Emergent Modality

Among Brahms’s solo Lieder that depict a piece-spanning shift between parallel minor and major tonics, “Todessehnen” (op. 86, no. 6), “Schwermut” (op. 58, no. 5), and “Dämmrung senkte sich von oben” (op. 59, no. 1) stand out for setting poetry that portrays a duality between burdensome life and transcendent death, or darkness versus light. This article explores how Brahms’s paradoxical treatment of the life-versus-death theme (associating death with an escape from suffering and the major mode, as noted in related analyses by ".fn_cite($platt_1992)." and ".fn_cite($suurpaa_2003).") correlates with a “tragic-to-transcendent” expressive genre (".fn_cite($hatten_1994).", 69) and enacts a series of poetic “turning points” (".fn_cite($huhn_2005).") that reflect the protagonist’s changing perception of temporality. I argue that the major mode emerges gradually in each song, first as an “implicit” (or “nascent”) tonic, then as a cadentially confirmed (or “realized”) key at the structural cadence. Close Schenkerian analyses of all songs show that their minor-to-major progressions are neither immediate nor direct. Rather, the songs share four tonal features that facilitate the modal change, enact a shift from “tragic” to “transcendent” expression, and actualize “poetic turning points:” 1) the parallel major emerges as a cadentially unconfirmed, nascent tonic; 2) prolongations of ".fn_flat('')."VI or IV delay a cadence in the parallel major key and convey the speaker’s entrance into new temporalities and perceptions; 3) the structural cadence confirms the major key and lays the modal conflict to rest; and 4) the postlude echoes the minor form of ".fn_scaledegree("6").", as if recalling the protagonist’s earlier struggles. The elevated expression of cadential ".fn_figbass("",64)." chords near the structural cadence—treated in the manner of “arrival six-four” chords (".fn_cite($hatten_1994).", 15)—suggests the actualization of a “transcendent” expression and either a future or intensified present temporality that the poem implies but does not realize.

Two crystallographic forms and the absolute structure of 5α,14α-androstane

5α,14α-Androstane (C19H32) crystallizes in two different polymorphic forms in the same vapor diffusion experiment. The major form (Form I) crystallizes as thin plates in the space group P21, with Z = 4. These plates are twinned along a long c axis of length 43 Å and readily suffer from radiation damage when diffracted. The minor form (Form II) crystallizes as fine needles in the space group P212121, Z = 3. In the minor form, 5α,14α-androstane cocrystallizes with 5α,14α-androstan-17-one, an oxidation product of 5α,14α-androstane. The presence of 5α,14α-androstan-17-one in the minor form of the crystals was confirmed by HR-MS. Form II can be crystallized as a pure form without the ketone impurity using a different solvent system. High level density functional theory (DFT) lattice free energy calculations were performed and show that both pure forms are isoergic within the estimated error of the calculations.

The Redox Potential of the β-93-Cysteine Thiol Group in Human Hemoglobin Estimated from In Vitro Oxidant Challenge Experiments

Glutathionyl hemoglobin is a minor form of hemoglobin with intriguing properties. The measurement of the redox potential of its reactive β-93-Cysteine is useful to improve understanding of the response of erythrocytes to transient and chronic conditions of oxidative stress, where the level of glutathionyl hemoglobin is increased. An independent literature experiment describes the recovery of human erythrocytes exposed to an oxidant burst by measuring glutathione, glutathione disulfide and glutathionyl hemoglobin in a two-hour period. This article calculates a value for the redox potential E0 of the β-93-Cysteine, considering the erythrocyte as a closed system at equilibrium described by the Nernst equation and using the measurements of the literature experiment. The obtained value of E0 of −121 mV at pH 7.4 places hemoglobin as the most oxidizing thiol of the erythrocyte. By using as synthetic indicators of the concentrations the electrochemical potentials of the two main redox pairs in the erythrocytes, those of glutathione–glutathione disulfide and of glutathionyl–hemoglobin, the mechanism of the recovery phase can be hypothesized. Hemoglobin acts as the redox buffer that scavenges oxidized glutathione in the oxidative phase and releases it in the recovery phase, by acting as the substrate of the NAD(P)H-cofactored enzymes.

Pengharapan Baru: Menginterpretasi Ulangan 1:1-8 dengan Pendekatan Kanonis Brevard S. Childs

This paper is an attempt to find out the canonical meaning of the insertion of the text of Deuteronomy 1: 1-8 in the overall framework of Deuteronomy. The method used in this research is canonical hermeneutics developed by Brevard S. Childs, this approach enables the interpreter to see the intent of the editor of the Scriptures in the preparation of text sequences in such a way as to the perspective of the final canon. The canonical analysis shows that Deuteronomy 1: 1-8 is the initial part of the minor form (chapters 1-4) that is deliberately inserted and placed at the front as a close link to the previous book (even the first four books of the holy book) and is both an introduction and legitimacy of authority Deuteronomy even for the whole Deuteronomic History. This text comes from the editor of the exile and gives a message of new hope for the exiled Israeli community.This paper is an attempt to find out the canonical meaning of the insertion of the text of Deuteronomy 1: 1-8 in the overall framework of Deuteronomy. The method used in this research is canonical hermeneutics developed by Brevard S. Childs, this approach enables the interpreter to see the intent of the editor of the Scriptures in the preparation of text sequences in such a way as to the perspective of the final canon. The canonical analysis shows that Deuteronomy 1: 1-8 is the initial part of the minor form (chapters 1-4) that is deliberately inserted and placed at the front as a close link to the previous book (even the first four books of the holy book) and is both an introduction and legitimacy of authority Deuteronomy even for the whole Deuteronomic History. This text comes from the editor of the exile and gives a message of new hope for the exiled Israeli community.

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

Colon mucus segregates the intestinal microbiota from host tissues, but how it organizes to function throughout the colon is unclear. In mice, we found that colon mucus consists of two distinct O-glycosylated entities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including the microbiota, and a minor form derived from the distal colon, which adheres to the major form. The microbiota directs its own encapsulation by inducing Muc2 production from proximal colon goblet cells. In turn, O-glycans on proximal colon–derived Muc2 modulate the structure and function of the microbiota as well as transcription in the colon mucosa. Our work shows how proximal colon control of mucin production is an important element in the regulation of host-microbiota symbiosis.

Glandular and Cystic Bladder Cystitis: Case Report and Review of the Literature

Glandular-cystic bladder cystitis is a rare, benign non-tumor condition, preferentially located on the area of the bladder trigone and can simulate a malignant tumor. It is a benign reactive metaplasia of the bladder submucosa, characterized by hyperplasia of the islets of Von Brunn and cystic. It is classified among reactive epithelial anomalies of the urothelium, such as islet hyperplasia of Von Brünn, cystitis, glandular cystitis, nephrogenic metaplasia and epidermoid metaplasia. It presents a clinical diagnostic challenge having the expression of a simple recurrent cystitis and misleading the radiological diagnosis evoking a malignant tumor of the bladder. Its certainty diagnosis is histological. We report the case of a 38-year-old young man who consulted for recurrent cystitis. The CT scan showed a vegetative tissue structure of the middle and left medial vesical floor, sawtooth 3 cm long axis suspecting a tumor of the bladder. The patient underwent transurethral resection of the bladder lesion. The histological and immunohistochemical examination concluded with glandular and cystic cystitis (minor form). In the light of this observation, we will discuss the diagnostic difficulties, the pathophysiological mechanisms, the radiological aspects, the anatomopathological, therapeutic features and the prognosis of this rare condition. The literature regarding this entity has been reviewed and the differential diagnosis was discussed.

Cleft Lip

Cleft lip is one of the most common congenital anomalies that present to plastic surgeons. Care involves a multidisciplinary approach to address both aesthetic and functional needs. This review covers embryology, epidemiology, classification, and anatomy. It also provides a more in-depth description of treatment for unilateral, bilateral, and minor form clefts. Given the spectrum of presentation and the multiple tissue types involved, the general principles of reconstructive surgery are used as the framework for this review. This review contains 16 figures, 3 tables, and 119 references. Keywords: cheiloplasty, cleft lip, Fisher repair, microform cleft lip, Millard repair, orbicularis muscle, primary rhinoplasty, septoplasty, Tennison-Randall repair

Surgical strategy for patients with late-diagnosed minor form of cleidocranial dysplasia: three cases

Introduction: Cleidocranial dysplasia is a genetic disease affecting bone growth. Observations: 3 patients, aged 12, 14, and 15 followed an orthodontic and surgical treatment to solve an eruption issue of the permanent teeth. Temporary teeth were extracted and impacted teeth were progressively exposed by multiple surgeries under local anesthesia. Anchorages were placed on the teeth and a traction started, on incisors and molars first, then on premolars, and finally on canines. The treatments lasted for 6 to 8 years. Comments: These patients presented minor form of cleidocranial dysplasia which only affected the teeth. The difficulty of these cases lied in the lateness of their diagnosis and treatment. Adaptations had to be made to simplify treatment plans (shortened dental arch, premolar extractions, etc.).