The use of Artificial Intelligence for the Detection of Covert Channels attacks in New Generation Internet Protocol IPv6

Being instrumental to the Qatar National Vision 2030 activities and following up with “achieving security, stability and maintaining public safety” objectives, the present paper aims to safeguard the information and monitor internet communications in the region effectively. The increased dependence on internet-based technologies in all facets of life challenges the government and policymakers with the need for an effective shield mechanism against passive and active security violations. The present paper adopted an artificial intelligence-based solution for detecting suspicious communications. Further, a dataset created which was generated by simulating a number of attacks and normal communications was used for both training and testing the model. The proposed model produces an accuracy of 100% with a score of 1 for precision, recall, and F1 score. The project forward is a novel, efficient approach for detecting covert channels and suspicious communication.

Resolving the kinetics of individual aqueous reaction steps of actinyl (AnO2+ and AnO22+; An=U, Np, and Pu) tricarbonate complexes with ferrous iron and hydrogen sulfide from first principles

The solubility and mobility of actinides (An), like uranium, neptunium, and plutonium, in the environment largely depends on their oxidation states. Actinyls (AnV,VIO2+/2+(aq)) form strong complexes with available ligands, like carbonate (CO32−), which may inhibit reduction to relatively insoluble AnIVO2(s). Here we use quantum-mechanical calculations to explore the kinetics of aqueous homogeneous reaction paths of actinyl tricarbonate complexes ([AnO2(CO3)3]5−/4−) with two different reductants, [Fe(OH)2(H2O)4]0 and [H2S(H2O)6]0. Energetically-favorable outer-sphere complexes (OSC) are found to form rapidly, on the order of milliseconds to seconds over a wide actinyl concentration range (pM to mM). The systems then encounter energy barriers (Ea), some of which are prohibitively high (>100 kJ/mol for some neptunyl and plutonyl reactions with Fe2+ and H2S), that define the transition from outer- to inner-sphere complex (ISC; for example, calculated Ea of ISC formation between UO2+ and UO22+ with Fe2+ are 35 and 74 kJ/mol, respectively). In some reactions, multiple OSCs are observed that represent different hydrogen bonding networks between solvent molecules and carbonate. Even when forming ISCs, electron transfer to reduce An6+ and An5+ is not observed (no change in atomic spin values or lengthening of An–Oax bond distances). Proton transfer from bicarbonate and water to actinyl O was tested as a mechanism for electron transfer from Fe2+ to U6+ and Pu6+. Not all proton transfer reactions yielded reduction of An6+ to An5+ and only a few pathways were energetically-favorable (e. g. H+ transfer from H2O to drive Pu6+ reduction to Pu5+ with ΔE = −5 kJ/mol). The results suggest that the tricarbonate complex serves as an effective shield against actinide reduction in the tested reactions and will maintain actinyl solubility at elevated pH conditions. The results highlight reaction steps, such as inner-sphere complex formation and electron transfer, which may be rate-limiting. Thus, this study may serve as the basis for future research on how they can be catalyzed by a mineral surface in a heterogeneous process.

Accountability and Blame Avoidance After Crises

The post-crisis accountability process is a purification ritual that serves to channel public emotions and enables re-equilibration after a severe disturbance of the sociopolitical order. Crisis accountability literature can be reviewed in terms of forums, actors, and consequences. This setup allows a systematic discussion of how crises impact: the accountability process in influencing its setting (the forum); the strategies of accountees and their opponents (actors); and the resulting outcomes in terms of reputation damage, sanctions, and restoration (consequences). There is a clear distinction between formal and informal accountability forums, with the media being almost exclusively informal, and judicial forums, accident investigators, and political inquiries having formal authority over accountability assessments. Yet, through the presence of formal authorities in media reporting, and because media frames influence the work of formal authorities, the different forums intensively interact in accountability processes. Looking at accountability strategies reveals that the number of actors involved in blame games is likely rising because of increasingly networked crisis responses, and the role of actors has become more important and personal in the crisis aftermath and accountability process. The consequences and success of individual actors in influencing the accountability outcomes is shaped by both institutional settings and individual skills and strategies. A current political power position that exceeds prior mistakes is an effective shield, and denial is the least effective though most commonly used strategy. Accountability processes remain a balancing act between rebuttal and repair. Yet after major crisis, renewal is possible, and post-crisis accountability can play a crucial role therein.

Insights into Ebola Virus VP35 and VP24 Interferon Inhibitory Functions and their Initial Exploitation as Drug Targets

Upon viral infection, the interferon (IFN) system triggers potent antiviral mechanisms limiting viral growth and spread. Hence, to sustain their infection, viruses evolved efficient counteracting strategies to evade IFN control. Ebola virus (EBOV), member of the family Filoviridae, is one of the most virulent and deadly pathogen ever faced by humans. The etiological agent of the Ebola Virus Disease (EVD), EBOV can be undoubtedly considered the perfect example of a powerful inhibitor of the host organism immune response activation. Particularly, the efficacious suppression of the IFN cascade contributes to disease progression and severity. Among the EBOVencoded proteins, the Viral Proteins 35 (VP35) and 24 (VP24) are responsible for the EBOV extreme virulence, representing the core of such inhibitory function through which EBOV determines its very effective shield to the cellular immune defenses. VP35 inhibits the activation of the cascade leading to IFN production, while VP24 inhibits the activation of the IFN-stimulated genes. A number of studies demonstrated that both VP35 and VP24 is validated target for drug development. Insights into the structural characteristics of VP35 and VP24 domains revealed crucial pockets exploitable for drug development. Considered the lack of therapy for EVD, restoring the immune activation is a promising approach for drug development. In the present review, we summarize the importance of VP35 and VP24 proteins in counteracting the host IFN cellular response and discuss their potential as druggable viral targets as a promising approach toward attenuation of EBOV virulence.

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, the only available antitubercular vaccine fails to provide an effective shield against adult lung tuberculosis, which is the most prevalent form. Hence, there is a pressing need for effective antitubercular drugs and vaccines. This review highlights recent advances in the study of selected M. tuberculosis key molecular determinants of infection and vulnerable targets whose structures could be exploited for the development of new antitubercular agents.