Indigenous economic development is a distinctive activity that operates at the intersection of social and economic development and entrepreneurship wherein economic and entrepreneurial activities are moderated by a community’s particular social, cultural, environmental, and economic values and by access to resources contained within or proximate to their traditional territories. As Indigenous peoples act on their inherent rights and assert their sovereignty in the judicial courts, the political arena, the economic arena, and in the court of public opinion, a deeper understanding of the issues regarding Indigenous Worldviews, Indigenous Rights and Relations, Sovereignty, Self-Determination, and Self-Governance, the interplay between Indigenous and Political Economy, Sociopolitical Development, Sustainable Development, Indigenous Enterprise, Leadership and Management, Health and Well-being, as well as methods and approaches is needed to support, strengthen, and increase Indigenous economic development, self-determination, and sovereignty.