Attempt to Develop Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (Rhabdophis tigrinus) Venom Injection

Disseminated intravascular coagulation, a severe clinical condition caused by an underlying disease, involves a markedly continuous and widespread activation of coagulation in the circulating blood and the formation of numerous microvascular thrombi. A snakebite, including that of the Yamakagashi (Rhabdophis tigrinus), demonstrates this clinical condition. Thus, an animal model using Yamakagashi venom was constructed. Yamakagashi venom was administered to rats, and its lethality and the changes in blood coagulation factors were detected after venom injection. When 300 μg venom was intramuscularly administered to 12-week-old rats, (1) they exhibited hematuria with plasma hemolysis and died within 48 h; (2) Thrombocytopenia in the blood was observed in the rats; (3) irreversible prolongation of prothrombin time in the plasma to the measurement limit occurred; (4) fibrinogen concentration in the plasma irreversibly decreased below the measurement limit; and (5) A transient increase in the plasma concentration of D-dimer was observed. In this model, a fixed amount of Rhabdophis tigrinus venom injection resulted in the clinical symptom similar to the human pathology with snakebite. The use of the rat model is very effective in validating the therapeutic effect of human disseminated intravascular coagulation condition due to snakebite.

From Quantum Probabilities to Quantum Amplitudes

The task of reconstructing the system’s state from the measurements results, known as the Pauli problem, usually requires repetition of two successive steps. Preparation in an initial state to be determined is followed by an accurate measurement of one of the several chosen operators in order to provide the necessary “Pauli data”. We consider a similar yet more general problem of recovering Feynman’s transition (path) amplitudes from the results of at least three consecutive measurements. The three-step histories of a pre- and post-selected quantum system are subjected to a type of interference not available to their two-step counterparts. We show that this interference can be exploited, and if the intermediate measurement is “fuzzy”, the path amplitudes can be successfully recovered. The simplest case of a two-level system is analysed in detail. The “weak measurement” limit and the usefulness of the path amplitudes are also discussed.

Uncertainty principle and superradiance

Associate Professor Hasegawa Yuji of the Vienna University of Technology and Professor Masaaki Ozawa of Nagoya University and other scholars published empirical results against Heisenberg's uncertainty principle on January 15, 2012.They got a measurement result with a smaller error than the Heisenberg uncertainty principle, which proved the measurement advocated by the Heisenberg uncertainty principle.This article follows the method I used to study superradiation and connects the uncertainty principle with the superradiation effect. I found that under the superradiation effect, the measurement limit of the uncertainty principle can be smaller.

Measurement of Flight Dynamics of a Frisbee Using a Triaxial MEMS Gyroscope

A Frisbee with a mass of 0.21 kg, diameter of 0.27 m and moment of inertia (MOI) of 0.002 kg·m2 was instrumented with a triaxial gyroscope. The Frisbee was thrown at low angular velocities as the measurement limit of a single gyroscope was at 6.065 rps. The angular velocities of the triaxial gyroscope were analysed to study the attitude of a Frisbee before and after release. The angular velocities measured were post-processed and the following data were obtained: spin rate at release—3.9–6.14 rps; user-induced peak torque—0.483–0.9 Nm, and peak angular acceleration—204–358 rad/s2; and power input 7.53–19.56 W. The Frisbee wobbled at release which decreased during the flight due to a damping effect. This affected the spin decay, the reduction of wobble lead to a reduced drag force and thus to a smaller spin decay, which was initially 1.12–0.31 rev/s2 and then asymptoted to 0.11–0.01 rev/s2.

Hydrogeological characteristics of candidate sites for high-level waste disposal in South Korea

<p>Geological disposal of High-Level Radioactive Waste (HLRW) is considered to be one of the best disposal methods that can stably and semi-permanently isolate high-level radioactive waste from the biosphere. In this study, three types of potential host rocks for HLRW disposal were selected and the hydrogeological characteristics were investigated using deep drilling cores collected at about 50 m intervals in the borehole of a depth of 1 km. The rocks used in this study were granites and gneiss which are crystalline rock, and mudstone which is a sedimentary rock. The results of the study showed that the average porosity of granite was 0.48% and the permeability ranged from 7.87 × 10<sup>-19</sup> m<sup>2</sup> to 1.39 × 10<sup>-21</sup> m<sup>2</sup> except for samples outside the measurement limit (4.04 × 10<sup>-22</sup> m<sup>2</sup>). The average porosity of gneiss was 0.49% and the permeability ranged from 3.62 × 10<sup>-18</sup> m<sup>2</sup> to 4.58 × 10<sup>-22</sup> m<sup>2</sup>. The average porosity of mudstones was 3.62% and the values of permeability for most mudstone samples were lower than the measurement limit. For SEM-EDS analysis, many microcracks were observed in the crystalline rock samples having high permeability. On the other hand, there were almost no microcracks in crystalline rock samples having low permeability, and even if there were cracks, the cracks were filled with fillers such as clay minerals. These results indicate that the presence of microcracks or the filling of cracks in crystalline rocks has a significant effect on the flow of groundwater through the host rock.</p>

Low-Frequency Noise Evaluation on a Commercial Magnetoimpedance Sensor at Submillihertz Frequencies for Space Magnetic Field Detection

The purpose of this study was to measure the low-frequency noise and basic performance of a commercial magnetoimpedance (MI) sensor at sub-millihertz frequencies for use in space missions. Normally, space missions require measuring very weak magnetic fields with a long integration time, such as the space gravitational wave detection mission requiring sub-millihertz frequencies. We set up a platform for measuring the performance on this MI sensor, including low-frequency noise, measurement limit, linearity, and temperature stability. The results show that the low-frequency noise of the MI sensor is below 10 nT/√Hz at 1 mHz and below 100 nT/√Hz at 0.1 mHz; its measurement limit is 600 pT. The MI sensor is characterized by high precision, small size, and low noise, demonstrating considerable potential for application in magnetically sensitive experiments requiring long integration time. This is an effect way to solve the problem that there is on one suitable magnetic sensor at space magnetic field detection, but the sensor requires improvements in temperature stability.

Monitoring continuous spectrum observables: the strong measurement limit

We revisit aspects of monitoring observables with continuous spectrum in a quantum system subject to dissipative (Lindbladian) or conservative (Hamiltonian) evolutions. After recalling some of the salient features of the case of pure monitoring, we deal with the case when monitoring is in competition with a Lindbladian evolution. We show that the strong measurement limit leads to a diffusion on the spectrum of the observable. For the case with competition between observation and Hamiltonian dynamics, we exhibit a scaling limit in which the crossover between the classical regime and a diffusive regime can be analyzed in details.