Blockchain is distributed ledger technology. Its advancement has been compared to the rise of the internet with debate about the technology's probability to disrupt multiple industries including healthcare, transportation, real estate, public domains, manufacturing, intellectual property, education, and financial services. It is predicted that the blockchain will have a major impact on many trust-based environments due to its nature of recording any digital transaction that is secure, efficient, transparent, auditable, and resistant to the outage, thereby providing the much-needed security in the transfer of assets in cyberspace. This chapter will highlight some of the business processes that can be disrupted by blockchain technology.