The flow in a generic, high-pressure turbine vane was simulated using an in-house DDES code. Two different operating conditions were simulated with one leading to a shock wave while the other does not. One case was used to validate the capability of the DDES method to capture shock waves and other flow structures using an inlet Reynolds number of 271,000 and an exit Mach number of 0.840. The test conditions for the other case were an inlet Reynolds number of 265,000 and an exit Mach number of 0.927, which is representative of a transonic, high pressure turbine vane which was used to further investigate the flow field. The DDES simulations from the first case are compared with published experimental data, RANS simulations and LES simulations. Then, DDES results for two cases with adiabatic and isothermal boundary conditions are compared. The numerical simulations with the isothermal boundary condition are further used to study the flow phenomena with wake vortices, shock waves, pressure waves, wake-shock interactions, and wake-pressure wave interactions. The effects of the pressure waves on the vane heat transfer are also analyzed.