scholarly journals Spectrum of Lipid Abnormality among Thyroid Disorder Patients in Ucms-Th, South Western Region

2018 ◽  
Vol 4 (2) ◽  
pp. 20-24
Author(s):  
N Gautam ◽  
A Jayan ◽  
Raju Kumar Dubey ◽  
AC Jha ◽  
B Sharma ◽  
...  
Keyword(s):  
Subclinical Hypothyroidism ◽  
Close Association ◽  
Large Population ◽  
Treatment Protocol ◽  
Primary Hypothyroidism ◽  
Thyroid Disorder ◽  
Medical Sciences ◽  
Elisa Method ◽  
Lipid Abnormality ◽  
Primary Hyperthyroidism

INTRODUCTION: Hypothyroidism is the most common cause of secondary dyslipidemia. Thus, thyroid function test should be carried out before starting any hypolipidemic drugs. Even among thyroid disorder, hypothyroidism is more associated with cardiovascular and associated problems and if not detected earlier, it leads to severe clinical consequences. Our study assesses the frequency and spectrum of dyslipidemia in various types of thyroidal illness in the population residing in south western part of Nepal.MATERIALS AND METHODS: This is a cross sectional study carried out in suspected thyroid disorder patients (n=276) and categorized as Euthyroidism (n=55), Subclinical Hypothyroidism (n=89), Primary Hypothyroidism (n=122) and Primary Hyperthyroidism (n=10) patients and to see the association with lipid profiles in the Department of Biochemistry, Universal College of Medical Sciences Teaching Hospital, Bhairahawa Nepal. Serum fT / fT4 and TSH estimations were carried out by competitive 3 ELISA method and Sand-wich double antibody ELISA method respectively using commercially supplied reagents (Human, Germany). The criteria for dyslipidemia was obtained by National Cholesterol Education Expert Panel/ Adult Treatment Protocol III (NCEP/ATPIII).RESULTS: Out of 276 cases the dyslipidemia was observed in 183 cases (66.30%).The dyslipidemia was mostly associated with  primary hypothyroidism (55.07%) followed by Subclinical Hypothyroidism (38.04%) than Euthyroid (5.79 %) and Primary Hyperthyroidism (3.62 %) respectively. Out of all cases, the spectrum of dyslipidemia was mostly observed for decreased HDL (18.5 %) followed by increased TG (10.1 %). Moreover, it is significantly differ in relation in HDL (p=0.009), TG/HDL (p=0.02) and Non-HDL/HDL (p=0.033) where as non significant as compared to other lipid profile in different groups.CONCLUSION: Our study revealed the close association of thyroidal illness with dyslipidemia with increased TG, low HDL, increased TG/HDL and Non-HDL/HDL. The increased TG/HDL and/or Non-HDL/HDL could be better indicator than single lipid abnormality which needs to be ascertained prospectively in large population. Journal of Universal College of Medical Sciences (2016) Vol.04 No.02 Issue 14, page: 20-24 

scholarly journals Clinical Profile of Thyroid Disorders – A retrospective study at BPKIHS

2018 ◽  
Vol 2 (2) ◽  
pp. 19-25
Author(s):  
Anuskha Agrawal ◽  
Nidhi Rani ◽  
Robin Maskey
Keyword(s):  
Retrospective Study ◽  
Subclinical Hypothyroidism ◽  
Primary Hypothyroidism ◽  
Clinical Profile ◽  
Thyroid Disorders ◽  
American Thyroid Association ◽  
Thyroid Disorder ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Endocrinology Clinic

Background: The thyroid gland produces two key metabolic hormones which regulate metabolic rate, growth and development. They play vital roles in digestion, heart and muscle function, brain development and maintenance of bones. People suffering from thyroid disorders may have autoimmune disease, ranging from primary hypothyroidism, Hashimoto’s thyroiditis, to hyperthyroidism caused by Graves’ disease. Objectives: To study clinical profile of thyroid disorders in endocrinology clinic of BPKIHS, Nepal. Methods: This is a hospital based retrospective study of past five years (2012 – 2017) done in department of internal medicine at B.P. Koirala Institute of Health Sciences, in which thyroid disorder patient records from the endocrinology clinic will be compiled together will be analyzed after classifying them according to the guidelines of the American Thyroid Association (ATA). Results: Among 584 thyroid disorder cases that were sampled, higher prevalence of thyroid disorders was seen in females, and the Male: Female ratio was 1:4.13. Most common type of thyroid disorder was Hypothyroidism (29.6%) followed by Subclinical hypothyroidism (28.3%). Conclusions: Thyroid disorders are more common in females than males and hypothyroidism being commonest thyroid disorder in our setup. Subclinical hypothyroidism is second commonest followed by hyperthyroidism. In Subclinical hypothyroidism Anti TPO antibody is most commonly found to be positive.

scholarly journals Subclinical Hypothyroidism in Pregnancy - A Case Series

2017 ◽  
Vol 16 (1) ◽  
pp. 53-60
Author(s):  
Samir Sahu ◽  
Praruti Dash ◽  
Subhasree Ray
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Large Population ◽  
Medical Science ◽  
Treatment Protocol ◽  
Case Series ◽  
Overt Hypothyroidism ◽  
Foetal Development ◽  
Beneficial Effects ◽  
In Pregnancy

Background: Effects of overt hypothyroidism on pregnancy outcomes and foetal development are well established and treatment protocol is reputable.Method and material: The prevalence and effects of subclinical hypothyroidism (SCH) on pregnancy are not yet clear. Hence, universal screening of all pregnant women is still debatable and treatment of detected sub clinical hypothyroidism is yet to have general consensus as data regarding beneficial effects of treatment to mother and foetus in SCH cases is inadequate.Result: Odisha is a known endemic area of Iodine deficiency and reports of occurrences of SCH in Odisha are very limited. This study is a case series, done to detect the prevalence of SCH in pregnancy in the ante-natal unit of a medical college and hospital catering to a large population of Odisha.Conclusion: This prospective study included screening of the pregnant women for thyroid function and follow – up of the cases with SCH till confinement to record any adverse effects of the thyroid dysfunction on obstetric outcome.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.53-60

scholarly journals Thyroid disorders in reproductive age presenting with abnormal uterine bleeding

2021 ◽  
Vol 8 (2) ◽  
pp. 259-263
Author(s):  
Roshnibala Sahu ◽  
Sudhuanshu Kumar Rath
Keyword(s):  
Subclinical Hypothyroidism ◽  
Reproductive Function ◽  
Abnormal Uterine Bleeding ◽  
Later Life ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Medical Sciences ◽  
Life Threatening

Abnormal uterine bleeding (AUB) is a frequently encountered clinical presentation in gynecological OPD. They are not life threatening but can cause social, psychological and occupational disturbances. As thyroid hormones play a major role in the menstrual and reproductive function of women, studying for thyroid disorder in patients with AUB should be a logical step.This is a prospective observational study conducted in Kalinga Institute of Medical Sciences, BBSR, Odisha. Two hundred and eighty patients of age group 18 to 45 years presenting with AUB were included in this study. All were subjected to routine investigations along with thyroid function tests.Out of 280 patients, 56 patients (20%) had thyroid abnormality. Among which 26 were diagnosed as subclinical hypothyroidism, 24 had hypothyroidism and 6 patients had hyperthyroidism. The frequent menstrual symptom associated with hypothyroidism and subclinical hypothyroidism was menorrhagia. Oligomenorrhea was seen in 50% of hyperthyroid patients.Any type of menstrual disorder should be considered as a possible presenting symptom of thyroid dysfunction and thyroid assessment deemed necessary in such cases, so that we can treat patients at the earliest and prevent morbidities in later life.

Incidence and treatment of feline renal lymphoma: 27 cases

2021 ◽  
pp. 1098612X2098436
Author(s):  
Ashlyn G Williams ◽  
Ann E Hohenhaus ◽  
Kenneth E Lamb
Keyword(s):  
Median Survival ◽  
Clinical Stage ◽  
Large Population ◽  
Clinical Signs ◽  
Treatment Protocol ◽  
Central Nervous System Involvement ◽  
Data Set ◽  
Hematopoietic Malignancy ◽  
Renal Lymphoma ◽  
Multicentric Lymphoma

Objectives Lymphoma is the most common feline hematopoietic malignancy. Incidence of renal lymphoma has not been reported as a subset of a large population of feline lymphoma cases. Previous studies have reported renal lymphoma as both a singular entity as well as a component of multicentric disease. The clinical presentation, diagnostic evaluation, therapy and outcomes related to renal lymphoma have not been reported since Mooney et al in 1987. This retrospective study aimed to describe the incidence of renal lymphoma, clinical signs, treatment and survival. Methods Using a database of cats diagnosed with lymphoma between January 2008 and October 2017, cats with renal lymphoma were selected for further analysis. Cases were retrospectively staged according to Mooney et al (1987) and Gabor et al (1998). Data collected included age, clinical signs, clinicopathologic data, diagnostic imaging findings, lymphoma diagnostic method(s), treatment protocol(s) and survival time. Analyses comparing median survival based on therapy administered, renal lymphoma vs multicentric lymphoma, central nervous system involvement, presence of azotemia, anemia and International Renal Interest Society (IRIS) stage at diagnosis were performed. Results From a population of 740 cats with lymphoma, 27 cats had renal lymphoma (incidence, 3.6%), and 14 of those cats had multicentric lymphoma. Fewer stage IV and V cases were identified in this data set compared with Mooney et al; however, not all cats were completely staged. Median survival (range) for cats receiving corticosteroids alone compared with those receiving an L-CHOP (L-asparaginase, vincristine, cyclophosphamide, doxorubicin, prednisolone)-based protocol was 50 days (20–1027 days) in the corticosteroid group and 203 days (44–2364 days) for the L-CHOP group ( P = 0.753) for cats that died secondary to lymphoma. Conclusions and relevance Neither clinical stage nor other factors were predictive of survival. Prospective studies are required to determine the optimal chemotherapy protocol.

scholarly journals Correlation of Serum zinc with TSH in hyperthyroidism

2015 ◽  
Vol 7 (1) ◽  
pp. 66-69
Author(s):  
Satwika Sinha ◽  
Kaushik Kar ◽  
Anindya Dasgupta ◽  
Saubhik Basu ◽  
Sukanta Sen
Keyword(s):  
Significant Positive Correlation ◽  
Zinc Supplementation ◽  
Colorimetric Method ◽  
Serum Zinc ◽  
Serum Copper ◽  
Medical Sciences ◽  
Elisa Method ◽  
Serum Ceruloplasmin ◽  
Serum T4 ◽  
Hyperthyroid Patients

Aims and Objectives: Trace elements may have a role in progression of hyperthyroidism. We planned to estimate the serum zinc, copper and ceruloplasmin in hyperthyroids.Materials and Methods: 41 hyperthyroid patients and 32 control subjects were taken for the study. Serum T4,TSH ,zinc, copper and ceruloplasmin were estimated in them. T4 and TSH were estimated by ELISA method. Zinc and copper were estimated by colorimetric method. Serum ceruloplasmin were estimated by  Ravins method.Results: Significant decrease of TSH (p<0.0001)and zinc(p<0.0001) were found in hyperthyroids in comparision to controls. Serum copper and ceruloplasmin were significantly  elevated(p<0.0001) in them. Significant positive correlation  between TSH and zinc was observed in case group.Conclusion: Zinc defficiency may contribute to the worsening of hyperthyroidism. Zinc supplementation may improve the condition.Asian Journal of Medical Sciences Vol.7(1) 2015 66-69

scholarly journals Normocytic Normochromic Anemia Revealed an Early Onset Hashimoto’s Hypothyroidism in an Infant: A Case Report

2021 ◽  
pp. 1-5
Author(s):  
Manal Mustafa Khadora ◽  
Maysa Saleh ◽  
Rawah Idres ◽  
Sura Ahmed Al-Doory ◽  
Mahmoud Ahmed Radaideh
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Autoimmune Thyroiditis ◽  
Subclinical Hypothyroidism ◽  
Early Onset ◽  
Clinical Presentation ◽  
Primary Hypothyroidism ◽  
Normocytic Normochromic Anemia ◽  
Wide Range ◽  
Normochromic Anemia

Autoimmune thyroiditis is very rare etiology of primary hypothyroidism in infancy. Hypothyroidism has a wide range of clinical presentation, from subclinical hypothyroidism to overt type. It is unclear what pathological mechanisms connect thyroid function and erythropoiesis or how thyroid disease can contribute to anemia. We report a 12-month-old infant who presented with anemia associated with early onset of overt autoimmune thyroiditis. The peculiarity of our case enables us to draw attention of physician to consider acquired hypothyroidism in the differential diagnosis of unexplained anemia even if the neonatal screening is normal and congenital hypothyroidism is a remote possibility.

scholarly journals Is it necessary to increase the dose of levothyroxine in patients with hypothyroidism who use omeprazole?

2014 ◽  
Vol 58 (7) ◽  
pp. 731-736 ◽  
Author(s):  
Raquel de Carvalho Abi-Abib ◽  
Mário Vaisman
Keyword(s):  
Treatment Protocol ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Sample Median ◽  
Significant Difference ◽  
The Mean ◽  
One Year ◽  
Dose Dependent ◽  
Entire Treatment ◽  
Tsh Levels

Objective It is believed that gastric pH interferes in levothyroxine absorption. Omeprazole, which acts by blocking the secretion of gastric acid, might interfere in hypothyroidism control in patients using levothyroxine and this effect could be dose dependent. The present study aimed to investigate this possibility. Subjects and methods Twenty-one patients with primary hypothyroidism who had been using a stabilized levothyroxine dosage for at least one year were selected and randomly assigned to take omeprazole at the dosage of 40 mg or 20 mg per day. The mean levels of thyroid-stimulating hormone (TSH) before and 3 months after omeprazole usage were compared in the entire sample and in each group. Results Ten patients concluded the entire treatment protocol in the 20 mg group and nine patients in the 40 mg group. There was no significant difference in TSH levels before and 3 months after omeprazole treatment in the entire patient sample (median levels: 2.28 vs. 2.30 mU/L, respectively: p = 0.56). Analysis of each subgroup (20 and 40 mg) showed no significant variation in TSH levels before and 3 months after omeprazole treatment (median levels: 2.24 vs. 2.42 mU/L, p = 0.62, and 2.28 vs. 2.30 mU/L, p = 0.82, respectively). No significant difference in the absolute (p = 0.93) or relative (p = 0.87) delta were observed between the two subgroups. Conclusion Omeprazole in the dosage of 20 or 40 mg/day does not interfere in a clinically relevant manner in the treatment of patients with hypothyroidism that was previously under control.

scholarly journals A prospective descriptive study of evaluation of menstrual disorders in thyroid dysfunction

2021 ◽  
Vol 10 (7) ◽  
pp. 2759
Author(s):  
Durgavathi Kothapalli ◽  
Kamesari Kolluru
Keyword(s):  
Subclinical Hypothyroidism ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Endometrial Biopsy ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Menstrual Disorders ◽  
Menstrual Irregularities ◽  
Hypothyroid Patients ◽  
Common Manifestation

Background: Menstrual irregularities are common with thyroid disorders. It has been reported that hyperthyroidism the most common manifestation is simple oligomenorrhea and hypothyroidism usually is associated with polymenorrhea. Present study has been designed to evaluate the menstrual and endometrial patterns in women with thyroid disorders in costal Andhra Pradesh.Methods: During the study period of two years and ten months we have enrolled 110 patients with clinical presentation of thyroid disorder with menstrual irregularities as per our study criteria. Based on report patients were divided in to three groups, hyperthyroid, hypothyroid and subclinical hypothyroidism. Based on abnormal menstrual pattern patients were divided in to menorrhagia, oligomenorrhea, polymenorrhea, and amenorrhea groups. Endometrial biopsy was taken from women in perimenopausal age group and histopathological examination was done to know the pattern of endometrium.Results: Subclinical hypothyroidism was present in 24 (21.81%) patients, hypothyroidism was present in 52 (47.27%) patients and hyperthyroidism was present in 34 (30.90%) patients. amenorrhea was present in 26 (23.63%) patients, oligomenorrhea was present in 12 (10.90%) patients, Intermenstrual bleeding was present in 2 (1.81%) patients, Menorrhagia was present in 44 (40%) patients which was most common type of menstrual disorder and Polymenorrhagia was present in 26 (23.63%) patients.Conclusions: Hypothyroidism is most common thyroid disorder followed by hyperthyroidism and subclinical hypothyroidism is least common. We have found that menstrual irregularities are more common in hypothyroid patients than hyperthyroid. Menorrhagia and Polymenorrhagia is more common than amenorrhoea and oligomenorrhea in hypothyroid patients. 

scholarly journals A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital

2015 ◽  
Vol 1 (2) ◽  
pp. 105 ◽  
Author(s):  
Sudeb Mukherjee ◽  
Suhana Datta ◽  
Pramathanath Datta ◽  
Apurba K. Mukherjee ◽  
Indira Maisnam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Tertiary Care ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Care Hospital ◽  
Thyroid Disorder

<p class="abstract"><strong><span lang="EN-US">Background: </span></strong>The association between thyroid dysfunction and DM has long been recognized, although the prevalence of thyroid dysfunction among diabetes population varies in different studies. This study destined to know the prevalence of thyroid dysfunction of recently diagnosed type 2 diabetes mellitus patients.  </p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong>Retrospective chart review of 60 patients with type 2 diabetes mellituswas done. Total 60 patients (male 51, female9) fulfillingdiagnostic criteria for diabetes mellitus according to ADA (American Diabetes Association) criteria were analysed by doing Thyroid Function Test (FT4,TSH).</p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong><span lang="EN-US"> 75% of patients have the biochemical features of thyroid dysfunction. Subcategorically in descending order of frequency they are - Subclinical hypothyroidism (33.33%) (defined by no symptoms or clinical fetures of hypothyroidism but biochemically TSH level in the range of above 5 mIU/ml but below 10 mIU/ml with normal FT4 level), 15% of patients each for overt hypothyroidism (either clinical features or Biochemically TSH &gt;10 mIU/ml or FT4 below normal), and subclinical hyperthyroidism (only biochemical low level of TSH &lt;0.34 mIU/ml in this study) and 11.667% patients show the features of clinical hyperthyroidism (clinical or FT4 level well above normal range along with low TSH).</span></p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> Avery high prevalence of thyroid dysfunction in this part of world in contrast to Europe &amp; US suggest routine screening for thyroid disorder in recently diagnosed type 2 diabetes mellitus.</span></p>

scholarly journals ASSOCIATION OF HYPOTHYROIDISM IN TYPE 2 DIABETES MELLITUS AND DIABETIC KIDNEY DISEASE

2020 ◽  
pp. 1-2
Author(s):  
Anjana jose ◽  
J.K. Mukkadan* ◽  
Manju kamal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Thyroid Disorder ◽  
Low T3

Diabetes mellitus (DM) has emerged as a major public health problem in India. Diabetic nephropathy have higher prevalence of thyroid disorder when compared with diabetes mellitus. The present study compared the levels of thyroid hormones between type 2 diabetes mellitus with and without diabetic nephropathy. Among 192 diabetes mellitus patients those who have nephropathy, euthyroid was 124(64.6%), low T3 was 14(7.3%), subclinical hypothyroidism was 36(18.8%) and overt hypothyroidism was 18(9.4%) and other 192 patients those who haven't nephropathy, euthyroid was 159(82.8%), low T3 was 7(3.6%), subclinical hypothyroidism was 11(5.7%) and overt hypothyroidism was 15(7.8%). We found a statistically signicant correlation between TSH and urine protein creatinine ratio (urine PCR). Routine assessment of thyroid hormones in patients will help to improve general wellbeing and reduce the mortality risk.

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