scaling laws
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Author(s):  
Fabai Wu ◽  
Daan R. Speth ◽  
Alon Philosof ◽  
Antoine Crémière ◽  
Aditi Narayanan ◽  
...  

AbstractEukaryotic genomes are known to have garnered innovations from both archaeal and bacterial domains but the sequence of events that led to the complex gene repertoire of eukaryotes is largely unresolved. Here, through the enrichment of hydrothermal vent microorganisms, we recovered two circularized genomes of Heimdallarchaeum species that belong to an Asgard archaea clade phylogenetically closest to eukaryotes. These genomes reveal diverse mobile elements, including an integrative viral genome that bidirectionally replicates in a circular form and aloposons, transposons that encode the 5,000 amino acid-sized proteins Otus and Ephialtes. Heimdallaechaeal mobile elements have garnered various genes from bacteria and bacteriophages, likely playing a role in shuffling functions across domains. The number of archaea- and bacteria-related genes follow strikingly different scaling laws in Asgard archaea, exhibiting a genome size-dependent ratio and a functional division resembling the bacteria- and archaea-derived gene repertoire across eukaryotes. Bacterial gene import has thus likely been a continuous process unaltered by eukaryogenesis and scaled up through genome expansion. Our data further highlight the importance of viewing eukaryogenesis in a pan-Asgard context, which led to the proposal of a conceptual framework, that is, the Heimdall nucleation–decentralized innovation–hierarchical import model that accounts for the emergence of eukaryotic complexity.


2022 ◽  
Vol 131 (1) ◽  
pp. 013304
Author(s):  
V. Giannetti ◽  
A. Piragino ◽  
C. A. Paissoni ◽  
E. Ferrato ◽  
D. Estublier ◽  
...  

2022 ◽  
Author(s):  
Sandesh Kamath ◽  
Yaping Shao ◽  
Eric Ribeiro Parteli

2022 ◽  
Vol 16 (1) ◽  
pp. 1-15
Author(s):  
Philipp Bernhard ◽  
Simon Zwieback ◽  
Nora Bergner ◽  
Irena Hajnsek

Abstract. Arctic ice-rich permafrost is becoming increasingly vulnerable to terrain-altering thermokarst, and among the most rapid and dramatic of these changes are retrogressive thaw slumps (RTSs). They initiate when ice-rich soils are exposed and thaw, leading to the formation of a steep headwall which retreats during the summer months. The impacts and the distribution and scaling laws governing RTS changes within and between regions are unknown. Using TanDEM-X-derived digital elevation models, we estimated RTS volume and area changes over a 5-year time period from winter 2011/12 to winter 2016/17 and used for the first time probability density functions to describe their distributions. We found that over this time period all 1853 RTSs mobilized a combined volume of 17×106 m3 yr−1, corresponding to a volumetric change density of 77 m3 yr−1 km−2. Our remote sensing data reveal inter-regional differences in mobilized volumes, scaling laws, and terrain controls. The distributions of RTS area and volumetric change rates follow an inverse gamma function with a distinct peak and an exponential decrease for the largest RTSs. We found that the distributions in the high Arctic are shifted towards larger values than at other study sites We observed that the area-to-volume scaling was well described by a power law with an exponent of 1.15 across all study sites; however the individual sites had scaling exponents ranging from 1.05 to 1.37, indicating that regional characteristics need to be taken into account when estimating RTS volumetric changes from area changes. Among the terrain controls on RTS distributions that we examined, which included slope, adjacency to waterbodies, and aspect, the latter showed the greatest but regionally variable association with RTS occurrence. Accounting for the observed regional differences in volumetric change distributions, scaling relations, and terrain controls may enhance the modelling and monitoring of Arctic carbon, nutrient, and sediment cycles.


2022 ◽  
Vol 73 ◽  
pp. 26-39
Author(s):  
Jordan S. Weaver ◽  
Jarred C. Heigel ◽  
Brandon M. Lane

2021 ◽  
Vol 119 (1) ◽  
pp. e2109649118
Author(s):  
David H. Brookes ◽  
Amirali Aghazadeh ◽  
Jennifer Listgarten

Fitness functions map biological sequences to a scalar property of interest. Accurate estimation of these functions yields biological insight and sets the foundation for model-based sequence design. However, the fitness datasets available to learn these functions are typically small relative to the large combinatorial space of sequences; characterizing how much data are needed for accurate estimation remains an open problem. There is a growing body of evidence demonstrating that empirical fitness functions display substantial sparsity when represented in terms of epistatic interactions. Moreover, the theory of Compressed Sensing provides scaling laws for the number of samples required to exactly recover a sparse function. Motivated by these results, we develop a framework to study the sparsity of fitness functions sampled from a generalization of the NK model, a widely used random field model of fitness functions. In particular, we present results that allow us to test the effect of the Generalized NK (GNK) model’s interpretable parameters—sequence length, alphabet size, and assumed interactions between sequence positions—on the sparsity of fitness functions sampled from the model and, consequently, the number of measurements required to exactly recover these functions. We validate our framework by demonstrating that GNK models with parameters set according to structural considerations can be used to accurately approximate the number of samples required to recover two empirical protein fitness functions and an RNA fitness function. In addition, we show that these GNK models identify important higher-order epistatic interactions in the empirical fitness functions using only structural information.


2021 ◽  
Author(s):  
Laure Chevalier ◽  
Harro Schmeling

Abstract. Fluid flow through rock occurs in many geological settings on different scales, at different temperature conditions and with different flow velocities. Depending on these conditions the fluid will be in local thermal equilibrium with the host rock or not. To explore the physical parameters controlling thermal non-equilibrium the coupled heat equations for fluid and solid phases are formulated for a fluid migrating through a resting porous solid by Darcy flow. By non-dimensionalizing the equations three non-dimensional numbers can be identified controlling thermal non-equilibrium: the Peclet number Pe describing the fluid velocity, the heat transfer number A describing the local interfacial heat transfer from the fluid to the solid, and the porosity ϕ. The equations are solved numerically for the fluid and solid temperature evolution for a simple 1D model setup with constant flow velocity. Three stages are observed: a transient stage followed by a stage with maximum non-equilibrium fluid to solid temperature difference, ∆Tmax, and a stage approaching the steady state. A simplified time-independent ordinary differential equation for depth-dependent (Tf  – Ts) is derived and analytically solved. From these solutions simple scaling laws of the form (Tf  – Ts) = f (Pe, A, ϕ, H), where H is the non-dimensional model height, are derived. The solutions for ∆Tmax and the scaling laws are in good agreement with the numerical solutions. The parameter space Pe, A, ϕ, H is systematically explored. In the Pe – A – parameter space three regimes can be identified: 1) at high Pe (> 1) strong thermal non-equilibrium develops independently of Pe and A; 2) at low Pe (< 1) and low A (< 1) non-equilibrium decreases proportional to decreasing Pe; 3) at low Pe (<1) and large A (>1) non-equilbrium scales with Pe/A and thus becomes unimportant. The porosity ϕ has only a minor effect on thermal non-equilibrium. The time scales for reaching thermal non-equilibrium scale with the advective time-scale in the high Pe-regime and with the interfacial diffusion time in the other two low Pe – regimes. Applying the results to natural magmatic systems such as mid-ocean ridges can be done by estimating appropriate orders of Pe and A. Plotting such typical ranges in the Pe – A regime diagram reveals that a) interstitial melt flow is in thermal equilibrium, b) melt channelling as e.g. revealed by dunite channels may reach moderate thermal non-equilibrium, and c) the dyke regime is at full thermal non-equilibrium.


Author(s):  
Dongrong Zhang

Abstract It has long been known from measurements that buoyant motions cause the mean-velocity profile (MVP) in thermally-stratified, wall-bounded turbulent flows to significantly deviate from its constant-density counterpart. Theoretical analysis has restricted attention to an “intermediate layer” of the MVP, akin to the celebrated “log layer” in the constant-density case. Here, for thermally-stratified plane-Couette flows, we study the shape and scaling of the whole MVP. We elucidate the mechanisms that dictate the shape of the MVP by using the framework of the spectral link (Gioia et al.; 2010), and obtain scaling laws for the whole MVP by generalizing the Monin-Obukhov similarity theory.


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