Primary Autoimmune Hemolytic Anemia Due To Warm Reactive Autoantibodies: A Rare Case Report

Autoimmune hemolytic anemia (AIHA) is an acquired form of hemolytic anemia in which autoantibodies target red blood cell (RBC) membrane antigens, inducing cell rupture (lysis). It affects both pediatric and adult populations, although its presentation in childhood is relatively rare, with the annual incidence estimated to be approximately 0.8 per 100,000 individuals under 18 years old [3]. Here we report one such a rare case of autoimmune hemolytic anemia due to primary warm reactive autoantibodies in a 3 year old female child. As there was presence of hemolysis in peripheral blood smear & other investigations also, Direct coomb’s test was done & it came out to be positive which was suggestive of autoimmune hemolytic anemia, as following lab reports are suggestive of continuous destruction of RBC & after introduction of steroids parameters of hemolysis came out to be normal suggestive of warm reactive autoantibodies type of AIHA. Clinically also patient improved & her urine colour also became normal after when prednisolone started. Patient also did not have any features of secondary causes of warm autoantibody like Systemic lupus erythematous, immunodeficiency disorders, ulcerative colitis & lymphoproliferative disorders so it was considered primary or idiopathic. W-AIHA tends to have a chronic course and is not expected to subside without treatment. It can be a fatal disease, with a mortality rate of up to 4% in children, either because of the acuity of the presentation or because of being refractory to treatment and requiring multiple lines of therapy with frequently associated toxicity [14]. Fortunately our patient responded to steroid therapy.

Non/Living Queerings, Undoing Certainties, and Braiding Vulnerabilities: A Collective Reflection

The ongoing global pandemic of Covid-19 has exposed SARS-CoV-2 as a potent non-human actant that resists the joint scientific, public health and socio-political efforts to contain and understand both the virus and the illness. Yet, such a narrative appears to conceal more than it reveals. The seeming agentiality of the novel coronavirus is itself but one manifestation of the continuous destruction of biodiversity, climate change, socio-economic inequalities, neocolonialism, overconsumption and the anthropogenic degradation of nature. Furthermore, focusing on the virus – an entity that holds an ambiguous status between the ‘living’ and ‘non-living’ – brings into question the issue of the agentiality of non/living matter. While the story of viral potency seems to get centre stage, overshadowing the complex and perverse entanglement of processes and phenomena which activated these potentials in the first place, the Covid-19 pandemic also becomes a prism that sheds light on the issues of environmental violence; social and environmental injustices; more-than-human agentiality; and ethico-political responses that the present situation may mobilise. This article serves as a written record of joint conversations between artists and researchers in the working group ‘Non/Living Queerings’ that formed part of the online series of events ‘Braiding Friction’ organised by the research project Biofriction. The article strives to capture the collective effort of braiding and weaving a variety of situated perspectives, theoretical toolboxes, knowledges and experiences against the background of the ongoing Covid-19 pandemic. In particular, the text focuses on the issues of crisis, ‘amplification effect’, viral agency and the changing notions of humanity.

Modeling of the effect of a high-pressure jet of cement mortar on the surrounding soil environment when performing jet grouting columns using jet technology

The main idea of jet grouting technology is the implementation of processes aimed at changing the characteristics of soils, creating materials with the necessary properties on their basis and forming underground elements with specified parameters from these materials. The high pressure of the cement mortar jet leads to soil blending and its continuous destruction within the radius of impact of the jet. According to some authors, the jet outside the destructive radius does not affect the surrounding soil environment. In compliance with practical studies performed at construction sites in Kyiv, Ukraine, the data on changes in the physical and mechanical characteristics of the soil surrounding the soil-cement column were obtained. This fact led to a more detailed study of the effect of a high-pressure jet on the surrounding soil during the execution of columns using jet technology.

Correlation in Size of Right Lobe and Caudate Lobe of Liver in Normal and Chronic Liver Disease Patients' By Using Ultrasonography

Chronic liver disease in the clinical aspect is a disorder process of the liver. It involves the changes of continuous destruction and regeneration of the liver parenchyma progressing to fibrosis and cirrhosis.

COMPETING HERITAGE: CURATING THE POST-CONFLICT HERITAGE OF ROMAN SYRIA

Since the beginning of the armed conflicts and public uprisings that accompanied and followed the ‘Arab Spring’ that started in 2010, cultural heritage sites have been hit hard, damaged and often destroyed by different perpetrators. The Syrian Civil War has resulted in unprecedented damage to cultural heritage sites, monuments, and facilities. This has provoked observers, politicians, and international and national non-government organizations to debate about the impacts of damaging Syria's ‘irreplaceable’ patrimony and how to safeguard its past from the ongoing destructive actions. This paper investigates the transformation of the terminology of heritage—and the uses of heritage—in Syria before and during the ongoing conflict, and how the internationally renowned term ‘heritage’ emerged to promote the destruction of Syria's cultural patrimony. This paper explores the semantics and impacts of the continuous destruction and the ongoing reconstruction plans on the cultural heritage of Syria. To conclude, I argue that those destructive actions started a process of ‘heritagizing’ the present which will eventually become a part of the Syrian collective memory.

Investigating the effectiveness of advertising on declining social networks

In this paper we aim to investigate the question if it’s worth it to advertise on declining social networks or not. Our investigations are based on computer simulations using a previously defined and here simplified model of information spreading. To make our results as close to the real life as possible we run simulations both on a real network sample and on several generated networks representing as well classical scale-free-like social topologies as declining social networks. As a result we found how the continuous destruction of the network affects the spreading, changing also the effectiveness of the advertising.

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

Reactive oxygen species are involved in the aging process and diseases. Despite the important role of Cu/Zn SOD (superoxide dismutase) encoded by SOD1, SOD1−/− mice appear to grow normally under conventional breeding conditions. In the present paper we report on a novel finding showing a distinct connection between oxidative stress in erythrocytes and the production of autoantibodies against erythrocytes in SOD1−/− mice. Evidence is presented to show that SOD1 is primarily required for maintaining erythrocyte lifespan by suppressing oxidative stress. A SOD1 deficiency led to an increased erythrocyte vulnerability by the oxidative modification of proteins and lipids, resulting in anaemia and compensatory activation of erythropoiesis. The continuous destruction of oxidized erythrocytes appears to induce the formation of autoantibodies against certain erythrocyte components, e.g. carbonic anhydrase II, and the immune complex is deposited in the glomeruli. The administration of an antioxidant, N-acetylcysteine, suppressed erythrocyte oxidation, ameliorated the anaemia, and inhibited the production of autoantibodies. These data imply that a high level of oxidative stress in erythrocytes increases the production of autoantibodies, possibly leading to an autoimmune response, and that the intake of antioxidants would prevent certain autoimmune responses by maintaining an appropriate redox balance in erythrocytes.