best practice for a research group. Many aspects will be useful for researchers working part-time, flexible hours, remotely or at multiple sites, but we emphasise that the aim of this contribution is to share our personal experiences and not to cover every theme in what is an extremely complex set of global circumstances.

scholarly journals Hygienic Assessment Of Emission Influence From A Chemical Plant On Population’s Household Conditions, Well-Being And Health

2021 ◽  
Vol 03 (01) ◽  
pp. 76-80
Author(s):  
Zainab Naimova ◽  
◽  
Khurliman Kurbanova ◽  
Honbuvi Khakimova ◽  
Zokir Bulyaev ◽  
...  
Keyword(s):  
Natural Water ◽  
Industrial Production ◽  
Economic Activity ◽  
Technological Progress ◽  
Well Being ◽  
Anthropogenic Factors ◽  
Environmental Load ◽  
Continuous Increase ◽  
Natural Landscapes ◽  
The Impact

The impact of economic activity, as well as scientific and technological progress on the environment is characterized by production of large amount of pollutants, waste and other factors that lead to changes in natural landscapes, pollution of the atmosphere and natural water resources. Continuous increase and expansion in industrial production of chemicals inevitably entail rise of their environmental load. Exceeding thresholds ecosystems’ reliability under the influence of extreme anthropogenic factors can cause significant changes in conditions of existence and functioning of biogeocenoses.

scholarly journals Impact of the COVID-19 Pandemic on Cardiovascular Science: Anticipating Problems and Potential Solutions: A Presidential Advisory From the American Heart Association

Circulation ◽  
2021 ◽  
Author(s):  
Elizabeth M. McNally ◽  
Mitchell S.V. Elkind ◽  
Ivor J. Benjamin ◽  
Mina K. Chung ◽  
Glenn H. Dillon ◽  
...  
Keyword(s):  
Clinical Research ◽  
Biomedical Research ◽  
Research Participation ◽  
Heart Association ◽  
Well Being ◽  
Biomedical Science ◽  
Experimental Science ◽  
Research Activity ◽  
Key Steps ◽  
The Impact

The coronavirus disease 2019 (COVID-19) pandemic has had worldwide repercussions for health care and research. In spring 2020, most non–COVID-19 research was halted, hindering research across the spectrum from laboratory-based experimental science to clinical research. Through the second half of 2020 and the first half of 2021, biomedical research, including cardiovascular science, only gradually restarted, with many restrictions on onsite activities, limited clinical research participation, and the challenges associated with working from home and caregiver responsibilities. Compounding these impediments, much of the global biomedical research infrastructure was redirected toward vaccine testing and deployment. This redirection of supply chains, personnel, and equipment has additionally hampered restoration of normal research activity. Transition to virtual interactions offset some of these limitations but did not adequately replace the need for scientific exchange and collaboration. Here, we outline key steps to reinvigorate biomedical research, including a call for increased support from the National Institutes of Health. We also call on academic institutions, publishers, reviewers, and supervisors to consider the impact of COVID-19 when assessing productivity, recognizing that the pandemic did not affect all equally. We identify trainees and junior investigators, especially those with caregiving roles, as most at risk of being lost from the biomedical workforce and identify steps to reduce the loss of these key investigators. Although the global pandemic highlighted the power of biomedical science to define, treat, and protect against threats to human health, significant investment in the biomedical workforce is required to maintain and promote well-being.

scholarly journals Volume 25, Issue 1 (March 2021) Physiol Pharmacol 2021, 25(1): 1-6 | Back to browse issues page 10.32598/ppj.25.1.10 XML Print Download citation: BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks Send citation to: Mendeley Zotero RefWorks Najafi H, Zarei R, Alimoradian A, Asafari M, Mohammadi M, Samadi F, et al . A review on humane endpoints in animal experimentation for biomedical research. Physiol Pharmacol. 2021; 25 (1) :1-6 URL: http://ppj.phypha.ir/article-1-1606-en.html A review on humane endpoints in animal experimentation for biomedical research

2020 ◽  
Vol 25 (1) ◽  
pp. 1-6
Author(s):  
Houshang Najafi ◽  
◽  
Reza Zarei ◽  
Abbas Alimoradian ◽  
Mohaddeseh Asafari ◽  
...  
Keyword(s):  
Biomedical Research ◽  
Ethical Issues ◽  
Clinical Symptoms ◽  
Scientific Information ◽  
Animal Experimentation ◽  
Laboratory Animals ◽  
Medical Sciences ◽  
Animal Suffering ◽  
Reference Manager ◽  
Animal Use

Introduction: The use of animals in experiments and their role in the development of medical sciences are undeniable. Humane endpoints terminate pain and distress in laboratory animals, which are experimented in painful procedures and an involuntary manner. This study was going to review studies published in this area to assist researchers in developing their approach. Methods: Articles used in this review study were obtained from relevant databases including Pubmed, Scopus, Science Direct, OVID, SID, Magiran and Google scholar. Results: “Humane endpoints” or killing the animal humanely means the point at which an experimental animal’s pain and/or distress is terminated. This pain and distress are not necessarily accompanied by clinical symptoms and it can also be recognized by biochemical, physiological and molecular biomarkers testing. Conclusion: Regarding the extensive use of laboratory animals, the aim is not only to take care of animals but also to develop knowledge and prevent unintentional animal suffering and death. Increasing awareness of ethical issues regarding research animal use needs scientific information and designing experiments, which are terminated immediately after achieving main goals. Otherwise, it threatens the life of animal and leads to the animal suffering.

scholarly journals FORMULA FOR THE WELL-BEING OF EXPERIMENTAL ANIMALS: 3R + 1R

2017 ◽  
pp. 018
Author(s):  
Nikola M. Stojanović ◽  
Milica M. Todorovska
Keyword(s):  
Animal Experiments ◽  
Well Being ◽  
Experimental Information ◽  
Experimental Animals ◽  
Animal Protection ◽  
Responsible Behavior ◽  
Animal Use ◽  
The 19Th Century ◽  
Over Time

Animals were first used for research purposes at the beginning of the development of both biology and medicine. However, the expansion in the use of animals for laboratory purposes began in the 19th century. During an experiment, animals may experience fear, deprivation, disease, and various degrees of pain. Animal Protection activists oppose to animal experiments and it is, therefore, necessary to harmonize the worldwide regulations on the use of animals for scientific purposes. More than 50 years ago, Russell and Burch were the first to define the 3R rule. It consists of the following three principles: Replacement, Reduction and Refinement. Over time, one more R was added to stand for Responsibility, meaning a responsible behavior of those who implement the 3R rule. Replacement means that, if possible, each experimental animal model should be replaced by an in vitro method or be reduced to a smaller number of animals used. Reduction is defined as a reduced number of animals used to obtain certain experimental information, while Refinement is a reduction in the frequency or severity of inhumane procedures applied to animals that have yet to be used. The 3R (+1R) rule has its drawbacks, but it is a very important aspect of animal use regulation, which is essential. These rules are used to direct animal users towards an adequate experimental model, but also to be a reminder of the appropriate use of experimental animals at a given time.

scholarly journals An Estimate of the Number of Animals Used for Scientific Purposes Worldwide in 2015

2019 ◽  
Vol 47 (5-6) ◽  
pp. 196-213 ◽  
Author(s):  
Katy Taylor ◽  
Laura Rego Alvarez
Keyword(s):  
European Union ◽  
Animal Experiments ◽  
Genetic Mutation ◽  
The European Union ◽  
National Statistics ◽  
Publication Rates ◽  
Eu Directive ◽  
Animal Use ◽  
Gm Animals ◽  
The Impact

Few attempts have been made to estimate the global use of animals in experiments, since our own estimated figure of 115.2 million animals for the year 2005. Here, we provide an update for the year 2015. Data from 37 countries that publish national statistics were standardised against the definitions of ‘animals’ and ‘procedures’ used in the European Union (EU) Directive 2010/63/EU. We also applied a prediction model, based on publication rates, to estimate animal use in a further 142 countries. This yielded an overall estimate of global animal use in scientific procedures of 79.9 million animals, a 36.9% increase on the equivalent estimated figure for 2005, of 58.3 million animals. We further extrapolated this estimate to obtain a more comprehensive final global figure for the number of animals used for scientific purposes in 2015, of 192.1 million. This figure included animals killed for their tissues, normal and genetically modified (GM) animals without a harmful genetic mutation that are used to maintain GM strains and animals bred for laboratory use but not used. Since the 2005 study, there has been no evident increase in the number of countries publishing data on the numbers of animals used in experiments. Without regular, accurate statistics, the impact of efforts to replace, reduce and refine animal experiments cannot be effectively monitored.

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