Mesolithic Sites in the Upper Tobol

The article introduces prehistoric artifacts from the sites of Karasor-5, Karasor-6, and Karasor-7 obtained in 1998. The archaeological site of Karasor is located in the Upper Tobol region, near the town of Lisakovsk. Stone tools, pottery fragments, a ceramic item, and a bronze arrow head were collected from a sand blowout, which had destroyed the cultural layer. The paper gives a detailed description of the pottery. The stone tools were examined using the technical and typological analysis, which featured the primary splitting, the morphological parameters and size of plates, the ratio of blanks, plates, flakes, and finished tools, the secondary processing methods, and the typological composition of the tools. The nature of the raw materials was counted as an independent indicator. The pottery fragments, the bronze arrow head, and the ceramic item belonged to the Bronze Age and the Early Iron Age. The stone industry of the Karasor archeological cluster proved to be a Mesolithic monument of the Turgai Trough. The technical and typological analysis revealed a close similarity with the Mesolithic sites of the Southern and Middle Trans-Urals, as well as the forest-steppe part of the Tobol-Irtysh interfluve. The stone artifacts were dated from the Mesolithic to the Early Iron Age.

AB0779 CAN INFLAMMATION COEXIST IN PATIENTS WITH PROGRESSIVE PSEUDORHEUMATOID DYSPLASIA?

Background:Progressive pseudorheumatoid dysplasia(PPRD) is considered as a degenerative genetic bone disorder. It is caused by loss of function mutation in WNT-1 inducible signaling pathway protein-3(WISP-3)1. WISP-3 gene function is required for the normal function of cartilage and skeletal development. The patients are normal at birth and start developing symptoms around 3-6 years of age2. The disease is characterised by stiffness, pain, deformity due to enlargement of the ends of short and long bones. Often, such patients are misdiagnosed as Juvenile idiopathic arthritis(JIA). In general, PPRD being considered as non-inflammatory disease, immunosuppressants or disease modifying anti rheumatic drugs(DMARDS) like methotrexate treatment are not used for treatment.Objectives:We report a patient with characteristic findings of PPRD but with coexisting clinical and imaging evidence of inflammation.Methods:16 year old male boy born of third degree consanguineous asymptomatic parents presented with progressive swelling, deformity of bilateral small and large joints of upper and lower limbs. He also had pain in both hip and knee for past two years. Pain is associated with difficulty in walking and squatting. On examination he had bony enlargement around bilateral elbow, wrist, proximal and distal interphalangeal joints(Figure 1A). He also had restriction of bilateral hip movements and swelling of bilateral knee with effusion. He had exaggerated lumbar lordosis and flexion deformity of bilateral hip, knee. His blood counts, ESR, CRP were normal. Analysis of Knee joint synovial fluid showed cell count of 200/mm3 with no crystals and sterile culture. USG knee showed evidence of synovial thickening with increased power Doppler signals. Skeletal survey showed typical findings of PPRD with enlargement of epiphysis and osteoarthritis changes(Figure 1B). MRI hip showed minimal effusion, synovial thickening, edema with STIR hyperintensity and enlargement of bilateral femoral epiphysis. MRI knee showed minimal effusion, marrow edema in patella(Figure 1C, arrow head), femoral condyle, diffuse synovial thickening with contrast enhancement(Figure 1D, arrow) and deformed patellar contour. Immunological tests showed negative RF, ACPA and positive ANA(Hep2) speckled 4+. Immunoblot for ENA was negative. His ophthalmological evaluation showed no evidence of uveitis.Figure 1.Clinical picture showing typical hand deformity and swelling at bone ends(A), hand radiograph showing epiphyseal enlargement(B), MRI knee T2 STIR showing bone marrow edema(arrow head) in patella(C) and synovial thickening(arrow) with contrast enhancement in fat saturated T1 MRI with contrast.Results:Patient tested positive for homozygous mutation in WISP-3 gene. He was treated with ibuprofen and supportive measures. Orthopedic consultation obtained and planned for hip, knee replacement during follow up. Follow up imaging and acute phase response was advised after three months.Conclusion:Although PPRD was classically described as a degenerative disease, the findings presented in our case show coexisting inflammation. Bone marrow edema in weight bearing areas, synovial effusion may be explained as part of cartilage degeneration like in osteoarthritis but synovial hypertrophy with contrast enhancement, power Doppler signals in ultrasound, ANA positivity may be signs of coexisting inflammatory or autoimmune phenomenon.References:[1]Hurvitz JR, Suwairi WM et al. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat Genet. 1999 Sep;23(1):94-8. doi: 10.1038/12699. PMID: 10471507.[2]Garcia Segarra N, Mittaz L et al. The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): a review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals. Am J Med Genet C Semin Med Genet. 2012 Aug 15;160C(3):217-29. doi: 10.1002/ajmg.c.31333. Epub 2012 Jul 12. PMID: 22791401.Disclosure of Interests:None declared

Morphology of immature stages and life cycle of Monotoma testacea Motschulsky (Coleoptera: Monotomidae)

The egg, all three larval instars, and pupa are described for the cucujoid beetle species Monotoma (s. str.) testacea Motschulsky, which develops in decomposing plant matter. Adults and larvae were fed with baker’s yeast under laboratory conditions; this food source allowed for successful breeding of several generations. Detailed and illustrated descriptions of all immature stages are given. It is suggested that simple, pointed setae may represent a diagnostic character for Monotoma (s. str.), whereas clavate setae characterize Monotoma (Gyrocecis). Only minor differences in the number and patterns of setae were found between first, second and third larval instars, supporting observations of previous authors. Morphological differences are listed to distinguish between the three larval instars. An arrow-head aggregation of coarse asperities on the frontal region of the L1 larva, lacking in older instars, is hypothesized to be an egg-burster. Only 34–42 days elapsed from egg laying to emergence of the adult; the egg stage lasted 5–6 days; L1 larvae 2–3 days; L2 3–5 days; L3 2–5 days; the immovable prepupal stage 12–13 days; and the pupa 7–10 days. One female laid 1–5 eggs daily, averaging ~1.5 egg per day during her entire life; the total number of eggs in two independent cultures produced by one female accompanied by one male was 57 and 94.

Arrow R-CNN for handwritten diagram recognition

We address the problem of offline handwritten diagram recognition. Recently, it has been shown that diagram symbols can be directly recognized with deep learning object detectors. However, object detectors are not able to recognize the diagram structure. We propose Arrow R-CNN, the first deep learning system for joint symbol and structure recognition in handwritten diagrams. Arrow R-CNN extends the Faster R-CNN object detector with an arrow head and tail keypoint predictor and a diagram-aware postprocessing method. We propose a network architecture and data augmentation methods targeted at small diagram datasets. Our diagram-aware postprocessing method addresses the insufficiencies of standard Faster R-CNN postprocessing. It reconstructs a diagram from a set of symbol detections and arrow keypoints. Arrow R-CNN improves state-of-the-art substantially: on a scanned flowchart dataset, we increase the rate of recognized diagrams from 37.7 to 78.6%.

Pengaruh model latihan UMAC-CPF dalam meningkatkan kelincahan pemain sepakbola cerebral palsy Indonesia

Penelitian ini bertujuan untuk mengetahui pengaruh model latihan UMAC-CPF dalam meningkatkan kelincahan pemain Tim Cerebral Palsy Football Indonesia Asean Paragames Philippines 2020. Rancangan penelitian dengan one group pretest-posttest design menggunakan metode penelitian pre-experimental. Sampel penelitian semua atlet sepakbola cerebral palsy Tim Indonesia Asean Paragames 2020 yaitu 14 orang. Data dikumpulkan dengan instrument Arrow Head Test. Teknis analisis data uji-t dengan taraf signifikansi 5%. Hasil analisis data menunjukkan bahwa model latihan UMAC-CPF secara signifikan meningkatkan kelincahan pemain dengan nilai thitung sebesar 9.169, sehingga dapat disimpulkan bahwa model latihan UMAC-CPF layak digunakan untuk meningkatkan kelincahan Pemain Tim CP Football Indonesia Asean Paragames Philippines 2020. Diharapkan penelitian ini dapat dikembangkan oleh peneliti lain dengan melibatkan faktor lain seperti kecepatan, power, dan daya tahan.

Compressive Property of an Auxetic-Knitted Composite Tube Under Quasi-Static Loading

This research investigates the compressive property of a novel composite based on a weft-knitted auxetic tube subjected to a quasi-static compression test. In order to maximize the influence of the fiber content on the compression test, a Kevlar yarn was used in knitting the tubular samples using three different auxetic arrow-head structures (i.e. 4 × 4, 6 × 6 and 8 × 8 structure). A quasi-static compression test was conducted under two different impact loading speeds (i.e. 5 mm/min and 15 mm/min loading speed). The results indicate that the energy absorption (EA) property of the auxetic composite is highly influenced by the auxeticity of the knitted tubular fabric.