scholarly journals Association of Microbiota with Oral Potential Malignant Disorder: A Mini Review

2021 ◽  
pp. 704-708
Author(s):  
Prasada Rao Namburi ◽  
Krishnan Mahalakshmi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Microbiota ◽  
Oral Potentially Malignant Disorders ◽  
Diagnosis And Prognosis ◽  
Increased Risk ◽  
Potentially Malignant

Most of the oral squamous cell carcinoma (OSCC) are often preceded by oral potentially malignant disorders (OPMDs). OPMDs are defined as oral mucosal lesions and conditions which are at increased risk for undergoing alteration to oral cancer. OPMDs grow in a complex tissue microenvironment to acquire oral squamous cell carcinoma (OSCC) characteristics. Oral microbiota associated with OPMD may appear as potential biomarkers as these species may help in the diagnosis and prognosis of OPMD to OSCC. This association of microbiota to OPMD and may be helpful in the early treatment before the initiation of oral cancer. This article reviews the literature on association between microbiota and Oral potential malignant disorders.

scholarly journals Detection of Helicobacter pylori in Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders at a Tertiary Care Centre in Gujarat: A Case-Control Study

2021 ◽  
Author(s):  
Himani Bhardwaj Pandya ◽  
Shivangi Patel ◽  
Rajvi Patel ◽  
Urvi Patel ◽  
Sheel Patel ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Helicobacter Pylori ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
H Pylori

Introduction: Oral squamous cell carcinoma (OSCC) contribute to 90% of cancer cases in head and neck region and entails remarkable morbidity and mortality inspite of immense research and advances. Amongst other causes, infection with Helicobacter pylori is an emerging cause of OSCC. There is still perplexity in the exact etiopathogenesis of H. pylori related oral cancer. Aim: In order to explore this much unattended area, present study was aimed to find out the association between H. pylori in premalignant disorders and OSCC. Materials and methods: A Prospective case-control Pilot study of 35 patients (11 confirmed cases of Oral squamous cell carcinoma and 24 with oral potentially malignant disorders along with 15 age and sex matched healthy control) from June 2018 - September 2018 was conducted in the Department of Microbiology, Smt. B. K. Shah Medical Institute, Piparia, Gujarat. H. pylori was detected by methods like Rapid urease test, Gram’s staining and Serology. Results: H. pylori was detected in five cases with OSCC with male predominance and mean age 45.6 yrs. All the five positive patients were severely addicted to tobacco and betel quid since decades. Tobacco was found to be the major risk of OSCC with the OD of 16.19, followed by betel quid (OD-4.56) and H. pylori infection (OD-0.83). Conclusion: The results of this pilot study do not establish a definite causal relationship between H. pylori and OSCC due to the low sample size. Study definitely offers an avenue for further work on larger populations to confirm this possible association.

scholarly journals Detection of Human Papilloma Virus in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

2021 ◽  
Vol 17 (3) ◽  
pp. 279-285
Author(s):  
Snehashish Ghosh ◽  
Sartaj Singh Wazir ◽  
Rajesh Shah ◽  
Manoj Kumar Upadhyay ◽  
Rahul Gupta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Potentially Malignant Disorders ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Human Papilloma Virus 16

Introduction: Human Papilloma Virus 16 and 18 affects the keratinocytes of oral mucosa and skin and can lead to the development of dysplastic lesions and ultimately into invasive oral squamous cell carcinoma. The objective of the present study was to evaluate the presence of human Papilloma virus 16 and 18 DNA in already diagnosed oral potentially malignant disorders and oral squamous cell carcinoma. Methods: 200 biopsy specimens (50 each) of already diagnosed leukoplakia, oral lichen planus (OLP), oral submucous fibrosis (OSMF) and oral squamous cell carcinoma was included for the study. A total 50 control tissue sections, which were obtained during removal of impacted teeth were also included in the study. All 250 specimens were subjected to polymerase chain reaction (PCR) for the identification of HPV 16 and 18. The results are analyzed using Statistical Package of Social Sciences (SPSS) version 16 software and Pearson’s chi square test was used for statistical analysis. Results: HPV 16 and 18 was noted in all the OPMDS and oral cancer specimens but the results were not statistically significant. However, not even a single case of control tissue showed the presence of HPV 16 and 18. Conclusions: The results of the present study shows HPV 16 and 18 is present in oral cancer as well as OPMDS, therefore it could be implicated in the pathogenesis of the above mentioned conditions.

scholarly journals Age And Gender Predilection Of Habits And Oral Cancer Among An Outpatient Population Visiting A Dental Hospital

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1850-1854
Author(s):  
Anubhav Das ◽  
Gheena S ◽  
Ravindra Kumar Jain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P Value ◽  
Age Group ◽  
Heavy Smoking ◽  
Increased Risk ◽  
Risk Of Cancer

Oral Squamous Cell Carcinoma (OSCC) is the most common neoplasm representing more than 80% of all oral cancer cases. Squamous cell carcinoma is defined as a “malignant epithelial neoplasm exhibiting squamous differentiation as characterized by the formation of keratin and/ or the presence of intercellular bridges”.Most of the epidemiological studies have revealed that heavy smoking and alcohol intake are the most important risk factors for oral cancer. Poor dental hygiene, accompanied by tooth loss, certain oncogenic viruses have been associated with an increased risk of cancer. The purpose of this study was to analyze the gender and age predilection of habits and oral cancer among an outpatient population visiting a dental college. This was a retrospective study (2019-2020) in which data on 34 Oral Squamous Cell Carcinoma(OSCC) were investigated. The patient records were reviewed and analysed between January 2019 and March 2020. All the 34 patient data were tabulated in excel, reviewed and was classified according to the border's grading system. Following which data was imported to SPSS software by IBM for descriptive statistical analysis and chi-square test was performed. A significant association between OSCC and age group (45-50 Years) was observed though it was statistically insignificant. (p value=0.64). Males have a higher incidence of OSCC compared to females in the same age group. A significant association is observed between Gutka, Smoking and pan chewing with OSCC. OSCC is the most commonly occurring oral cancer and there is a high predilection of the OSCC with age, gender and habits. Dentists play a key role in screening, detection and treatment of oral malignancies and can help in educating the public to bring about more awareness towards prevention of Oral Cancer.

scholarly journals Dysbiosis of Oral Microbiota During Oral Squamous Cell Carcinoma Development

2021 ◽  
Vol 11 ◽  
Author(s):  
Purandar Sarkar ◽  
Samaresh Malik ◽  
Sayantan Laha ◽  
Shantanab Das ◽  
Soumya Bunk ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Indian Subcontinent ◽  
Critical Role ◽  
Oral Microbiome ◽  
Oral Microbiota ◽  
Microbial Composition

Infection with specific pathogens and alterations in tissue commensal microbial composition are intricately associated with the development of many human cancers. Likewise, dysbiosis of oral microbiome was also shown to play critical role in the initiation as well as progression of oral cancer. However, there are no reports portraying changes in oral microbial community in the patients of Indian subcontinent, which has the highest incidence of oral cancer per year, globally. To establish the association of bacterial dysbiosis and oral squamous cell carcinoma (OSCC) among the Indian population, malignant lesions and anatomically matched adjacent normal tissues were obtained from fifty well-differentiated OSCC patients and analyzed using 16S rRNA V3-V4 amplicon based sequencing on the MiSeq platform. Interestingly, in contrast to the previous studies, a significantly lower bacterial diversity was observed in the malignant samples as compared to the normal counterpart. Overall our study identified Prevotella, Corynebacterium, Pseudomonas, Deinococcus and Noviherbaspirillum as significantly enriched genera, whereas genera including Actinomyces, Sutterella, Stenotrophomonas, Anoxybacillus, and Serratia were notably decreased in the OSCC lesions. Moreover, we demonstrated HPV-16 but not HPV-18 was significantly associated with the OSCC development. In future, with additional validation, this panel could directly be applied into clinical diagnostic and prognostic workflows for OSCC in Indian scenario.

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