Rash and skin complaints comprise a common pediatric chief complaint and among the top 20 reasons patients present to the emergency department. For this reason, it is important for emergency physicians to be able to distinguish life-threatening rashes from those that are benign. This chapter reviews common dermatologic conditions seen in pediatrics, such as eczema, erythema multiforme, Henoch–Schonlein purpura, scabies, tinea infections, urticaria, impetigo, and ecthyma. For each presentation, the incidence, epidemiology, typical and atypical presentations, diagnosis, differential diagnosis, treatment, disposition, complications, and clinical algorithms are reviewed. The chapter focuses on topics that are clinically relevant to patients seen in the emergency department, including admission requirements, discharge instructions, return precautions, and subspecialist follow-up.