Advances and gaps in SARS-CoV-2 infection models

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

Strengthening the Global Nuclear Safety Regime

Nuclear power is an important component of the global response to climate change. Nuclear power provides continuous electricity and can overcome the intermittency of the renewable energy sources dependent on wind and sun. Assurance of nuclear safety is essential for further expanding nuclear power as a part of the global response to climate change. The commitment to safety must be a universal priority, as the prospects for nuclear power everywhere would be adversely influenced by the public outcry following a serious nuclear event anywhere. The importance of the global nuclear safety regime was revealed by the accident at the Fukushima Daiichi NPP. The accident reinforced that in addition to the need to have a competent national nuclear safety system in place, it is ultimately important to have an international system that ensures that the relevant national institutions diligently and effectively fulfil their roles. This chapter examines the current global nuclear safety regime and suggests improvements, including through safety inspection, greater transparency measures, increased harmonization of standards, and others.

One Health Approach: A Data-Driven Priority for Mitigating Outbreaks of Emerging and Re-Emerging Zoonotic Infectious Diseases

This paper discusses the contributions that One Health principles can make in improving global response to zoonotic infectious disease. We highlight some key benefits of taking a One Health approach to a range of complex infectious disease problems that have defied a more traditional sectoral approach, as well as public health policy and practice, where gaps in surveillance systems need to be addressed. The historical examples demonstrate the scope of One Health, partly from an Australian perspective, but also with an international flavour, and illustrate innovative approaches and outcomes with the types of collaborative partnerships that are required.

Observed and model simulated inter-annual variability of the Indian monsoon

The Center for Ocean-Land-Atmosphere (COLA) general circulation model has been integrated seven times with observed global sea surface temperature (SST) for the years 1979-98. The model-simulated annual cycle, the seasonal mean and the interannual variability of the summer monsoon rainfall and circulation over the Indian region are compared with the corresponding observations. It if found that, although this model has shown remarkable success in simulating the local and global response of tropical SST anomalies, the model shows poor skill in simulating the interannual variability of monsoon rainfall over India. While it is true that the correlation between the observed tropical Pacific SST and the Indian summer monsoon rainfall for the most recent 20 years itself is considerably over India is largely related to the systematic errors of the model in simulating the climatological mean monsoon circulation and rainfall, especially over the oceanic regions.

Single-Dose 13-Valent Conjugate Pneumococcal Vaccine in People Living With HIV – Immunological Response and Protection

BackgroundPatients living with HIV (PLHIV) are prone to invasive pneumococcal disease. The 13-valent conjugated pneumococcal vaccine (PCV13) is currently recommended for all PLHIV, followed in most guidelines by a 23-valent polysaccharide pneumococcal vaccine. Data are scarce concerning the immunological efficacy of PCV13 among PLHIV.ObjectiveTo assess the immunological response at one month, and the immunological protection at 1-, 6-, and 12 months in PLHIV with a CD4 cell count above 200 cells/µl after a single dose of PCV13, as measured by both ELISA and opsonophagocytic assay (OPA).MethodsPLHIV with CD4 cell count >200 cells/µl were included. Specific IgG serum concentrations for eight serotypes by ELISA and seven serotypes by OPA were measured at baseline, 1-, 6-, and 12 months after the PCV13 vaccination. Global response was defined as a two-fold increase from baseline of specific IgG antibody levels (μg/ml) assayed by ELISA or as a four-fold increase in OPA titer from baseline, for at least five serotypes targeted by PCV13. Global protection was defined as an IgG-concentration ≥1 µg/ml by ELISA or as an opsonization titer ≥LLOQ by OPA for at least five tested serotypes targeted by PCV13. Factors associated with global response and global protection were assessed using logistic regression.ResultsOf the 38 PLHIV included, 57.9% and 63.2% were global responders, 92.1% and 78.9% were globally protected at one month, and 64.7% and 55.9% were still protected at 12 months, by ELISA and OPA respectively. A CD4/CD8 ratio of >0.8 was significantly associated with a better global response by OPA (OR=6.11, p=0.02), and a CD4 nadir <200 was significantly associated with a poorer global response by ELISA (OR=0.22, p=0.04). A CD4 cell count nadir <200 and age over 50 years were associated with poorer global protection by OPA at M1 (OR=0.18, p=0.04) and M12 (OR= 0.15, p=0.02), respectively. Plasma HIV RNA viral load <40 copies/ml was significantly associated with a better global protection at M1 by ELISA and OPA (OR=21.33, p=0.025 and OR=8.40, p=0.04)ConclusionVaccination with PCV13 in these patients induced immunological response and protection at one month. At one year, more than half of patients were still immunologically protected.

The Role of the WTO in the Global Response to the COVID-19 Pandemic

The WTO and international trade have proven more important than ever during the COVID-19 pandemic. Indeed, without the delivery of food, medicines, masks and vaccines through commerce, the pandemic could not be contained. The WTO basic principles - transparency, non-discrimination, the prohibition against border restrictions, disciplines on subsidies to industrial and agriculture products, to name a few, and in particular the WTO monitoring system have helped countries collaborating and coordinating their actions to contain the pandemic and mitigate trade and global supply chain disruptions on essential goods. In addition, during this crisis, the WTO Secretariat and its Director-General assumed enhanced responsibilities to assist Members with their extraordinary needs. The WTO became the global forum for Members’ coordination of border and internal trade-related actions, for the debate on intellectual property and the request for waiving patent protections on vaccines, while playing an active role in stimulating the expansion of vaccine production capacity in developing countries. This article contends that the response of the WTO has augmented and legitimatized its role as a global governance forum.

Reprioritising Sustainable Development Goals in the Post-COVID-19 Global Context: Will a Mandatory Corporate Social Responsibility Regime Help?

The impact of COVID-19 on the United Nations Sustainable Development Goals (SDGs) continues to be researched. Initial signals warn of significant setbacks in achieving SDG targets by 2030. The achievement of SDGs could abet improved protection from future pandemics. This article suggests reprioritizing SDGs to facilitate a more robust global response to future pandemics. Specifically, we recommend that SDGs 3, 6, 5 and 4 (in that order) are prioritized in order to optimize efforts at a more inclusive and resilient socio-economic recovery post-pandemic. This paper suggests that mandatory CSR regimes enable governments, in combination with corporate fiscal resources, to influence the selection and progress of these SDGs. The case of India’s mandatory CSR regime is employed to illustrate our position. This study extends the debate on SDGs by raising the possibility of universal concentration on a few critical SDGs.

Dynamics and length scales in vertical convection of liquid metals

Using complementary experiments and direct numerical simulations, we study turbulent thermal convection of a liquid metal (Prandtl number $\textit {Pr}\approx 0.03$ ) in a box-shaped container, where two opposite square sidewalls are heated/cooled. The global response characteristics like the Nusselt number ${\textit {Nu}}$ and the Reynolds number $\textit {Re}$ collapse if the side height $L$ is used as the length scale rather than the distance $H$ between heated and cooled vertical plates. These results are obtained for various Rayleigh numbers $5\times 10^3\leq {\textit {Ra}}_H\leq 10^8$ (based on $H$ ) and the aspect ratios $L/H=1, 2, 3$ and $5$ . Furthermore, we present a novel method to extract the wind-based Reynolds number, which works particularly well with the experimental Doppler-velocimetry measurements along vertical lines, regardless of their horizontal positions. The extraction method is based on the two-dimensional autocorrelation of the time–space data of the vertical velocity.