Enhanced habit formation in Tourette syndrome: dopamine release and striatal disinhibition modulate shortcut connections in a hierarchical model of cortico-basal ganglia loops

In the Gilles de la Tourette syndrome, tics are often considered as habitual responses towards unwanted premonitory urges. Support for the relationship between tics and habits comes from devaluation protocols, which reveal that unmedicated Tourette patients show an increased tendency towards responses to devalued outcomes. We use a neuro-computational model of hierarchically organized cortico-basal ganglia-thalamo-cortical loops to shed more light on enhanced habit formation of Tourette patients. In our model, habitual behavior emerges from cortico-thalamic shortcut connections, where enhanced habit formation can be linked to faster plasticity in the shortcut or to a stronger feedback from the shortcut to the basal ganglia. Irregular activity in such shortcut connections may have different pathophysiological origins. Based on our model, we explore decreased local striatal inhibition, which may correspond to a loss of inhibitory interneurons, and increased dopaminergic modulation of striatal medium spiny neurons as causes for irregular shortcut plasticity or activation. Both lead to higher rates of response towards devalued outcomes in our model, similar to what is observed in Tourette patients. Our results support the view of tics in Tourette syndrome as maladaptive habits. We suggest to reveal more shortcuts between cortico-basal ganglia-thalamo-cortical loops in the human brain and study their potential role in the development of the Tourette syndrome.

Habits and Goals in Human Behavior: Separate but Interacting Systems

People automatically repeat behaviors that were frequently rewarded in the past in a given context. Such repetition is commonly attributed to habit, or associations in memory between a context and a response. Once habits form, contexts directly activate the response in mind. An opposing view is that habitual behaviors depend on goals. However, we show that this view is challenged by the goal independence of habits across the fields of social and health psychology, behavioral neuroscience, animal learning, and computational modeling. It also is challenged by direct tests revealing that habits do not depend on implicit goals. Furthermore, we show that two features of habit memory—rapid activation of specific responses and resistance to change—explain the different conditions under which people act on habit or pursue goals Finally, we test these features with a novel secondary analysis of action-slip data. We find that habitual responses are activated regardless of goals, but can be performed in concert with goal pursuit.

Mindfulness of Death

This chapter studies Buddhist practices around death. Buddhist practice includes a wide range of reflections on death. Impermanence can be easy to accept as an abstract, intellectual idea, but death makes it personal and tangible. As such, these reflections can seem pretty grim. That is why it is important to remember their role in the larger contexts of Buddhist practice. They help an individual to get used to harsh truths about how the world is and change habitual responses to accommodate those truths. The idea is to reflect on the reality of death from a certain frame of mind—a diagnostic one intended to shed light on difficult aspects of reality and how one's intuitive responses deny or distort them. In a Buddhist context, the individual reflects on difficult things like death in order to better deal with it, to be able to forge a life in full view of such difficult facts.

Motor Conflict: Revealing Involuntary Conditioned Motor Preparation Using Transcranial Magnetic Stimulation

Preparing actions to achieve goals, overriding habitual responses, and substituting actions that are no longer relevant are aspects of motor control often assumed to be driven by deliberate top-down processes. In the present study, we investigated whether motor control could come under involuntary control of environmental cues that have been associated with specific actions in the past. We used transcranial magnetic stimulation (TMS) to probe corticospinal excitability as an index of motor preparation, while participants performed a Go/No-Go task (i.e., an action outcome or no action outcome task) and rated what trial was expected to appear next (Go or No-Go). We found that corticospinal excitability during a warning cue for the upcoming trial closely matched recent experience (i.e., cue–outcome pairings), despite conflicting with what participants expected would appear. The results reveal that in an action–outcome task, neurophysiological indices of motor preparation show changes that are consistent with participants learning to associate a preparatory warning cue with a specific action, and are not consistent with the action that participants explicitly anticipate making. This dissociation with conscious expectancy ratings reveals that conditioned responding and motor preparation can operate independently of conscious expectancies about having to act.

Towards Autonomous Transportation. Passengers’ Experiences, Perceptions and Feelings in a Driverless Shuttle Bus in Finland

Autonomous vehicles, electrification, and ride-sharing appear to be the next big change in the field of mobility. It can lead to safer roads, less congestion, and reduced parking. In this research, we focus on real-life user experiences of a driverless shuttle bus. We are interested to know what kind of perceptions and feelings people have when they travel in an autonomous shuttle bus. Therefore, we apply Harry Triandis´ Theory of Interpersonal Behaviour (TIB), which recognizes that human behavior is not always rational. Human behaviour, and its change, is linked to the intention, the habitual responses, and the situational constraints and conditions. The qualitative data (n = 44) were collected in 2017 by semi-structured interviews in Espoo, Finland. The interviewees were passengers who travelled a predefined route in a driverless shuttle bus. We applied inductive content analysis. The findings were compared in the theoretical framework of TIB. According to the results, a lack of human driver was not a problem for the passengers. They were surprised how safe and secure they felt in the autonomous vehicle. More specifically, passengers´ perceptions were similar to when travelling by a metro or a tram, where a passenger rarely interacts with the driver, or even witnesses the existence of the driver. However, the results suggest that people are much more intolerant of accidents caused by autonomous vehicles than by humans. On a general level, positive attitudes towards autonomous vehicles can be supported by giving people possibilities to try autonomous vehicles in a safe, real-life environment. The decision whether to use a driverless shuttle bus or not correlates highly with the contextual factors. Route and flexibility are the most important reasons for behavioral changes.

Financial Regulation and Risk Management in Development Banks

Should development banks (DBs) be regulated? Is Basel regulation a suitable framework for them? With regard to risk management, do DBs entail different characteristics from private banks? What are the main challenges posed by the new Basel regulations for DBs? This chapter explores these largely unexplored questions and the habitual responses to them. The answers are built upon a reconstruction of the theoretical arguments in favour of financial regulation; a historical description of the evolution of the Basel Agreements framework; a few analytical generalizations built upon an exploratory case study; and a review of the literature on risk management practices in DBs as well as interviews with risk management specialists and Brazilian regulatory agencies.

Switch costs in inhibitory control and voluntary behavior: A computational study of the antisaccade task

An integral aspect of human cognition is the ability to inhibit habitual responses in order to initiate complex, rule-guided actions. Moreover, humans have also the ability to alternate between different sets of rules or tasks, at the cost of degraded performance when compared to repeating the same task, a phenomenon called the ‘task switch cost’. While it is recognized that switching between tasks requires often to inhibit habitual responses, the interaction between these two forms of cognitive control has been much less studied than each of them separately. Here, we use a computational model to draw a bridge between inhibitory control and voluntary action generation and thereby provide a novel account of seemingly paradoxical findings in the task switch literature. We investigated task switching in the mixed antisaccade task, in which participants are cued to saccade either in the same or in the opposite direction to a peripheral stimulus. Our model demonstrates that stopping a habitual action leads to increased inhibitory control that persists on the next trial. However, enhanced inhibition affects only the probability of generating habitual responses, and, contrary to previous accounts, cannot be characterized as proactive task interference. In addition, our model demonstrates that voluntary actions (but not habitual responses) are slower and more prompt to errors on switch trials compared to repeat trials. We conclude that precisely the interaction between these two effects explains a variety of contradictory findings reported in the literature.

Time-dependent competition between habitual and goal-directed response preparation

Converging evidence indicates that separate goal-directed and habitual systems compete to control behavior1. However, it has proven difficult to reliably induce habitual behavior in human participants2–4. We reasoned that habits may be present in the form of habitually prepared responses, but are overridden by goal-directed processes, preventing their overt expression. Here we show that latent habits can be unmasked by limiting the time participants have to respond to a stimulus. Participants trained for 4 days on a visuomotor association task. By continuously varying the time allowed to prepare responses, we found that the probability of expressing a learned habit followed a stereotyped time course, peaking 300-600ms after stimulus presentation. This time course was captured by a computational model of response preparation in which habitual responses are automatically prepared at short latency, but are replaced by goal-directed responses at longer latency. A more extensive period of practice (20 days) led to increased habit expression by reducing the average time of movement initiation. These findings refine our understanding of habits, and show that practice can influence habitual behavior in distinct ways: by promoting habit formation, and by modulating the likelihood of habit expression.

Behavioral therapy for Tourette syndrome and chronic tic disorders

Purpose of review:To summarize behavioral interventions for the treatment of primary tic disorders.Recent findings:Although tics were attributed to a disordered weak volition, the shift towards neurobiological models of tic disorders also transformed nonpharmacologic treatment practices. Current international guidelines recommend habit reversal training, comprehensive behavioral intervention, and exposure and response prevention as first-line therapies for tics. Appropriate patient selection, including age and presence of comorbidities, are salient clinical features that merit consideration. Evidence for further behavioral interventions is also presented.Summary:Currently recommended behavioral interventions view tics as habitual responses that may be further strengthened through negative reinforcement. Although availability and costs related to these interventions may limit their effect, Internet-based and telehealth approaches may facilitate wide accessibility. Novel nonpharmacologic treatments that take different approaches, such as autonomic modulation or attention-based interventions, may also hold therapeutic promise.

Addiction History Associates with the Propensity to Form Habits

Learned habitual responses to environmental stimuli allow efficient interaction with the environment, freeing cognitive resources for more demanding tasks. However, when the outcome of such actions is no longer a desired goal, established stimulus–response (S-R) associations or habits must be overcome. Among people with substance use disorders (SUDs), difficulty in overcoming habitual responses to stimuli associated with their addiction in favor of new, goal-directed behaviors contributes to relapse. Animal models of habit learning demonstrate that chronic self-administration of drugs of abuse promotes habitual responding beyond the domain of compulsive drug seeking. However, whether a similar propensity toward domain-general habitual responding occurs in humans with SUDs has remained unclear. To address this question, we used a visuomotor S-R learning and relearning task, the Hidden Association between Images Task, which employs abstract visual stimuli and manual responses. This task allows us to measure new S-R association learning and well-learned S-R association execution and includes a response contingency change manipulation to quantify the degree to which responding is habit-based, rather than goal-directed. We find that people with SUDs learn new S-R associations as well as healthy control participants do. Moreover, people with an SUD history slightly outperform controls in S-R execution. In contrast, people with SUDs are specifically impaired in overcoming well-learned S-R associations; those with SUDs make a significantly greater proportion of perseverative errors during well-learned S-R replacement, indicating the more habitual nature of their responses. Thus, with equivalent training and practice, people with SUDs appear to show enhanced domain-general habit formation.