Incremental benefit of interdisciplinary care in resource identification in an adolescent and young adult (AYA) oncology care model.

228 Background: Conventional health care models inadequately address the complex needs of adolescents and young adults (AYAs, defined as patients aged 15-39) with cancer, thus necessitating AYA programs. While grounded in the integration of medical and psychosocial care, the best AYA care model has not been identified. We sought to evaluate the comparative impact of one-on-one AYA clinic visits versus interdisciplinary team care on AYA-specific resource identification. Methods: We identified patients seen at the University of Wisconsin (UW) AYA Oncology program between 1/21/2021-5/13/2021. Patients in this program have a one-on-one clinic visit with an AYA physician followed four days later by case presentation at an AYA interdisciplinary team (IDT) meeting. We conducted retrospective chart review to evaluate novel resources identified by the AYA IDT meeting versus those previously identified during the one-on-one AYA clinic visit. Resources identified had to be novel from those already used by or identified for the patient. Results: We identified 32 patients seen by the UW AYA Oncology program. Prior to their AYA clinic visit, patients saw an average of 2.0 AYA-specific services (range 0-6, defined as those services listed in table). As seen in table, an average of 2.8 novel AYA-specific resources were identified for each patient (range 0-5) during the one-on-one AYA clinic visit. Following the AYA IDT meeting, additional novel resources were identified in 100% of patients, with an average of 2.6 additional resources identified per patient (range 1-7). Considering all resources identified by the AYA Oncology program (clinic visit + IDT), an average of 5.4 novel resources were identified per patient (range 2-10). AYA-Specific Resource Identification (n=32). Conclusions: Supporting the importance of dedicated AYA care models, we found that all patients in our study had novel AYA-specific resources identified by the UW AYA Oncology program. Resources identified by the physician-led one-on-one AYA clinic visit were not comprehensive as additional resources were identified for each patient at the AYA IDT meeting only four days later. These objective data support the critical importance of AYA interdisciplinary care as well as the use of an AYA IDT meeting model as a method to include interdisciplinary team care in AYA programs despite possible resource constraints.[Table: see text]

Grounding Sustainable Tourism in Science—A Geographic Approach

This paper presents empirical research that supports territorial approaches to tourism product development that ground tourism in science, as a mechanism to support sustainable tourism heritage conservation goals. Scientific Tourism (ST), in this context, builds on the scientific heritage of a geography, matching researchers with local actors and tourists, through a five-stage iterative process that leads to new scientific knowledge, advancing theory and building relevance for communities through socio-cultural and economic development. This article focuses on the initial stage of the ST product development process, documenting empirical research conducted within the geographies surrounding the Palena River watershed in the Aysén Region of Chilean Patagonia. Both geo-structured literature review methods and results are presented and discussed to illustrate how the outcomes, including a series of maps, can inform and ground actors’ processes of heritage resource identification, justification, conservation, and exhibition, through the development of pilot ST initiatives within the territory. Similar research approaches may prove valuable for other low-density and peripheral geographies that share an interest in grounding tourism on the science taking place within their geography.

Particle Size-Frequency Distributions of the OSIRIS-REx Candidate Sample Sites on Asteroid (101955) Bennu

We manually mapped particles ranging in longest axis from 0.3 cm to 95 m on (101955) Bennu for the Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer (OSIRIS-REx) asteroid sample return mission. This enabled the mission to identify candidate sample collection sites and shed light on the processes that have shaped the surface of this rubble-pile asteroid. Building on a global survey of particles, we used higher-resolution data from regional observations to calculate particle size-frequency distributions (PSFDs) and assess the viability of four candidate sites for sample collection (presence of unobstructed particles ≤ 2 cm). The four candidate sites have common characteristics: each is situated within a crater with a relative abundance of sampleable material. Their PSFDs, however, indicate that each site has experienced different geologic processing. The PSFD power-law slopes range from −3.0 ± 0.2 to −2.3 ± 0.1 across the four sites, based on images with a 0.01-m pixel scale. These values are consistent with, or shallower than, the global survey measurements. At one site, Osprey, the particle packing density appears to reach geometric saturation. We evaluate the uncertainty in these measurements and discuss their implications for other remotely sensed and mapped particles, and their importance to OSIRIS-REx sampling operations.

Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis

Purpose To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs). Methods We studied high TIL treatments (metabolic suppression, hypothermia (< 35 °C), intensive hyperventilation (PaCO2 < 4 kPa), and secondary decompressive craniectomy) in patients receiving ICP monitoring in the ICU stratum of the CENTER-TBI study. A random effect logistic regression model was used to determine between-centre variation in their use. A propensity score-matched model was used to study the impact on outcome (6-months Glasgow Outcome Score-extended (GOSE)), whilst adjusting for case-mix severity, signs of brain herniation on imaging, and ICP. Results 313 of 758 patients from 52 European centres (41%) received at least one high TIL treatment with significant variation between centres (median odds ratio = 2.26). Patients often transiently received high TIL therapies without escalation from lower tier treatments. 38% of patients with high TIL treatment had favourable outcomes (GOSE ≥ 5). The use of high TIL treatment was not significantly associated with worse outcome (285 matched pairs, OR 1.4, 95% CI [1.0–2.0]). However, a sensitivity analysis excluding high TIL treatments at day 1 or use of metabolic suppression at any day did reveal a statistically significant association with worse outcome. Conclusion Substantial between-centre variation in use of high TIL treatments for TBI was found and treatment escalation to higher TIL treatments were often not preceded by more conventional lower TIL treatments. The significant association between high TIL treatments after day 1 and worse outcomes may reflect aggressive use or unmeasured confounders or inappropriate escalation strategies. Take home message Substantial variation was found in the use of highly intensive ICP-lowering treatments across European ICUs and a stepwise escalation strategy from lower to higher intensity level therapy is often lacking. Further research is necessary to study the impact of high therapy intensity treatments. Trial registration The core study was registered with ClinicalTrials.gov, number NCT02210221, registered 08/06/2014, https://clinicaltrials.gov/ct2/show/NCT02210221?id=NCT02210221&draw=1&rank=1 and with Resource Identification Portal (RRID: SCR_015582).

TemplateFlow: a community archive of imaging templates and atlases for improved consistency in neuroimaging

Neuroimaging templates and corresponding atlases play a central role in experimental workflows and are the foundation for reporting standardised results. The proliferation of templates and atlases is one relevant source of methodological variability across studies, which has been recently brought to attention as an important challenge to reproducibility in neuroscience. Unclear nomenclature, an overabundance of template variants and options, inadequate provenance tracking and maintenance, and poor concordance between atlases introduce further unreliability into reported results. We introduce TemplateFlow, a cloud-based repository of human and nonhuman imaging templates paired with a client application for programmatically accessing resources. TemplateFlow is designed to be extensible, providing a transparent pathway for researchers to contribute and vet templates and their associated atlases. Following software engineering best practices, TemplateFlow leverages technologies for unambiguous resource identification, data management, versioning and synchronisation, programmatic extensibility, and continuous integration. By equipping researchers with a robust resource for using and evaluating templates, TemplateFlow will contribute to increasing the reliability of neuroimaging results.

TemplateFlow: a community archive of imaging templates and atlases for improved consistency in neuroimaging

Neuroimaging templates and corresponding atlases play a central role in experimental workflows and are the foundation for reporting standardised results. The proliferation of templates and atlases is one relevant source of methodological variability across studies, which has been recently brought to attention as an important challenge to reproducibility in neuroscience. Unclear nomenclature, an overabundance of template variants and options, inadequate provenance tracking and maintenance, and poor concordance between atlases introduce further unreliability into reported results. We introduce TemplateFlow, a cloud-based repository of human and nonhuman imaging templates paired with a client application for programmatically accessing resources. TemplateFlow is designed to be extensible, providing a transparent pathway for researchers to contribute and vet templates and their associated atlases. Following software engineering best practices, TemplateFlow leverages technologies for unambiguous resource identification, data management, versioning and synchronisation, programmatic extensibility, and continuous integration. By equipping researchers with a robust resource for using and evaluating templates, TemplateFlow will contribute to increasing the reliability of neuroimaging results.

Policy Strategies to Revive Rural Land in Peri-Metropolitan Towns: Resource Identification, Capitalization, and Financialization

Previous planning for rural revival in towns has emphasized construction and government-led policies. However, we argue that the dilemmas of peri-metropolitan rural areas, such as Desakota in China, are far more complex faced with rural super village and hollowed village transformations. Rural revival planning needs to coordinate with the development of urbanized and rural areas towards multifunctional goals and plans as a whole. Therefore, we selected the town master plan of Lijia, a typical peri-metropolitan village in China, as a case study. Through a historical–interpretative approach involving analysis of planning policies, questionnaires, and in-depth interviews with the key stakeholders involved, we structured the process and mechanism of rural revival in Lijia into three phases: resource identification, capitalization, and financialization. In different phases, different stakeholders adopt different roles. The government takes a leading role in resource identification and capitalization, while firms take a leading role in the process of financialization. “Market-dominant and government-guided” planning stimulates villagers to participate in rural revival. We highlight the importance of multifunctional land-use in terms of rural revival in the master planning of peri-metropolitan villages and provide a practical reference for uniting multiple stakeholders, including governments, firms, and villagers.

Horizontal Web Searching and Navigational Resource Identification

Generally speaking, horizontal search engines are meant to deal with general web queries. In the context of this chapter, the authors investigated the act of navigational resource identification in the light of horizontal web searching. State-of-the-art navigational resource identification is reluctant to the distinct characteristics of the navigational queries and specific users' treatments toward different searching tasks. Consequently, in this chapter, the authors discussed a new mechanism for navigational resource identification according to previous findings.