<p>Natural mesolite type zeolite was collected, modified by sulphuric acid treatment and characterized by using Powder-X ray diffraction, Scanning electron microscopy and Energy dispersive spectroscopy, Fourier transform infrared spectroscopy. Temperature programmed ammonia desorption, Brunauer-Emmer-Teller surface area analysis. Modified dealuminated mesolite shows an efficient catalytic activity for one pot synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones derivatives, via one pot three component condensation of benzaldehyde, ethylacetoacetate and hydroxylamine hydrochloride. Present method offers several advantages over the reported methods like a simple and inexpensive modification of catalyst, mild reaction condition, easy separation of catalyst, simple work-up procedure, nonchromatographic isolation and purification desired product and excellent yield. Furthermore, catalyst could be reused without significant loose in activity. Copyright © 2017 BCREC GROUP. All rights reserved</p><p><em>Received: 25<sup>th</sup> August 2016; Revised: 10<sup>th</sup> October 2016; Accepted: 17<sup>th</sup> October 2016</em></p><strong>How to Cite:</strong> Pawar, G.T., Gadekar, S.P., Arbad, B.R., Lande, M.K. (2017). Modification, Characterization, and Catalytic Application of Mesolite for One Pot Synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones. <em>Bulletin of Chemical Reaction Engineering & Catalysis</em>, 12 (1): 32-40 (doi:10.9767/bcrec.12.1.655.32-40)<p><strong>Permalink/DOI:</strong> http://dx.doi.org/10.9767/bcrec.12.1.655.32-40</p><p> </p>