LRTM effect and electronic crystal imaging on silicon surface

Some interesting phenomena have been observed in the laser reflecting Talbot magnification (LRTM) effect discovered at first, in which the high-order nonlinear imaging and the plasmonic structures imaging occur. The LRTM effect images were obtained on the 1D and 2D photonic crystals fabricated by using nanosecond pulsed laser etching on silicon surface, where the high-order nonlinear imaging on the 1D and 2D photonic crystals was observed interestingly. The theory result is consistent with the experimental one, which exhibits that the suitable wave-front shape of injection beam selected in optical route can effectively enlarge the magnification rate and elevate the resolution of the Talbot image. Especially the periodic plasmonic structures on silicon surface have been observed in the LRTM effect images, which have a good application in the online detection of pulsed laser etching process. The temporary reflecting Talbot images exhibit that the electrons following with photonic frequency float on plasma surface to form electronic crystal observed on silicon at first, which is similar with the Wigner crystal structure.

Divergent ⇒ complex amplitudes in two dimensional string theory

In a recent paper, Balthazar, Rodriguez and Yin found remarkable agreement between the one instanton contribution to the scattering amplitudes of two dimensional string theory and those in the matrix model to the first subleading order. The comparison was carried out numerically by analytically continuing the external energies to imaginary values, since for real energies the string theory result diverges. We use insights from string field theory to give finite expressions for the string theory amplitudes for real energies. We also show analytically that the imaginary parts of the string theory amplitudes computed this way reproduce the full matrix model results for general scattering amplitudes involving multiple closed strings.

Cross-Neutralizing Activity of Monoclonal Antibodies Against N501Y Mutant Strain of SARS-CoV-2

The dominant N501Y mutation in the spike protein that SARS-CoV-2 virus uses to bind to the human ACE2 receptor were found in the UK, which has aroused global concern and worried. Mutations in spike protein may, in theory, result in more infectious and spreading more easily. In order to evaluate the broad-spectrum protective effect of the monoclonal antibodies(mAbs), we compared the neutralization activities of six prepared mAbs against SARS-CoV-2 with pseudovirus neutralization assay. Only one of them showed a decrease of 6 folds in neutralizing activity to N501Y mutant strain, compared with the wild type strain. We should continue to monitor emergence of new variants in different regions to study their infectivity and neutralization effect.

Relations between Levels of Government in Handling the Covid-19 pandemic in Indonesia: A Study on Relations between the Central Government and the Provincial Government of DKI Jakarta

The Covid-19 pandemic has plagued various countries in this hemisphere. The spread of this pandemic has a significant impact on all aspects of life in various countries, including Indonesia. Various efforts have been made by both the central and regional governments in dealing with this problem, but in the process they are often faced with problems of differences in views and attitudes between levels of government, for example difference understanding that occurs between the Central Government and the Provincial Government of DKI Jakarta. This problem occurs because of weak inter-governmental coordination in making public policies. This ineffective inter-governmental relationship, of course, can cause public confusion in complying with all existing policies so that it will lead to not achieving the goal of handling cases. The purpose of this study is to analyze how inter-governmental relations in handling Covid-19 in Indonesia, especially between the Central Government and the Provincial Government of DKI Jakarta. The research method used in this research is literature study. While the data from the literature study is coded based on the indicators of the main theory. Result shows that there are a number of problems regarding the relation between central government and the government of DKI Jakarta Province in which most of the problems lie more on institutional and demographic factors rather than the other four factors.

Consistent QFT description of non-standard neutrino interactions

Neutrino oscillations are precision probes of new physics. Apart from neutrino masses and mixings, they are also sensitive to possible deviations of low-energy interactions between quarks and leptons from the Standard Model predictions. In this paper we develop a systematic description of such non-standard interactions (NSI) in oscillation experiments within the quantum field theory framework. We calculate the event rate and oscillation probability in the presence of general NSI, starting from the effective field theory (EFT) in which new physics modifies the flavor or Lorentz structure of charged-current interactions between leptons and quarks. We also provide the matching between the EFT Wilson coefficients and the widely used simplified quantum-mechanical approach, where new physics is encoded in a set of production and detection NSI parameters. Finally, we discuss the consistency conditions for the standard NSI approach to correctly reproduce the quantum field theory result.

$\mathcal{I}$/$c$-extremization in M/F-duality

We study the holographic dual to cc-extremization for 2d (0,2)(0,2) superconformal field theories (SCFTs) that have an AdS_33 dual realized in Type IIB with varying axio-dilaton, i.e. F-theory. M/F-duality implies that such AdS_33 solutions can be mapped to AdS_22 solutions in M-theory, which are holographically dual to superconformal quantum mechanics (SCQM), obtained by dimensional reduction of the 2d SCFTs. We analyze the corresponding map between holographic cc-extremization in F-theory and \mathcal{I}ℐ-extremization in M-theory, where in general the latter receives corrections relative to the F-theory result.

De Novo Phosphoinositide Synthesis in Zebrafish Is Required for Triad Formation but Not Essential for Myogenesis

Phosphoinositides (PIPs) and their regulatory enzymes are key players in many cellular processes and are required for aspects of vertebrate development. Dysregulated PIP metabolism has been implicated in several human diseases, including a subset of skeletal myopathies that feature structural defects in the triad. The role of PIPs in skeletal muscle formation, and particularly triad biogenesis, has yet to be determined. CDP-diacylglycerol-inositol 3-phosphatidyltransferase (CDIPT) catalyzes the formation of phosphatidylinositol, which is the base of all PIP species. Loss of CDIPT should, in theory, result in the failure to produce PIPs, and thus provide a strategy for establishing the requirement for PIPs during embryogenesis. In this study, we generated cdipt mutant zebrafish and determined the impact on skeletal myogenesis. Analysis of cdipt mutant muscle revealed no apparent global effect on early muscle development. However, small but significant defects were observed in triad size, with T-tubule area, inter terminal cisternae distance and gap width being smaller in cdipt mutants. This was associated with a decrease in motor performance. Overall, these data suggest that myogenesis in zebrafish does not require de novo PIP synthesis but does implicate a role for CDIPT in triad formation.

N-loss stoichiometry in a Peru ODZ eddy

Assuming heterotrophic denitrification as the dominant microbial process, Richards (1965) formulated a stoichiometry governing nitrogen loss in open-ocean oxygen deficient zones (ODZs). It prescribes the quantitative coupling between the oxidation of organic matter by NO–3 in the absence of O2 and the corresponding production of CO2, N2, and PO–34. Applied globally, this relationship defines key linkages between the C, N, and P cycles. However, the validity of Richards's stoichiometry is challenged by recognition of complex microbial N processing in ODZs including anammox as an important pathway and nitrite reoxidation. Whereas Richards's stoichiometry would result in N2-N production to NO–3 removal rates of 1.17, dominance by anammox with respect to biogenic N2 production could in theory result in a ratio as high as 2. Ratios with PO–34 production provide an additional constraint on the quantity and composition of respired organic matter. Here we use a mesoscale eddy with extreme N-loss in the Peru ODZ as a "natural laboratory" to examine N-loss stoichiometry. Its intense biogeochemical signatures, relatively well-defined timescales, and simplified hydrography allowed for the development of strong co-occurring gradients in NO–3, NO–2, biogenic N2, and PO–34. The production of biogenic N2 as compared with the removal of NO–3 (analyzed either directly or as N deficits) was slightly less than predicted by Richards's stoichiometry and did not at all support any "excess" biogenic N2. PO–34 production, however, was twice the expectation from Richards's stoichiometry suggesting that respired organic matter was P-rich as compared with C:N:P Redfield composition. These results suggest major gaps remain between current understanding of microbial N pathways in ODZs and their net biogeochemical output.

Reflectivity of HIV/AIDS Survivors as Risk Society in Dealing with Medical Risk

People Living with HIV/AIDS (PLWHA) are associated with death, but this study disagrees with such social construction. This qualitative research with phenomenological approach aimed to analyze the reflectivity of HIV/AIDS survivors in dealing with medical risk in Surakarta, Indonesia, using observation, in-depth interview, medical record, and viral load test and supported with information obtained from the informants analyzed using Beck’s risk society theory. Result showed HIV/AIDS survivors undertook a healthy life and kept surviving because they performed reflexive modernization on medical risk. Some PLWHAs encountered side effects of ARV therapy. CD4 level of 50/ml led to blackish skin and itchiness, but after 3-month ARV therapy, the blackish skin disappeared. Some PLWHAs always developed morning sickness, itchiness and skin reddishness due to abacavir consumption. To avoid it, they consume liquid food like juice or milk. Steve-Johnson’s Syndrome occurred in the first week during ARV consumption on average. Opened communication, information, and nutrition counseling are very desirable. ARV schedule should be complied with, because ARV incompliance can suppress viral load and increase ARV resistance. Routine HIV test and ARV compliance can improve body immune system thereby making HIV/AIDS status undetected.

M Segment-Based Minigenomes and Virus-Like Particle Assays as an Approach To Assess the Potential of Tick-BornePhlebovirusGenome Reassortment

ABSTRACTBunyaviruses have a tripartite negative-sense RNA genome. Due to the segmented nature of these viruses, if two closely related viruses coinfect the same host or vector cell, it is possible that RNA segments from either of the two parental viruses will be incorporated into progeny virions to give reassortant viruses. Little is known about the ability of tick-borne phleboviruses to reassort. The present study describes the development of minigenome assays for the tick-borne viruses Uukuniemi phlebovirus (UUKV) and Heartland phlebovirus (HRTV). We used these minigenome assays in conjunction with the existing minigenome system of severe fever with thrombocytopenia syndrome (SFTS) phlebovirus (SFTSV) to assess the abilities of viral N and L proteins to recognize, transcribe, and replicate the M segment-based minigenome of a heterologous virus. The highest minigenome activity was detected with the M segment-based minigenomes of cognate viruses. However, our findings indicate that several combinations utilizing N and L proteins of heterologous viruses resulted in M segment minigenome activity. This suggests that the M segment untranslated regions (UTRs) are recognized as functional promoters of transcription and replication by the N and L proteins of related viruses. Further, virus-like particle assays demonstrated that HRTV glycoproteins can package UUKV and SFTSV S and L segment-based minigenomes. Taken together, these results suggest that coinfection with these viruses could lead to the generation of viable reassortant progeny. Thus, the tools developed in this study could aid in understanding the role of genome reassortment in the evolution of these emerging pathogens in an experimental setting.IMPORTANCEIn recent years, there has been a large expansion in the number of emerging tick-borne viruses that are assigned to thePhlebovirusgenus. Bunyaviruses have a tripartite segmented genome, and infection of the same host cell by two closely related bunyaviruses can, in theory, result in eight progeny viruses with different genome segment combinations. We used genome analogues expressing reporter genes to assess the abilities ofPhlebovirusnucleocapsid protein and RNA-dependent RNA polymerase to recognize the untranslated region of a genome segment of a related phlebovirus, and we used virus-like particle assays to assess whether viral glycoproteins can package genome analogues of related phleboviruses. Our results provide strong evidence that these emerging pathogens could reassort their genomes if they were to meet in nature in an infected host or vector. This reassortment process could result in viruses with new pathogenic properties.