coupled motion
Recently Published Documents


TOTAL DOCUMENTS

184
(FIVE YEARS 24)

H-INDEX

23
(FIVE YEARS 2)

2022 ◽  
Vol 10 (1) ◽  
pp. 113
Author(s):  
Tao He ◽  
Dakui Feng ◽  
Liwei Liu ◽  
Xianzhou Wang ◽  
Hua Jiang

Tank sloshing is widely present in many engineering fields, especially in the field of marine. Due to the trend of large-scale liquid cargo ships, it is of great significance to study the coupled motion response of ships with tanks in beam waves. In this study, the CFD (Computational Fluid Dynamics) method and experiments are used to study the response of a ship with/without a tank in beam waves. All the computations are performed by an in-house CFD solver, which is used to solve RANS (Reynold Average Navier-Stokes) equations coupled with six degrees-of-freedom solid-body motion equations. The Level Set Method is used to solve the free surface. Verification work on the grid number and time step size has been conducted. The simulation results agree with the experimental results well, which shows that the numerical method is accurate enough. In this paper, several different working conditions are set up, and the effects of the liquid height in the tank, the size of the tank and the wavelength ratio of the incident wave on the ship’s motion are studied. The results show the effect of tank sloshing on the ship’s motion in different working conditions.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Pratik Rajesh Chheda ◽  
Grant T. Cooling ◽  
Sondra F. Dean ◽  
Jonah Propp ◽  
Kathryn F. Hobbs ◽  
...  

AbstractOne of our greatest challenges in drug design is targeting cryptic allosteric pockets in enzyme targets. Drug leads that do bind to these cryptic pockets are often discovered during HTS campaigns, and the mechanisms of action are rarely understood. Nevertheless, it is often the case that the allosteric pocket provides the best option for drug development against a given target. In the current studies we present a successful way forward in rationally exploiting the cryptic allosteric pocket of H. pylori glutamate racemase, an essential enzyme in this pathogen’s life cycle. A wide range of computational and experimental methods are employed in a workflow leading to the discovery of a series of natural product allosteric inhibitors which occupy the allosteric pocket of this essential racemase. The confluence of these studies reveals a fascinating source of the allosteric inhibition, which centers on the abolition of essential monomer-monomer coupled motion networks.


2021 ◽  
Vol 240 ◽  
pp. 109955
Author(s):  
Zheng Fu ◽  
Yunbo Li ◽  
Jiaye Gong ◽  
Dapeng Zhang ◽  
Ang Li
Keyword(s):  

2021 ◽  
Vol 198 ◽  
pp. 110703
Author(s):  
Y.L. Li ◽  
X. Cheng ◽  
W.H. Duan ◽  
W.J. Qiang

2021 ◽  
Author(s):  
Romain Costil ◽  
Mira Holzheimer ◽  
Stefano Crespi ◽  
Nadja A. Simeth ◽  
Ben L. Feringa
Keyword(s):  

2021 ◽  
Vol 35 (4) ◽  
pp. 598-608
Author(s):  
Hua-cheng He ◽  
Sheng-wen Xu ◽  
Lei Wang ◽  
Xue-feng Wang

2021 ◽  
Author(s):  
Wonjoon Moon ◽  
Shin Hye Chung ◽  
Juhea Chang

Abstract This study aimed to evaluate the efficacy of three sonic irrigation systems for removal of calcium hydroxide dressing from the apical root canal. A total of 96 single-rooted teeth in three categories of root canal curvatures (straight: 0–5⁰, moderate: 6–20⁰, and severe: > 20⁰ were allocated to four groups: conventional needle irrigation, EndoActivator, EQ-S, and Vibringe. The root canals were instrumented using Protaper NEXT and filled with calcium hydroxide. After removal of calcium hydroxide, the remaining volume of calcium hydroxide was measured by micro-CT analysis. Data were compared among root canal curvatures and irrigation systems using the Kruskal-Wallis test and Mann-Whitney test (p < .05). The oscillating range of each irrigation system was measured using light-coupled motion tracking. The volumes of calcium hydroxide remained in the canals of severe curvature were significantly lower than in those of straight curvature (p < .05). In the canals of moderate or severe curvature, EQ-S showed the highest removal percentage, followed by EndoActivator, Vibringe, and needle irrigation (p < .05). Light-coupled tracking showed the largest oscillating range in EQ-S (p < .05). Sonically activated irrigation systems with a flexible tip can be beneficial for cleaning of intracanal medication in the curved apical canals.


2021 ◽  
Vol 116 ◽  
pp. 110220
Author(s):  
Shumeng Yang ◽  
Stephen P. Canton ◽  
MaCalus V. Hogan ◽  
William Anderst

Sign in / Sign up

Export Citation Format

Share Document