Clinical Experience with PEGylated Hyaluronic Acid Fillers: A 3-year Retrospective Study

BACKGROUND: Hyaluronic acid fillers are the most used worldwide, thanks to the high biocompatibility and safety profile of HA and it is also the only substance that can be “dissolved” due to the hyaluronidase effect. AIM: A retrospective clinical evaluation of the outcomes following PEG cross-linked HA-based filler injection was performed. METHODS: Data were collected from December 2017 to June 2020. A total of 65 patients (12 M, 53 F), age ranging 28–62 year’s old (mean age 42.3), were treated. Exclusion criteria were applied and in accord to treatment plan, were used specific site injections and fillers. Follow-up was evaluated between 6 months and 2 years. RESULTS: A total of 61 treatments using 124 vials of HA filler crosslinked with PEG were performed. CONCLUSION: In conclusion, from 2014, HA fillers having PEG as cross-linker agent have been introduced in the european market. Several papers have been published in order to evaluate the features of these fillers, although, to the best of our knowledge, this is the first clinical paper regarding their use.

Tau peptide signals are seen in Parkinson subjects by Broderick Probe® sensors

This “short but sweet” clinical paper is about a next generation “uptick” nanotechnology that demonstrates a unique, real time imaging inventive art enabling a different kind of look at the brain, actually, to see inside neuronal and glial circuitry in the brain and spinal cord of the living human being and animal. “Lewy body dementia is characterized by the abnormal buildup of proteins into masses known as Lewy bodies. This protein is also associated with Parkinson’s disease. People who have Lewy bodies in their brains also have the plaques and tangles associated with Alzheimer's disease. Apr 26, 2019, Mayo clinic”.1 This is the problem and thus far, the problem is addressed primarily after autopsy, called post mortem, also problematic. Therefore, the purpose of this paper is to introduce the online and real time and spatial sensitive voltaic image of the Tau peptide complex video-tracked by the BRODERICK PROBE® biomedical sensors in striatum of the living Parkinson subject. This nanoprobe enables studies of the striking consequences among intensities of phosphorylated Tau. Identifying Tau on line is unmistakably relevant to longevity, both individual and societal and this relevance is inexorably critical to and on behalf of humanity per se.

Addressing Nursing Scholarship: A Framework for Currency and Number of References

Background Timeliness and number of references in written work is often a topic of controversy. Decisions about choice of references become complex when there is little recent published information or a great deal of important historical work on a topic. Purpose The study aim was to develop a framework to guide authors to determine the number and currency of references to support their writing. Methods This study used a descriptive design with three steps: review of journal author information for guidance about reference currency (n = 247); correspondence with journal editors (n = 27); and a survey of nurse educators (n = 44) regarding currency and number of references in written assignments. Results Findings affirmed that recent literature is vital for nursing scholarship. Numerical guidelines offered were not based on identifiable consensus or rationale. Historical perspectives published over 5 or 10 years earlier are valued, even sometimes required. For a clinical paper, citation of the most current literature is viewed by editors and educators as essential, and may suffice. Conclusion Based on the findings of this study and our search of the literature, we developed three decision making algorithms for searching the literature and selecting references by currency and number.

Culturally Congruent Health Care of COVID-19 in Minorities in the United States: A Clinical Practice Paper From the National Coalition of Ethnic Minority Nurse Associations

Introduction: Race and ethnicity along with social determinants of health have been identified as risk factors for COVID-19. The purpose of this clinical paper is to provide an overview of the National Coalition of Ethnic Minority Nurse Associations (NCEMNA), present COVID-19 epidemiological data on five racial–ethnic groups, identify culturally congruent health care strategies for each group, and provide directions for practice and research. Method: NCEMNA collaborated to provide a clinical paper that addresses information about COVID-19 and culturally congruent health care in five racial–ethnic groups. Results: Every organization presented common themes across the different groups and unique perspectives that each group is faced with during this challenge. Discussion: This article provides an introduction to the issues that minority groups are facing. It is imperative that data are collected to determine the extent of the impact of COVID-19 in diverse communities in the country.

A Clinical Report on the Relationships Between Metabolism and Obesity, Type 2 Diabetes, Cardiovascular Risk by Using the GH-Method: Math-Physical Medicine

By using the GH-Method: math-physical medicine and big data on one particular patient (the author), this clinical paper describes the relationship between his metabolic state and medical conditions, including obesity, type 2 diabetes (T2D), and cardiovascular risk.

Clinical and naturalistic substrates differ in bacterial communities and in their effects on skin microbiota in captive fire salamanders (Salamandra salamandra)

The fire salamander (Salamandra salamandra and its relatives) is of increasing priority for ex situ conservation due to the spread of the fungal pathogen Batrachochytrium salamandrivorans in Europe. In captivity, the species may be maintained on a clinical paper-based or a naturalistic substrate, either of which has its own advantages and disadvantages. However, the impact of these two substrates on bacterial microbiotas within an enclosure and on the salamanders themselves is unknown. To investigate this, we maintained captive fire salamanders on either paper towels or a naturalistic substrate and quantified the culturable microbiotas of both substrates across the one-week lifespan of a paper towel and of the salamanders themselves over a six-month period. We found significant differences in the bacterial communities associated with the two substrates. Over a week-long period, there were major fluctuations in the community composition and abundance on paper towels while on the naturalistic substrate bacterial communities were relatively stable. The skin microbiota of salamanders were indistinguishable at the beginning of the study but after six months differed significantly between the two treatments, although the bacterial morphotypes present remained relatively similar compared with changes between substrates. These data show that husbandry protocols may have a strong influence on the culturable bacterial communities to which captive amphibians are exposed. Nevertheless, the animals were apparently able to maintain their own microbiota to a considerable degree. These findings should be borne in mind when determining husbandry protocols. Given the relative benefits of both types of enclosure, it is possible that a hybrid approach could be used whereby a small amount of naturalistic substrate is provided in a container within an otherwise clinical enclosure, to act as a bacterial reservoir.