Regulation of Apelin-13 on Bcl-2 and Caspase-3 and Its Effects on Adipocyte Apoptosis

Objective. The effects of apelin-13 on the expression of Bcl-2 and caspase-3 factors and the apoptosis of adipocytes were studied at the cellular and animal levels. Methods. 3T3-L1 preadipocytes were cultured and grouped. The third-generation cells were added to the control DMSO solvent and amidation-modified apelin-13. The expression of Bcl-2 and caspase-3 were detected. The cell growth viability and cell apoptosis were detected. DOI model rats were established. The effects of apelin-13 on DOI rat biochemical indicators, the expression of Bcl-2, caspase-3, and cell apoptosis were investigated by injecting amidation-modified apelin-13 through the tail vein. Result. In in vitro experiments, amidation-modified apelin-13 can significantly reduce the growth viability of adipocytes and the expression of Bcl-2, increase the expression of caspase-3, and promote the apoptosis of adipocytes. Animal experiments also show that apelin-13 modified by amidation can adjust the abnormal biochemical indicators of DOI rats, decrease the expression of Bcl-2 in adipose tissue, increase the expression of caspase-3, and promote the apoptosis of adipocytes. Conclusion. Amidation of apelin-13 can promote fat cell apoptosis and reduce the incidence of obesity. The mechanism may be accomplished by inhibiting Bcl-2 and caspase-3 factors. This study helps us understand the effect of apelin-13 on fat cell apoptosis and hopes to provide a basis for the development of antiobesity drugs.

Diffusion of innovations: a guiding framework for public health

Exploring the behavior change process has been of interest and importance to public health professionals, to translate research into practice. Diffusion of innovations (DOI) model has been extensively applied in public health to examine the process by which innovation is passively communicated to individuals and groups. It builds on a staged model of awareness, persuasion, decision, implementation, and confirmation; and categorizes communities into innovators (2.5%), early adopters (13.5%), early majority (34%), late majority (34%) and laggards (16%). It reflects on the diversity of strategies to be applied for different cadres of the society to bring about a wholistic change. Nonetheless, DOI suffers from ‘pro-innovation’ and ‘individual blame’ bias, as it fails to account for the influence of societal, cultural, and extraneous factors affecting individual behavior change. The social networks theory (SNT) in contrast, explains behavior change based on social networks and their influences. It builds on the constructs of homophily, centralization, reciprocity, transitivity, and density; and fills the void in the DOI model. We suggest public health professionals to combine the constructs of DOI and SNT in rolling out behavior change interventions, to yield a comprehensive approach.

Diffusion Theory in Integrative Approaches

Diffusion is the process through which new ideas, technologies, products, or processes are spread through communication among members of a social system via communication channels over time. Diffusion is a specialized form of communication that focuses on disseminating information about new ideas, products, technologies, services, or regulations. It is an especially important form of communication because it promotes social progress in the evaluation and adoption of important new ideas to address social issues. Diffusion helps to reduce uncertainty about how to address difficult issues and provides direction for achieving social goals. A large body of research has been conducted from many disciplines on the diffusion of innovations since the original publication of Everett M. Rogers’ seminal book The Diffusion of Innovations in 1962, which is now in its fifth edition (2003). In this book, he introduced the Diffusion of Innovations (DOI) model, which describes a general process of adopting new ideas across multiple populations, cultures, and applications. This research has examined innovations in fields such as agriculture, engineering, sales, education, architecture, technology, public policy, and health care, and has been applied to a range of different issues, such as the adoption of new technologies, consumer purchasing behaviors, and public support for political issues and candidates, but has been especially influential in guiding strategic health promotion. The DOI model has contributed to a greater understanding of health behavior change, including adoption of health promotion recommendations. The model has led to a broad scope of practical applications for promoting public health.

DOI of Local Information Service Database Based on CALIS-Standard

The unstable linking of network and difficult finding on internet make information resources lacking of durability so the sharing of digital information resource and the location management has become the key research of the serving of information resources. The paper puts forward CALIS-DOI model fitting the requirements of local information service database construction by analyzing application situation of DOI in building local information resources services and fully considering the functions of CALIS in building of local information resources service. The model will be put into the local information resource serving systems and serve for digital location and information transmit.

ON THE DOI MODEL FOR THE SUSPENSIONS OF ROD-LIKE MOLECULES IN COMPRESSIBLE FLUIDS

Polymeric fluids arise in many practical applications in biotechnology, medicine, chemistry, industrial processes, and atmospheric sciences. In this paper, the Doi model for the suspensions of rod-like molecules in a compressible fluid is investigated. The model under consideration describes the interaction between the orientation of rod-like polymer molecules on the microscopic scale and the macroscopic properties of the fluid in which these molecules are contained. Prescribing arbitrarily the initial density of the fluid, the initial velocity, and the initial orientation distribution in suitable spaces, we establish the global-in-time existence of a weak solution to our model defined on a bounded domain in the three-dimensional space. The proof relies on the construction of an approximate sequence of solutions by introducing appropriate regularization and the establishment of compactness.

The General Embedded Kernel Simulation System Model

According to in-depth study of embedded system architecture and working principles, this paper proposes an embedded kernel simulation system model – Device Operation Interface (DOI) model based in the computer simulation theory. Furthermore, an embedded 8051 simulated kernel is designed and developed based on this model. The 8051 simulation system achieves loading, compiling and linking the C language source file, simulates the process of 8051 command execution and displays the results through interfaces. The DOI model contributes to the reuse in different experimental simulation platforms