scholarly journals Secondary Metabolites from Marine-Derived Fungi and Actinobacteria as Potential Sources of Novel Colorectal Cancer Drugs

Marine Drugs ◽  
2022 ◽  
Vol 20 (1) ◽  
pp. 67
Author(s):  
Elin Julianti ◽  
Ikram Ammar Abrian ◽  
Marlia Singgih Wibowo ◽  
Muhammad Azhari ◽  
Nadya Tsurayya ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Secondary Metabolites ◽  
Marine Fungi ◽  
Indole Alkaloids ◽  
Cytotoxic Agents ◽  
Chemical Structures ◽  
Colorectal Cancer Cell Lines ◽  
The World ◽  
Aspergillus Sp

Colorectal cancer is one of the most common cancers diagnosed in the world. Chemotheraphy is one of the most common methods used for the pharmacological treatment of this cancer patients. Nevertheless, the adverse effect of chemotherapy is not optimized for improving the quality of life of people who are older, who are the most vulnerable subpopulation. This review presents recent updates regarding secondary metabolites derived from marine fungi and actinobacteria as novel alternatives for cytotoxic agents against colorectal cancer cell lines HCT116, HT29, HCT15, RKO, Caco-2, and SW480. The observed marine-derived fungi were from the species Aspergillus sp., Penicillium sp., Neosartorya sp., Dichotomomyces sp., Paradendryphiella sp., and Westerdykella sp. Additionally, Streptomyces sp. and Nocardiopsis sp. are actinobacteria discussed in this study. Seventy one compounds reviewed in this study were grouped on the basis of their chemical structures. Indole alkaloids and diketopiperazines made up most compounds with higher potencies when compared with other groups. The potency of indole alkaloids and diketopiperazines was most probably due to halogen-based functional groups and sulfide groups, respectively.

scholarly journals Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3227
Author(s):  
Yuanwei Liu ◽  
Kishneth Palaniveloo ◽  
Siti Aisyah Alias ◽  
Jaya Seelan Sathiya Seelan
Keyword(s):  
Secondary Metabolites ◽  
Soft Coral ◽  
Marine Fungi ◽  
Indole Alkaloids ◽  
Structural Diversity ◽  
Future Research ◽  
Soft Corals ◽  
Diverse Range ◽  
Symbiotic Relationships ◽  
Bioactive Secondary Metabolites

Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, which produce chemically diverse, bioactive secondary metabolites as part of their symbiotic nature with the soft coral hosts. The most prolific groups of compounds are terpenoids and indole alkaloids. Annually, there are more bio-active compounds being isolated and characterised. Thus, the importance of the metabolite compilation is very much important for future reference. This paper compiles the diversity of Sarcophyton species and metabolites produced by their associated marine fungi, as well as the bioactivity of these identified compounds. A total of 88 metabolites of structural diversity are highlighted, indicating the huge potential these symbiotic relationships hold for future research.

scholarly journals Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 417
Author(s):  
Marlou-Floor Kenkhuis ◽  
Floortje Mols ◽  
Eline H. van Roekel ◽  
José J. L. Breedveld-Peters ◽  
Stéphanie O. Breukink ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Research ◽  
Post Treatment ◽  
Research Fund ◽  
American Institute ◽  
The World ◽  
Lifestyle Recommendations ◽  
Longitudinal Associations

Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.

scholarly journals Natural Indole Alkaloids from Marine Fungi: Chemical Diversity and Biological Activities

2021 ◽  
Author(s):  
Jiao Li ◽  
Chun-Lin Zhuang
Keyword(s):  
Marine Fungi ◽  
Biological Activities ◽  
Indole Alkaloids ◽  
Structural Diversity ◽  
Heterocyclic Ring ◽  
Chemical Diversity ◽  
Pharmaceutical Development ◽  
Chemical Structures ◽  
Clinical Drugs ◽  
Unique Chemical

The indole scaffold is one of the most important heterocyclic ring systems for pharmaceutical development, and serves as an active moiety in several clinical drugs. Fungi derived from marine origin are more liable to produce novel indole-containing natural products due to their extreme living environments. The indole alkaloids from marine fungi have drawn considerable attention for their unique chemical structures and significant biological activities. This review attempts to provide a summary of the structural diversity of marine fungal indole alkaloids including prenylated indoles, diketopiperazine indoles, bisindoles or trisindoles, quinazoline-containing indoles, indole-diterpenoids, and other indoles, as well as their known biological activities, mainly focusing on cytotoxic, kinase inhibitory, antiinflammatory, antimicrobial, anti-insecticidal, and brine shrimp lethal effects. A total of 306 indole alkaloids from marine fungi have been summarized, covering the references published from 1995 to early 2021, expecting to be beneficial for drug discovery in the future.

scholarly journals Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2774
Author(s):  
Mohamed M. Radwan ◽  
Suman Chandra ◽  
Shahbaz Gul ◽  
Mahmoud A. ElSohly
Keyword(s):  
Phenolic Compounds ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Cannabis Sativa ◽  
Complex Mixture ◽  
Isolation And Identification ◽  
Early 19Th Century ◽  
Chemical Structures ◽  
The World ◽  
Methods Of Isolation

Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents. More than 500 compounds have been reported from C. sativa, of which 125 cannabinoids have been isolated and/or identified as cannabinoids. Cannabinoids are C21 terpeno-phenolic compounds specific to Cannabis. The non-cannabinoid constituents include: non-cannabinoid phenols, flavonoids, terpenes, alkaloids and others. This review discusses the chemistry of the cannabinoids and major non-cannabinoid constituents (terpenes, non-cannabinoid phenolics, and alkaloids) with special emphasis on their chemical structures, methods of isolation, and identification.

scholarly journals Marine Fungi: the missing tile in the Ocean Biodiversity mosaic

2018 ◽  
Author(s):  
Giovanna Cristina Varese ◽  
Elena Bovio ◽  
Laura Garzoli ◽  
Giorgio Gnavi ◽  
Anna Poli ◽  
...  
Keyword(s):  
Climate Change ◽  
Secondary Metabolites ◽  
Mediterranean Sea ◽  
Marine Environment ◽  
Marine Fungi ◽  
Biodiversity Hotspot ◽  
Marine Organisms ◽  
Specific Host ◽  
The World

In recent years, the Mycotheca Universitatis Taurinensis (MUT) carried out several research programs aiming to assess the marine fungal biodiversity mainly in the Mediterranean Sea, a biodiversity hotspot in the world. Several biotic and abiotic marine substrates,, were investigated: algae, seagrasses, invertebrates, wood, water and sediments from natural and anthropic sites. The isolated fungi cover all fungal groups, despite taxa belonging to Ascomycetes are predominant. Our results show how marine fungi are ubiquitous in the oceans and play key roles in several niches despite often neglected. Preliminary studies show that, in marine ecosystems as in the terrestrial one, some taxa are ubiquitary while others are specific and closely related to a specific host or substrate. The distribution of the mycobiota in the marine environment is far from being fully described. It is therefore difficult to understand how marine fungi can respond to climate change and/or interact with other marine organisms. To date, marine fungi have been studied principally for the production of secondary metabolites. Despite they shown to be an untapped source of novel molecules of biotechnological importance, almost unknown remains the role of these metabolites in interactions with other organisms that populate the Ocean.

scholarly journals Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 4032
Author(s):  
Solomon Tesfaye ◽  
Kaleab Asres ◽  
Ermias Lulekal ◽  
Yonatan Alebachew ◽  
Eyael Tewelde ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Cytotoxic Agents ◽  
Future Perspective ◽  
The World ◽  
Drug Discovery Program ◽  
Phytochemical Constituents ◽  
Anticancer Drug Discovery

This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.

Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology

2019 ◽  
Vol 19 (9) ◽  
pp. 751-761 ◽  
Author(s):  
Jignesh Lunagariya ◽  
Poonam Bhadja ◽  
Shenghui Zhong ◽  
Rohit Vekariya ◽  
Shihai Xu
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Indole Alkaloids ◽  
Indole Alkaloid ◽  
Marine Natural Product ◽  
Marine Resources ◽  
Chronological Order ◽  
Biological Targets ◽  
Chemical Agents ◽  
The World

Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates for diverse biological targets. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin which has been isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, was tested for several therapeutic potentials such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti- larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activities as well as a means of other chemical agents. Herein, we summarized the discovery and isolation of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects. Additionally, synthesis of caulerpin and its functional analogues have also been reviewed.

scholarly journals Information design for bowel cancer detection

2019 ◽  
Vol 25 (2) ◽  
pp. 125-156
Author(s):  
Maria dos Santos Lonsdale ◽  
Li-Chin Ni ◽  
Chenyi Gu ◽  
Maureen Twiddy
Keyword(s):  
Colorectal Cancer ◽  
Cancer Detection ◽  
Bowel Preparation ◽  
Bowel Cancer ◽  
Information Design ◽  
User Performance ◽  
Motion Graphics ◽  
The World ◽  
Health Related

Abstract Colorectal cancer is one of the most commonly occurring cancers in the world, and colonoscopy is the most sensitive procedure to detect it. Colonoscopy success depends on the quality of bowel preparation, yet the way information is designed and communicated to patients does not meet their needs. By considering how information is conveyed through three different outputs (booklet, motion graphics and app), this study investigates the advantages of using visualised information when communicating bowel preparation instructions for colonoscopy screening. A user-centered multiple-methods approach was followed and results show how user performance benefits from the use of information visualisation. A set of guidelines is given to inform the development of bowel preparation instructions and other similar health related communications.

scholarly journals Marine Fungi: the missing tile in the Ocean Biodiversity mosaic

2018 ◽  
Author(s):  
Giovanna Cristina Varese ◽  
Elena Bovio ◽  
Laura Garzoli ◽  
Giorgio Gnavi ◽  
Anna Poli ◽  
...  
Keyword(s):  
Climate Change ◽  
Secondary Metabolites ◽  
Mediterranean Sea ◽  
Marine Environment ◽  
Marine Fungi ◽  
Biodiversity Hotspot ◽  
Marine Organisms ◽  
Specific Host ◽  
The World

In recent years, the Mycotheca Universitatis Taurinensis (MUT) carried out several research programs aiming to assess the marine fungal biodiversity mainly in the Mediterranean Sea, a biodiversity hotspot in the world. Several biotic and abiotic marine substrates,, were investigated: algae, seagrasses, invertebrates, wood, water and sediments from natural and anthropic sites. The isolated fungi cover all fungal groups, despite taxa belonging to Ascomycetes are predominant. Our results show how marine fungi are ubiquitous in the oceans and play key roles in several niches despite often neglected. Preliminary studies show that, in marine ecosystems as in the terrestrial one, some taxa are ubiquitary while others are specific and closely related to a specific host or substrate. The distribution of the mycobiota in the marine environment is far from being fully described. It is therefore difficult to understand how marine fungi can respond to climate change and/or interact with other marine organisms. To date, marine fungi have been studied principally for the production of secondary metabolites. Despite they shown to be an untapped source of novel molecules of biotechnological importance, almost unknown remains the role of these metabolites in interactions with other organisms that populate the Ocean.

Search for anti-dengue secondary metabolites from two Diospyros endophytes, Aspergillus sp. and Phomopsis sp

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
LA Peyrat ◽  
V Eparvier ◽  
C Eydoux ◽  
JC Guillemot ◽  
D Stien ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Aspergillus Sp
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