Elisa Teixeira Bernardes
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Carolina Cappi
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Marina de Marco e Souza
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Marcelo Queiroz Hoexter
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Priscila Chacon
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AbstractBackgroundCognitive performance has been studied in subclinical obsessive-compulsive (OC) adults and in adults relatives of OCD patients. Meanwhile, no study has been conducted with children under the same conditions. Across a sample with 49 participants, we investigated whether children and adolescents at high-risk (HR) for OCD (n=18) would present an impaired performance on neurocognitive domains compared to healthy controls (HC, n=31), especially in visuoconstructive ability, executive functions, and intellectual efficiency, functions previously associated with OCD.MethodsFor the HR group, we considered the first-degree children relatives of patients with OCD that present obsessive-compulsive symptoms (OCS), but do not meet diagnostic criteria for OCD. Child psychiatric diagnoses were assessed by the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL) by experienced and trained psychologists and OCS were measured by Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).ResultsAlthough we did not find differences in the domains previously hypothesized, a Multivariate Analysis of Variance (MANOVA) revealed impairments in processing speed in HR group (p =0.019; F=3.115), and a t-test identified a higher IQ discrepancy in HR group when compared to HC (p =0.030; t =-2.239), and a discrepancy in verbal and non-verbal abilities as in the memory and working memory tasks.ConclusionsOur results suggest that differences in motor and processing speed and in IQ discrepancy are already present and were identified in a non-clinical sample of HR subjects. Further studies should investigate neurocognitive domains as possible predictors of pediatric OCD.