New Robust Projection to Latent Structure

In many actual nonlinear systems, especially near the equilibrium point, linearity is the primary feature and nonlinearity is the secondary feature. For the system that deviates from the equilibrium point, the secondary nonlinearity or local structure feature can also be regarded as the small uncertainty part, just as the nonlinearity can be used to represent the uncertainty of a system (Wang et al. 2019). So this chapter also focuses on how to deal with the nonlinearity in PLS series method, but starts from an different view, i.e., robust PLS. Here the system nonlinearity is considered as uncertainty and a new robust $$\mathrm{L}_1$$ L 1 -PLS is proposed.

Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis

Retinal oxidative stress is a common secondary feature of many retinal diseases. Though it may not be the initial insult, it is a major contributor to the pathogenesis of highly prevalent retinal dystrophic diseases like macular degeneration, diabetic retinopathy, and retinitis pigmentosa. We explored the role of superoxide dismutase 3 (SOD3) in retinal homeostasis since SOD3 protects the extracellular matrix (ECM) from oxidative injury. We show that SOD3 is mainly extracellularly localized and is upregulated as a result of environmental and pathogenic stress. Ablation of SOD3 resulted in reduced functional electroretinographic responses and number of photoreceptors, which is exacerbated with age. By contrast, overexpression showed increased electroretinographic responses and increased number of photoreceptors at young ages, but appears deleterious as the animal ages, as determined from the associated functional decline. Our exploration shows that SOD3 is vital to retinal homeostasis but its levels are tightly regulated. This suggests that SOD3 augmentation to combat oxidative stress during retinal degenerative changes may only be effective in the short-term.

Privatising Property

This chapter describes how the body served to privatise property and to establish the human subject, instead of the natural order, at the centre of the law. Whereas modern science expelled humanity from the world’s centre, a second revolution in the law achieved the opposite. It begat legal modernity and the right to private property that supports capitalism. The site for this revolution was early modern theories of natural rights. The chapter traces the genealogy of the concept of private property, from Hugo Grotius via Samuel von Pufendorf to John Locke, through this tradition and under the lens of the body, underscoring the extent to which they broke from premodern Thomist theories of natural law, whose default mode of property relations were communal. It then shows how Locke deployed the most effective legitimation of capitalism by locating the original mechanism by which property is privatised in ‘the hand that grabs’ – by corporealising it. The chapter then turns to the particular, labouring bodies that were explicitly excluded from Locke’s embodied labour theory of value: slaves. Slavery was not simply a practice Locke was deeply invested in personally, or an embarrassing but secondary feature of his political writings. It was, rather, part and parcel of the constitutive logic by which he articulated a racialised right to private property.

Sensor Systems for FRP Lightweight Structures: Automotive Features Based on Serial Sensor Products

To achieve resource efficiency and an increased performance, as well as a higher safety and more features for vehicles, lightweight composites are a central sphere of activity for automotive innovations. This becomes particularly striking if the focus is not only a reduced vehicle weight but also an efficient overall concept. In addition to compatible material technologies and component design, new electronic solutions are of interest. A research contribution at the Robert Bosch Company deals with the direct integration of a current automotive acceleration sensor in fiber-reinforced polymer (FRP) parts. The sensor is part of the passive vehicle safety. Primarily, the principal application of the currently mounted sensor as an integrated part of the vehicle structure was proven. Sensor-integrated parts were evaluated on their sensing functionality as well as their structural performance. The present research is done to use the integrated sensor for a secondary feature. The study shows that the sensor can also be an indicator for the condition of its surrounding FRP structure. Hence, the sensor integration makes it possible to derive a secondary feature for automobiles by using the current sensor for future functionalized lightweight structures.

Opposite asymmetries of face and trunk and of kissing and hugging, as predicted by the axial twist hypothesis

The contralateral organization of the forebrain and the crossing of the optic nerves in the optic chiasm represent a long-standing conundrum. According to the Axial Twist Hypothesis (ATH) the rostral head and the rest of the body are twisted with respect to each other to form a left-handed half turn. This twist is the result, mainly, of asymmetric, twisted growth in the early embryo. Evolutionary selection tends to restore bilateral symmetry. Since selective pressure will decrease as the organism approaches symmetry, we expected a small control error in the form of a small, residual right-handed twist. We found that the mouth-eyes-nose (rostral head) region shows a left-offset with respect to the ears (posterior head) by up to 0.8° (P < 0.01, Bonferroni-corrected). Moreover, this systematic aurofacial asymmetry was larger in young children (on average up to 3°) and reduced with age. Finally, we predicted and found a right-sided bias for hugging (78%) and a left-sided bias for kissing (69%). Thus, all predictions were confirmed by the data. These results are all in support of the ATH, whereas the pattern of results is not (or only partly) explained by existing alternative theories. As of the present results, the ATH is the first theory for the contralateral forebrain and the optic chiasm whose predictions have been tested empirically. We conclude that humans (and all other vertebrates) are fundamentally asymmetric, both in their anatomy and their behavior. This supports the thesis that the approximate bilateral symmetry of vertebrates is a secondary feature, despite their being bilaterians.

A.04 The classification of autosomal recessive cerebellar ataxias: a consensus statement from the society for research on the cerebellum and ataxias task force

Background: There is currently no accepted classification of recessive cerebellar ataxias, a group of disorders characterized by important genetic heterogeneity and complex phenotypes. The objective of this task force was to build a consensus and develop a clinical and pathophysiological classification for recessive ataxias. Methods: The work of this task force was based on a scoping systematic review of the literature that identified recessive disorders characterized primarily by a cerebellar motor syndrome and cerebellar degeneration. The task force regrouped 12 international ataxia experts who decided on general orientation and specific issues. Results: We identified 59 disorders that are classified as primary recessive ataxias. For each of these disorders, we present geographical and ethnical specificities along with distinctive clinical and imagery features. The primary recessive ataxias were organized in a clinical and a pathophysiological classification, and we present a general clinical approach to the patient presenting with ataxia. We also identified a list of 48 complex multisystem disorders in which ataxia is a secondary feature. Conclusions: This classification is based on a scoping systematic review of the literature and results from a sconsensus among a panel of international experts. It promotes a unified understanding of recessive cerebellar disorders for clinicians and researchers.

Opposite asymmetries of face and trunk and of kissing and hugging, as predicted by the axial twist hypothesis

The contralateral organization of the forebrain and the crossing of the optic nerves in the optic chiasm represent a long-standing conundrum. According to the Axial Twist Hypothesis (ATH) the rostral head and the rest of the body are twisted with respect to each other to form a left-handed half turn. This twist is the result, mainly, of asymmetric, twisted growth in the early embryo. Evolutionary selection tends to restore bilateral symmetry. Since selective pressure will decrease as the organism approaches symmetry, we expected a small control error in the form of a small, residual right-handed twist. We found that the mouth-eyes-nose (rostral head) region shows a left-offset with respect to the ears (posterior head) by up to 0.8° (P<0.01, Bonferroni-corrected). Moreover, this systematic aurofacial asymmetry was larger in young children (on average up to 3°) and reduced with age. Finally, we predicted and found a right-sided bias for hugging (78%) and a left-sided bias for kissing (69%). Thus, all predictions were confirmed by the data. These results are all in support of the ATH, whereas the pattern of results is not explained by existing alternative theories. As of the present results, the ATH is the first theory for the contralateral forebrain and the optic chiasm whose predictions have been tested empirically. We conclude that humans (and all other vertebrates) are fundamentally asymmetric, both in their anatomy and their behavior. This supports the thesis that the approximate bilateral symmetry of vertebrates is a secondary feature, despite their being bilaterians.

Opposite asymmetries of face and trunk and of kissing and hugging, as predicted by the axial twist hypothesis

The contralateral organization of the forebrain and the crossing of the optic nerves in the optic chiasm represent a long-standing conundrum. According to the Axial Twist Hypothesis (ATH) the rostral head and the rest of the body are twisted with respect to each other to form a left-handed half turn. This twist is the result, mainly, of asymmetric, twisted growth in the early embryo. Evolutionary selection tends to restore bilateral symmetry. Since selective pressure will decrease as the organism approaches symmetry, we expected a small control error in the form of a small, residual right-handed twist. We found that the mouth-eyes-nose (rostral head) region shows a left-offset with respect to the ears (posterior head) by up to 0.8° (P<0.01, Bonferroni-corrected). Moreover, this systematic aurofacial asymmetry was larger in young children (on average up to 3°) and reduced with age. Finally, we predicted and found a right-sided bias for hugging (78%) and a left-sided bias for kissing (69%). Thus, all predictions were confirmed by the data. These results are all in support of the ATH, whereas the pattern of results is not explained by existing alternative theories. As of the present results, the ATH is the first theory for the contralateral forebrain and the optic chiasm whose predictions have been tested empirically. We conclude that humans (and all other vertebrates) are fundamentally asymmetric, both in their anatomy and their behavior. This supports the thesis that the approximate bilateral symmetry of vertebrates is a secondary feature, despite their being bilaterians.

EXCURSION AS A METHOD OF COGNITION

A critical analysis of the essence of the excursion was given. It is noted that the available definitions often make focus on the scientific function of the excursion, which actually is not important. It is also not possible to consider excursion as entertainment. This is its secondary feature. A certain change in the essence of excursion occurred as a result of technical progress, which led to some reduction of the role of the tour guide. It is now possible that excursion takes place without him. The excursion is not necessarily a collective event. An individual excursion is possible as well. A new definition of the excursion is given, which corresponds to its true essence: «excursion is a visit to interesting places in order to gain new knowledge and impressions. It is a way of spending free time and a method of getting of knowledge”. Thus, the most important function of the excursion is the getting of a new knowledge, which is a basis of other functions, in particular, educational one. In turn, knowledge is gained through the use of certain scientific methods. Typically, these methods are divided into empirical and theoretical ones, in other words, methods of data collection and methods of their processing. The first group of methods includes observation, measurement, experiment, survey. The most common method in the excursion is observation, which is at the same time an integral part of other, more complicated methods. Numerous examples are given about the use of these methods in excursions, which enrich excursions, activate excursionists. There are also numerous theoretical methods of cognition: description, explanation, comparison, analogy, analysis, synthesis, induction, deduction, systematization, classification, and some others. Among these methods, the most important in the excursion is a description. In many cases, this is the only method used by tour guides. At the same time, the abuse of this method impairs the effectiveness of excursion, in particular, a result of losing the attention of excursionists. Another widely used method is an explanation. The spread of this method and its effectiveness is facilitated by the fact that it gives answers to the questions, which are not entirely clear. Many examples have been shown that excursion involves not only the use of these methods of cognition (both empirical and theoretical), but can itself be considered as such a separate method. The peculiarity of this method is to combine the classical methods of cognition, as well as the essential components of the excursion, namely the movement of excursionists, approaching to the excursion objects, their showing and commenting. All these peculiarities have additional influence on human feelings. It can be used not only by the visual and hearing organs but also by others. This enhances the attention of excursionists and, accordingly, promotes better assimilation of information. As a result, some excursions are remembered for life.