Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model

Accurately identifying epileptogenic zone (EZ) using high-frequency oscillations (HFOs) is a challenge that must be mastered to transfer HFOs into clinical use. We analyzed the ability of a convolutional neural network (CNN) model to distinguish EZ and non-EZ HFOs. Nineteen medically intractable epilepsy patients with good surgical outcomes 2 years after surgery were studied. Five-minute interictal intracranial electroencephalogram epochs of slow-wave sleep were selected randomly. Then 5 s segments of ripples (80–200 Hz) and fast ripples (FRs, 200–500 Hz) were detected automatically. The EZs and non-EZs were identified using the surgery resection range. We innovatively converted all epochs into four types of images using two scales: original waveforms, filtered waveforms, wavelet spectrum images, and smoothed pseudo Wigner–Ville distribution (SPWVD) spectrum images. Two scales were fixed and fitted scales. We then used a CNN model to classify the HFOs into EZ and non-EZ categories. As a result, 7,000 epochs of ripples and 2,000 epochs of FRs were randomly selected from the EZ and non-EZ data for analysis. Our CNN model can distinguish EZ and non-EZ HFOs successfully. Except for original ripple waveforms, the results from CNN models that are trained using fixed-scale images are significantly better than those from models trained using fitted-scale images (p < 0.05). Of the four fixed-scale transformations, the CNN based on the adjusted SPWVD (ASPWVD) produced the best accuracies (80.89 ± 1.43% and 77.85 ± 1.61% for ripples and FRs, respectively, p < 0.05). The CNN using ASPWVD transformation images is an effective deep learning method that can be used to classify EZ and non-EZ HFOs.

China’s environmental miracle

. The article is devoted to the analysis of China’s great breakthrough in the fi eld of environmental protection. In recent years, the country has made enormous efforts to help reduce the anthropogenic impact on the environment: it has become an advanced manufacturer of consumables in the fi eld of "green" energy, has included the environment in the strategic development plan, adjusted the tax system, which has allowed us to achieve great results and consider these large-scale transformations a real miracle, worthy of attention in the aspect of learning from experience.

Test scores’ robustness to scaling: The scale_transformation command

Social scientists frequently rely on the cardinal comparability of test scores to assess achievement gaps between population subgroups and their evolution over time. This approach has been criticized because of the ordinal nature of test scores and the sensitivity of results to order-preserving transformations that are theoretically plausible. Bond and Lang (2013, Review of Economics and Statistics 95: 1468–1479) document the sensitivity of measured ability to scaling choices and develop a method to assess the robustness of changes in ability over time to scaling choices. In this article, I present the scale_transformation command, which expands the Bond and Lang (2013) method to more general cases and optimizes their algorithm to work with large datasets. The command assesses the robustness of an achievement gap between two subgroups to any arbitrary choice of scale by finding bounds for the original gap estimation. Additionally, it finds scale transformations that are very likely and unlikely to benchmark against the results obtained. Finally, it also allows the user to measure how much gap growth coefficients change when including controls in their specifications.

Simple and Rapid Method for Wogonin Preparation and Its Biotransformation

Wogonin is one of the most active flavonoids from Scutellaria baicalensis Georgi (baikal skullcap), widely used in traditional Chinese medicine. It exhibits a broad spectrum of health-promoting and therapeutic activities. Together with baicalein, it is considered to be the one of main active ingredients of Chinese medicines for the management of COVID-19. However, therapeutic use of wogonin may be limited due to low market availability connected with its low content in baikal skullcap and lack of efficient preparative methods for obtaining this compound. Although the amount of wogonin in skullcap root often does not exceed 0.5%, this material is rich in wogonin glucuronide, which may be used as a substrate for wogonin production. In the present study, a rapid, simple, cheap and effective method of wogonin and baicalein preparation, which provides gram quantities of both flavonoids, is proposed. The obtained wogonin was used as a substrate for biotransformation. Thirty-six microorganisms were tested in screening studies. The most efficient were used in enlarged scale transformations to determine metabolism of this xenobiotic. The major phase I metabolism product was 4’-hydroxywogonin—a rare flavonoid which exhibits anticancer activity—whereas phase II metabolism products were glucosides of wogonin. The present studies complement and extend the knowledge on the effect of substitution of A- and B-ring on the regioselective glycosylation of flavonoids catalyzed by microorganisms.

Aggregating Multidimensional Criteria in Audit Decision Making

Measuring total performance of prospective alternatives in decision making (DM) needs aggregation of their noncomparable properties which often have different scales of measure. In order to address this, scale transformations and normalization are applied, but problems of validation of such additive models and interpretation of the physical sense of the result arise. In this paper, a multiplicative performance aggregation of properties' values is suggested for DM. Application of the approach enables consistent and unambiguous ranking of the alternatives allowing values of all their properties of interest. A realistic example of DM related to audit activity planning is considered where several competing control areas should be selected into an audit plan. Beyond audit planning, the approach is generalizable to other DM problems in corporate management and governance where one needs to rank alternatives compared in multiple dimensions.

Historical Research and Directions of French Royal Expansion in 16th — 17th Centuries

In the seventeenth century, the search for the “forgotten” rights of the king were an important aid in organizing French expansion, mainly in the eastern and northeastern directions. At the sovereign courts of Lorraine, Alsace and Franche-Comté “chambers of annexations” (chambres d’annexion) were created in 1680 to organize search for archival documents supporting royal claims to neighboring lands. The idea of creating special institutions engaged in the search for documents revealing the precedents of relations with other countries and forgotten rights, that French king had supposedly enjoyed in those parts, was expressed back during the reign of Henry II. In 1556, Raoul Spifame, a lawyer at the Paris Parliament, published a book consisting of fictitious royal decrees, of which many would be implemented in the future. Among other things he ordered, on behalf of the king, the creation of thirty chambers, each specializing in the search for documents in the “treasury of charters” relating to a particular province. He had determined the composition of these chambers, the procedure for work and the form of reporting, — all this in order to arm the king with knowledge of his forgotten rights and the content of antique treaties and agreements. The nomenclature of “provincial chambers” is especially interesting, from the Chambers of Scotland and England to the Chamber of Tunisia and Africa, as well as the Chamber of Portugal and the New Lands. Much more attention was attracted by those lands to which a century later the French expansion would be directed: Franche-Comté, Artois and Flanders, Lorraine, the Duchy of Cleves. But more than half of chambers specialized in the Italian lands. This is not surprising, since in the 1550s France was entering the climax of the Italian Wars. Under Henry II (1547—1559) one of the four secretaries of state, Jean du Thier, was the person responsible for the southwestern direction of French policy. There is reason to believe that Spifame was associated with du Thier or with other members of the king’s “reform headquarters”. The large-scale transformations already at work were interrupted by the unexpected death of Henry II and the subsequent Wars of Religion. But continuity was inherent in the “spirit of the laws” of the Ancien Régime, so Spifame was able to predict future developments, including the creation of “chambers of annexation”.

Challenges of teaching humanities in innovative educational environment

This article analyzes the issues of implementation of innovations and respective methodology of teaching humanities in universities. The aim of this article is to reveal challenges related with implementation and use of advanced innovative methods of teaching humanities in universities. This work substantiates the concept that modern processes occurring in education are direct consequence of complicated and deep transformations in culture, economy, policy of the World. Adaptation of life to wide-scale transformations is impossible without holistic comprehension of motives, trends and prospects of further social development, including education. The novelty of the work is in development of certain theoretic models of education development, which is rapidly moving away from the differentiation and fragmentation of scientific disciplines, modules and is concentrated on their integration. Another novelty in the existing paradigm of education can be presented by targeting of potential not just on distance methods but on creation of innovative education systems based, for instance, on technologies of virtual reality (VR). This work proves that in VR the educational components or prototypes can be presented by such units as virtual laboratory (workshop), lecture spaces, displaying of considered entities, network educational establishments.

Expanding the boundaries of the social-humanitarian knowledge of the world

The article is a review of the book by T.A. Alekseeva Theory of International Relations as Political Philosophy and Science (Moscow: Aspect Press; 2019). The last decades have been marked by large-scale transformations: the spatial-temporal characteristics of political processes change - political time accelerates, political space shrinks, sequence of the political development stages changes; boundaries between internal and external, center and periphery, material and immaterial blur. Despite the fact that these changes affect both domestic and international policies, the complexity of global political shifts significantly exceeds all internal conflicts. However, understanding of large-scale transformations lags behind the need for their meaningful interpretation. The need to understand the essence of large-scale processes is an inevitable and serious challenge for the management system. Thus, we need a theory of international research that would become a basis for both understanding the essence of changes and predicting the future development. Based on the achievements of foreign and Russian theory of international relations, T.A. Alekseeva presents a detailed conceptualization of this science. In the book, all its essential components are described in detail and combined into a logically consistent system, which brings the theory of international relations to a new level of the theoretical-methodological conceptualization. The authors comprehensive analysis allows to use its results for solving practical problems, in particular, for resolving international crisis situations, implementing large-scale projects of scientific diplomacy, and training a new generation of experts.

Hyperbolic Rules in Genomes, the Harmonic Progression and Recurrence Sequences in Algebraic Biology

The article is devoted to biological models using recurrence sequences, which are connected with the harmonic progression 1, 1/2, …, 1/n, and some cooperative properties of genomes. The harmonic progression is itself one of the recurrence sequences based on the harmonic mean. This progression appears in the hyperbolic rules of oligomer cooperative organization in eukaryotic and prokaryotic genomes. This allows thinking that the harmonic progression is also related to inherited physiological systems, which must be structurally consistent with the genetic coding system for their transmission to descendants and survival in evolution. The harmonic progression is one of historically known mathematical series, whose features were studied by Pythagoras, Leibniz, Newton, Euler, Fourier, Dirichlet, Riemann. It is widely used in many known algorithms and is closely related to some other important mathematical objects, for example, the function of the natural logarithm and harmonic numbers. Accordingly, the article describes the possibilities of using these interrelated mathematical objects to model biological structures, including logarithmic spirals and some other. Modeling inherited spiral configurations seems to be a particularly urgent task, since they are extremely common at all levels of organization of living bodies and, according to Goethe, are lines of life. The principle of a recurrence similarity, that is a special similarity of parts and transformations presented in recurrence sequences of numbers and matrix operators (the scale similarity and scale transformations are only particular cases of such similarity), is considered as one of the key principles of structural organization of living bodies.