Evaluation of fNIRS signal components elicited by cognitive and hypercapnic stimuli

Functional near infrared spectroscopy (fNIRS) measurements are confounded by signal components originating from multiple physiological causes, whose activities may vary temporally and spatially (across tissue layers, and regions of the cortex). Furthermore, the stimuli can induce evoked effects, which may lead to over or underestimation of the actual effect of interest. Here, we conducted a temporal, spectral, and spatial analysis of fNIRS signals collected during cognitive and hypercapnic stimuli to characterize effects of functional versus systemic responses. We utilized wavelet analysis to discriminate physiological causes and employed long and short source-detector separation (SDS) channels to differentiate tissue layers. Multi-channel measures were analyzed further to distinguish hemispheric differences. The results highlight cardiac, respiratory, myogenic, and very low frequency (VLF) activities within fNIRS signals. Regardless of stimuli, activity within the VLF band had the largest contribution to the overall signal. The systemic activities dominated the measurements from the short SDS channels during cognitive stimulus, but not hypercapnic stimulus. Importantly, results indicate that characteristics of fNIRS signals vary with type of the stimuli administered as cognitive stimulus elicited variable responses between hemispheres in VLF band and task-evoked temporal effect in VLF, myogenic and respiratory bands, while hypercapnic stimulus induced a global response across both hemispheres.

Functional versus morphological assessment of vascular age in patients with coronary heart disease

Communicating cardiovascular risk based on individual vascular age (VA) is a well acknowledged concept in patient education and disease prevention. VA may be derived functionally, e.g. by measurement of pulse wave velocity (PWV), or morphologically, e.g. by assessment of carotid intima-media thickness (cIMT). The purpose of this study was to investigate whether both approaches produce similar results. Within the context of the German subset of the EUROASPIRE IV survey, 501 patients with coronary heart disease underwent (a) oscillometric PWV measurement at the aortic, carotid-femoral and brachial-ankle site (PWVao, PWVcf, PWVba) and derivation of the aortic augmentation index (AIao); (b) bilateral cIMT assessment by high-resolution ultrasound at three sites (common, bulb, internal). Respective VA was calculated using published equations. According to VA derived from PWV, most patients exhibited values below chronological age indicating a counterintuitive healthier-than-anticipated vascular status: for VAPWVao in 68% of patients; for VAAIao in 52% of patients. By contrast, VA derived from cIMT delivered opposite results: e.g. according to VAtotal-cIMT accelerated vascular aging in 75% of patients. To strengthen the concept of VA, further efforts are needed to better standardise the current approaches to estimate VA and, thereby, to improve comparability and clinical utility.

Crowdsourcing Ideas Using Product Prototypes: The Joint Effect of Prototype Enhancement and the Product Design Goal on Idea Novelty

When soliciting novel product ideas from the “crowd,” companies may opt to show a prototype in order to steer the generation of ideas in the desired direction. On the one hand, the more features the prototype incorporates, the larger the potential for activating relevant knowledge in memory that may serve as a basis for generating novel ideas. On the other hand, it increases the risk of fixation on the incorporated features, which may inhibit the generation of novel ideas. Based on the “dual pathway to creativity” theory, which identifies the depth and breadth of exploration of one’s knowledge base as cognitive pathways to the generation of novel ideas, we argue that the number (and type) of features included in the prototype in combination with the design goal, that is, generating ideas for functional versus aesthetic product improvements, determines whether the positive effects outweigh the negative effects. With a functional design goal, we find that exposure to a prototype with more features leads to more novel ideas as a result of a more thorough exploration of one’s knowledge base. However, with an aesthetic design goal, exposure to a prototype with more features leads to less novel ideas because of a narrower exploration. The latter effect is driven by people’s tendency to consider the whole or gestalt of the prototype when generating aesthetic ideas. This negative effect can, thus, be mitigated by stimulating people to employ a nonholistic, piecemeal thinking style. This paper was accepted by Ashish Arora, entrepreneurship and innovation.

Evaluation of fNIRS Signal Components Elicited by Cognitive and Hypercapnic Stimuli

Functional near infrared spectroscopy (fNIRS) measurements are confounded by signal components originating from multiple physiological causes, whose activities may vary temporally and spatially (across tissue layers, and regions of the cortex). Furthermore, the stimuli can induce evoked effects, which may lead to over or underestimation of the actual effect of interest. Here, we conducted a temporal, spectral, and spatial analysis of fNIRS signals collected during cognitive and hypercapnic stimuli to characterize effects of functional versus systemic responses. We utilized wavelet analysis to discriminate physiological causes and employed long and short source-detector separation (SDS) channels to differentiate tissue layers. Multi-channel measures were analyzed further to distinguish hemispheric differences. The results highlight cardiac, respiratory, myogenic, and very low frequency (VLF) activities within fNIRS signals. Regardless of stimuli, activity within VLF band had the largest contribution to the overall signal. The systemic activities dominated the measurements from the short SDS channels during cognitive stimulus, but not hypercapnic stimulus. Importantly, results indicate that characteristics of fNIRS signals vary with type of the stimuli administered as cognitive stimulus elicited variable responses between hemispheres in VLF band and task-evoked temporal effect in VLF, myogenic and respiratory bands, while hypercapnic stimulus induced a global response across both hemispheres.

An ethics analysis of the rationale for publicly funded plastic surgery

Background Healthcare systems are increasingly struggling with resource constraints, given demographic changes, technological development, and citizen expectations. The aim of this article is to normatively analyze different suggestions regarding how publicly financed plastic surgery should be delineated in order to identify a well-considered, normative rationale. The scope of the article is to discuss general principles and not define specific conditions or domains of plastic surgery that should be treated within the publicly financed system. Methods This analysis uses a reflective equilibrium approach, according to which considered normative judgements in one area should be logically and argumentatively coherent with considered normative judgements and background theories at large within a system. Results and conclusions In exploring functional versus non-function conditions, we argue that it is difficult to find a principled reason for an absolute priority of functional conditions over non-functional conditions. Nevertheless, functional conditions are relatively easier to establish objectively, and surgical intervention has a clear causal effect on treating a functional condition. Considering non-functional conditions that require plastic surgery [i.e., those related to appearance or symptomatic conditions (not affecting function)], we argue that the patient needs to experience some degree of suffering (and not only a preference for plastic surgery), which must be ‘validated’ in some form by the healthcare system. This validation is required for both functional and non-functional conditions. Functional conditions are validated by distinguishing between statistically normal and abnormal functioning. Similarly, for non-functional conditions, statistical normality represents a potential method for distinguishing between what should and should not be publicly funded. However, we acknowledge that such a concept requires further development.

Could Putting the Mesenchymal Stem Cells Technology into Practice Be an Optimistic Therapy for The Critically Ill COVID-19?

COVID-19 comes to light, quickly developing status. Daily, we know more about the human new coronavirus (HCoV19), which is extremely infective with heavy pneumonia connected with fast virus reproduction. Emerging in Wuhan China 31 December 2019, the contemporary COVID-19 outbreak has quickly overripe taking place directly between individuals so contagion extending to be a world health emergency at present on pandemic level. The pandemic has had deep impacts on everyday lifetime towards numerous of the world. Presently no therapy, no specified remedies or inoculations are ready to treat the patients with COVID-19 pollution and investigators here and there the globe are jostling to recognize present medication or synthesis that could be functional versus it. Therefore, there is a great unmet requirement for a secure and efficient therapy for COVID-19 contaminated cases, particularly the serious cases. What types of therapies might now assist? What are the lab craft strategies to restraining coronavirus? Ago mid-February, one tactic that has acquired rising attraction is stem cell therapy, curing that have often been saw as a potential magic bullet by despairing patients suffering from degenerative incurable conditions. In plentiful of these diseases, truth has so far to coincide with the hype. The cell based-therapy doings by supporting the body’s precocious refractory reply in an orientation that could goal the coronavirus. Now stem cell-based therapy for COVID-19 is earning incentive in China. The tally of the world emergency has visible governments frequently proclamation the company global to develop in the search for a cure, and the Australian corporate Mesoblast – a global commander in cell-based therapies for a lot of illnesses – are earned recently the approval to start clinical trials of their possess stem cell based product against COVID-19. Taking into consideration that generality of the dead sick people were produced by serious inflammation reaction, it is extremely demanding to advance efficient curative factors and strategies for that cases. I present an accurate lab modality in preparing mesenchymal stem cells (MSCs) which might be a perfect option to cure the seriously sick novel COVID-19 cases. Beneath this situation, I suppose that blood derived MSCs generated from the critically ill novel COVID-19 patient itself (autologous) suggested as a treatment for him. Therefore, my viewpoint spots a modern curative strategy.

Fatigue in multiple sclerosis: Does the functional or structural damage prevail?

Fatigue in multiple sclerosis (MS) is a highly invalidating symptom, lacking efficacious drugs. This topical review aims at assessing the signs in the literature of functional versus structural damage prevalence at the origin of MS fatigue by focusing on papers that assessed the two counterparts in the same patients, paying attention that the fatigue levels do not correlate with clinical severity. We summarize and discuss evidence of increased levels of fatigue occurring together with the alterations of functional connectivity at multiple levels, in the absence of any relationship with lesion load and local atrophy of the involved structures. Specifically, neuronal communication mainly altered in the corticomuscular synchronizations, between hemispheric homologs and in the resting-state networks involved in emotion (cingulate cortex) and effort-reward balance (striatum and inferior parietal lobule). Finally, given the functional prevalence in neuronal network alterations at the origin of fatigue in MS, we highlight the relevance of developing treatments aiming at compensating the neuronal electric communication dysfunctions.