Probing tricarbocyanine dyes for targeted delivery of anthracyclines

Heptamethine carbocyanine dyes possess bright fluorescence in the near IR range and affinity to cancer cells. Thus, these dyes could be utilized as fluorescent labels and vectors for drug delivery in their covalent conjugates with cytotoxic compounds. In this work we synthesized four drug-dye conjugates of tricarbocyanine dyes with anthracycline drug daunorubicin using a CuAAC reaction. Conjugates with hydrophobic dyes possess submicromolar cytotoxicity. Fluorescent imaging revealed significant accumulation of the conjugates in mitochondria, suggesting an enhancement of an additional mechanism of anthracycline cytotoxicity – generation of ROS. The hypothesis was supported by significant reduction of activity of the conjugates in presence of an antioxidant compound.

High-speed format 1000BASE-SX / LX transmission through the atmosphere by vortex beams near IR range with help modified SFP-transmers DEM-310GT

The possibility of constructing a near-infrared atmospheric optical communication system based on a pair of media converters of a signal format 100Base-TX / 1000BASE-T to format 1000BASE-SX / LX with SFP transceivers DEM-310GT was experimentally investigated. The FAN-OUT TUBING FTB900 SN-Y4 fiber cable connector, coming from the receiving radiation collimator for matching with the DEM-310GT transceiver, was modified. The transmitting radiation collimator is supplemented by a spiral phase plate to form a vortex beam. The influence of atmospheric influence on the data rate is analyzed.

Люминесценция Pd и Pt бензогидропорфиразинов в ближнем ИК диапазоне

Phosphorescence in the near-IR range under stationary lamp excitation was studied of three palladium and three platinum complexes of benzocondensed hydroporphyrazine phthalocyanine analogues in which molecule one or two isoindole fragments are replaced by a hydrogenated pyrrole ring, giving macrocycles of photosynthetic pigments analogues of chlorin, bacteriochlorin and isobacteriochlorin types. For the first time, the phosphorescence spectra of trans-dibenzotetrahydroporphyrazines (for both platinum and palladium) have been registered, which detection failed during long time due to the record removal of 0-0 bands from the visible area (1.67 and 1.52 µm for Pd and Pt), and also because of the small quantum yield of phosphorescence. The fluorescence of these complexes was also detected.in the near-IR range. On the basis of comparison of experimental results with own and literature data for palladium complexes of a number of tetrapyrroles is shown the approximate additivity of the influence of structural factors — hydrogenation of pyrrole rings, aza- and benzo substitution — on the energy of the lower triplet state T1. The information obtained is essential for targeted creation of emitters in the near-IR range (1.0-1.7 µm).