scholarly journals Myeloperoxidase and Paraoxonase Activity in Acute Coronary Syndrome Patients

2021 ◽  
pp. 108-114
Author(s):  
Sowmya Varadhan ◽  
Ramesh Venkatachalam ◽  
A. Supriya Simon
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Oxidized Ldl ◽  
Predictive Marker ◽  
Significant Negative Correlation ◽  
Cross Sectional ◽  
Medical College ◽  
Coronary Syndrome ◽  
Anti Oxidant

Background: Myeloperoxidase (MPO), an oxidative stress related enzyme is elevated in Coronary Artery Disease (CAD) and is involved in development of atherosclerotic plaque. Paraoxonase (PON) an enzyme protein associated with HDL serves as an antioxidant and plays an important role in preventing the formation of Oxidized LDL (OxLDL). This suggests a conflicting role of MPO and PON in development of cardiovascular disease and atherosclerosis. Aim: Present study was done to evaluate and compare MPO/PON ratio in Acute Coronary Syndrome (ACS) patients with controls. The study evaluates and compares the pro oxidant and pro inflammatory enzyme, MPO and anti-oxidant and anti-inflammatory enzyme, PON in ACS patients with controls. Oxidative marker, Malondialdehyde (MDA) and anti-oxidant marker, Reduced Glutathione (GSH) was assessed in ACS patients and compared with controls. An attempt was also made to correlate MPO/PON ratio to markers of oxidative stress (MDA and GSH). Methods: Cross-sectional study carried out in Dr. Somervell Memorial CSI Medical College, Trivandrum, Kerala, India.50 ACS patients from Cardiac Care Unit and 50 age and sex matched controls without CAD from Medical College Health Checkup was selected. Results: MPO and MPO/PON ratio were significantly high and PON  was significantly lower in ACS patients compared to controls. Total cholesterol, Triglyceride, LDL, MDA were significantly high in ACS patients. Statistically significant positive correlation was observed between MPO/PON and MDA. Significant negative correlation was observed between MPO/PON and GSH. Conclusion: Myeloperoxidase and MPO/PON ratio was significantly high in ACS patients than controls. This is suggestive of the role of MPO in oxidative damage to lipoproteins in CAD patients. Prooxidant, Paraoxonase ,and antioxidant, GSH is lowered in ACS patients as a result of the increased oxidative stress. This study suggests that MPO/PON1 ratio can be used as a predictive marker of ACS.

scholarly journals Role of Diabetic Dyslipidemia on Coronary Atherosclerotic Severity in Acute Coronary Syndrome

2017 ◽  
Vol 31 (2) ◽  
pp. 65-69
Author(s):  
Golam Mahfuz Rabbani ◽  
Afzalur Rahman ◽  
Anisur Rahman Khan ◽  
Nur Hossain ◽  
Muhammad Badrul Alam ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Analytical Study ◽  
Cross Sectional ◽  
High Tc ◽  
Medical College ◽  
Coronary Syndrome ◽  
Low Hdl ◽  
Artery Disease ◽  
Age Range

Aims: To evaluate the association of coronary atherosclerotic severity in diabetic dyslipidemic patients of acute coronary syndrome.Methods: This was a cross sectional comparative analytical study, done in the Department of Cardiology, Sir Salimullah Medical College Mitford Hospital and Ibrahim Cardiac Hospital & Research Institute, Dhaka, during September 2009 to August 2010.Results: Most of the patients (57.5%) were in the age range of 40-70 years. Atherosclerotic severity in diabetic ACS patients was significantly higher with low HDL, high TC/HDL and high LDL/HDL ratio. Low HDL, high TC/HDL and high LDL/HDL ratio are indicators of the extent and severity of coronary artery disease. More frequent dyslipidemia in diabetic ACS patients were low HDL and it was about 54%.Conclusion: Atherosclerotic severity in diabetic acute coronary syndrome patients was significantly more in dyslipidemic group than non dyslipidemic group.Bangladesh Heart Journal 2016; 31(2) : 65-69

scholarly journals Frequency of CYP2C19*2 Allele in Patients with Acute Coronary Syndrome: A Cross-sectional Study from Central Kerala, India

2021 ◽  
Author(s):  
Christina Ann George ◽  
Shibu Thadathil Sreedharan ◽  
Smitha Kalarikkal Satheesan ◽  
Sindhu Panakkaparambil Surendranath
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Government Medical College ◽  
Sectional Study ◽  
Therapy Failure ◽  
Cross Sectional ◽  
Medical College ◽  
Coronary Syndrome ◽  
Variant Genotype ◽  
Study Population

Introduction: Ischaemic Heart Diseases (IHD) are increasing at an alarming rate globally. Pharmacotherapy, the mainstay of management of IHD, has Dual Antiplatelet Therapy (DAPT) at its crux. DAPT, comprising of clopidogrel and aspirin, is used often for 12 months in medically managed Acute Coronary Syndrome (ACS). Clopidogrel being a prodrug, needs to be activated after ingestion, mainly by Cytochrome family of enzymes, for the desired pharmacological effects. Abnormal enzymes that convert clopidogrel to its active form can reduce the effectiveness of the drug. Therefore, Single Nucleotide Polymorphisms (SNPs) of the enzymes involved, would predispose the patient to therapy failure and recurrence of the illness. This study aims at identifying the presence of a genetic variant associated with clopidogrel responsiveness in patients with ACS. Aim: To estimate the frequency of CYP2C19*2 allele in patients with ACS presenting to Government Medical College, Thrissur, Kerala, India. Materials and Methods: Present study was a cross-sectional study done among 60 patients who presented to Government Medical College, Thrissur with ACS, between June 2018 to June 2019. Having obtained informed consent from the participants blood samples were collected in Ethylene diamine tetra-acetic Acid (EDTA) tubes. Samples were used to look for presence of CYP2C19*2 allele by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Out of 60 patients 38 were males and 22 were females. Most common age group was 61-65 years. The frequency of CYP2C19*2 allele was 41% in the study population and the variant genotype (AA/AG) was present in 62%. Conclusion: The variant genotype was found to be present in a high frequency in the study population implying the high risk for therapy failure in the study population. This asserts the need to probe the matter further, as the gene is also implicated in the metabolism of several other drugs. The introduction of pharmacogenomic testing prior to initiation of therapy may be therefore recommended for better treatment outcome. However, to validate the same, further studies with larger sample size may be necessary.

scholarly journals The Role of Neutrophil Lymphocyte Ratio as a Major Adverse Cardiac Events Predictor and Its Correlation with Coronary Severity in Acute Coronary Syndrome Patients with Chronic Kidney Disease: A Case Control and Cross-Sectional Study

2021 ◽  
Vol 9 (B) ◽  
pp. 1758-1763
Author(s):  
Suzanna Immanuel ◽  
Eka Ginanjar ◽  
Fahrani Imanina Putri Nurtyas ◽  
Ninik Sukartini ◽  
Yusra Yusra ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Coronary Syndrome ◽  
Case Control ◽  
Gensini Score ◽  
Cardiac Events ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Adverse Cardiac Events

BACKGROUND: Acute coronary syndrome (ACS) patients with chronic kidney disease (CKD) are known to have a higher risk of mortality compared to ACS patients without CKD. In ACS patients with CKD, chronic inflammation plays an important role in morphological and functional changes in endothelial cells, resulting in atherosclerosis acceleration associated with coronary severity that leads to an increase in major adverse cardiac events (MACE). AIM: Therefore, this study aims to determine the role of neutrophil lymphocyte ratio (NLR) as a predictor of MACE and its correlation with coronary severity in ACS patients with CKD. METHODS: The study was conducted at National General Hospital Cipto Mangunkusumo Jakarta, Indonesia in October to November 2019. We used quota sampling with two designs study. First, a nested case control study was conducted with a total of 59 ACS patients with CKD: 31 subjects who had experienced MACE as a case group and 28 subjects who had not experienced MACE as a control group. Second, a correlative study with a cross-sectional approach was undertaken. RESULTS: There was no significant difference or relationship between NLR and MACE (p > 0.05; OR = 2.16 [95% CI = 0.63–7.51]), also no correlation between NLR and coronary severity degree assessed using the Gensini score (r = 0.10; p = 0.474). CONCLUSION: NLR can not predict MACE in ACS patients with CKD nor be employed interchangeably with the Gensini score in assessing coronary severity in ACS patients with CKD.

Role of hsCRP as an indicator of prognosis in acute coronary syndrome

2019 ◽  
Vol 10 (2) ◽  
pp. 97-100
Author(s):  
Ashok Thaned ◽  
◽  
Triveni Ayyanna ◽  
Sunil K ◽  
◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Syndrome

scholarly journals Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients

Metabolites ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 412
Author(s):  
Martin Malý ◽  
Martin Hajšl ◽  
Kamila Bechyňská ◽  
Ondřej Kučerka ◽  
Martin Šrámek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
High Performance ◽  
Coronary Syndrome ◽  
Lipidomic Analysis ◽  
Comprehensive Information ◽  
Group A ◽  
Fatty Acyls ◽  
Group D ◽  
Standard Marker

Alterations in lipid metabolism mediated by oxidative stress play a key role in the process of atherosclerosis and superimposed thrombosis; these can lead to acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Multiple studies have shown that the formation of atheromatous lesions is initiated by oxidation of low-density lipoproteins incorporated into the intima of the vessel wall. Here, we studied lipids in plasma samples from three cohorts: 61 patients with ACS (group A), 49 patients with AIS (group D), and 82 controls (group K). Untargeted lipidomics based on high-performance liquid chromatography coupled to mass spectrometry (UHPLC-HRMS) was employed to obtain comprehensive information on whether relationships exist between these patient categories based on lipid patterns. In addition, malondialdehyde (MDA) as a standard marker of oxidative stress was monitored. The most characteristic lipids in group K were fatty acyls of hydroxyfatty acids (FAHFAs). As expected, MDA concentrations were the lowest in group K. Our findings can better explain ongoing pathologies, both acute and chronic, with the potential for future diagnosis and treatment.

Red wine reduces oxidative stress in patients with acute coronary syndrome

2005 ◽  
Vol 104 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Eduardo Guarda ◽  
Iván Godoy ◽  
Rocío Foncea ◽  
Druso D. Pérez ◽  
Carlos Romero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Red Wine ◽  
Coronary Syndrome
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