Reptile-like physiology in Early Jurassic stem-mammals

Despite considerable advances in knowledge of the anatomy, ecology and evolution of early mammals, far less is known about their physiology. Evidence is contradictory concerning the timing and fossil groups in which mammalian endothermy arose. To determine the state of metabolic evolution in two of the earliest stem-mammals, the Early Jurassic Morganucodon and Kuehneotherium, we use separate proxies for basal and maximum metabolic rate. Here we report, using synchrotron X-ray tomographic imaging of incremental tooth cementum, that they had maximum lifespans considerably longer than comparably sized living mammals, but similar to those of reptiles, and so they likely had reptilian-level basal metabolic rates. Measurements of femoral nutrient foramina show Morganucodon had blood flow rates intermediate between living mammals and reptiles, suggesting maximum metabolic rates increased evolutionarily before basal metabolic rates. Stem mammals lacked the elevated endothermic metabolism of living mammals, highlighting the mosaic nature of mammalian physiological evolution.

Research Progress of Betalain in Response to Adverse Stresses and Evolutionary Relationship Compared with Anthocyanin

Betalains are applicable to many aspects of life, and their properties, characteristics, extraction and biosynthesis process have been thoroughly studied. Although betalains are functionally similar to anthocyanins and can substitute for them to provide pigments for plant color, it is rare to study the roles of betalains in plant responses to adverse environmental conditions. Owing to their antioxidant capability to remove excess reactive oxygen species (ROS) in plants and humans, betalains have attracted much attention due to their bioactivity. In addition, betalains can also act as osmotic substances to regulate osmotic pressure in plants and play important roles in plant responses to adverse environmental conditions. The study of the physiological evolution of betalains is almost complete but remains complicated because the evolutionary relationship between betalains and anthocyanins is still uncertain. In this review, to provide a reference for the in-depth study of betalains compared with anthocyanins, the biochemical properties, biosynthesis process and roles of betalains in response to environmental stress are reviewed, and the relationship between betalains and anthocyanins is discussed.

Janzen’s Hypothesis Meets the Bogert Effect: Connecting Climate Variation, Thermoregulatory Behavior, and Rates of Physiological Evolution

Understanding the motors and brakes that guide physiological evolution is a topic of keen interest, and is of increasing importance in light of global climate change. For more than half a century, Janzen’s hypothesis has been used to understand how climatic variability influences physiological divergence across elevation and latitude. At the same time, there has been increasing recognition that behavior and physiological evolution are mechanistically linked, with regulatory behaviors often serving to dampen environmental selection and stymie evolution (a phenomenon termed the Bogert effect). Here, we illustrate how some aspects of Janzen’s hypothesis and the Bogert effect can be connected to conceptually link climate, behavior, and rates of physiological evolution in a common framework. First, we demonstrate how thermal heterogeneity varies between nighttime and daytime environments across elevation in a tropical mountain. Using data from Hispaniolan Anolis lizards, we show how clinal variation in cold tolerance is consistent with thermally homogenous nighttime environments. Elevational patterns of heat tolerance and the preferred temperature, in contrast, are best explained by incorporating the buffering effects of thermoregulatory behavior in thermally heterogeneous daytime environments. In turn, climatic variation and behavior interact to determine rates of physiological evolution, with heat tolerance and the preferred temperature evolving much more slowly than cold tolerance. Conceptually bridging some aspects of Janzen’s hypothesis and the Bogert effect provides an integrative, cohesive framework illustrating how environment and behavior interact to shape patterns of physiological evolution.

Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

We review the hemodynamic, metabolic and cellular parameters affected during early ischemia and their changes as a function of approximate cerebral blood flow ( CBF) thresholds. These parameters underlie the current practical definition of an ischemic penumbra, namely metabolically affected but still viable brain tissue. Such tissue is at risk of infarction under continuing conditions of reduced CBF, but can be rescued through timely intervention. This definition will be useful in clinical diagnosis only if imaging techniques exist that can rapidly, and with sufficient accuracy, visualize the existence of a mismatch between such a metabolically affected area and regions that have suffered cell depolarization. Unfortunately, clinical data show that defining the outer boundary of the penumbra based solely on perfusion-related thresholds may not be sufficiently accurate. Also, thresholds for CBF and cerebral blood volume ( CBV) differ for white and gray matter and evolve with time for both inner and outer penumbral boundaries. As such, practical penumbral imaging would involve parameters in which the physiology is immediately displayed in a manner independent of baseline CBF or CBF threshold, namely pH, oxygen extraction fraction ( OEF), diffusion constant and mean transit time ( MTT). Suitable imaging technologies will need to meet this requirement in a 10–20 min exam.

Physiology, phylogeny, and the energetic roots of life

Before the days of molecular phylogenies, the standard way of viewing microbial evolution was as process of physiological evolution: the ordering of the sequence of events in which different pathways that microbes use to harness carbon and energy arose. The physiological view of microbial evolution was, of course, replaced in the 1980s by a gene centered view of microbial evolution that was built around the ribosomal RNA tree of life, also called the universal tree or the three domain tree. The universal tree installed long sought order into microbial systematics, but left physiological evolution out in the cold, because physiology never mapped properly onto the rRNA tree. That was not because the universal tree had an incorrect branching pattern. Rather it was because physiological characters have never mapped neatly onto any phylogenetic tree for prokaryotes, regardless of its topology. The reason is that prokaryotes, though they have an undeniable tendency to vertically inherit their ribosome, distribute the physiological traits that enable synthesis of ribosomes via lateral gene transfer (LGT). Geochemical isotope evidence harbors evidence for the existence of physiological processes, not for phylogeny, because LGT decouples physiology from phylogeny in prokaryotes. If we want a fuller picture of microbial evolution, we will have to incorporate aspects of physiology, phylogeny, and the geological record. The issue of how physiology got started has always been interesting. Non-fermentative substrate level phosphorylations as they occur in some acetogens and methanogens now look like good candidate reactions for that starting point, helping to put chemical roots on life's tree.