scholarly journals A Systematic Review of the Potential Implication of Salivary Secretions in Covid-19 Patients

Author(s):  
Salem Mohammed Hassan Alharthi ◽  
Laila Mohammed Alanazi ◽  
Dalal Jumah Alturaif ◽  
Wesam Yousef Othman Alibrahim ◽  
Waleed Yahya Binammar ◽  
...  

As reported on 23rd May 2021, there are a total of 167,313,629 confirmed cases of Covid-19 all across the world with a mortality of about 3,473,851 whereas in Saudi Arabia 439,847 were registered cases of covid-19 and 7,237 deaths. According to the World Health Organization (WHO) a total of 12,244,264 people were vaccinated with Covid-19 vaccination. Covid-19 is a respiratory infectious disease. More recent researches on SARS-COV-2 suggests the entry of the virus into the host cell using the host entry factors like TMPRSS-2, TMPRSS-4 and ACE-2 in the oral tissues. The spike proteins of the SARS COV-2 attaches to the ACE-2 and TMPRSS2 of the salivary gland. Saliva provides the lubrication of the oral cavity, initiation of digestion and provides immunity in host. A complete research of all the articles was done using databases like: SCOPUS, PUBMED, EMBASE and WEB OF SCIENCE. In case of SARS CoV-2, the salivary glands act as reservoir for the virus. Intake of these viruses present in infectious saliva droplets found in the air would lead to the transmission of infection to an individual. Saliva is more efficient when compared to the blood as it doesn't clot. A reduced secretion of saliva is observed in patients post the covid 19 disease.


Healthcare ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 83
Author(s):  
Jéssica Tavares ◽  
Gonçalo Santinha ◽  
Nelson P. Rocha

Background: Health care provided to older adults must take into account the characteristics of chronic diseases and the comorbidities resulting from ageing. However, health services are still too oriented towards acute situations. To overcome this problem, the World Health Organization (WHO) proposed a set of Age-Friendly Principles that seek to optimize the provision of health care for this population. This article aims to understand how such Principles are considered in the implementation of age-friendly health care worldwide. Methods: A systematic review was conducted to synthesize the literature on age-friendly health care in accordance with the PRISMA recommendations in the PubMed, Web of Science, and Scopus databases. Results: The research identified 34 articles, with only seven recognizing the WHO Principles and only four using the implementation toolkit. In addition, in the context of primary care, three studies recognize the WHO Principles, but only two use the toolkit. Conclusions: The WHO Principles are being implemented in health care, but in a smaller scale than desired, which reveals possible flaws in their dissemination and standardization. Thus, a greater scientific investment in age-friendly health care should be considered, which represents a greater operationalization of the Principles and an evaluation of their effectiveness and impacts.



2021 ◽  
pp. 1-9
Author(s):  
Manuel Ruiz-Adame

Background: The World Health Organization has estimated that worldwide around 50 million people have dementia. The World Alzheimer Report estimated that between 2 and 10% of all cases of dementia begin before the age of 65. Early and young onset dementias (EYOD) provoke more working, social, family, and economic consequences than late onset dementias. All general studies about costs of dementias show that most of them are indirect or social costs. Despite that, very few studies have been performed in EYOD. Objective: To do a systematic review of literature about indirect or social costs in EYOD to know the state of knowledge and to discover gaps that should be filled. Methods: A systematic review was performed in the main database: Scopus, PsychInfo, Web of Science (Web of Science Core Collection, Medline and SciELO), and CINAHL. Additionally, we looked for reviews in Cochrane and in the International Prospective Register Of Systematic Reviews (PROSPERO). Results: Most of the studies are about costs of dementias in general, but they do no differentiate costs for the case of EYOD. Many studies highlight the increased costs for EYOD but very little included evidence of that. 135 papers were selected. Finally, only two were studies providing data. EYOD reduce the odds to get or maintain a job. Most of the care is provided by informal caregivers. The costs in EYOD are 39.26% higher among EYOD than in late onset. Conclusion: There is a lack of studies about social and indirect costs in EYOD. More evidence is needed.



2021 ◽  
pp. 104365962110469
Author(s):  
Giorgia Rudes ◽  
Claudia Fantuzzi

Introduction: The World Health Organization states that suicide is the second leading cause of death among youngs, and racism has been proven to have detrimental effects on both physical and mental health. These two plagues represent a public health priority, especially for susceptible minorities. Method: This systematic review analyzed 23 studies from multiple database searches, to understand the relationship between racism and suicidality in young minority groups. Results: The review demonstrated the correlation between racism and suicidality with the consequent development of mental disorders. There is strong evidence that the main suicide risk factor is acculturation, interpreted as the assimilation of the dominant culture with the loss of values from one’s cultural background. Discussion: Health care professionals should not underestimate the risk of suicidality associated with racism. Prevention is crucial and it should be implemented from a young age, in schools, through a joint intervention with children and their families, aiming toward integration without acculturation.



2021 ◽  
pp. 172-180
Author(s):  
Fitrio Deviantony ◽  
Grysha Viofananda ◽  
Nurul Hidayah ◽  
Nadhifa Eriyanti

permasalahan serius di dunia dan Indonesia. Data dari World Health Organization sekitar 21 juta orang mengalami skizofrenia. Prevalensi skizofrenia di Indonesia mengalami peningkatan proporsi per 1000 penduduk (1,7%) pada tahun 2013 menjadi (7%) pada tahun 2018. Faktanya terapi keperawatan untuk halusinasi belum optimal sedangkan teknologi terus berkembang seperti Virtual Reality (VR). VR mampu menurunkan gejala pada skizofrenia dengan kemampuan membuat perilaku interaktif dan tersimpan dalam otak agar tidak menimbulkan halusinasi. Teknologi ini digunakan untuk mengetahui manfaat E-Health Nursing VR sebagai terapi halusinasi pada pasien skizofrenia. Metode penelitian menggunakan systematic review dari 5 database yaitu Nature, Frontiers, BMC, Science Direct, NEJM sehingga didapat total 55 literatur. Mayoritas 63% mengulas terapi VR untuk mengurangi halusinasi pada skizofrenia. Perkembangan manfaat VR diverifikasi dalam beberapa pengobatan: skizofrenia, PTSD, kecemasan, akrofobia, ganguan citra tubuh, claustrophobia, dan lain-lain. Beberapa studi skizofrenia menyatakan terapi VR sangat efektif menangani delusi, halusinasi, gejala kepribadian skizoid. VR juga berguna dalam rehabilitas kognitif pada orang dewasa atau anak-anak autis dalam keterampilan dan kemandirian. Kesimpulan penelitian ini adalah VR terbukti efektif sebagai terapi kesehatan jiwa di masa mendatang. Disisi lain terdapat terapi psikologis pilihan seperti terapi perilaku kognitif, dan psikoterapi interpersonal. Oleh karenanya diperlukan kombinasi terapi VR dengan terapi komplementer tersebut dalam mengurangi halusinasi pada skizofrenia.   Mental health become a severe problem in the world and Indonesia. Data from the World Health Organization (WHO, 2016) estimated that 21 million people have schizophrenia. The prevalence of schizophrenia in Indonesia has increased proportion per 1000 population (1,7%) in 2013 to (7%) in 2018. In fact of nursing, therapy for hallucination is not optimal while constantly evolving technology such as Virtual Reality (VR). VR can reduce symptoms in schizophrenia with the ability to create interactive behavior and stored in the brain in order to cause hallucinations. The objective of this study was to review the benefit of VR as a hallucination therapy in schizophrenia patients. This research used a systematic literature review from five databases Nature, Frontiers, BMC, Science Direct, NEJM, and resulted in the retrieval of 55 papers. The majority of a result found a 63% review in Virtual Reality therapy can reduce hallucination in schizophrenia. VR is a technology browser and manipulator sensory environment in real-time 3D. The progressing benefit of VR verified in the treatment of schizophrenia, PSTD, anxiety, acrophobia, body image disorder, claustrophobia, and others. Some studies of schizophrenia declare that virtual reality therapy is effective in treating delusions, hallucinations, and a symptom of schizoid behavior. VR also has benefits in cognitive rehabilitation in adults or children with autism's inability and self-reliance. VR has a bright future as the treatment of mental health. The progressing of technology and research has an excellent opportunity for VR to reduce schizophrenia. Moreover, there is psychological therapy, such as cognitive-behavioral therapy and interpersonal psychotherapy. Therefore a combination needed of virtual therapy with the complementary therapy for reducing hallucination in schizophrenia.



Author(s):  
Ali Mustafa Qamar ◽  
Rehan Ullah Khan ◽  
Suliman Alsuhibany

COVID-19 was declared a pandemic by World Health Organization in March 2020. Since then, it has attracted the enormous attention of researchers from around the world. The world has gone through previous instances of corona-viruses such as Severe Acute Respiratory Syndrome and Middle Eastern Respiratory Syndrome. Nevertheless, none was of these were of this serious nature as COVID-19. In this research, we carry out a bibliometric analysis of coronavirus research using the Scopus database. However, we restricted ourselves to the Gulf Cooperation Council countries, comprising Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates. The analysis was performed using Biblioshiny software. We analyzed 4288 articles written by 24226 researchers from 1994 till 2021, published in 1429 sources. The number of authors per publication is 5.65. A bulk of the research (more than 68%) appeared in the form of articles. More than 43% of the publications appeared in 2020 and more than 44% in 2021. Saudi Arabia appears the most-cited country, followed by Qatar. Journal of Infection and Public Health published the most number of papers, whereas New England Journal of Medicine is the most-cited one. Memish, Z.A. wrote the maximum number of papers. The top source, according to the H-index, is the Journal of Virology. Furthermore, the two most prolific universities are King Saud University and King Abdulaziz University, both from Saudi Arabia. The research uncovered deep learning as a niche theme used in recent publications. The research landscape continues to alter as the pandemic keeps on evolving.



Author(s):  
Afsaneh Noormandi ◽  
Mohammad Fathalipour ◽  
Reza Daryabeygi-Khotbehsara ◽  
Soheil Hassanipour

Background and objective: COVID-19 has since been declared a global pandemic by the World Health Organization (WHO), infecting millions worldwide. The use of Interferon (INF) subtypes previously examined in the treatment of SARS and MERS is also being initiated in some clinical trials. Although different clinical trials were evaluated IFNs in the treatment of COVID-19, their efficacy and safety remain unknown. Therefore, this study aims to systematically assess IFNs efficacy and safety in treating patients with COVID-19. Methods: The protocol has been registered in the PROSPERO International Prospective Register (CRD42020200643) on 24 July 2020. This protocol has been arranged according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015 checklist. Discussion: Due to lack of approved medication for the covid-19 treatment and also various mutations of this virus, evaluated the efficacy and safety of medications by various studies could help for finding treatments with high effectiveness. IFNs are one of the medications that have been administered in covid-19 infection.  Moreover, the best time of administration and dose of this medication was unknown. Although meta-analysis is a potent source for assessing the accuracy of subjects, heterogeneity of articles is a potent limitation of our work.



PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0198125 ◽  
Author(s):  
Susan L. Norris ◽  
Veronica Ivey Sawin ◽  
Mauricio Ferri ◽  
Laura Raques Sastre ◽  
Teegwendé V. Porgo


2003 ◽  
Vol 31 (4) ◽  
pp. 485-505 ◽  
Author(s):  
David P. Fidler

In March 2003, the world discovered, again, that I humanity's battle with infectious diseases continues. The twenty-first century began with infectious diseases, especially HIV/AIDS, being discussed as threats to human rights, economic development, and national security. Bioterrorism in the United States in October 2001 increased concerns about pathogenic microbes. The global outbreak of severe acute respiratory syndrome (SARS) in the spring of 2003 kept the global infectious disease challenge at the forefront of world news for weeks. At its May 2003 annual meeting, the World Health organization (WHO) asserted that SARS is “the first severe infectious disease to emerge in the twenty-first century” and “poses a serious threat to global health security, the livelihood of populations, the functioning of health systems, and the stability and growth of economies.”



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