Efficient Direct Nitrosylation of α-Diimine Rhenium Tricarbonyl Complexes to Structurally Nearly Identical Higher Charge Congeners Activable towards Photo-CO Release

The reaction of rhenium α-diimine (N-N) tricarbonyl complexes with nitrosonium tetrafluoroborate yields the corresponding dicarbonyl-nitrosyl [Re(CO)2(NO)(N-N)X]+ species (where X = halide). The complexes, accessible in a single step in good yield, are structurally nearly identical higher charge congeners of the tricarbonyl molecules. Substitution chemistry aimed at the realization of equivalent dicationic species (intended for applications as potential antimicrobial agents), revealed that the reactivity of metal ion in [Re(CO)2(NO)(N-N)X]+ is that of a hard Re acid, probably due to the stronger π-acceptor properties of NO+ as compared to those of CO. The metal ion thus shows great affinity for π-basic ligands, which are consequently difficult to replace by, e.g., σ-donor or weak π-acids like pyridine. Attempts of direct nitrosylation of α-diimine fac-[Re(CO)3]+ complexes bearing π-basic OR-type ligands gave the [Re(CO)2(NO)(N-N)(BF4)][BF4] salt as the only product in good yield, featuring a stable Re-FBF3 bond. The solid state crystal structure of nearly all molecules presented could be elucidated. A fundamental consequence of the chemistry of [Re(CO)2(NO)(N-N)X]+ complexes, it that the same can be photo-activated towards CO release and represent an entirely new class of photoCORMs.

Anosmia and COVID-19: perspectives on its association and the pathophysiological mechanisms involved

With the spread of SARS-CoV-2, contingency measures and plans to facilitate the screening of infected patients are needed. Changes in olfaction have been cited as symptoms of the disease, and it is important to prove or exclude its association with this condition to refine the symptomatic criteria for early isolation. This article aims to analyze the association between olfactory disorders and SARS-CoV-2 infection as well as investigate the possible underlying pathophysiological mechanisms. The research was carried out using the PubMed, Science Direct, and LILACS databases on May 9, 2020, and updated on May 21. Combinations of MeSH descriptors and the Boolean operator, “AND,” were used: coronavirus infections AND olfactory disorders, coronavirus infections, and neurological manifestations. A total of 1187 articles were found in the databases, of which 17 were included in the study. The data suggest that changes in smell are strongly associated with Covid-19, especially in women and patients with fever; these changes increase the degree of suspicion of Covid-19, and they warrant early implementation of isolation and surveillance measures. There are still gaps in the elucidation of the pathways involved in the loss of smell caused by SARS-CoV-2; however, the great affinity of the virus for ACE-2 receptors, which are present in large quantities in the nasal cavity and olfactory bulb, has been considered.

Early Years, Early Films

Rosi's cinematic sensibility was influenced by his father's photography and sketching, his formative years he spent in Naples, and his apprenticeship with Visconti. La sfida (The Challenge, 1958), his debut work, which shows great affinity with the work of Cartier-Bresson, announces Rosi's future themes: the seductions and traps of power, the collusion between organized crime and business, the harsh social reality of Italy's South. His second, more ambitious work, I magliari (The Swindlers, 1959), is one of the first Italian films confronting the cultural and ethnic issues arising from southern Italian emigration. The film, which alternates documentary-like scenes with popular Italian comedy, is enhanced by the location shooting that will become a hallmark of Rosi's cinema. Rosi departs from the overly melodramatic style of La sfida and develops an aesthetic characterized by a realist exactness of space and penchant for exploring psychological states of mind.

Music as Art and Science: An Evaluation

Music is presented in this discourse as a coin with two sides –thus as an Art also as a science. Looking at music as an Art draws one’s attention to the artistic features and characteristics of music such as styles and skills of performances as in dancing, singing, playing instrument and its position in other related areas with similar attributes. On the other hand, seeing music from the perspective of a science, the study of acoustics, sound productions, mathematical relationships and intervallic applications are evident. Art involves creative thinking and inspiration to achieve an expected goal or a set objective. Science on its own employs knowledge interaction and inquiries to produce new scientific discoveries. Music co-habits these two complex entities in a seemingly integrative association. This paper therefore is a critical examination and evaluation of musical potency that qualifies it as an art as well as science. The argument is anchored on qualitative evaluation of materials drawn from related literatures and sources. It finally draws the conclusion that since music fits in properly, and performs creditably as an art, as well as maintains great affinity with science, it should be treated as a bicameral discipline. Keywords: Art, Science, Relationship, Music, Imagination, Inspiration

Selective removal of cationic micro-pollutants using disulfide-linked network structures

Micropollutants are found in all water sources, even after thorough treatments that include membrane filtration. We have developed swellable di-sulfide covalent organic polymers (COPs) with great affinity towards cationic textile micropollutants.

Multispectroscopic analysis and molecular modeling to investigate the binding of beta lactoglobulin with curcumin derivatives

Bovine beta lactoglobulin (β-lg), the major whey protein, has a great affinity for a wide range of organic compounds like fatty acids, retinoletc.

Nishida and Plotinus

Kitarō Nishida is the most important and representative philosopher in modern Japan, who now attracts increasing attention internationally. He endeavored to give a logical foundation to the Eastern way of thinking through his confrontation with Western philosophers. The aim of this paper is to recover the modern and intercultural significance of Plotinus’ philosophy in the light of Nishida’s philosophy. Nishida refers to Plotinus repeatedly, expressing his deep empathy, though his philosophy, which professes itself to be highly critical, is not mysticism. When we compare him with Plotinus, we can find a great affinity in their fundamental structure. ‘Absolute nothingness (zettai mu)’, the basis of all reality in Nishida’s philosophy, is prior to both subjectivity and objectivity, and corresponds to the Plotinian One, which transcends both thinking and being. The correspondence between their logical structures consists in regarding subjectivity and objectivity as developments of an indefinite principle that transcends and precedes the discrimination of the two, and determination as determination of what is indeterminate. However, differing from Plotinus, Nishida lays stress on corporality, ordinariness and individuality. Though Plotinus was never pessimistic about this world, the experience emphasized in the Enneads was not earthly, while Nishida’s ‘radical ordinariness’ was the standpoint to which we should attain in a mundane life. When we compare Plotinus with Nishida, we encounter the intersection of the West and the East, antiquity and modernity, and mysticity and ordinariness.

Programmed stereoselective assembly of DNA-binding helical metallopeptides

We have applied solid phase peptide synthesis methods for the construction of peptide ligands that coordinate Fe(ii) ions and fold into chiral peptide helicates that show great affinity and chiral selectivity for three-way DNA junctions and promising cell-internalization properties.

Taxonomy and paleobiogeography of late Bathonian brachiopods from Gebel Engabashi, northern Sinai

A brachiopod fauna of late Bathonian age recovered from the Kehailia Formation from Gebel Engabashi in northern Sinai consists of six species (two rhynchonellids and four terebratulids) referred to six genera, of which one genus and two species are new: Globirhynchia sphaerica (Cooper, 1989) new combination, Daghanirhynchia angulocostata Cooper, 1989, Ectyphoria sinaiensis new species, Cooperithyris circularis new genus and species, and new material: Avonothyris species A, and Ptyctothyris species A. The brachiopods described herein comprise a fauna located at the northern part of the Indo–African Faunal Realm within the Jurassic Ethiopian Province. They extend the geographic distribution of those taxa that show great affinity with the Jurassic brachiopod fauna of Saudi Arabia described by Cooper (1989). Differentiation of the endemic faunas that is so characteristic of many of these Ethiopian Province faunas is becoming more well-defined.