Effect of MDI Actuation Timing on Inhalation Dosimetry in a Human Respiratory Tract Model

Accurate knowledge of the delivery of locally acting drug products, such as metered-dose inhaler (MDI) formulations, to large and small airways is essential to develop reliable in vitro/in vivo correlations (IVIVCs). However, challenges exist in modeling MDI delivery, due to the highly transient multiscale spray formation, the large variability in actuation–inhalation coordination, and the complex lung networks. The objective of this study was to develop/validate a computational MDI-releasing-delivery model and to evaluate the device actuation effects on the dose distribution with the newly developed model. An integrated MDI–mouth–lung (G9) geometry was developed. An albuterol MDI with the chlorofluorocarbon propellant was simulated with polydisperse aerosol size distribution measured by laser light scatter and aerosol discharge velocity derived from measurements taken while using a phase Doppler anemometry. The highly transient, multiscale airflow and droplet dynamics were simulated by using large eddy simulation (LES) and Lagrangian tracking with sufficiently fine computation mesh. A high-speed camera imaging of the MDI plume formation was conducted and compared with LES predictions. The aerosol discharge velocity at the MDI orifice was reversely determined to be 40 m/s based on the phase Doppler anemometry (PDA) measurements at two different locations from the mouthpiece. The LES-predicted instantaneous vortex structures and corresponding spray clouds resembled each other. There are three phases of the MDI plume evolution (discharging, dispersion, and dispensing), each with distinct features regardless of the actuation time. Good agreement was achieved between the predicted and measured doses in both the device, mouth–throat, and lung. Concerning the device–patient coordination, delayed MDI actuation increased drug deposition in the mouth and reduced drug delivery to the lung. Firing MDI before inhalation was found to increase drug loss in the device; however, it also reduced mouth–throat loss and increased lung doses in both the central and peripheral regions.

Planar LIF/MIE ratio droplet sizing using structured laser sheet imaging at elevated ambient pressures

LIF/Mie ratio-metric imaging was used to characterize sprays produced by a simple hollow-cone pressure atomizer, operating under elevated ambient pressures up to 10 atm. A structured laser sheet was used as the source of illumination to suppress the multiple scattered light, generating images that are free of the artefacts typically found in conventional laser sheet images. The resulting LIF/Mie ratio-metric images were calibrated using Phase Doppler anemometry to generate axial planar maps of the spray’s Sauter-mean diameter (SMD). This calibration methodology was applied over a range of ambient pressures and liquid flows to assess the robustness of the structured LIF/Mie ratio-metric imaging as a droplet sizing technique. The test fluids consisted of conventional and alternative jet fuels as well as nozzle calibration fluid. Results presented in the paper indicate both the effectiveness and certain limitations of the technique.

Analysis of Volume Distribution and Evaluation of the Spraying Spectrum in Terms of Spraying Quality

Assessment of the quality of the operation of agricultural nozzles on the basis of transverse volume distribution and spatial methods of analysis for stream spraying spectra is insufficient, and positive result do not guarantee that the intended and effective spraying effects are obtained. Tests were carried out to assess the quality of nozzles on the basis of transverse volume distribution analysis, microstructure characteristics, and detailed analysis of places where an unexpected change in the nature of the transverse volume distribution (increase in volume) was noted. The subjects of the study were RS11003 flat fan nozzles and a measuring stand equipped with a grooved table, which was used to carry out tests. During the tests, the unit flow rate from the nozzles, the transverse volume distribution of liquids from individual table grooves, and the corresponding CV distribution coefficients of variation were recorded. Detailed tests were carried out for the selected nozzle, consisting of spot measurement of droplet characteristics in individual liquid stream bands. The widths of these bands were constant and equal to the width of the measuring table groove. Measurements were made using analyzer 2D-Laser Doppler Anemometry/Phase Doppler Anemometry (2D-LDA/PDA) from Dantec Dynamics. The analysis of the results obtained from the grooved table and the droplet characteristics in individual stream bands showed clear and unexpected changes in the nature of the transverse volume distribution for all tested nozzles. These changes, consisting of a local increases in droplet diameters (with a reduced number of occurrences), can cause a significant reduction in the quality and effectiveness of spraying, despite the positive fulfillment of generalized normative criteria for their assessment.

Impact of the Primary Break-Up Strategy on the Morphology of GDI Sprays in 3D-CFD Simulations of Multi-Hole Injectors

The scientific literature focusing on the numerical simulation of fuel sprays is rich in atomization and secondary break-up models. However, it is well known that the predictive capability of even the most diffused models is affected by the combination of injection parameters and operating conditions, especially backpressure. In this paper, an alternative atomization strategy is proposed for the 3D-Computational Fluid Dynamics (CFD) simulation of Gasoline Direct Injection (GDI) sprays, aiming at extending simulation predictive capabilities over a wider range of operating conditions. In particular, attention is focused on the effects of back pressure, which has a remarkable impact on both the morphology and the sizing of GDI sprays. 3D-CFD Lagrangian simulations of two different multi-hole injectors are presented. The first injector is a 5-hole GDI prototype unit operated at ambient conditions. The second one is the well-known Spray G, characterized by a higher back pressure (up to 0.6 MPa). Numerical results are compared against experiments in terms of liquid penetration and Phase Doppler Anemometry (PDA) data of droplet sizing/velocity and imaging. CFD results are demonstrated to be highly sensitive to spray vessel pressure, mainly because of the atomization strategy. The proposed alternative approach proves to strongly reduce such dependency. Moreover, in order to further validate the alternative primary break-up strategy adopted for the initialization of the droplets, an internal nozzle flow simulation is carried out on the Spray G injector, able to provide information on the characteristic diameter of the liquid column exiting from the nozzle.

Comparison of Near-Nozzle Spray Performance of Gas-to-Liquid and Jet A-1 Fuels Using Shadowgraph and Phase Doppler Anemometry

The gas-to-liquid (GTL) fuel, a liquid fuel synthesized from natural gas through Fischer–Tropsch process, exhibits better combustion and, in turn, lower emission characteristics than the conventional jet fuels. However, the GTL fuel has different fuel properties than those of regular jet fuels, which could potentially affect its atomization and combustion aspects. The objective of the present work is to investigate the near-nozzle atomization characteristics of GTL fuel and compare them with those of the conventional Jet A-1 fuel. The spray experiments are conducted at different nozzle operating conditions under standard ambient conditions. The near-nozzle macroscopic spray characteristics are determined from the shadowgraph images. Near the nozzle exit, a thorough statistical analysis shows that the liquid sheet dynamics of GTL fuel is different from that of Jet A-1 fuel. However, further downstream, the microscopic spray characteristics of GTL fuel are comparable to those of the Jet A-1 fuel.

Measurements in swirling spray flames at blow-off

Various characteristics of swirling spray flames of ethanol, n-heptane, n-decane, and n-dodecane have been measured at conditions far from and close to blow-off using phase Doppler anemometry and OH* chemiluminescence, OH-planar laser-induced fluorescence, and Mie scattering at 5 kHz. The blow-off transient has also been examined. The OH* showed that the two main heat release regions lie around the spray jet at the inner recirculation zone and along the outer shear layer between the inner recirculation zone and the annular air jet. The heat release region is shortened and more attached as the flame approached blow-off. Mie images and phase Doppler anemometry data showed a wider dispersion of the ethanol spray compared to the other fuels. Similar spatial distributions of the Sauter mean diameter were observed for the four fuels for identical flow conditions, with the Sauter mean diameter value increasing with decreasing fuel volatility, but with the exception of significant presence of droplets in the nominally hollow cone for the ethanol spray. The OH-planar laser-induced fluorescence measurements showed an intermittent lift-off from the corner of the bluff body and the average lift-off height decreased with increasing air velocity, with less extinction along the inner flame branch especially for the heavier fuels. At the blow-off conditions, local extinctions appeared at both flame branches. The blow-off process followed a gradual reduction of the size of the flame, with the less volatile fuels showing a more severe flame area reduction compared to the condition far from blow-off. The average blow-off duration, [Formula: see text], calculated from the evolution of the area-integrated OH* signal, was a few tens of milliseconds and for all conditions investigated the ratio [Formula: see text] /( D/ UB) was around 11, but with large scatter. The measurements provide useful information for validation of combustion models focusing on local and global extinction.

Effects of Fluid Properties on Spray Characteristics of a Flow-Blurring Atomizer

In order to understand the reasons for the apparent benefits of using a flow-blurring (FB) atomizer in a combustion system, it is necessary to first examine fundamental spray characteristics under nonreacting conditions. Previous work on FB atomizers, however, has mostly involved only water and a relatively narrow range of parameters. In this study, a phase Doppler anemometry (PDA) instrument was used to characterize FB atomizer sprays and determine the effects of varying surface tension and viscosity of the liquid. Operating at room pressure and temperature (i.e., a “cold spray”), droplet sizes and velocities were measured for water, a water/surfactant mixture (lower surface tension), a water/glycerol mixture (higher viscosity), and glycerol (much higher viscosity). For all of the tested fluids, with the exception of pure glycerol, the FB atomizer produced small droplets (below 50 μm) whose size did not vary significantly in the radial or axial direction, particularly above a characteristic distance from the atomizer exit. Results show that the spray is essentially unaffected by a 4.5× decrease in surface tension or a 7× increase in viscosity, and that Sauter mean diameter (SMD) only increased by approximately a factor of three when substituting glycerol (750× higher viscosity) for water. The results suggest that the FB atomizer can effectively atomize a wide range of liquids, making it a useful fuel-flexible atomizer for combustion applications.

Analysis of PDA measurements in double injection GDI sprays

A N-heptane spray from a GDI multi-hole injector operated in ambient air at fixed conditions and with doubleinjection commands is studied with different experimental techniques to better understand the spray behaviors, focusing the analysis on the effect of different dwell times between the two pulses. Results from spray photographic analysis, fuel injected quantity, droplet velocity and sizing by Phase Doppler Anemometry are presented and compared. The peculiarities and usefulness of a complementary application of the different techniques is illustrated. The two spray pulses have the same time length, so that the first spray evolves in a nearly quiescent and clean ambient, while the second, nominally identical to the first one, evolves in its trailing edge. The direct comparison allows an immediate perception of the differences among the two sprays, at the different dwell times, where the shorter tested, 160 microseconds, was chosen as the one that shows the first appreciable effect with at least one of the used techniques; the differences are clearly evident in the PDA results, sufficiently visible from the injection rate, not appreciable in the imaging at short distance. The effect of the longerdwell times becomes more evident and is illustrated.DOI: http://dx.doi.org/10.4995/ILASS2017.2017.5007