scholarly journals An Improved Commercially Feasible Process for Flecainide Acetate

Author(s):  
Nilesh Takale ◽  
Neelakandan Kaliyaperumal ◽  
Gopalakrishnan Mannathusamy ◽  
Rajarajan Govindasamy

Commercially viable manufacturing process for Flecainide Acetate (I) conforming to regulatory specification and cost effective process is reported. Specifically, an improved process for the preparation of Flecainide Acetate allows isolation of anhydrous hydrochloride salt of Compound III, which facilitates the reduction of the pyridine ring with the only catalytic amount of platinum on carbon within 2 hours Therefore, simplifies the synthesis and isolation of Flecainide acetate on a commercial scale to a considerable extent.

Vaccine ◽  
2021 ◽  
Author(s):  
Ahd Hamidi ◽  
Femke Hoeksema ◽  
Pim Velthof ◽  
Angelique Lemckert ◽  
Gert Gillissen ◽  
...  

2013 ◽  
Vol 35 (1) ◽  
pp. 97-104 ◽  
Author(s):  
Laraib Alam Khan ◽  
Ali Hasan Mahmood ◽  
Bilal Hassan ◽  
Tahir Sharif ◽  
Shahaab Khushnod ◽  
...  

Processes ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1379
Author(s):  
Rohit Kumar ◽  
Protima Rauwel ◽  
Erwan Rauwel

Heavy metal pollution of aquatic media has grown significantly over the past few decades. Therefore, a number of physical, chemical, biological, and electrochemical technologies are being employed to tackle this problem. However, they possess various inescapable shortcomings curbing their utilization at a commercial scale. In this regard, nanotechnology has provided efficient and cost-effective solutions for the extraction of heavy metals from water. This review will provide a detailed overview on the efficiency and applicability of various adsorbents, i.e., carbon nanotubes, graphene, silica, zero-valent iron, and magnetic nanoparticles for scavenging metallic ions. These nanoparticles exhibit potential to be used in extracting a variety of toxic metals. Recently, nanomaterial-assisted bioelectrochemical removal of heavy metals has also emerged. To that end, various nanoparticle-based electrodes are being developed, offering more efficient, cost-effective, ecofriendly, and sustainable options. In addition, the promising perspectives of nanomaterials in environmental applications are also discussed in this paper and potential directions for future works are suggested.


2010 ◽  
Vol 2010 (DPC) ◽  
pp. 001607-001611
Author(s):  
Philip E. Rogren ◽  
Pierangelo Magni ◽  
Maura Mazzola ◽  
Mark Shaw ◽  
Giovanni Graziosi ◽  
...  

Ceramic engineer and manufacturing executive, Philip E. Rogren will explain why molded array packages such as QFNs promise significant cost advantages compared to competitive packaging techniques. He will also describe why there are significant limitations for array packaging techniques based on lead frames. Audiences will learn about the feature of lead frame based packages that is responsible for virtually all of these limitations: Every package terminal and die paddle is a portion of the continuous metal structure that is the lead frame. Every terminal and die paddle is connected to, and held in proper position by, otherwise useless metal projections extending out of the package site to supporting portions of the lead frame. This planer, unitary structure presents limitations in the design of packages, limiting lead counts to around 70 leads and impacting performance because of increased lead to lead parasitic. The structure also adds process steps and cost to the assembly operation. In this presentation Rogren will describe a novel MAP substrate that features print formed, discrete terminal structures and die paddles arrayed on a sacrificial steel substrate. This structure eliminates the disadvantages of the interconnected lead frame based technology. In addition, this manufacturing process substantially reduces the pollution-causing process steps and it eliminates non-recyclable waste.


Author(s):  
Mark R. Anderson ◽  
Peter L. Klein

Many factors come into play in a successful turbomachinery design, but peak aerodynamic performance, maximum operating range, stress levels, and manufacturability are generally the dominant concerns. Depending on the application, other considerations such as acoustics, size, weight, and environmental issues can also come into the picture. The most effective designers take a holistic approach, which tries to incorporate all of these concerns at the beginning of the design process. One of the challenges facing aerodynamicists is a basic understanding of how these downstream issues can be accommodated in the initial design process. Typically, an aerodynamic engineer has minimal knowledge of manufacturing methods such as 5-axis machining. This paper will provide a basic understanding of the subsequent manufacturing impact of various decisions typically made during the preliminary and detailed aerodynamic design process. The paper will focus on radial turbomachinery, but much of the information provided is common for axial turbomachinery produced by 5-axis Computer Numerical Controlled (CNC) machining. In the initial phase of the design, basic layout decisions generally dictate the overarching manufacturing process. For components produced with 5-axis machining, these would typically be: flank milled or point milled, open or covered impeller, and for covered impellers, integral or welded shroud. The relative costs of these processes are considered in this work along with first-order estimates of their typical impact on aerodynamic performance and stress levels. Once a general layout (and accompanying manufacturing process) is determined, other geometric parameters of the components drive secondary costs in the manufacturing process. The secondary parameters include main blade count, the presence of splitter blades, the blade length, thickness, curvatures, leading and trailing edge shapes, and fillet radii. The use of Computational Fluid Dynamics (CFD) and numerical optimization has driven even more choices into blade shapes, such as splitter blades with different shapes and offsets from the main blade, bowed blades, irregular blade patterns, and non-axisymmetric hub shapes. In many cases, the aerodynamicists and CFD analysts have pushed geometry further than manufacturing capabilities are ready to accept. These secondary costs, and the aerodynamic compromises needed to reduce them, are also considered here. This paper attempts to lay out the basic principles of cost-effective manufacturing, and how these can be considered as early in the design process as possible. Specific examples are considered, and quantitative information is provided which can help guide the designer from the beginning and avoid expensive reworks resulting from downstream revisions. This paper will provide a framework for collaboration between aerodynamic engineers and the manufacturing teams assigned to produce the parts they have designed.


Author(s):  
Huan Zhang ◽  
Zixuan Zhang ◽  
Huaqing Ren ◽  
Newell Moser ◽  
Jian Cao

Incremental sheet forming is a flexible manufacturing process that does not require dedicated dies nor custom tooling. Hole-flanging via the ISF process is rapid and cost-effective, especially in prototyping and low-volume production. In this study, a double-sided incremental hole-flanging method was considered where the top and bottom tools were used as the forming tool and supporting tool respectively. Utilization of these generic, stylus tools provides enhanced flexibility and replaces the need for specific blank holders. The double-sided incremental hole-flanging method was experimentally studied with various toolpath techniques for the forming and supporting tools. Two toolpath strategies were determined that developed a successful symmetric hole-flange. The measured wall thickness was found to be comparatively uniform along the wall of the flange, while in-plane strains demonstrate excellent material formability. Additionally, the optimum strategy was trialed on a self-designed complex profile with shrink flange and stretch flange occur alternatively in an effort to demonstrate the flexibility and generality of the proposed double-sided incremental hole-flanging method. Possible future work in this area is also discussed.


2011 ◽  
Vol 66-68 ◽  
pp. 140-145 ◽  
Author(s):  
Zheng Jeremy Li

The application of automation to industries brings revolution for manufacturing techniques and allows more sophisticated, flexible, reliable, and cost-effective manufacturing process control. Automation is to use control system to reduce human labor intervention during manufacturing processes and production. It plays very important role and puts strong impact in industries. Automation is not only significantly increasing the production speed but also more accurately controlling product quality. The automated manufacturing can maintain consistent quality, shorten lead time, simplify material handling, optimize work flow, and meet the product demand for flexibility and convertibility in production. The current economic globalization requires significant labor cost reduction through industry automation, better machine tools, and efficient production process. This paper is to design and develop a new automated and high speed machinery system for filling high viscous liquids. It includes the design of automated and high speed machinery, computer aided modeling and simulation of automated mechanical system, and prototype testing. The major advantages of this new automated and high speed liquid filling system include reliable function, high volume filling rates, good sealing capacity, and cost-effective manufacturing process. This new automated and high speed manufacturing systems has been analyzed by computer aided modeling and simulation, and verified through prototype testing. Both results indicate that this automated and high speed manufacturing systems can keep high product quantity and reliable product quality.


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