Study of analgesic property of diacerein in rat

Background: Diacerein has been known as an anti-osteoarthritic agent that is usually given along with other analgesic drugs. Still there is no evidence of the analgesic effect of diacerein alone. So this pilot study was undertaken to assess the analgesic property at supra-spinal level by using the tail-flick method.Methods: Diacerein at doses of 50, 100 and 200 mg/kg was given to Albino wistar rats weighing approximately 100-200 grams along with distilled water as placebo. All drugs were given by oral routes and the analgesic effect was evaluated using analgesiometer at baseline, 15 min, 30 min, 60 min and 120 min. Analgesic activity was measured as change in tail flick latency from baseline in animals.Results: Diacerein showed significant increase in tail flick latency and showed promising analgesic activity compared to placebo starting from 15 mins till 60 mins. However the effect persisted up to one hour only and after which it started decreasing.Conclusions: Diacerein at all the three doses possess dose dependant analgesic activity that is maximally effective up to 60 minutes.

ACUTE TOXICITY STUDIES AND EVALUATION OF ANALGESIC PROPERTY OF TECTONA GRANDIS METHANOLIC SEED EXTRACT IN SWISS ALBINO MICE

Objective: Tectona grandis which is well known as teak possesses a wide range of applications in Indian and African folklore medicine. All the plant parts are having diverse bioactivities, especially the seeds, having hair growth-promoting activity, anti-inflammatory, and antimicrobial activity. Xanthones, proteins, amino acids, and fatty acids have been isolated from the oil and seeds of T. grandis. Methods: The present study was to explore the antinociceptive properties of methanolic seed extract of T. grandis. Dried seeds of the plant were defatted with non-polar solvents such as petroleum ether and extracted with methanol. Acetic acid-induced writhing test, tail flick test, and tail immersion test were employed for the extract using Swiss albino mice. Results: From the results, it is clear that the methanolic teak seed extract is safe at 1000 mg/kg and having a potent analgesic property (at a dose of 200–250 mg/kg body weight) by inhibiting pain response time. Conclusion: It can be concluded that the methanolic seed extract of T. grandis is analgesic in nature. It is considered as safe and the activity may be due to the presence of various bioactive chemicals such as flavonoids, xanthones, and glycosides.

Leech Therapy - A unique treatment in Ayurveda

As mentioned in Ayurveda, Rakta itself is life for human being. If it get vitiated (impure) by means of unhealthy food habits and seasonal change is going to induce many disease. There is a unique worm - Leech which is used therapeutically to treat certain diseases induced by impure blood. Medicinal leeches are used for therapeutic purpose; these will suck only impure blood and relieve the symptoms. While sucking leaches leave saliva into the blood stream, which contain many medicinal properties. Out of which Hirudin is the main content which is having very effective anti-coagulant and analgesic property, because of this analgesic property, the process of sucking is painless. Leaches are mainly used in skin diseases as acne, Kusta, Visarpa, recurrent abscess along with these certain diseases which involve impairment of the blood circulation such as varicose veins deep vein thrombosis non healing ulcers and necrosis are also get benefited by leech therapy which improve the blood circulation by stimulating blood capillaries. Hence in this paper the uses of leech therapy are mentioned for the society to get benefited.